CN-118717823-B - Application of composition in preparation of product for preventing or improving colon blackening

CN118717823BCN 118717823 BCN118717823 BCN 118717823BCN-118717823-B

Abstract

The invention relates to an application of a composition in preparing a product for preventing or improving colon blackening, wherein the composition comprises the following raw materials of 33.7wt% of pumpkin peel, 20.8wt% of pumpkin pedicel, 12.9wt% of pumpkin collaterals, 7.9wt% of poria cocos, 9.0wt% of tremella and 15.7wt% of xylooligosaccharide. The composition disclosed by the invention has the advantages that the components are reasonably proportioned, and experiments prove that the accumulation of lipofuscin in the colon can be reduced so as to prevent the colon from blackening, and the deposited lipofuscin in the colon can be removed so as to improve the colon from blackening. Therefore, the composition of the present invention has the effect of preventing and improving the blackening of the colon, and can be used for preparing products for preventing or improving the blackening of the colon.

Inventors

WANG TIANTIAN
WANG HONGDI
KANG LIJUAN
PI GUOPEI
ZHU ZHIMING
ZHAO DAPENG
ZHANG JIAN
WU QI
LI YINQING
WANG GUANGLU

Assignees

河北御芝林生物科技有限公司

Dates

Publication Date: 20260508
Application Date: 20240601

Claims (1)

1. The application of the composition in preparing the medicine for improving the colon blackening comprises 33.7wt% of pumpkin coat, 20.8wt% of pumpkin pedicel, 12.9wt% of pumpkin collaterals, 7.9wt% of poria cocos, 9.0wt% of tremella and 15.7wt% of xylooligosaccharide, wherein the colon blackening is changed into aloe-induced colon blackening.

Description

Application of composition in preparation of product for preventing or improving colon blackening Technical Field The invention belongs to the technical field of traditional Chinese medicine compositions, and relates to an application of a composition in preparing a product for preventing or improving colon blackening. Background The colonic melanosis (melanosiscoli, MC) is a non-inflammatory bowel disease which is mainly characterized by colonic mucosa melanin pigmentation, and is essentially characterized by a large amount of lipofuscin contained in macrophages in the lamina propria of colonic mucosa. In recent years, the detection rate of the colon melanosis is increased year by year, and both men and women are in a gradually rising trend. Colonoscopy of the colonic melanosis is manifested by a variable degree and extent of pigmentation of the colonic mucosa, which may exhibit a net-like or granular change that is diffusely distributed over the colonic mucosa or localized over a segment of the mucosa of the colon. The impact of colon blackening on the life and mind of the patient is not negligible, especially in view of images such as leopards on enteroscopy report sheets, which is fear, and related studies indicate that colon blackening leads to an increase in the incidence of colonic polyps. In 2009, the digestive system department of the national hospitals of white main body and the central hospitals of Taian city published an article entitled "56 cases of clinical analysis of colon blackness" in Chinese medicine guide, which states that 56 cases of colon blackness patients who are treated in hospitals all appear as mucosal pigmentation under the lens, wherein 6 cases of polyps are accompanied. Therefore, it is significant to develop products capable of improving colon blackening. However, no specific treatment method or product is available for colon blackening, and patients are often required to improve intestinal environment through diet therapy so as to achieve the purpose of improving colon blackening. But has long dietary therapy period and insignificant effect. In addition, there are some traditional Chinese medicine compositions developed for constipation as a main symptom and colon blackening as a combined symptom, but since the therapeutic rules of the traditional Chinese medicine compositions are often bowel relaxing, bowel motility improving and the like, the traditional Chinese medicine compositions can effectively improve constipation, but the effect of improving colon blackening is not obvious, and the administration period is long. In view of this, developing a product that has a remarkable effect, a short administration period, and can specifically improve colon blackening becomes a problem to be solved by those skilled in the art. Disclosure of Invention In order to solve the problems in the prior art, the invention provides an application of a composition in preparing a product for preventing or improving colon blackening, and the invention adopts the following technical scheme: the application of the composition in preparing the product for preventing or improving the colonic blackening comprises the following raw materials of 33.7wt% of pumpkin coat, 20.8wt% of pumpkin pedicel, 12.9wt% of pumpkin collaterals, 7.9wt% of poria cocos, 9.0wt% of tremella and 15.7wt% of xylooligosaccharide. In a preferred embodiment of the invention, the colon blackening comprises aloe vera-induced colon blackening. In a preferred embodiment of the invention, the preventing of colonic blackening comprises reducing accumulation of lipofuscin in the colon. In a preferred embodiment of the invention, said improving of colonic blackening comprises clearing deposited lipofuscin from the colon. Compared with the prior art, the invention has the beneficial effects that: the composition disclosed by the invention has the advantages that the components are reasonably proportioned, and experiments prove that the accumulation of lipofuscin in the colon can be reduced so as to prevent the colon from blackening, and the deposited lipofuscin in the colon can be removed so as to improve the colon from blackening. Therefore, the composition provided by the invention has the effect of preventing and improving colon blackening. Drawings FIG. 1 is a visual view of the colon of five groups of test animals according to the present invention; FIG. 2 is a graphical representation of the relative area percent of colon blackening for five groups of test animals according to the present invention; FIG. 3is a schematic representation of HE staining of five groups of test animals according to the invention; FIG. 4 is a schematic representation of melanin staining in five groups of test animals according to the present invention; Fig. 5 is a graphical representation of the relative area percent of melanin regions for five groups of test animals in accordance with the present invention. Detailed Description The present invention is