CN-117902326-B - Conveying system and conveying method for loading carrier in column chromatography

CN117902326BCN 117902326 BCN117902326 BCN 117902326BCN-117902326-B

Abstract

The invention relates to a conveying system for loading carriers in column chromatography, which comprises a storage device, a first conveying device, a plurality of chromatographic columns, a second conveying device, a drying device, a gas-solid separation device and a gas-solid separation device, wherein the storage device is used for storing the loading carriers, a feed inlet of the first conveying device is connected with a first discharge outlet pipeline of the storage device, the chromatographic columns are connected in parallel through pipelines, a first feed inlet of each chromatographic column is connected with a discharge outlet pipeline of the first conveying device, a feed inlet of the second conveying device is connected with a first discharge outlet pipeline of each chromatographic column, the drying device is connected with a discharge outlet pipeline of the second conveying device, a discharge outlet of the drying device is connected with a feed inlet pipeline of the storage device, and a feed inlet of the gas-solid separation device is connected with a second discharge outlet pipeline of the storage device. The conveying system and the conveying method can reduce the physical labor and realize full-closed operation.

Inventors

CHEN QI
CHAI JIAN
CHENG HUA
GAO YUXIN

Assignees

中国石油化工股份有限公司
中石化上海工程有限公司
中石化炼化工程（集团）股份有限公司

Dates

Publication Date: 20260508
Application Date: 20221019

Claims (7)

1. A carrier loading delivery system for column chromatography, comprising: -a storage device (1), the storage device (1) being for storing the loading carrier; The feeding port of the first conveying device (51) is connected with the first discharging port pipeline of the storage device (1); The device comprises a plurality of chromatographic columns (2), wherein the chromatographic columns (2) are connected in parallel through pipelines, a first feed inlet of each chromatographic column (2) is connected with a discharge outlet pipeline of a first conveying device (51), a second feed inlet of each chromatographic column (2) is connected with a discharge outlet pipeline of an upstream working section, the upstream working section conveys raw materials and eluting solution to the chromatographic columns (2), a second discharge outlet of each chromatographic column (2) is connected with a feed inlet pipeline of a downstream working section, and the chromatographic columns (2) convey eluting products to the downstream working section; The feed inlet of the second conveying device (52) is connected with the first discharge outlet pipeline of each chromatographic column (2); the feeding hole of the drying device (3) is connected with the discharging hole of the second conveying device (52) through a pipeline, and the discharging hole of the drying device (3) is connected with the feeding hole of the storage device (1) through a pipeline; And the gas-solid separation device (4), the feed inlet of the gas-solid separation device (4) is connected with the second discharge port of the storage device (1) through a pipeline, the first discharge port of the gas-solid separation device (4) is connected with the third feed inlet pipeline of each chromatographic column (2), the gas-solid separation device (4) conveys inert gas to the chromatographic columns (2), and the second discharge port of the gas-solid separation device (4) is connected with the feed inlet pipeline of the waste material working section.
2. The delivery system of claim 1, wherein the loading carrier comprises at least one of silica gel, activated carbon, or polymeric porous microspheres.
3. The delivery system of claim 1, wherein the eluting solution comprises at least one of ethanol, petroleum ether, or n-hexane.
4. A conveyor system according to claim 1, characterized in that the first conveyor means (51) and the second conveyor means (52) are both auger conveyors.
5. A conveyor system according to claim 1, characterized in that the drying device (3) is a screw dryer.
6. A conveying system according to claim 1, characterized in that the gas-solid separation device (4) is a cyclone.
7. A method of transporting a packed support in column chromatography using the transport system according to any one of claims 1 to 6, characterized by comprising the steps of: s1, conveying the filling carrier from the storage device (1) to the chromatographic column (2) through the first conveying device (51); S2, conveying raw materials and eluting solution to the chromatographic column (2) by the upstream working section; After the end of the elution, the washing liquid, Said chromatographic column (2) delivering an eluted product to said downstream section; s3, conveying the filling carrier from the chromatographic column (2) to the drying device (3) through the second conveying device (52), and simultaneously conveying inert gas to the chromatographic column (2) through the gas-solid separation device (4); S4, conveying the dried filling carrier from the drying device (3) to the storage device (1) through the pressure provided by the inert gas, wherein the filling carrier with the tiny particle size is wrapped by the inert gas to the gas-solid separation device (4); S5, removing the filling carrier with the tiny particle size from the gas-solid separation device (4).

