Search

CN-118161570-B - Traditional Chinese medicine composition for treating transmissible gastroenteritis of suckling piglets

CN118161570BCN 118161570 BCN118161570 BCN 118161570BCN-118161570-B

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating Transmissible Gastroenteritis (TGE) of a suckling piglet, which effectively solves the problems that in the prior art, the transmissible gastroenteritis is only used for treating the transmissible gastroenteritis of a fattening pig or a sow with lighter illness state and very low death rate, the TGE with heavier illness state and high death rate of the suckling piglet is not used, and dehydration and acidosis of the suckling piglet cannot be corrected rapidly.

Inventors

  • ZHANG GUOZHONG
  • LIANG AIJUN
  • SONG SHUPING
  • WANG GUANXIAO
  • ZHANG YANGYANG
  • Chai Shuxia
  • Yan Pilin
  • YUAN SHUAI

Assignees

  • 烟台瑞谷生物科技有限公司

Dates

Publication Date
20260508
Application Date
20240124

Claims (9)

  1. 1. A traditional Chinese medicine composition for treating transmissible gastroenteritis of suckling piglets is characterized by comprising, by mass, 5-15 parts of radix adenophorae, 5-15 parts of radix glehniae, 5-15 parts of dendrobe, 5-15 parts of polygonatum odoratum, 5-15 parts of dogwood and 10-30 parts of oyster.
  2. 2. The traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets, which is characterized by comprising, by mass, 10 parts of radix adenophorae, 10 parts of radix glehniae, 10 parts of dendrobe, 10 parts of rhizoma polygonati officinalis, 10 parts of dogwood and 20 parts of oyster.
  3. 3. A method for preparing a traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets based on any one of claims 1-2, which is characterized by comprising the following steps: s1, weighing raw materials according to a formula, cracking oyster, and soaking in water for 1 hour; S2, mixing the raw materials of the adenophora root, the glehnia root, the dendrobium, the fragrant solomonseal rhizome and the dogwood together, adding water to soak for 1 hour When in use; S3, decocting oyster for 2 hours, adding other 5 raw materials, decocting for 1 hour, and filtering to obtain a first stock solution; s4, decocting the residues for 40 minutes, and filtering to obtain a second stock solution; s5, combining the first stock solution and the second stock solution, concentrating the filtrate to a relative density of 1.1-1.2 at 90 ℃, adding ethanol, refrigerating and standing, and filtering to obtain a third stock solution; s6, recovering ethanol from the third stock solution filtrate, adding water, filling, and sterilizing to obtain the product.
  4. 4. The method for preparing a Chinese medicinal composition for treating transmissible gastroenteritis of piglets according to claim 3, wherein the ethanol content is 65% -75% in step S5, and the refrigerating and standing time is 48 hours.
  5. 5. In the preparation method S5 of the traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets according to claim 3, the filtrate is concentrated to a relative density of 1.17 at 90 ℃.
  6. 6. In the step S6 of the method for preparing a traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets of claim 3, the ratio of the third stock solution filtrate to water is 4:1.
  7. 7. A method for preparing a traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets based on any one of claims 1-2, which is characterized by comprising the following steps: s1, weighing raw materials according to a formula, cracking oyster, and soaking in water for 1 hour; s2, mixing the raw materials of the adenophora root, the coastal glehnia root, the dendrobium, the fragrant solomonseal rhizome and the dogwood together, adding water to soak for 1 hour: S3, decocting oyster for 2 hours, adding other 5 raw materials, decocting for 1 hour, and filtering to obtain a first stock solution; s4, decocting the residues for 40 minutes, and filtering to obtain a second stock solution; S5, combining the first stock solution and the second stock solution, concentrating the filtrate to a relative density of 1.30-1.33 at 20 ℃ to obtain clear paste; S6, adding sugar and dextrin into the clear paste to prepare granules, and drying to obtain the finished product.
  8. 8. In the step S6 of the preparation method of the traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets, the ratio of the clear paste to the sugar to the dextrin is 1:2.5:1.
  9. 9. The traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets according to any one of claims 1-2, wherein the dosage form of the traditional Chinese medicine composition is any one of a traditional Chinese medicine oral liquid, a traditional Chinese medicine granule, a traditional Chinese medicine fluid extract, a tablet and a capsule.

