Search

CN-118104646-B - Environment response intelligent release nano pesticide and preparation method and application thereof

CN118104646BCN 118104646 BCN118104646 BCN 118104646BCN-118104646-B

Abstract

The invention belongs to the field of pesticide preparations, and particularly relates to an environment-responsive intelligent release nano pesticide and a preparation method and application thereof. The environment response intelligent release nano pesticide provided by the invention comprises a first hydrophobic fiber layer, a hydrophilic fiber layer and a second hydrophobic fiber layer, wherein the hydrophilic fiber layer is arranged between the first hydrophobic fiber layer and the second hydrophobic fiber layer, pesticide active ingredients and hydrophilic ingredients are loaded in the hydrophilic fiber layer, and hydrophobic ingredients are loaded in the first hydrophobic fiber layer and the second hydrophobic fiber layer. The pesticide active ingredient is loaded into the inner layer nanofiber, so that the dispersibility of the pesticide active ingredient is remarkably improved, the biological activity of the pesticide active ingredient is improved, and the outer layer nanofiber can be used for isolating the environment so as to improve the thermal stability and oxidation resistance of the pesticide active ingredient. The hydrophobic outer layer can reduce water permeability, increase the diffusion path of water, reduce the burst release of pesticide active ingredients, realize the matching of the supply and the demand of the pesticide and the environment, and improve the pesticide utilization rate.

Inventors

  • GAO SHUANG
  • LIU BO
  • FU YING
  • YAN HONGLEI
  • Xiu Yue
  • YANG GUANG

Assignees

  • 东北农业大学

Dates

Publication Date
20260508
Application Date
20240229

Claims (7)

  1. 1. The environment response intelligent release nano pesticide is characterized by comprising a first hydrophobic fiber layer, a hydrophilic fiber layer and a second hydrophobic fiber layer, wherein the hydrophilic fiber layer is arranged between the first hydrophobic fiber layer and the second hydrophobic fiber layer, and pesticide active ingredients and hydrophilic ingredients are loaded in the hydrophilic fiber layer; The first hydrophobic fiber layer and the second hydrophobic fiber layer are loaded with hydrophobic components, wherein the hydrophobic components are ethyl cellulose; The hydrophilic component is gelatin; The pesticide active ingredients comprise one or more of chlorothalonil, difenoconazole, hexaconazole, tebuconazole, picoxystrobin, boscalid, pyraclostrobin, prothioconazole, propiconazole, carbendazim, azoxystrobin, kresoxim-methyl, thiophanate-methyl, thiram, metalaxyl, hymexazol, fluazinam, prochloraz, cyazofamid, thifluzamide, dimethomorph, fluopicolide, quinoline copper, tricyclazole, iprodione, diethofencarb, triazolone, epoxiconazole, flusilazole and fluazinam; The mass of the pesticide active ingredient which intelligently releases the nano pesticide load in response to the environment of each m 2 is 0.1-500 mg; The specific surface area of the first hydrophobic fiber layer is 100-2000 m 2 ·g -1 , the porosity is 40-95%, the specific surface area of the second hydrophobic fiber layer is 100-2000 m 2 ·g -1 , and the porosity is 40-95%.
  2. 2. The environmentally-responsive intelligent release nano pesticide according to claim 1, wherein the thickness of the first hydrophobic fiber layer is 0.1-100 μm, the thickness of the hydrophilic fiber layer is 0.1-100 μm, and the thickness of the second hydrophobic fiber layer is 0.1-100 μm.
  3. 3. The method for preparing the environment-responsive intelligent release nano pesticide according to any one of claims 1-2, which is characterized by comprising the following steps: Carrying out first electrostatic spinning on the first hydrophobic layer electrostatic spinning precursor solution to obtain a first hydrophobic fiber layer; Carrying out second electrostatic spinning on the hydrophilic layer electrostatic spinning precursor solution on the first hydrophobic fiber layer to obtain a hydrophilic fiber layer; carrying out third electrostatic spinning on the hydrophilic fiber layer by using the second hydrophobic layer electrostatic spinning precursor solution to form a second hydrophobic fiber layer, so as to obtain the environment response intelligent release nano pesticide; The hydrophilic layer electrostatic spinning precursor liquid comprises pesticide active ingredients, hydrophilic ingredients and a hydrophilic layer solvent; The first hydrophobic layer electrostatic spinning precursor solution and the second hydrophobic layer electrostatic spinning precursor solution independently comprise a hydrophobic component and a hydrophobic layer solvent.
  4. 4. The method according to claim 3, wherein the mass ratio of the pesticidal active ingredient to the hydrophilic ingredient is (1-10): 50.
  5. 5. The preparation method of the water-repellent layer according to claim 3, wherein the water-repellent layer solvent comprises deionized water, ethanol and acetic acid, the volume ratio of the deionized water, the ethanol and the acetic acid is 1 (2-3): (7-10), and the ratio of the mass of the water-repellent component to the volume of the water-repellent layer solvent is (3-11) g (10-20) mL.
  6. 6. The preparation method according to claim 3, wherein the conditions of the first electrostatic spinning, the second electrostatic spinning and the third electrostatic spinning independently comprise 10-20 kV voltage, 5-20 cm of receiving distance of a collector, 10-200 rpm of rotating speed of the collector, 0.2-20 mL/h of pushing speed of an injection pump and 10% -80% of relative humidity.
  7. 7. The use of an environmentally-responsive smart release nano pesticide as claimed in any one of claims 1 to 2 or prepared by a method as claimed in any one of claims 3 to 6 in agriculture.

