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CN-118638450-B - Medical endoscope antifogging agent and application thereof

CN118638450BCN 118638450 BCN118638450 BCN 118638450BCN-118638450-B

Abstract

The utility model provides a medical endoscope antifogging agent and an application thereof, belonging to the field of medical appliances. The medical endoscope antifogging agent consists of cellulose, zwitterionic polymer, deionized water and ethanol, wherein the cellulose accounts for 0.001-10wt%, the zwitterionic polymer accounts for 0.001-10wt%, the ethanol accounts for 40-90wt%, the rest is deionized water, the cellulose can form a film on the surface of the medical endoscope, and the zwitterionic polymer can resist adhesion of biological components in a body. The medical endoscope antifogging agent combines cellulose and zwitterionic polymer, exerts long-time antifogging, can obviously reduce adhesion of biological components in a body to the endoscope, enables the endoscope to keep high transmittance in the body in the operation process, enables the view field to be clear in the operation, and improves the operation accuracy. Solves the technical problems that the prior medical endoscope antifogging agent has short antifogging time and is easy to adhere biological components in the body.

Inventors

  • CAI YINGLI
  • JIANG JUNHUI
  • SHEN YAODONG
  • HUANG HANG
  • WEI TAO
  • LUO TAO

Assignees

  • 辉擎医疗科技(嘉兴)有限公司

Dates

Publication Date
20260508
Application Date
20240703

Claims (7)

  1. 1. A medical endoscope antifogging agent is characterized by comprising 0.001-10wt% of cellulose, 40-90wt% of zwitterionic polymer, and the balance of deionized water, wherein the cellulose is used for forming a film on the surface of a medical endoscope, the zwitterionic polymer is used for resisting adhesion of biological components in a body, the ethanol and the deionized water are mutually dissolved, so that the cellulose and the zwitterionic polymer are favorably paved on the surface of the medical endoscope, the transmittance of the medical endoscope antifogging agent is improved, the zwitterionic polymer is one or more of polymethyl acryloylethyl sulfobetaine, poly 2-methacryloyloxyethyl phosphorylcholine, polymethyl acryloylethyl carboxylic betaine, polymethyl acryloylethyl trifluoropropyl carboxylic betaine, the transmittance of the medical endoscope antifogging agent after film forming is 90-100%, and the relative contact angle of the medical endoscope antifogging agent at the temperature of 22-25 ℃ and the relative humidity of 20-35 degrees.
  2. 2. The medical endoscope antifogging agent according to claim 1, wherein the weight percentage of cellulose is 0.002-5 wt%, the weight percentage of the zwitterionic polymer is 0.002-5 wt%, the weight percentage of ethanol is 65-80 wt%, and the rest is deionized water.
  3. 3. The medical endoscope antifogging agent according to claim 1, wherein the cellulose is one or more of cellulose acetate, cellulose butyrate, cellulose phthalate, cellulose nitrate, cellulose sulfate, cellulose phosphate, cellulose propionate, cellulose acetate butyrate, ethyl cellulose, ethyl methyl cellulose, benzyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxyethyl cellulose, and carboxyethyl cellulose.
  4. 4. The medical endoscope antifogging agent according to claim 1, wherein the cellulose has a molecular weight of 20,000~500,000 Da.
  5. 5. The medical endoscope antifogging agent according to claim 1, wherein the zwitterionic polymer has a molecular weight of 10,000~100,000 Da.
  6. 6. The medical endoscope antifogging agent according to any one of claims 1 to 5, wherein an antifogging time of the medical endoscope antifogging agent in a body is 120 minutes or longer.
  7. 7. Use of the medical endoscope antifogging agent according to any one of claims 1 to 5 in clinical operations.

