CN-117695315-B - Application of fir oil in preparing medicine for promoting hair growth and relieving alopecia

Abstract

The invention provides an application of fir oil in preparing a medicament for promoting hair growth and relieving alopecia, belonging to the technical field of application of fir oil. According to the invention, the research shows that the fir oil can promote the hair growth of normal hair removal and damaged hair removal mice, is safe to use, can be singly used or matched with traditional Chinese medicinal materials or chemical medicines with hair growth effects, is used for treating alopecia areata, seborrheic alopecia, chemotherapy alopecia, senile alopecia or chronic telogen alopecia, and meets the demands of people on anti-alopecia products.

Inventors

• Yu Haiqian
• HUANG YIHAI
• Hu Yangye
• WANG HENGBIN
• PAN YAOZONG
• WU HAO
• MENG XIANGJIE
• WU YI

Assignees

• 雷允上药业集团有限公司

Dates

Publication Date

20260512

Application Date

20231117

Priority Date

20230817

Claims (12)

1. 1. The application of the fir wood oil in preparing the medicine for promoting hair growth and relieving hair loss is characterized by comprising, by weight, 18-70% of alpha-cedrol, 1-25% of alpha-cedrene, 0-11% of beta-cedrene, 0-5% of alpha-pinene and 1-5% of thuja.
2. 2. The use according to claim 1, wherein the alopecia is alopecia areata, seborrheic alopecia, chemotherapeutical alopecia, senile alopecia or chronic telogen alopecia.
3. 3. The use according to claim 1, wherein the fir wood oil is prepared from fir wood, the preparation method comprising the steps of: Pulverizing stem, root and trunk of fir, and extracting with supercritical CO 2 under the assistance of microwave to obtain fir oil.
4. 4. Use according to claim 3, wherein the crushed particle size is 3-50mm.
5. 5. Use according to claim 3, wherein the extraction temperature is 30-45 ℃, the CO 2 temperature is 25-75 ℃, the CO 2 flow rate is 1-10L/h, the extraction pressure is 15-55Mpa, and the extraction time is 1-8h.
6. 6. The use according to claim 3, wherein the supercritical CO 2 extraction is performed by heating with microwaves and intermittently starting the microwaves and maintaining the temperature.
7. 7. The use according to claim 1, wherein said fir wood oil is used alone or in combination with a hair-growing herb or chemical.
8. 8. The use according to claim 7, wherein the chinese herbal medicine is ginger.
9. 9. The use according to claim 7, wherein the chemoattractant is minoxidil.
10. 10. The use according to claim 1, wherein the fir oil is formulated with a pharmaceutically acceptable carrier into an external or oral formulation.
11. 11. The use according to claim 10, wherein the external preparation is any one of a shampoo, a hair rinse, a conditioner, a lotion, an essence, an ointment, a gel, a patch, a tincture or a spray, and the oral preparation is any one of a tablet, a capsule, a granule, a pill or an oral liquid.
12. 12. The use according to claim 10, wherein the pharmaceutically acceptable carrier is at least one of a filler, binder, disintegrant, lubricant, solubilizer, permeation enhancer, suspending agent, wetting agent, pigment, essence, solvent, surfactant or flavoring agent.

Description

Application of fir oil in preparing medicine for promoting hair growth and relieving alopecia The present application relies on and claims priority from chinese patent application 202311036678.0 filed on 8/17 of 2023, which is incorporated herein by reference in its entirety. Technical Field The invention relates to the technical field of application of fir oil, in particular to application of fir oil in preparing a medicament for promoting hair growth and relieving alopecia. Background Hair loss, which occurs in the head and is also known as alopecia or hair loss, can also occur in any part of the body and is an aesthetic problem of concern to the general public. Common head hair loss types and causes are androgenic alopecia, alopecia areata, systemic diseases (such as cutaneous lupus erythematosus and hormone-related diseases), drugs (chemotherapeutics), infections (such as fungal infections), somatic stresses (such as hyperpyrexia, surgery, major diseases, sudden weight loss, pregnancy), psychological stress, skin injuries (such as wounds), and the like. Targeted treatments may be performed according to the cause of hair loss, and common treatments include drug treatments such as minoxidil, finasteride, surgical treatments such as hair transplantation, and the like. However, minoxidil, a finasteride drug, has very remarkable side effects, finasteride has a potential risk of external genital deformity in the male fetus and is therefore forbidden in childbirth or pregnant women, minoxidil has a short effect, and several adverse reactions such as itching, dermatitis, etc. have been reported. And the operation treatment cost is high, and the maintenance compliance rate of postoperative patients is low. The traditional Chinese medicine has strong adaptability, less side effects, easy acquisition and low cost, and researches prove that a plurality of traditional Chinese medicines have the effects of preventing alopecia and promoting hair growth. For example, patent CN111603495A discloses a solution of ligusticum chuanxiong plant extract and its application in preparing hair growth promoting medicine, and the ligusticum chuanxiong plant extract is selected for hair growth research, specifically can promote proliferation of human dermal papilla cells, can increase hair follicle cell number, promote hair follicle growth, and increase hair growth length, and has hair growth promoting effect. For another example, patent CN101628047a discloses a traditional Chinese medicine for treating alopecia, which mainly comprises fresh gardenia, fresh walnut and fresh arborvitae twig, specifically, the fresh gardenia, fresh walnut, fresh arborvitae twig and winter snow water are mashed into mud, then soaked in winter snow water for two hours and then the hair is combed, and the hair is continuously washed for 10 days, and clinical use proves that the traditional Chinese medicine can be used for 10 days, so that symptoms can be relieved when the traditional Chinese medicine is used, and abnormal alopecia can be prevented after the traditional Chinese medicine is used. Fir oil is obtained from stem, branch, core, bark, root, etc. of fir Cunninghamia lanceolata (lamb.) Hook of Cunninghamiae Lanceolatae, and can be extracted by steam extraction, dry distillation, supercritical extraction, etc. to obtain yellow semitransparent oily liquid. Representative components of fir oil include alpha-pinene, alpha-cypress, beta-cypress, thunberg, cypress brain. At present, fir oil is mainly used for flavoring, but at present, the fir oil is not used for preventing alopecia and promoting hair regeneration, and has the effects of suspending hair loss and promoting hair regeneration, and has low side effect and good development prospect and commercial value. The invention provides basis for developing safe, efficient and low-cost hair-growing medicines and products. Disclosure of Invention Aiming at the defects of the prior art, the invention provides the application of fir oil in preparing the medicines for promoting the hair growth and relieving the alopecia, and aiming at the crowds such as alopecia areata, seborrheic alopecia, chemotherapy alopecia, senile alopecia, chronic telogen alopecia and the like, the fir oil has the effects of preventing the hair loss and promoting the hair regeneration, has low side effect and has better development prospect and commercial value. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: The application of fir wood oil in preparing medicine for promoting hair growth and relieving alopecia is disclosed, wherein the alopecia is alopecia areata, seborrheic alopecia, chemotherapy alopecia, senile alopecia, and chronic telogen alopecia. Further, the fir oil is prepared from fir by a conventional extraction and separation method. Preferably, the extraction method includes, but is not limited to, steam extraction, retorting or supercritical CO 2 extraction, and the