CN-118512508-B - Traditional Chinese medicine composition for treating cerebral infarction

CN118512508BCN 118512508 BCN118512508 BCN 118512508BCN-118512508-B

Abstract

The application belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating cerebral infarction. The traditional Chinese medicine composition comprises the following raw materials in parts by weight, namely, ligusticum wallichii, astragalus membranaceus, radix puerariae, uncaria and compound fungus mushrooms, wherein the traditional Chinese medicine composition is prepared by the following steps of crushing ligusticum wallichii, astragalus membranaceus, radix puerariae and uncaria, extracting active ingredients by adopting a water extraction and alcohol precipitation method to obtain an extracting solution, S2, crushing the compound fungus mushrooms, adding deionized water, boiling at normal pressure, extracting, adding zymogen, sealing and fermenting to obtain a fermentation liquor, and S3, merging the extracting solution and the fermentation liquor, concentrating under reduced pressure, and spray drying to obtain the traditional Chinese medicine composition. The application has simple formula and safe components, and has wide clinical application prospect by promoting blood circulation of the brain, relieving brain tissue injury, and promoting nerve cell repair and regeneration through various effects of promoting blood circulation, removing blood stasis, tonifying qi, consolidating superficial resistance, clearing heat, detoxicating, dilating blood vessels, calming liver wind and the like.

Inventors

LU TIANJIAO
LI DIAO
Lu Meixi
XIE ZHIJIAN
ZHAO DONGLI

Assignees

哈尔滨市中医医院

Dates

Publication Date: 20260505
Application Date: 20240611

Claims (7)

1. A traditional Chinese medicine composition for treating cerebral infarction is characterized by being prepared from the following raw materials, by weight, 10-15 parts of ligusticum wallichii, 15-30 parts of astragalus mongholicus, 10-15 parts of radix puerariae, 6-12 parts of uncaria, and 8-15 parts of compound mushrooms; The compound mushrooms are Morchella esculenta and black fungus with the mass ratio of 1:2.8-3.2; the preparation method of the traditional Chinese medicine composition for treating cerebral infarction comprises the following preparation steps: s1, crushing Ligusticum wallichii, astragalus root, kudzuvine root and uncaria, extracting active ingredients by adopting a water extraction and alcohol precipitation method to obtain an extracting solution; s2, crushing the composite mushrooms, adding deionized water, boiling and extracting at normal pressure, and adding zymophyte for sealing fermentation to obtain fermentation liquor; s3, combining the extracting solution and the fermentation liquor, and concentrating under reduced pressure and spray drying to obtain the traditional Chinese medicine composition; The fermentation bacteria in the step S2 are compounded by pichia pastoris and lactobacillus plantarum, and the ratio of the viable bacteria number of the pichia pastoris to the viable bacteria number of the lactobacillus plantarum is 1:3.5-4.
2. The traditional Chinese medicine composition for treating cerebral infarction according to claim 1, which is characterized by being prepared from the following raw materials, by weight, 12-14 parts of ligusticum wallichii, 18-26 parts of astragalus mongholicus, 12-14 parts of radix puerariae, 8-10 parts of uncaria, and 10-14 parts of compound mushrooms.
3. The traditional Chinese medicine composition for treating cerebral infarction according to claim 1 or 2, which is characterized by being prepared from the following raw materials, by weight, 13 parts of ligusticum wallichii, 24 parts of astragalus mongholicus, 12 parts of radix puerariae, 9 parts of uncaria, and 12 parts of compound mushrooms.
4. The traditional Chinese medicine composition for treating cerebral infarction according to claim 1, wherein the specific operation of step S1 is as follows: s11, selecting high-quality medicinal materials such as ligusticum wallichii, astragalus, radix puerariae and uncaria, cleaning, drying under 55-65 ℃ hot air, crushing the dried medicinal materials, and sieving with a 60-100-mesh sieve; S12, adding deionized water into medicinal material powder according to a mass ratio of 1:8-12, mixing, heating to boil, maintaining the boiling state, extracting for 1-2h, filtering, adding ethanol into filtrate to ensure that the total alcohol concentration reaches 65-75%, standing overnight, filtering to remove sediment, centrifuging supernatant, controlling the centrifugal speed to 8000-10000r/min, and centrifuging for 5-10min to obtain an extract.
5. The traditional Chinese medicine composition for treating cerebral infarction according to claim 1, wherein the specific operation of step S2 is as follows: S21, selecting high-quality compound mushrooms, cleaning, drying under 55-65 ℃ hot air, crushing the dried compound mushrooms, and sieving with a 60-100-mesh sieve; S22, adding deionized water into the mushroom powder according to the feed-liquid ratio of 1:15-20, boiling for 20-40min, and cooling to room temperature to obtain a to-be-fermented liquid; S23, controlling the viable count of zymophyte in the liquid to be fermented to be 1 multiplied by 10 8 -3×10 8 cfu/ml, adding zymophyte into the liquid to be fermented, sealing the liquid to be fermented for 7-11h at room temperature, centrifuging to remove sediment, controlling the centrifugal rotating speed to be 8000-10000r/min, and centrifuging for 5-10min to obtain the fermentation liquid.
6. The composition of claim 1, wherein in step S3, the pharmaceutical excipients may be added after spray drying to prepare the desired dosage form of the composition.
7. The traditional Chinese medicine composition for treating cerebral infarction according to claim 6, wherein the pharmaceutical excipients include, but are not limited to, disintegrants, binders, lubricants, fillers, flavoring agents.

