CN-118403120-B - Preparation method of preparation containing radix scrophulariae for treating stranguria

CN118403120BCN 118403120 BCN118403120 BCN 118403120BCN-118403120-B

Abstract

The invention provides a preparation method of a preparation for treating stranguria through continuous cropping, which belongs to the technical field of pharmaceutical preparations, and comprises the steps of mixing bighead atractylodes rhizome, grassleaved sweetflag rhizome and beta-cyclodextrin, respectively carrying out dynamic extraction, decompressing and concentrating, centrifugally emulsifying to obtain volatile ointment powder, carrying out reflux extraction on the residual bighead atractylodes rhizome and grassleaved sweetflag rhizome dregs after volatile oil extraction to obtain bighead atractylodes rhizome and grassleaved sweetflag rhizome medicinal powder, carrying out reflux extraction on eight medicines including akebia stem, polygonum aviculare, cape jasmine, rheum officinale, red sage root, rhizoma dioscoreae, poria cocos and liquorice, preparing eight medicine medicinal powder, carrying out reflux extraction on three medicines including coptis chinensis, radix sophorae flavescentis and fringed pink, and finally carrying out uniform mixing on the volatile ointment powder, the bighead atractylodes rhizome, the grassleaved sweetflag rhizome medicinal powder, the eight medicine medicinal powder and the three medicine powder to prepare the preparation for treating stranguria through continuous cropping. According to the invention, the volatile oil in the bighead atractylodes rhizome and the grassleaved sweetflag rhizome is included while being extracted in the dynamic extraction process, so that the loss caused by adhesion equipment in the volatile oil extraction and separation process can be avoided, the utilization rate of the volatile oil is improved, and the curative effect of the product is further improved.

Inventors

ZOU YAN
WANG ZHIQIANG
LI DAN
JIANG GUOZHI
LI ZHENJIANG

Assignees

神威药业集团有限公司
京津冀联创药物研究（北京）有限公司

Dates

Publication Date: 20260508
Application Date: 20240325

Claims (5)

1. The preparation method of the preparation for treating stranguria by continuous cropping is characterized by comprising the following steps: Pulverizing rhizoma atractylodis macrocephalae and rhizoma acori graminei, adding 35-40 vol% of ethanol water solution and 0.006-0.008 times of beta-cyclodextrin, dynamically extracting for 2-3 hours at 55-60 ℃, and filtering to obtain volatile oil liquid medicine and rhizoma atractylodis macrocephalae and rhizoma acori graminei dregs; concentrating the volatile oil liquid medicine at 55-60 ℃ and minus 0.08-0.10 MPa under reduced pressure, wherein the relative density of the concentrated liquid is 1.05-1.08 after concentration, centrifugally emulsifying by a colloid mill, adding an adhesive, uniformly mixing, and drying to obtain volatile ointment powder; Adding 55-60vol% ethanol water solution into the bighead atractylodes rhizome and grassleaf sweelflag rhizome dregs, carrying out reflux extraction, cooling to room temperature, carrying out solid-liquid separation, recovering ethanol from the obtained liquid until no ethanol smell exists, concentrating under reduced pressure, drying, and crushing to obtain bighead atractylodes rhizome and grassleaf sweelflag rhizome medicinal powder, wherein the weight ratio of the bighead atractylodes rhizome to grassleaf sweelflag rhizome medicinal powder to an adhesive is 1:0.0008-0.001; Taking eight medicines of akebia stem, polygonum aviculare, gardenia, rheum officinale, red-rooted salvia root, rhizoma dioscoreae septemlobae, poria cocos and liquorice, adding 55-60 vol% of ethanol aqueous solution, carrying out reflux extraction, cooling to room temperature, filtering, recovering ethanol until no ethanol smell exists, concentrating under reduced pressure, drying and crushing to obtain eight medicine powder; taking three medicines of coptis chinensis, radix sophorae flavescentis and fringed pink, adding 80-90 vol% ethanol aqueous solution, carrying out reflux extraction, filtering, recovering ethanol until no ethanol smell exists, concentrating under reduced pressure, drying, and crushing to obtain three medicine powder; mixing volatile ointment powder, atractylodis rhizoma, rhizoma Acori Graminei powder, eight medicinal powders and three medicinal powders to obtain a powder; the radix scrophulariae stranguria treating powder is one of the radix codonopsis stranguria treating preparations; the weight ratio of bighead atractylodes rhizome, grassleaved sweetflag rhizome, clematis stem, polygonum aviculare, gardenia, rheum officinale, red-rooted salvia root, yam rhizome, poria cocos, liquorice, coptis chinensis, kuh-seng and fringed pink is 70:30:90:90:60:80:80:80:90:30:120:90:90.
2. The preparation method of the preparation of the radix coptidis stranguria treating preparation, which is characterized in that the weight ratio of bighead atractylodes rhizome to grassleaf sweelflag rhizome powder to 35-40 vol% ethanol water solution is 1:4-6.
3. The preparation method of the preparation for treating stranguria, which is characterized in that, The weight ratio of the bighead atractylodes rhizome to the grassleaf sweelflag rhizome powder to the 55-60 vol% ethanol aqueous solution is 1:5-6; the weight ratio of the eight medicines to the 55-60 vol% ethanol aqueous solution is 1:5-6.
4. The preparation method of the preparation of the radix coptidis stranguria treating preparation, which is characterized in that the weight ratio of the three medicines to the 80-90 vol% ethanol water solution is 1:5-6.
5. The preparation method of the preparation of the radix scrophulariae for treating stranguria, according to claim 1, wherein the radix scrophulariae for treating stranguria is added with auxiliary materials and granulated to obtain radix scrophulariae for treating stranguria; the granules of the figwort root for treating stranguria are prepared into tablets or capsules by tabletting or bagging.