Description

Conveying system and conveying method for loading carrier in column chromatography Technical Field The invention relates to the technical field of column chromatography, in particular to a conveying system and a conveying method for a filling carrier in column chromatography. Background The filling carrier is used as an adsorption material in the column chromatography separation and purification process, and in the current recycling method of the filling carrier, a device matched with manual operation is mostly used, for example, a silica gel single column, a serial combined column or a parallel combined column, thus the heavy manual labor of procedures such as carrying, loading and unloading is involved, moreover, the non-fully-closed operation of the device can not meet the requirements of occupational health, and the device causes occupational injury to operators and harm to production environment. Therefore, there is a need for a system and method for transporting a loading carrier in column chromatography. Disclosure of Invention The invention aims at overcoming the defects in the prior art and provides a conveying system and a conveying method for a loading carrier in column chromatography. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a first aspect of the present invention provides a transport system for a packing carrier in column chromatography, comprising: a storage device for storing the loading carrier; the feeding port of the first conveying device is connected with the first discharging port pipeline of the storage device; The first feeding ports of the chromatographic columns are connected with the discharge port pipeline of the first conveying device, the second feeding ports of the chromatographic columns are connected with the discharge port pipeline of the upstream working section, and the second discharge ports of the chromatographic columns are connected with the feed port pipeline of the downstream working section; The feeding port of the second conveying device is connected with the first discharging port pipeline of each chromatographic column; the feeding hole of the drying device is connected with the discharging hole of the second conveying device through a pipeline, and the discharging hole of the drying device is connected with the feeding hole of the storage device through a pipeline; And the feed port of the gas-solid separation device is connected with the second discharge port of the storage device through a pipeline, the first discharge port of the gas-solid separation device is connected with the third feed port of each chromatographic column through a pipeline, and the second discharge port of the gas-solid separation device is connected with the feed port of the waste material working section through a pipeline. Preferably, the loading carrier comprises at least one of silica gel, activated carbon or high molecular porous microspheres. Preferably, the eluting solution comprises at least one of ethanol, petroleum ether or n-hexane. Preferably, the first conveying device and the second conveying device are both auger conveyors. Preferably, the drying device is a spiral belt dryer. Preferably, the gas-solid separation device is a cyclone separator. In a second aspect, the present invention provides a method for transporting a packing carrier in column chromatography, using a transport system as described above, comprising the steps of: s1, conveying the filling carrier from the storage device to the chromatographic column through the first conveying device; s2, conveying raw materials and eluting solution to the chromatographic column by the upstream working section; After the end of the elution, the washing liquid, The chromatographic column delivers eluted product to the downstream section; S3, conveying the filling carrier from the chromatographic column to the drying device through the second conveying device, and simultaneously conveying inert gas to the chromatographic column through the gas-solid separation device; S4, conveying the dried filling carrier from the drying device to the storage device through the pressure provided by the inert gas, wherein the filling carrier with the small particle size is wrapped and clamped by the inert gas to the gas-solid separation device; S5, removing the filling carrier with the tiny particle size from the gas-solid separation device. Compared with the prior art, the invention has the following technical effects: The conveying system and the conveying method can realize automatic control of cyclic use of the filling carrier, greatly reduce the manual labor, realize fully-closed operation, meet the requirements of foot occupation sanitation, and avoid injury to staff and the environment. Drawings FIG. 1 is a schematic diagram of a conveyor system according to the present invention; FIG. 2 is a schematic flow chart of the conveying method in the invention; Wherein, the referen