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CN-118615390-B - Traditional Chinese medicine composition for treating ulcerative colitis and preparation method, combined medicine and application thereof

CN118615390BCN 118615390 BCN118615390 BCN 118615390BCN-118615390-B

Abstract

The invention discloses a traditional Chinese medicine composition for treating ulcerative colitis, a preparation method thereof, a combined medicine and application thereof. The traditional Chinese medicine composition for treating ulcerative colitis is prepared from the following raw materials, by mass, 13-26 parts of astragalus mongholicus, 10-20 parts of honeysuckle, 10-20 parts of sargentgloryvine stem, 8-16 parts of dark plum fruit, 8-16 parts of hairyvein agrimony, 6-12 parts of allium macrostemon, 6-12 parts of platycodon grandiflorum, 3-6 parts of coptis chinensis and 1-3 parts of pseudo-ginseng powder. The result of constructing an animal model of ulcerative colitis through DSS induction shows that the traditional Chinese medicine composition has a certain treatment effect on ulcerative colitis. Clinical researches show that the traditional Chinese medicine composition disclosed by the invention is combined with mesalazine enteric-coated tablets, so that the Mayo score and serum inflammation index of patients with active ulcerative colitis can be reduced, the colonic mucosa inflammation and gastrointestinal symptoms can be improved, and the intestinal damp-heat type active ulcerative colitis can be effectively treated.

Inventors

  • WANG QI
  • DING XIA
  • LI YUAN

Assignees

  • 北京中医药大学

Dates

Publication Date
20260505
Application Date
20240726

Claims (8)

  1. 1. The traditional Chinese medicine composition for treating the intestinal damp-heat type active ulcerative colitis is characterized by being prepared from the following raw materials in parts by mass: 13-26 parts of astragalus membranaceus, 10-20 parts of honeysuckle, 10-20 parts of sargentgloryvine stem, 8-16 parts of dark plum fruit, 8-16 parts of hairyvein agrimony, 6-12 parts of allium macrostemon, 6-12 parts of platycodon grandiflorum, 3-6 parts of coptis chinensis and 1-3 parts of pseudo-ginseng powder.
  2. 2. The traditional Chinese medicine composition for treating ulcerative colitis in the intestinal damp-heat type active period according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials, by mass, 20 parts of astragalus mongholicus, 15 parts of honeysuckle, 15 parts of caulis sargentgloryvine, 12 parts of dark plum, 12 parts of hairyvein agrimony, 10 parts of allium macrostemon, 10 parts of platycodon grandiflorum, 5 parts of coptis chinensis and 1.5 parts of pseudo-ginseng powder.
  3. 3. The traditional Chinese medicine composition for treating ulcerative colitis in the active period of damp-heat in intestinal tract according to any one of claims 1 to 2, wherein the traditional Chinese medicine composition is a decoction.
  4. 4. The preparation method of the traditional Chinese medicine composition for treating intestinal damp-heat type active ulcerative colitis of claim 3, which is characterized by comprising the following steps of mixing the raw materials for preparing the traditional Chinese medicine composition according to the parts by mass, soaking the raw materials in water, decocting the raw materials, and collecting decoction to obtain the water decoction.
  5. 5. The method for preparing a traditional Chinese medicine composition for treating ulcerative colitis in a intestinal damp-heat type active period according to claim 4, wherein the soaking time is 20-30 minutes; The decoction time is controlled to be that each 100.5g of raw materials are decocted with 1000-1500 ml of water until the residual liquid is 150-300 ml; The times of the decoction are 2 times, and the decoction is combined after the decoction is finished.
  6. 6. Use of a traditional Chinese medicine composition according to any one of claims 1-3 for preparing a medicament for treating ulcerative colitis in the active phase of intestinal damp-heat type.
  7. 7. A medicament for treating ulcerative colitis in the active period of intestinal damp-heat type in combination, which is characterized by comprising the traditional Chinese medicine composition according to any one of claims 1-3 and mesalazine enteric-coated tablets.
  8. 8. The use of the medicament of claim 7 for the preparation of a medicament for the treatment of ulcerative colitis in the active phase of intestinal damp-heat.

