CN-117818985-B - Sterile packing material and method for carrying out automatic production by adopting same

CN117818985BCN 117818985 BCN117818985 BCN 117818985BCN-117818985-B

Abstract

The invention discloses an aseptic packaging material and a method for automatically producing the aseptic packaging material, belongs to the field of medicine packaging, and aims to solve the problem that the existing aseptic packaging material cannot be efficiently transmitted to butt-joint an aseptic bottle body and an aseptic rubber plug. Comprises a bottle body, a rubber plug, an aluminum cover, a nest plate and a gland. The bottle body, the rubber plug and the aluminum cover are fixed through the nest plate and the gland, most of time of the rubber plug and the aluminum cover is on the bottle body, the rubber plug and the aluminum cover only leave the bottle body in medicine split charging, extra space is not occupied, automatic operation is facilitated in limited space, the relative position between the rubber plug aluminum cover and the bottle body is determined, disordered distribution of the rubber plug aluminum cover is avoided, automation can be completely achieved, a process of manually placing the rubber plug aluminum cover to the bottle body before hot chamber production is avoided, the process is shortened, the production time is saved, the activity utilization rate of nuclides is improved due to the specificity of radioactive medicines, the production cost is saved, manual participation is avoided, and the risk of destroying the sterile environment of the bottle body is reduced.

Inventors

LI HUIYANG
CHEN YIMING
XU HONGJUN
SUN QILONG

Assignees

四川先通医药科技有限公司

Dates

Publication Date: 20260512
Application Date: 20240124

Claims (8)

1. The automatic production method is characterized in that the aseptic packaging material comprises a bottle body (1), a rubber plug (2), an aluminum cover (9), a nest plate (3) and a gland (4); A plurality of rows of containing holes are uniformly distributed on the nest plate (3) along the longitudinal direction, each row is provided with N containing holes with equal size, and the N containing holes in each row are uniformly distributed along the transverse direction; the bottle body (1) is formed by a bottom section (1A) where the bottle bottom is positioned and a top section (1B) where the bottle neck and the bottle mouth are positioned along the axial direction of the bottle body; the bottle comprises a bottle body (1), a containing hole, an aluminum cover (9), a rubber plug (2), a rubber plug and a rubber cover, wherein the containing hole is matched with the bottle body (1), the bottom section (1A) of the bottle body (1) is inserted into the containing hole, the top section (1B) is exposed out of the containing hole, the rubber plug (2) is freely plugged into the bottle mouth of the bottle body (1), and the aluminum cover (9) is freely covered on the bottle mouth of the bottle body (1); The pressing cover (4) covers the top of the aluminum cover (9), and the pressing cover (4) is detachably connected with the groove plate (3), and is provided with a limiting structure for limiting the nest plate (3) and the pressing cover (4) to move along a vertical linear track, and concave pin grooves (3E) which are matched with positioning pins (8) on the workbench are formed in four corners of the nest plate (3); The method comprises the following steps: step one, taking out a nest plate (3) and a gland (4) which hold a bottle body (1), centering a pin slot (3E) of the nest plate (3) on a positioning pin column (8) on a workbench, and integrally placing the nest plate (3) and the gland (4) on the workbench from top to bottom; step two, vertically taking down the gland (4); Step three, the filling machine clamps the bottle body (1) with the rubber plug (2) and the aluminum cover (9) to a filling table; Fourthly, clamping the aluminum cover (9) from the bottle mouth of the bottle body (1) along the vertical direction by a mechanical arm I of the filling machine, and then sucking the rubber plug (2) from the bottle mouth of the bottle body (1) along the vertical direction by the mechanical arm II; Fifthly, filling medicines into the bottle body (1); step six, a mechanical arm II of the filling machine plugs the rubber plug (2) back to the bottle mouth of the bottle body (1), and then the mechanical arm I covers the aluminum cover (9) back to the bottle mouth of the bottle body (1); And seventhly, rolling an aluminum cover (9) on the bottle mouth of the bottle body (1).
2. The method for automatic production by adopting sterile packing materials according to claim 1, wherein the limiting structure comprises a first positioning pin hole (3C) arranged around the nest plate (3), a second positioning pin hole (4C) which is arranged around the gland (4) and corresponds to the first positioning pin hole (3C), and a positioning pin (5) inserted into the first positioning pin hole (3C) and the second positioning pin hole (4C).
3. The method for automatic production by adopting sterile packing materials according to claim 2, wherein the first positioning pin hole (3C) is a blind hole with a closed bottom end, the top end of the positioning pin (5) is fixed in the second positioning pin hole (4C), and the bottom end of the positioning pin is movably inserted into the first positioning pin hole (3C).
4. The method for automatic production by adopting sterile packing materials according to claim 2, wherein the bottom end of the locating pin (5) is inserted into the locating pin hole II (4C), and the top end of the locating pin is movably inserted into the locating pin hole II (4C).
5. The method for automated production using sterile packing material according to any one of claims 1-4, wherein the two ends of the gland (4) are provided with the buckles (6) along the longitudinal direction, and the buckles (6) are detachably clamped at the two ends of the nest plate (3).
6. The method for automated production using sterile packaging material according to claim 5, wherein: The middle parts of the two ends of the nest plate (3) are provided with a first notch (3D) which is concaved inwards along the longitudinal direction; the middle parts of the two ends of the gland (4) are respectively provided with a bending part (4E) which bends downwards along the vertical direction, the two ends of the gland (4) are respectively provided with two concave notches (4D), and the two notches (4D) are symmetrical about the bending part (4E); buckle (6) are including U-shaped body (6A), pivot (6B) and spring (6C), and U-shaped body (6A) are installed in kink (4E) of gland (4) through pivot and spring (6C), and the top of U-shaped body (6A) is provided with manual portion (6D), and the bottom is provided with couple (6E), couple (6E) are located notch two (4D) of nest board (3) and articulate with nest board (3).
7. The method for automated production using sterile packing material according to any one of claims 1 to 4, wherein the nest plate (3) comprises a bottom plate (3A) at the bottom and a top plate (3B) above the bottom plate (3A), the bottom plate (3A) being spaced from the top plate (3B); the containing hole comprises a round limiting hole (3B 1) which penetrates through the top plate (3B) and is matched with the bottle body (1), and the bottom plate (3A) is used as the bottom of the containing hole.
8. The method for automated production using sterile packing material according to any one of claims 1 to 4, further comprising a nest box (7) for encasing the nest plate (3), the gland (4) and the bottle body (1).