Description

Traditional Chinese medicine composition for treating cerebral infarction Technical Field The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating cerebral infarction. Background Cerebral infarction, also known as ischemic stroke, is a disease in which cerebral blood supply is insufficient due to cerebral vessel occlusion, causing damage to brain tissue. Causes include intracranial and cervical atherosclerosis, cardiac embolism and other diseases, and hypertension, heart disease, diabetes, dyslipidemia and other high risk factors, and the middle-aged and elderly people are particularly susceptible. Cerebral infarction is one of the main diseases causing death and disability in the global scope, and particularly serious cerebral infarction can cause serious consequences such as paralysis, aphasia, blindness and the like, thereby bringing great pressure to patients, families and society. The incidence of cerebral infarction increases with increasing risk factors such as hypertension, diabetes, hyperlipidemia, heart disease, etc. The modern medicine mainly comprises thrombolytic treatment, anticoagulation treatment, defibrination treatment, cerebral vasodilation and the like. Among them, thrombolytic therapy refers to restoring brain blood supply by dissolving thrombus, and common drugs include alteplase and reteplase, and thrombolytic therapy has strict time window limitation, and is only applicable to patients with acute cerebral infarction and cerebral middle artery blood supply region infarction within the time window (usually 4-6 hours). Anticoagulation treatment aims at preventing new thrombosis, common anticoagulants include heparin, low molecular weight heparin and the like, and anticoagulation treatment is easy to increase bleeding risks, including subepidermal bleeding, urinary tract bleeding, digestive tract bleeding and even intracranial bleeding. Defibrillating treatment is a reduction of thrombotic load by lowering fibrinogen levels in the blood, and commonly used drugs such as recombinant human prourokinase for injection, defibrillating treatment also increases the risk of bleeding. The cerebral vasodilation is an interventional operation for dilating a stenosed or blocked cerebral blood vessel by using a balloon catheter and increasing cerebral blood flow, and the vascular wall may be damaged in the operation process, thrombus is formed, and the blood vessel may be restenosis after the operation, etc. Therefore, although the above treatment method can alleviate the symptoms of patients to some extent, there are corresponding limitations and the ideal therapeutic effect cannot be achieved. The traditional Chinese medicine classifies cerebral infarction into stroke category, and the etiology and pathogenesis are mainly that qi stagnation, blood stasis and turbid phlegm cause channel blockage. Therefore, the strategy of traditional Chinese medicine treatment is often to clear and activate the channels and collaterals, remove blood stasis and dredge vessels. In the prior art, the traditional Chinese medicine composition for treating cerebral infarction generally comprises a plurality of medicine components, mainly comprises medicines with the effects of activating blood circulation to dissipate blood stasis, eliminating phlegm and dredging collaterals and the like, has the problems that the medicine components are more, the action mechanism is complex, the rapid and accurate treatment cannot be carried out, the treatment effect is to be improved and the like, and the use of the main medicines for activating blood circulation to dissipate blood stasis is accompanied with the increase of bleeding risk. Based on the above statement, the application provides a traditional Chinese medicine composition for treating cerebral infarction. Disclosure of Invention In order to solve the problems that the traditional Chinese medicine composition for treating cerebral infarction generally comprises a plurality of medicine components and mainly comprises medicines with the effects of activating blood circulation to dissipate blood stasis, eliminating phlegm and dredging collaterals and the like, the traditional Chinese medicine composition has a plurality of medicine components, has a complex action mechanism, cannot be rapidly and accurately treated, has a treatment effect to be improved and the like, and the main use of the medicines for activating blood circulation to dissipate blood stasis is accompanied with the increase of bleeding risk, the application provides the traditional Chinese medicine composition for treating cerebral infarction. The application provides a traditional Chinese medicine composition for treating cerebral infarction, which adopts the following technical scheme: a Chinese medicinal composition for treating cerebral infarction comprises (by weight parts) rhizoma Ligustici Chuanxiong 10-15, r