Description

Environment response intelligent release nano pesticide and preparation method and application thereof Technical Field The invention belongs to the field of pesticide preparations, and particularly relates to an environment-responsive intelligent release nano pesticide and a preparation method and application thereof. Background The pesticide is an important production data in the agricultural field, and plays an important role in preventing and controlling diseases, insect pests, promoting grain yield increase and guaranteeing grain safety. Meanwhile, the use of pesticides also causes serious resource waste and environmental pollution. Firstly, most pesticides have complex production processes, large amounts of toxic intermediates and byproducts, and high organic solvent content in the traditional pesticide preparation. Secondly, a large amount of three wastes are generated in the pesticide production process. In addition, the existing pesticide is mainly prepared from traditional dosage forms such as emulsifiable concentrate, wettable powder, water dispersible granules and the like, and the specific gravity of the produced and used efficient and environment-friendly pesticide preparation is not high. The traditional pesticide formulation has short duration and low effective utilization rate, and can achieve ideal control effect only by repeated application, and finally a large amount of pesticide flows into the environment, so that serious resource waste and environmental pollution are caused, and the sustainable development of agriculture is severely restricted. Disclosure of Invention In view of the above, the invention aims to provide an environment-responsive intelligent release nano pesticide, a preparation method and application thereof, the environment-responsive intelligent release nano pesticide provided by the invention not only has good thermal stability, dispersibility and bioactivity, and can make specific response to external environment (temperature and pH value), realize matching of medicine and environment supply and demand, reduce pesticide dosage, raise pesticide utilization rate and reduce agricultural non-point source pollution caused by pesticide. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides an environment response intelligent release nano pesticide, which comprises a first hydrophobic fiber layer, a hydrophilic fiber layer and a second hydrophobic fiber layer, wherein the hydrophilic fiber layer is arranged between the first hydrophobic fiber layer and the second hydrophobic fiber layer, and pesticide active ingredients and hydrophilic ingredients are loaded in the hydrophilic fiber layer; the first hydrophobic fiber layer and the second hydrophobic fiber layer are loaded with hydrophobic components, wherein the hydrophobic components comprise one or more of ethyl cellulose, polylactic acid, chitosan, sodium alginate, polyvinylpyrrolidone and cellulose acetate; the hydrophilic component comprises one or more of gelatin, polycaprolactone, polyvinyl alcohol, polyethylene oxide, alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin, methyl-beta-cyclodextrin, 2-hydroxypropyl-gamma-cyclodextrin and 2-hydroxypropyl-alpha-cyclodextrin. Preferably, the pesticide active ingredient comprises one or more of chlorothalonil, difenoconazole, hexaconazole, tebuconazole, picoxystrobin, boscalid, pyraclostrobin, prothioconazole, propiconazole, carbendazim, azoxystrobin, kresoxim-methyl, thiophanate-methyl, thiram, metalaxyl, hymexazol, fluazinam, prochloraz, cyazofamid, thifluzamide, dimethomorph, fluopicolide, copper quinolinate, tricyclazole, iprodione, diethofencarb, triazolone, epoxiconazole, flusilazole and fluazinam. Preferably, the thickness of the first hydrophobic fiber layer is 0.1-100 μm, the thickness of the hydrophilic fiber layer is 0.1-100 μm, and the thickness of the second hydrophobic fiber layer is 0.1-100 μm. Preferably, the mass of the pesticide active ingredient which intelligently releases the nano pesticide load in each m 2 environmental response is 0.1-500 mg. Preferably, the specific surface area of the first hydrophobic fiber layer is 100-2000 m 2·g-1, the porosity is 40-95%, and the specific surface area of the second hydrophobic fiber layer is 100-2000 m 2·g-1, and the porosity is 40-95%. The invention also provides a preparation method of the environment response intelligent release nano pesticide, which comprises the following steps: Carrying out first electrostatic spinning on the first hydrophobic layer electrostatic spinning precursor solution to obtain a first hydrophobic fiber layer; Carrying out second electrostatic spinning on the hydrophilic layer electrostatic spinning precursor solution on the first hydrophobic fiber layer to obtain a hydrophilic fiber layer; carrying out third electrostatic spinning on the hydrophilic fiber layer by using the second hydrophobic layer electro