Description

Sterile packing material and method for carrying out automatic production by adopting same Technical Field The invention belongs to the field of medicine packaging, and particularly relates to a sterile packing material and a method for carrying out automatic production by adopting the sterile packing material. Background In the radiopharmaceutical production process, sterile packaging materials are used. The traditional aseptic package material comprises a bottle body, a rubber plug and an aluminum cover, wherein the bottle body is used for sub-packaging medicines, the medicines are sub-packaged into the bottle body, and the aluminum cover is pricked after the rubber plug is plugged, so that the sealing of the medicines is completed. Before medicine split charging, the bottle body and the rubber plug are completely separated, a plurality of bottle bodies are usually bundled into a bag through plastic, and a plurality of rubber plugs are individually packaged. The method is limited by the space size of a production shielding hot chamber, a complete washing, baking and filling line cannot be formed, at present, sterile products and sterile rubber plug aluminum covers are adopted for batch manual feeding and butt joint, limited operation space in the hot chamber is occupied, the production time of medicines is prolonged, nuclides in radioactive medicines continuously decay and are reduced along with time change, that is, the longer the production time is, the less available medicine active ingredients are, and the risk of bacteria contamination is higher. With advances in technology, radiopharmaceutical production processes are increasingly automated, but with the consequent need to implement complex automation in limited space, where robotic dispensing of pharmaceuticals in high-level clean environments is a relatively common automation operation. However, when the existing sterile packaging materials are used for packaging medicines, the bottle body is clamped by the mechanical arm, the rubber plug is manually placed at another position after being disassembled, the rubber plug is clamped from another position by the mechanical arm for installation, the required production space is large, and efficient and sterile butt joint of the sterile bottle body and the sterile rubber plug aluminum cover cannot be realized. Disclosure of Invention The invention aims to provide an aseptic packaging material, solve the problem that the existing aseptic packaging material cannot be used for efficiently conveying and butting an aseptic bottle body and an aseptic rubber plug, and improve production efficiency. The invention adopts the technical scheme that the sterile packaging material comprises a bottle body, a rubber plug, a nest plate and a gland; A plurality of rows of containing holes are uniformly distributed on the nest plate along the longitudinal direction, each row is provided with N containing holes with equal size, and the N containing holes in each row are uniformly distributed along the transverse direction; the bottle body is formed by a bottom section where the bottle bottom is positioned and a top section where the bottle neck and the bottle mouth are positioned along the axial direction of the bottle body; The bottle body comprises a containing hole, a rubber plug, a bottle body, a bottle neck, a rubber plug, a bottle neck, a bottle cover and a bottle cover, wherein the containing hole is matched with the bottle body; the gland covers the top of the rubber plug, is detachably connected to the groove plate and is provided with a limiting structure for limiting the nest plate and the gland to move along a vertical linear track. Further, the limiting structure comprises a first positioning pin hole, a second positioning pin hole and a positioning pin, wherein the first positioning pin hole is arranged on the periphery of the nest plate, the second positioning pin hole is arranged on the periphery of the gland and corresponds to the first positioning pin hole, and the positioning pin is inserted into the first positioning pin hole and the second positioning pin hole. Further, the first locating pin hole is a blind hole with a closed bottom end, the top end of the locating pin is fixed in the second locating pin hole, and the bottom end of the locating pin is movably inserted in the first locating pin hole. Furthermore, the bottom end of the locating pin is inserted into the second locating pin hole, and the top end of the locating pin is movably inserted into the second locating pin hole. Further, along longitudinal direction, the buckles are arranged at the two ends of the gland, and the buckles can be detachably clamped at the two ends of the nest plate. Further, a first notch which is concave inwards along the longitudinal direction is arranged in the middle of the two ends of the nest plate; The middle parts of the two ends of the gland are respectively provided with a bending part which bends downwards