CN-117771339-B - Plant essential oil composition with candida resisting activity and preparation method and application thereof

CN117771339BCN 117771339 BCN117771339 BCN 117771339BCN-117771339-B

Abstract

The invention discloses a plant essential oil composition with candida resisting activity and a preparation method thereof, and the plant essential oil composition consists of a pepper heavy oil component and a dry Jiang Qingyou component in a volume ratio of 1: 8~2:1. The research of the invention finds that after specific volume compatibility, especially after the single pepper heavy oil component or the dry Jiang Qingyou component is mixed according to the volume ratio of 1:8, the invention has a synergistic effect on candida albicans, candida tropicalis and candida glabrata, and the single pepper heavy oil component or the dry Jiang Qingyou component has a good synergistic effect on candida parapsilosis after being mixed according to the volume ratio of 2:1. The invention can be used for preparing the candida-resistant medicine by combining the pepper heavy oil component and the dry Jiang Qingyou component according to a specific volume ratio.

Inventors

WANG HANQING
LI GANG
MA WEIWEI
KONG XIANGFENG
CHEN LIANG

Assignees

宁夏医科大学

Dates

Publication Date: 20260505
Application Date: 20231211

Claims (2)

1. The application of the pepper heavy oil component and the dry Jiang Qingyou component with the volume ratio of 2:1 in preparing the medicine for resisting candida parapsilosis; the pepper heavy oil component is prepared by the following method: (1.1) extracting fructus Zanthoxyli essential oil, namely taking fructus Zanthoxyli medicinal materials, crushing, adding 12 times of water, soaking for 1h, then extracting for 6h by steam distillation, centrifuging, collecting fructus Zanthoxyli essential oil, and preserving at 4 ℃ in dark place; (1.2) extracting the pepper heavy oil, namely filling the pepper essential oil into a molecular distillation feeding bottle, filling liquid nitrogen into a cold trap, opening a refrigerating device, setting the temperature of a reflux water device to be 5 ℃, scraping the film at 240r/min, enabling the material flow to be 1mL/min, and collecting the pepper heavy oil component at 50 ℃ and 80Pa of distillation pressure; the dry Jiang Qingyou component is prepared by the following method: (2.1) extracting the essential oil of the dried ginger, namely taking the dried Jiang Yaocai, crushing, adding 20 times of water, extracting by steam distillation for 4 hours, centrifuging, collecting the essential oil of the dried ginger, and preserving at a dark temperature of 4 ℃; And (2.2) refining the dried ginger essential oil, namely filling the dried ginger essential oil into a molecular distillation feeding bottle, filling liquid nitrogen into a cold trap, opening a refrigerating device, setting the temperature of a reflux water device to be 5 ℃, scraping the film at the speed of 240r/min, controlling the material flow to be 1mL/min, distilling at the temperature of 90 ℃ and the distilling pressure of 100Pa, and collecting the dry Jiang Qingyou components.
2. The use according to claim 1, wherein the zanthoxylum bungeanum heavy oil fraction and the dry Jiang Qingyou fraction in a volume ratio of 2:1 are prepared with pharmaceutically acceptable carriers into suppositories, tablets, granules, capsules, pills, sprays, powders, ointments, mixtures, oral liquids or powder injections.

Description

Plant essential oil composition with candida resisting activity and preparation method and application thereof Technical Field The invention relates to a plant essential oil, in particular to a plant essential oil composition with anti-candida activity, and a preparation method and application thereof. Background The plant essential oil mainly refers to volatile components from flowers, leaves, stems, seeds, fruits, roots or barks of plants, has biological activities of resisting candida, oxidization, tumors and the like, and has good application prospects in the medicine and food industries. The pericarpium Zanthoxyli contains volatile oil, and the main ingredients of the oil are limonene, cumyl alcohol and niu er alcohol. In addition, the plant sterol and the unsaturated organic acid and other various compounds are contained. The pepper has aromatic smell, can increase appetite, has the efficacy of reducing blood pressure, and can dilate blood vessels, thereby having the function of reducing blood pressure. Zanthoxylum bungeanum has also the effect of expelling parasites, and can expel parasites by taking Zanthoxylum bungeanum water. Dry Jiang Weixin, warm nature, enter spleen, stomach, heart and lung meridians. Has effects of warming spleen and stomach, dispelling cold, restoring yang, dredging collaterals, eliminating dampness, resolving phlegm, warming lung, resolving fluid retention, etc. It is used for treating cold pain in stomach and abdomen, emesis, diarrhea, yang depletion, cough and asthma due to cold-retained fluid, and arthralgia due to cold-dampness. There is no report on the combined application of heavy oil and dry Jiang Qingyou of Zanthoxylum bungeanum to anti-candida. Disclosure of Invention The invention aims to screen out the combination of the pepper heavy oil and the dry Jiang Qingyou with the optimal volume ratio through a large number of experiments, thereby achieving the synergistic candida resistance application. The technical scheme adopted by the invention is as follows: A plant essential oil composition with anti-candida activity is composed of a pepper heavy oil component and a dry Jiang Qingyou component. As a preferable scheme, the plant essential oil composition with the candida resisting activity has the volume ratio of the pepper heavy oil component to the dry Jiang Qingyou component of 1:256-64:1. As a further preferable scheme, the plant essential oil composition with the candida resisting activity has the volume ratio of the pepper heavy oil component to the dry Jiang Qingyou component of 1:32-32:1. As a more preferable scheme, the plant essential oil composition with candida resisting activity has the volume ratio of the heavy oil component of the pepper to the dry Jiang Qingyou component of 1: 8~2:1. As a particularly preferred embodiment, the above-described plant essential oil composition having anti-candida activity has a volume ratio of the heavy oil component of Zanthoxylum bungeanum and the dry Jiang Qingyou component of 1:8 or 2:1. The invention relates to a plant essential oil composition with candida resisting activity, wherein (1) The pepper heavy oil component is prepared by the following method: (1.1) extracting fructus Zanthoxyli essential oil, namely taking fructus Zanthoxyli medicinal materials, crushing, adding water, soaking, then adopting steam distillation for extraction, centrifuging, collecting fructus Zanthoxyli essential oil, and cooling and storing in a dark place; (1.2) extracting the pepper heavy oil, namely filling the pepper essential oil into a molecular distillation feeding bottle, filling liquid nitrogen into a cold trap, opening a refrigerating device, distilling, and collecting the pepper heavy oil component; (2) The dry Jiang Qingyou component is prepared by the following method: (2.1) extracting the essential oil of the dried ginger, namely, taking the dried Jiang Yaocai, crushing, adding water, distilling and extracting by water vapor, centrifuging, collecting the essential oil of the dried ginger, and cooling and storing in a dark place; (2.2) refining the dried ginger essential oil, namely filling the dried ginger essential oil into a molecular distillation feeding bottle, filling liquid nitrogen into a cold trap, opening a refrigerating device, distilling, and collecting a dried Jiang Qingyou component. Preferably, the above plant essential oil composition having anti-candida activity, wherein (1) The pepper heavy oil component is prepared by the following method: (1.1) extracting fructus Zanthoxyli essential oil, namely taking fructus Zanthoxyli medicinal materials, crushing, adding 12 times of water, soaking for 1h, then extracting for 6h by steam distillation, centrifuging, collecting fructus Zanthoxyli essential oil, and preserving at 4 ℃ in dark place; (1.2) extracting the pepper heavy oil, namely filling the pepper essential oil into a molecular distillation feeding bottle, filling liquid nitrogen into a cold trap, opening