Description

Traditional Chinese medicine composition for treating ulcerative colitis and preparation method, combined medicine and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating ulcerative colitis, a preparation method, a combined medicine and application thereof. Background Ulcerative colitis (Ulcerative colitis, UC) is a chronic, non-specific inflammatory bowel disease characterized by a continuous, diffuse inflammatory change of the colorectal mucosa, the lesions of which are mainly limited to the colorectal mucosa and submucosa. The clinical manifestations of UC include diarrhea, mucopurulent bloody stool, abdominal pain, mild and severe conditions, and the patients often have repeated chronic courses of attack, which are characterized by alternate relief and recurrence. According to the clinical manifestations of UC, TCM classifies them as "chronic dysentery", "intestinal pi" or "diarrhea". Although the prevalence of UC in asia is relatively low compared to the european and american countries, its actual prevalence has shown a rising trend year by year in recent years. The current therapeutic strategies for UC are mainly focused on rapid induction remission during active periods of disease and long-term maintenance during remission periods, while preventing the occurrence of complications such as cancer. The common therapeutic drugs mainly comprise 5-aminosalicylic acid (mesalamine), glucocorticoid, immunosuppressant and biological agent for ascending stairs. However, these drugs have certain limitations, such as unstable efficacy, easy recurrence after drug withdrawal, side effects such as liver and kidney function damage and even bone marrow suppression, and the like, and the defects of increased potential infection risk, higher treatment cost, and the like. Clinical research results based on evidence-based medical evidence show that the traditional Chinese medicine has characteristics and advantages in the aspects of improving the clinical symptoms of UC, inducing and relieving, preventing recurrence, improving life quality, reducing complications and the like. Meanwhile, the Chinese medicine and western medicine are cooperated to treat UC, so that the effect of improving efficiency and reducing toxicity can be achieved, and the combination of the Chinese medicine and the western medicine has important significance for preventing and treating UC and researching curative effect. Basic research also proves that the traditional Chinese medicine can intervene UC from a plurality of links such as anti-inflammatory, immunity regulation, mucous membrane repair and the like. Therefore, there is a need to develop a combination of a traditional Chinese medicine composition and a traditional Chinese medicine synergetic western medicine, which has a remarkable curative effect on ulcerative colitis and has few side effects. Disclosure of Invention The invention aims to provide a traditional Chinese medicine composition for treating ulcerative colitis, a preparation method thereof, a combined medicine and application thereof. In order to achieve the above purpose, the invention adopts the following technical scheme: in the first aspect, the invention provides a traditional Chinese medicine composition for treating ulcerative colitis, which is prepared from the following raw materials, by mass, 13-26 parts of astragalus mongholicus, 10-20 parts of honeysuckle, 10-20 parts of sargentgloryvine stem, 8-16 parts of dark plum fruit, 8-16 parts of hairyvein agrimony, 6-12 parts of allium macrostemon, 6-12 parts of platycodon grandiflorum, 3-6 parts of coptis chinensis and 1-3 parts of pseudo-ginseng powder. Astragalus membranaceus is dried root of Astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Var. Mongholicus (bge.) Hsiao or Astragalus membranaceus Astragalus membranaceus (Fisch.) bge. Of Leguminosae, and has effects of invigorating qi, raising yang, consolidating exterior, suppressing sweating, inducing diuresis to alleviate edema, promoting salivation, nourishing blood, activating stagnancy, relieving arthralgia, removing toxic substances, expelling pus, healing sore, and promoting granulation; the flos Lonicerae is dried flower bud or flower with primary opening of Lonicera japonica Thunb Lonicera japonica Thunb of Caprifoliaceae, and has effects of clearing heat and detoxicating, dispelling pathogenic wind and heat; Caulis Sargentodoxae is dried stem of caulis Sargentodoxae Sargentodoxa cuneata (Oliv.) of family Akebiaceae, and has effects of clearing heat, removing toxic substances, promoting blood circulation, dispelling pathogenic wind, and relieving pain; The mume fructus is dry and near-mature fruit of Prunus mume Prunus mume (Sieb.) Sieb.et Zucc of Rosaceae, and has effects of astringing lung, astringing intestine, promoting salivation, and relieving ascar