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CN-117942631-B - Efficient blood product production device and process

CN117942631BCN 117942631 BCN117942631 BCN 117942631BCN-117942631-B

Abstract

The invention discloses a high-efficiency blood product production device and a high-efficiency blood product production process, which belong to the technical fields of biological pharmacy and blood products and comprise a shell, wherein a first electromagnet is fixedly connected to the inner top wall of the shell, a second electromagnet is fixedly connected to the inner bottom wall of the shell, a magnet ring is slidably matched with the inner side wall of the shell, a filter plate is fixedly connected to the inner side wall of the magnet ring, the interior of the shell is divided into an upper cavity and a lower cavity by the filter plate, a plurality of filter holes are formed in the filter plate, a plurality of upper pipes are fixedly connected to the top wall of the filter plate, a plurality of lower pipes are fixedly connected to the bottom wall of the filter plate, the upper pipes and the lower pipes are communicated with the filter holes, a feed inlet is formed in the top wall of the upper cavity, a first discharge hole is formed in the bottom wall of the lower cavity, a collecting assembly is communicated with the first discharge hole, the collecting assembly is used for sucking blood plasma in the shell, a second discharge hole is formed in the side wall of the upper cavity, and the filter inner net is used for solving the problems of the prior art that gel particles are blocked in the actual use process and the subsequent filtering effect is affected to a certain extent.

Inventors

  • LEI QINGCHANG
  • YANG XI
  • XI XIANGHUI
  • YANG JIN

Assignees

  • 南岳生物制药有限公司

Dates

Publication Date
20260508
Application Date
20231212

Claims (8)

  1. 1. The high-efficiency blood product production device is characterized by comprising a shell, wherein a first electromagnet is fixedly connected to the top wall of the shell, a second electromagnet is fixedly connected to the bottom wall of the shell, a magnet ring is slidably matched with the inner side wall of the shell, a filter plate is fixedly connected to the inner side wall of the magnet ring, the interior of the shell is divided into an upper cavity and a lower cavity by the filter plate, a plurality of filter holes are formed in the filter plate, a plurality of upper pipes are fixedly connected to the top wall of the filter plate, a plurality of lower pipes are fixedly connected to the bottom wall of the filter plate, the upper pipes and the lower pipes are communicated with the filter holes, a feed port is formed in the top wall of the upper cavity, an upper baffle for sealing the feed port is hinged to the side wall of the feed port, a first discharge port is formed in the bottom wall of the lower cavity, an electromagnetic valve is fixedly connected to the side wall of the first discharge port, a collecting assembly is communicated with the first discharge port, the collecting assembly is used for sucking plasma in the shell, a second discharge port is formed in the side wall of the upper cavity, and a lower baffle for sealing the second discharge port is hinged to the side wall of the second discharge port.
  2. 2. The apparatus of claim 1, further comprising a control system including a controller and a plurality of pressure sensors, the pressure sensors being vertically disposed along the inner side wall of the housing, the pressure sensors being configured to collect pressure information applied by the magnet ring to the inner side wall of the housing, the controller being configured to control operation of the first electromagnet and the second electromagnet based on the pressure information.
  3. 3. A device for producing a high-efficiency blood product according to claim 2, wherein the ends of the upper tube and the lower tube which are far from the filter plate are formed uniformly and are communicated with an arc-shaped bent tube.
  4. 4. A high-efficiency blood product production device according to claim 3, wherein the collecting assembly comprises a collecting bottle, a piston is slidably matched with the inner side wall of the collecting bottle, the piston divides the inner wall of the collecting bottle into a first chamber and a second chamber, a cylinder is arranged in the first chamber, one end of the cylinder is fixedly connected with the inner top wall of the collecting bottle, the other end of the cylinder is fixedly connected with the top wall of the piston, a first hose is communicated with the second chamber, and the other end of the first hose is communicated with the lower chamber.
  5. 5. The device of claim 4, wherein the first chamber is connected with a second hose, the second hose is connected with the upper chamber, and a check valve is fixedly connected to the connection part of the second hose and the upper chamber.
  6. 6. The apparatus of claim 5, wherein the inner wall of the upper chamber is fixedly connected with a baffle ring.
  7. 7. The device for producing blood products according to claim 6, wherein the bottom of the baffle ring is fixedly connected with a rubber pad.
  8. 8. A process for preparing high-efficient blood products, wherein the apparatus for preparing high-efficient blood products according to any one of claims 1-7 comprises the steps of, in the first step, adjusting the pH of the raw plasma to 6.46-6.66, adding into the apparatus, and adding gel particles into the apparatus; starting the device to enable the raw material plasma to be fully contacted with gel particles, enabling the coagulation factors to be fully adsorbed by the gel particles, separating the gel particles adsorbed with the coagulation factors through the device, adding an elution buffer solution into the gel particles adsorbed with the coagulation factors for eluting to obtain a crude product, and performing S/D virus inactivation on the crude product and filtering bacteria to obtain the blood product.