Description

Preparation method of preparation containing radix scrophulariae for treating stranguria Technical Field The invention relates to the technical field of pharmaceutical preparations, in particular to a preparation method of a preparation for treating stranguria by means of continuous cropping. Background The preparation for treating stranguria is prepared from 13 traditional Chinese medicines of coptis chinensis, radix sophorae flavescentis, fringed pink, caulis akebiae, polygonum aviculare, gardenia, rheum officinale, radix salviae miltiorrhizae, rhizoma dioscoreae septemlobae, poria cocos, bighead atractylodes rhizome, rhizoma acori graminei and liquorice, has the effects of clearing heat and eliminating dampness, and inducing diuresis and treating stranguria, and is used for the auxiliary treatment of non-gonococcal urethritis, and the symptoms of frequent urination, urgent urination, painful urination, red swelling and itching of urethra, secretion of urethral orifice, red tongue with yellow and greasy coating and soft pulse. The prescription has obvious curative effect in clinic and is safe and reliable. In the preparation process of the preparation, generally, the volatile oil is extracted from rhizoma atractylodis macrocephalae and rhizoma acori graminei by a steam distillation method, then the volatile oil is included by beta-cyclodextrin to obtain volatile oil inclusion compound, other medicines are extracted, concentrated, dried and crushed to obtain extract fine powder, and finally the volatile oil inclusion compound and the extract fine powder are mixed to prepare the preparation. However, the method needs to extract volatile oil first and then clathrate the volatile oil, but the mixed solution of the volatile oil extracted by a steam distillation method and water can cause volatile oil loss due to the problems of wall sticking and the like of the volatile oil in the subsequent cooling and separating process, thereby affecting the content of the volatile oil in the finished medicine and further affecting the curative effect of the finished medicine. Disclosure of Invention Aiming at the problems, the invention provides a preparation method of the preparation for treating stranguria by means of the radix codonopsis. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: a preparation method of a preparation for treating stranguria, the preparation method of the preparation comprises the following steps: pulverizing rhizoma Atractylodis Macrocephalae and rhizoma Acori Tatarinowii, adding 35-40vol% ethanol water solution and 0.006-0.008 times of beta-cyclodextrin, dynamically extracting, and filtering to obtain volatile oil liquid medicine and rhizoma Atractylodis Macrocephalae and rhizoma Acori Tatarinowii residue; concentrating the volatile oil liquid medicine under reduced pressure, centrifugally emulsifying by a colloid mill, adding adhesive, uniformly mixing, and drying to obtain volatile ointment powder; Adding 55-60vol% ethanol water solution into the bighead atractylodes rhizome and grassleaf sweelflag rhizome dregs, carrying out reflux extraction, cooling to room temperature, carrying out solid-liquid separation, recovering ethanol from the obtained liquid until no ethanol smell exists, concentrating under reduced pressure, drying, and crushing to obtain bighead atractylodes rhizome and grassleaf sweelflag rhizome medicinal powder; Taking eight medicines of akebia stem, polygonum aviculare, gardenia, rheum officinale, red-rooted salvia root, rhizoma dioscoreae septemlobae, poria cocos and liquorice, adding 55-60 vol% of ethanol aqueous solution, carrying out reflux extraction, cooling to room temperature, filtering, recovering ethanol until no ethanol smell exists, concentrating under reduced pressure, drying and crushing to obtain eight medicine powder; taking three medicines of coptis chinensis, radix sophorae flavescentis and fringed pink, adding 80-90 vol% ethanol aqueous solution, carrying out reflux extraction, filtering, recovering ethanol until no ethanol smell exists, concentrating under reduced pressure, drying, and crushing to obtain three medicine powder; mixing volatile ointment powder, atractylodis rhizoma, rhizoma Acori Graminei powder, eight medicinal powders and three medicinal powders to obtain a powder; The Lianshen Tonglin powder is one of the Lianshen Tonglin preparations. Further, the temperature of dynamic extraction is 55-60 ℃ and the time is 2-3 hours. Further, the temperature of the reduced pressure concentration is 55-60 ℃ and the vacuum degree is minus 0.08 to minus 0.10MPa. Further, after the reduced pressure concentration, the relative density of the concentrated solution obtained after concentration is 1.05-1.08. Further, the weight ratio of the bighead atractylodes rhizome to the grassleaf sweelflag rhizome powder to the 35-40 vol% ethanol aqueous solution is 1:4-6. Further, the weight ratio of the bighead atractyl