Description

Traditional Chinese medicine composition for treating transmissible gastroenteritis of suckling piglets Technical Field The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating transmissible gastroenteritis of suckling piglets. Background Transmissible Gastroenteritis (TGE) is a highly contagious intestinal disease caused by transmissible gastroenteritis virus (TGEV) characterized by vomiting, severe diarrhea and high mortality (usually 100%) in piglets of two weeks of age or less. Although pigs of different ages are susceptible to TGEV virus, mortality in pigs over 5 weeks of age is low. Epidemiology when a TGEV invades a pig farm, it often quickly infects pigs of all ages, especially in winter, most pigs develop varying degrees of anorexia, vomiting and diarrhea. The piglets are seriously ill, rapidly dehydrated, and the death rate of pigs with ages of 2-3 weeks is very high, but gradually decreases with age. Sows frequently develop morbidity, show anorexia and agalactia, further leading to increased mortality in lactating piglets. Modern medical treatment of TGE is a highly contagious intestinal disease caused by transmissible gastroenteritis virus (TGEV) characterized by vomiting, severe diarrhea and high mortality in piglets of less than two weeks of age. The piglets are seriously ill, rapidly dehydrated, and the death rate of pigs with ages of 2-3 weeks is very high, and is usually 100%. Current traditional chinese/middle veterinarian treatment TGE method: qu Ziming "New Zhongzhu veterinarian therapeutic university", beijing: china agricultural university Press, 1993.12, P288: treatment method: clearing away heat and toxic materials and stopping diarrhea. The prescription comprises 10 g of coptis chinensis, 12 g of white peony root, 15 g of pulsatilla chinensis, 12 g of garden burnet root charcoal, 15 g of dark plum fruit, 15 g of myrobalan, 6g of rheum officinale, 12 g of liquorice and 12 g of plantain seed. Decoct with water (25 kg pig dose). According to the statement of the manual for preventing and treating swine diseases, the disease is a viral disease, and no special effective treatment method exists. The only method is symptomatic treatment, reducing death of the suckling piglets, promoting early recovery, and giving a sufficient amount of clean drinking water containing electrolyte and certain nutrient components every day. Hu Yuanliang "Zhongveterinarian proved recipe and wonderful use fine edition", beijing: chemical industry Press, 2019.6, P140: transmissible gastroenteritis of swine Prescription 1 comprises coptis root 30 g, dark plum fruit 30 g, isatis root 15 g, cooked mugwort 15 g, medicated leaven 12 g, smilax glabra 10g, myrobalan 10g and licorice root 30 g. Has the effects of clearing heat and detoxicating, eliminating dampness and relieving diarrhea. (Xu Guyu Anhui agronomic advisory, 2016,8) Prescription 2 comprises coptis root 100 g, baikal skullcap root 100 g, isatis root 300 g, corktree bark 700 g and dried rehmannia root 300 g. Has the effects of clearing heat, drying dampness, cooling blood and detoxicating. (Dong Juncheng, china pig industry, 2008.2) Prescription 3 comprises coptis root 100 g, phellodendron bark 100 g, ash bark 100 g, magnolia bark 100 g, pulsatilla root 200 g, green tangerine peel 150 g, haw 200 g, radish seed 150 g, wrinkled giant hyssop 150 g, garden burnet root (stir-baked charcoal) 100 g, hairyvein agrimony 150 g, white atractylodes rhizome 100 g, myrobalan 150 g and licorice root 50 g. Has the effects of clearing heat and drying dampness, strengthening spleen and stopping diarrhea. (Zhao Yingzhen, journal of Chinese veterinary medicine, 2006.6) The traditional Chinese medicine/Chinese veterinarian treatment TGE has the efficacy of clearing heat and detoxicating, clearing heat and drying dampness, strengthening spleen and stopping diarrhea. In practice, because the formulas are used for TGE with low mortality rate and relatively light illness state of fattening pigs or sows, are not used for relatively heavy illness state and high mortality rate of suckling pigs, and cannot quickly correct dehydration and acidosis of the suckling pigs, although the formulas are matched with some measures such as strengthening feeding management and environment disinfection, ideal effects on the TGE of the suckling pigs cannot be obtained. At present, no effective drug treatment is specially aimed at the TGE of the suckling piglets and reduces the high mortality rate after the TGE of the suckling piglets, so that a drug is urgently needed, the TGE of the suckling piglets can be treated, and the great difficulty in pig raising production is solved. Disclosure of Invention Therefore, the invention provides a traditional Chinese medicine composition for treating transmissible gastroenteritis of piglets, which effectively relieves body dehydration and acidosis, and effectively treats TGE of