Description

Efficient blood product production device and process Technical Field The invention belongs to the technical field of biological pharmacy and blood products, and particularly relates to a high-efficiency blood product production device and process. Background Blood products (Blood products) are the collective names of plasma protein components and Blood cell components prepared from healthy human plasma or specifically immunized human plasma by separation and purification or recombinant DNA technology, and the prior art usually adopts a gel adsorption method to extract coagulation factors, and after gel adsorption, the coagulation factors need to be filtered and collected from the plasma, and washed so as to elute active protein components from the gel. At present, manual filtration is mainly used in gel filtration collection, the filtration efficiency is low, as gel particles of partial types are fragile, the concentration of solids is gradually increased along with the progress of filtration, the filtration pressure difference is increased, the fragile gel particles can be damaged due to the excessively high pressure difference, the material loss in the production process is increased, and the broken colloidal particles after breakage can also cause adverse effects on the subsequent production process after flowing into a plasma tank. In order to solve the problems, chinese patent publication No. CN108245986B discloses a plasma adsorption filtration device for producing blood products of coagulation factors, wherein a speed-adjustable stirring device is arranged at the top end of the plasma adsorption tank, the speed-adjustable stirring device consists of a speed-adjustable stirring motor and double-layer stirring paddles, a plasma liquid inlet and a gel adding hole are arranged at the top end of the plasma adsorption tank, a temperature-control interlayer is arranged on the tank body of the plasma adsorption tank, the temperature-control interlayer is controlled by temperature-control circulating water, a plasma liquid outlet is arranged at the bottom end of the plasma adsorption tank, a plasma transport system consists of a liquid transport pipeline and a liquid transport pump, a liquid outlet of the plasma transport system is connected with the bottom end of the plasma adsorption tank and a liquid inlet of the upper end of a gel filter, a speed-adjustable stirring scraper is arranged at the top end of the gel filter, the speed-adjustable stirring scraper consists of a speed-adjustable stirring motor and a vertical scraper, a filtering inner net is arranged inside the gel filter, the filtering inner net is coaxially arranged in the tank of the gel filter, movable upper end baffle and lower end baffle plates are respectively arranged at the two ends of the filtering inner net, a gel outlet is respectively arranged at the bottom end of the gel filter side, a liquid inlet and a discharge outlet are respectively arranged at the upper end and a lower end of the gel filter, an automatic controller is arranged at the side surface of the gel filter, and a pressure sensor is connected with the upper pressure sensor and lower end of the automatic controller is connected with the pressure sensor The device solves the problems that manual filtration is used in the prior art, the efficiency is low, gel particles are easy to damage, but the filtering inner net used by the device is possibly blocked by the gel particles in the actual use process, and the subsequent filtering effect is affected, so that the device and the process for producing the high-efficiency blood product are necessary to solve the problems that the filtering inner net used in the prior art is blocked by the gel particles in the actual use process and the subsequent filtering effect is affected to a certain extent. Disclosure of Invention The invention aims to provide a high-efficiency blood product production device and a high-efficiency blood product production process, which are used for solving the problems that a filtering inner net used in the prior art is possibly blocked by gel particles in the actual use process and the subsequent filtering effect is influenced to a certain extent. In order to achieve the purpose, the high-efficiency blood product production device comprises a shell, wherein the inner top wall of the shell is fixedly connected with a first electromagnet, the inner bottom wall of the shell is fixedly connected with a second electromagnet, the inner side wall of the shell is in sliding fit with a magnet ring, the inner side wall of the magnet ring is fixedly connected with a filter plate, the interior of the shell is divided into an upper cavity and a lower cavity by the filter plate, a plurality of filter holes are formed in the filter plate, the top wall of the filter plate is fixedly connected with a plurality of upper pipes, the bottom wall of the filter plate is fixedly connected with a plurality of lower pipes, the up