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CN-118453784-B - Traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, preparation method thereof and traditional Chinese medicine preparation thereof

CN118453784BCN 118453784 BCN118453784 BCN 118453784BCN-118453784-B

Abstract

The invention relates to the technical field of veterinary prevention and treatment medicines. The invention provides a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following components: indigo naturalis, fructus forsythiae, fructus Arctii, rhizoma Dryopteris Crassirhizomatis, radix Arnebiae, herba Taraxaci, radix et rhizoma Rhei, herba Scutellariae Barbatae, glycyrrhrizae radix, fructus Hordei Germinatus, bupleuri radix and fructus Canarii albi. The invention also provides a traditional Chinese medicine preparation comprising the traditional Chinese medicine composition. The technical scheme of the invention is adopted to combine the components, so that the effects of inhibiting pathogenic microorganisms and resisting PRRSV viruses can be effectively enhanced, the immunity can be improved, the disease resistance of pigs can be enhanced, the symptoms of mental depression, inappetence and the like caused by PRRSV can be relieved, the gastrointestinal health of animals can be conditioned, and meanwhile, the toxic and side effects are small, and the drug resistance is not easy to generate.

Inventors

  • BI JUNLONG
  • YIN GEFEN
  • Fu Shoupeng
  • WANG LEI
  • YANG JUN
  • ZHENG WANGHUA

Assignees

  • 云南农业大学

Dates

Publication Date
20260505
Application Date
20240507

Claims (8)

  1. 1. A traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome is characterized by comprising the following components, by weight, 22-35 parts of indigo naturalis, 20-26 parts of fructus forsythiae, 13-18 parts of burdock, 18-30 parts of rhizoma dryopteris crassirhizomae, 16-22 parts of lithospermum erythrorhizon, 10-17 parts of dandelion, 10-15 parts of rheum officinale, 11-16 parts of sculellaria barbata, 9-14 parts of liquorice, 9-13 parts of malt, 10-13 parts of radix bupleuri and 7-10 parts of fructus chebulae The preparation method of the traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome comprises the following steps: (1) Cutting radix et rhizoma Rhei, fructus forsythiae, herba Taraxaci and Glycyrrhrizae radix respectively, mixing, decocting in water, and filtering to obtain filtrate A; (2) Pulverizing fructus Arctii, radix Arnebiae, rhizoma Dryopteris Crassirhizomatis, herba Scutellariae Barbatae, fructus Hordei Germinatus, bupleuri radix and fructus Canarii albi respectively, mixing, reflux extracting, and filtering to obtain filtrate B; (3) Mixing the obtained filtrate A, filtrate B and indigo naturalis, and concentrating to obtain the final product; The water adding amount of the step (1) is 3-7 times of the total mass of the rheum officinale, the fructus forsythiae, the dandelion and the liquorice, the decoction time is 50-80 min/time, and the decoction time is 1-3 times; The solvent used in the reflux extraction in the step (2) is ethanol solution with the volume concentration of 65-85%, and the volume mass ratio of the solvent to the total mass of the burdock, the lithospermum erythrorhizon, the rhizoma dryopteris crassirhizomae, the barbed skullcap herb, the malt, the radix bupleuri and the Chinese olive is (8-15) mL (1-3) g.
  2. 2. The traditional Chinese medicine composition according to claim 1, which is characterized by being prepared from the following components, by weight, 24-32 parts of indigo naturalis, 21-25 parts of fructus forsythiae, 14-17 parts of burdock, 19-28 parts of rhizoma dryopteris crassirhizomae, 17-20 parts of lithospermum erythrorhizon, 12-16 parts of dandelion, 11-14 parts of rheum officinale, 12-15 parts of barbed skullcap herb, 10-13 parts of liquorice, 10-12 parts of malt, 10.5-12 parts of radix bupleuri and 8-9.5 parts of fructus Canarii albi.
  3. 3. The method for preparing a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome according to claim 1 or 2, which is characterized by comprising the following steps: (1) Cutting radix et rhizoma Rhei, fructus forsythiae, herba Taraxaci and Glycyrrhrizae radix respectively, mixing, decocting in water, and filtering to obtain filtrate A; (2) Pulverizing fructus Arctii, radix Arnebiae, rhizoma Dryopteris Crassirhizomatis, herba Scutellariae Barbatae, fructus Hordei Germinatus, bupleuri radix and fructus Canarii albi respectively, mixing, reflux extracting, and filtering to obtain filtrate B; (3) Mixing the obtained filtrate A, filtrate B and indigo naturalis, and concentrating.
  4. 4. The preparation method according to claim 3, wherein the water added in the step (1) is 3-7 times of the total mass of rheum officinale, fructus forsythiae, dandelion and liquorice, the decoction time is 50-80 min/time, and the decoction times are 1-3 times.
  5. 5. The preparation method of claim 3, wherein the solvent used in the reflux extraction in the step (2) is ethanol solution with the volume concentration of 65% -85%, and the volume mass ratio of the solvent to the total mass of the burdock, the lithospermum erythrorhizon, the rhizoma dryopteris crassirhizomae, the sculellaria barbata, the malt, the radix bupleuri and the fructus Canarii albi is (8-15) mL (1-3) g.
  6. 6. The method according to claim 3, wherein the time of the reflux extraction in the step (2) is 60 to 100 min/time, and the number of the reflux extractions is 1 to 4 times.
  7. 7. A Chinese medicinal preparation for preventing and/or treating porcine reproductive and respiratory syndrome, which is characterized by comprising the Chinese medicinal composition prepared by the preparation method according to any one of claims 3 to 6.
  8. 8. The traditional Chinese medicine preparation according to claim 7, wherein the dosage form of the traditional Chinese medicine preparation comprises oil, powder, granules or solution.