Description

Medical endoscope antifogging agent and application thereof Technical Field The disclosure relates to the field of medical instruments, in particular to a medical endoscope antifogging agent and application thereof. Background With the continuous development of minimally invasive surgery techniques, various surgeries are increasingly performed by means of hard endoscopes in surgery, and the success of the surgery requires not only a high level of operation techniques, but also the guarantee of clear vision is a key to the success of the surgery. In the operation process, the endoscope adopts a cold light source to provide illumination, the temperature of the endoscope is a certain difference from the temperature of the environment in the human body, and the temperature difference enables water vapor in the body cavity to generate water mist when encountering a colder endoscope lens, so that diagnosis and treatment efficiency is affected. The existing clinical common practice for defogging an endoscope is that a hot water preheating method is used for a lens, a tissue omentum wiping method and an iodophor wiping method are used. However, the defogging method has short defogging time, and cannot achieve the effect of long-time defogging. At present, the average fog-forming time of an endoscope defogged by a medical institution by adopting the existing method is 4-6 minutes, the surgical endoscopic operation time is about 26-90 minutes, and the individual complex operation can reach several hours. Therefore, the existing endoscope defogging method needs to frequently withdraw the endoscope lens from the human body to repeatedly wipe the fog in the operation process, thereby seriously affecting the progress and fluency of the operation. Moreover, the existing endoscope defogging method is easy to cause biological components such as blood, tissue fluid, bacteria and the like to adhere to the endoscope, so that the endoscope is polluted, the transmittance of the endoscope can be reduced to a certain extent, the definition of the visual field in the operation is affected, and the operation accuracy is further affected. In addition, bacteria adhere to the endoscope surface, which also tends to increase the risk of post-operative infection. Therefore, it would be of great significance to provide a medical endoscope antifogging agent and application thereof, which can solve or alleviate at least one of the above technical problems. Disclosure of Invention In view of the above technical problems, the present disclosure provides a medical endoscope antifogging agent and application thereof, which can achieve long antifogging time, high light transmittance, and can reduce adhesion of in vivo biological components such as blood, tissue fluid, bacteria, and the like on an endoscope, so as to solve or at least alleviate at least one technical problem existing in the above endoscope antifogging. According to a specific embodiment of the present disclosure, in a first aspect, the present disclosure provides a medical endoscope antifogging agent, which is composed of cellulose, zwitterionic polymer, deionized water and ethanol, wherein the weight percentage of the cellulose is 0.001wt% to 10wt%, the weight percentage of the zwitterionic polymer is 0.001wt% to 10wt%, the weight percentage of the ethanol is 40wt% to 90wt%, and the balance is deionized water, the cellulose is used for forming a film on the surface of the medical endoscope, and the zwitterionic polymer is used for resisting adhesion of biological components in a body. Further, in the medical endoscope antifogging agent, the weight percentage of cellulose is 0.002-5 wt%, the weight percentage of the zwitterionic polymer is 0.002-5 wt%, the weight percentage of ethanol is 65-80 wt%, and the rest is deionized water. Further, the cellulose is one or more of cellulose acetate, cellulose triacetate, cellulose butyrate, cellulose phthalate, cellulose nitrate, cellulose sulfate, cellulose phosphate, cellulose propionate, cellulose acetate butyrate, ethyl cellulose, ethyl methyl cellulose, benzyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl methyl cellulose, ethyl hydroxyethyl cellulose and carboxyethyl cellulose. Further, the zwitterionic polymer is one or more of poly (methacryloyl ethyl sulfobetaine), poly (2-methacryloyl oxyethyl phosphorylcholine), poly (methacryloyl ethyl carboxylic acid betaine), poly (methacryloyl ethyl trifluoropropyl carboxylic acid betaine). Further, the molecular weight of the cellulose is 20,000~500,000 Da. Further, the molecular weight of the cellulose is 20,000-100,000 Da. Further, the molecular weight of the zwitterionic polymer is from 10,000 Da to 100,000 Da. Further, the molecular weight of the zwitterionic polymer is 20,000-50,000 Da. Further, cellulose, zwitterionic polymer, deionized water and ethanol all meet YY/T0640-2016 general requirements for passive surgical implants.