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CN-117695347-B - Traditional Chinese medicine composition and application thereof in preparation of fungi inhibiting medicines

CN117695347BCN 117695347 BCN117695347 BCN 117695347BCN-117695347-B

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and application thereof in preparing medicines for inhibiting fungi. The composition provided by the invention comprises rhizoma dioscoreae, fructus cnidii, bistort rhizome, yam rhizome, murraya paniculata, dioscorea nipponica, tuber fleeceflower stem and fructus terminaliae, has the effect of inhibiting the growth of superficial dermatophytes (trichophyton rubrum, candida albicans and the like), is beneficial to reducing the generation of superficial dermatophyte infection, and has the potential of being developed into medicaments for treating the superficial dermatophyte infection.

Inventors

  • XIE LAN
  • ZHAO SHAN
  • CHENG JING

Assignees

  • 博奥生物集团有限公司
  • 清华大学

Dates

Publication Date
20260505
Application Date
20231219

Claims (7)

  1. 1. The traditional Chinese medicine composition for inhibiting trichophyton rubrum and/or candida albicans is characterized by being prepared from rhizoma dioscoreae, fructus cnidii, bistort rhizome, ningpo Yam rhizome, murraya paniculata, yellow yam, caulis polygoni multiflori and fructus Terminaliae Billericae, wherein the mass ratio of the rhizoma dioscoreae to the fructus cnidii, the bistort rhizome, the Ningpo Yam rhizome, the Murraya paniculata, the yellow yam, the caulis polygoni multiflori and the fructus Terminaliae Billericae is (10-20), 8-15, 10-15, 9-12, 12-20, 9-12.
  2. 2. The Chinese medicinal composition according to claim 1, wherein, The mass ratio of the yam rhizome, the cnidium fruit, the bistort rhizome, the yam rhizome, the murraya paniculata, the yellow yam, the tuber fleeceflower stem and the Terminalia chebula is 10:8:15:11:12:12:12:15:12; Or the mass ratio of the rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 10:15:12:10:9:10:20:9; Or the mass ratio of the rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 15:10:10:12:9:15:15:9; or the mass ratio of the rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 15:9:12:12:12:12:12:11; Or the mass ratio of the rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 12:9:15:15:9:12:14:9; or the mass ratio of rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 20:8:8:12:12:10:15:10.
  3. 3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following steps: Extracting rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, ningpo Yam rhizome, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae with 70% -95% ethanol respectively, concentrating the extractive solution, drying, and mixing to obtain the final product.
  4. 4. The method of claim 3, wherein the extraction is Soxhlet extraction and the volume ratio of ethanol to medicinal material is 15:1.
  5. 5. The use of the traditional Chinese medicine composition according to claim 1 or 2, or the traditional Chinese medicine composition prepared by the preparation method according to claim 3 or 4, for preparing a medicament for inhibiting trichophyton rubrum and/or candida albicans.
  6. 6. A medicament for preventing and treating trichophyton rubrum and/or candida albicans infection, which is characterized by comprising the traditional Chinese medicine composition according to claim 1 or 2 or the traditional Chinese medicine composition prepared by the preparation method according to claim 3 or 4.
  7. 7. The medicament according to claim 6, wherein the medicament is in the form of an ointment, gel or lotion.

Description

Traditional Chinese medicine composition and application thereof in preparation of fungi inhibiting medicines Technical Field The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition and application thereof in preparing medicines for inhibiting fungi. Background Fungal dermatological diseases refer to infectious diseases of the skin, mucous membranes, hair, nails and other parts caused by fungi, also called superficial mycoses or superficial mycoses, and are the most common infectious diseases of the dermatological department. Due to the characteristics of high morbidity and recurrence rate, poor patient compliance, toxic and side effects of western medicines, appearance of fungus drug-resistant strains and the like, the life quality of patients is seriously affected. Fungal dermatological diseases can be classified into tinea capitis (dermatophyte-infected head), tinea corporis (dermatophyte-infected body smoothening skin), tinea cruris (dermatophyte-infected groin), tinea manuum (dermatophyte-infected head curvature), tinea pedis (dermatophyte-infected foot, also called beriberi), onychomycosis (dermatophyte-infected nail) and the like, according to the site of dermatophyte infection. The main pathogenic bacteria of superficial fungal infection comprise dermatophytes, other common pathogenic bacteria comprise candida, malassezia and the like, and the main pathogenic bacteria of dermatophytes and the like are derived from 3 genera, namely trichophytes, epidermophytons and microsporophytes, wherein trichophytes rubrum accounts for more than 60% of dermatophytes. One of the candida yeasts, again one of the most common causes of dermatophyte infections, the warm, moist or sweaty areas provide a good environment for the yeasts to multiply, including the armpits, groin, the skin between the fingers and toes, the corners of the mouth, and the area under the breasts, etc. Allylamine and azole antifungal drugs are used clinically, and a series of adverse reactions such as liver and kidney function damage, anaphylactic reaction, gastrointestinal reaction and bone marrow toxicity are caused by using the antibiotics. Accurate diagnosis, clear and definite development stage of pathogenic bacteria and diseases, proper medicine types, dosage forms, dosages and treatment courses are selected, blind preventive medicine application is avoided, and reasonable combined medicine application is avoided, so that the treatment efficiency can be improved. This makes the discovery and identification of new blows and cues from synthetic chemicals or natural products an urgent task. Compared with synthetic chemicals, the traditional Chinese medicine has the advantages of various structures, low toxicity and the like. The traditional Chinese medicine provides a potential source for antifungal medicines, whether in a new form or as an original template with optimized structure, so as to obtain more effective and safer derivatives, and has great significance for developing and treating superficial skin fungal infection diseases. Disclosure of Invention In view of the above, the technical problem to be solved by the invention is to provide a traditional Chinese medicine composition and application thereof in preparing a medicine for inhibiting fungi. The traditional Chinese medicine composition provided by the invention is prepared from rhizoma dioscoreae, fructus cnidii, bistort rhizome, ningpo Yam rhizome, murraya paniculata, dioscorea panthaica, caulis polygoni multiflori and fructus terminaliae Billericae. In some embodiments, the mass ratio of the yam rhizome, the fructus cnidii, the bistort rhizome, the yam, the murraya paniculata, the yellow yam, the vine of multiflower knotweed and the fructus terminaliae bellae is (10-20), the mass ratio of (8-15), the mass ratio of (10-15), the mass ratio of (9-12), the mass ratio of (10-15), the mass ratio of (12-20) and the mass ratio of (9-12). In some embodiments, the mass ratio of rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, rhizoma Dioscoreae Nipponicae, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 10:8:15:11:12:12:15:12; In other specific embodiments, the mass ratio of rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, rhizoma Dioscoreae Nipponicae, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 10:15:12:10:9:10:20:9; In other embodiments, the mass ratio of rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, rhizoma Dioscoreae Nipponicae, herba Murrayae, rhizoma Dioscoreae Bulbiferae, caulis Polygoni Multiflori and fructus Terminaliae Billericae is 15:10:10:12:9:15:15:9; in other embodiments, the mass ratio of rhizoma Dioscoreae Septemlobae, fructus Cnidii, rhizoma Bistortae, rhizoma Dioscoreae Nipponicae, herba Murrayae, rh