Description

Traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, preparation method thereof and traditional Chinese medicine preparation thereof Technical Field The invention relates to the technical field of veterinary prevention and treatment medicines, in particular to a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, a preparation method thereof and a traditional Chinese medicine preparation thereof. Background Porcine reproductive and respiratory syndrome (Porcine reproductive and respiratory syndrome, PRRS), also known as "porcine reproductive and respiratory syndrome", is a highly contagious disease caused by porcine reproductive and respiratory syndrome virus (porcine reproductive andrespiratory syndrome virus, PRRSV) characterized by respiratory disorders in infected pigs, fever, anorexia, late abortion, premature birth, stillbirth, weak and mummy births of pregnant sows, pigs of various ages, particularly piglets. The disease is also an immunosuppressive disease, so that the immunity of infected pigs is low, the bodies of pigs are extremely easy to be secondarily and concurrently infected with various viruses, bacteria and parasites, and various diseases are mixed or secondarily infected, so that the pigs die in batches, and obvious economic loss is caused to the pig industry. At present, the common practice for preventing and treating the porcine reproductive and respiratory syndrome is to treat the porcine reproductive and respiratory syndrome virus vaccine by beating pigs and treat the porcine reproductive and respiratory syndrome virus vaccine by using antibiotics, but the effect is not ideal, and the synthetic antiviral western medicines can generate certain toxic and side effects to cause certain influence on normal cells of organisms. Based on the above, it is very necessary to research and obtain a drug with better prevention and treatment effect on porcine reproductive and respiratory syndrome and small toxic and side effects. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, which can effectively enhance the effects of inhibiting pathogenic microorganisms and resisting PRRSV viruses, improve the immunity of pigs, strengthen the disease resistance of the pigs, relieve the symptoms of mental depression, inappetence and the like caused by the diseases, regulate the health of gastrointestinal tracts of animals, has small toxic and side effects and is not easy to generate drug resistance through the compatibility of the components. In order to achieve the above object, the present invention provides the following technical solutions: The invention provides a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, which comprises the following components, by weight, 22-35 parts of indigo naturalis, 20-26 parts of fructus forsythiae, 13-18 parts of burdock, 18-30 parts of rhizoma dryopteris crassirhizomae, 16-22 parts of lithospermum erythrorhizon, 10-17 parts of dandelion, 10-15 parts of rheum officinale, 11-16 parts of sculellaria barbata, 9-14 parts of liquorice, 9-13 parts of malt, 10-13 parts of radix bupleuri and 7-10 parts of fructus Canarii albi. Preferably, the Chinese medicinal composition comprises, by weight, 24-32 parts of indigo naturalis, 21-25 parts of fructus forsythiae, 14-17 parts of burdock, 19-28 parts of rhizoma dryopterygii, 17-20 parts of lithospermum erythrorhizon, 12-16 parts of dandelion, 11-14 parts of rheum officinale, 12-15 parts of sculellaria barbata, 10-13 parts of liquorice, 10-12 parts of malt, 10.5-12 parts of radix bupleuri and 8-9.5 parts of Chinese olive. The invention provides a preparation method of a traditional Chinese medicine composition for preventing and/or treating porcine reproductive and respiratory syndrome, which comprises the following steps: (1) Cutting radix et rhizoma Rhei, fructus forsythiae, herba Taraxaci and Glycyrrhrizae radix respectively, mixing, decocting in water, and filtering to obtain filtrate A; (2) Pulverizing fructus Arctii, radix Arnebiae, rhizoma Dryopteris Crassirhizomatis, herba Scutellariae Barbatae, fructus Hordei Germinatus, bupleuri radix and fructus Canarii albi respectively, mixing, reflux extracting, and filtering to obtain filtrate B; (3) Mixing the obtained filtrate A, filtrate B and indigo naturalis, and concentrating. Preferably, the water adding amount in the step (1) is 3-7 times of the total mass of the astragalus, the weeping forsythia, the dandelion and the liquorice, the decoction time is 50-80 min/time, and the decoction time is 1-3 times. Preferably, the solvent used in the reflux extraction in the step (2) is ethanol solution with the volume concentration of 65% -85%, and the volume mass ratio