CN-118777173-B - Auxiliary diagnostic information providing device and blood analysis system

CN118777173BCN 118777173 BCN118777173 BCN 118777173BCN-118777173-B

Abstract

The application provides a 202310323347.9 divisional application, and provides an auxiliary diagnosis information providing device and a blood analysis system, wherein the auxiliary diagnosis information providing device comprises an acquisition module and an output module, wherein the acquisition module is used for acquiring sample detection data which is obtained by detecting and analyzing a biological sample of an object to be detected and contains a sample analysis image and/or sample detection parameters, and the output module is used for outputting an auxiliary diagnosis report which comprises auxiliary diagnosis category information and a target reference sample image according to the sample analysis image, first abnormal characteristic information which is identified based on the sample analysis image and/or second abnormal characteristic information which is identified based on the sample detection parameters. The auxiliary diagnosis report provides a target reference sample image which is a reference image of a historical diagnosis example with similarity meeting a preset condition and confirmed by microscopic examination for a doctor to quickly grasp the diagnosis basis of the currently obtained auxiliary diagnosis type information so as to judge the reliability of the current auxiliary diagnosis type information.

Inventors

WANG YUTING
FANG JIANWEI
HUO ZILING

Assignees

深圳市帝迈生物技术有限公司

Dates

Publication Date: 20260512
Application Date: 20230330

Claims (9)

1. An auxiliary diagnostic information providing apparatus, comprising: the system comprises an acquisition module, a detection module and a detection module, wherein the acquisition module is used for acquiring sample detection data obtained by detecting and analyzing a biological sample of an object to be detected, and the sample detection data comprises a sample analysis image and/or a sample detection parameter; A first abnormality identification module for obtaining first abnormality feature information characterizing an abnormality feature in the sample analysis image, and/or A second abnormality identification module for obtaining second abnormality characteristic information characterizing abnormality of a parameter value in the biological sample, which is determined based on the sample detection parameter; An output module for outputting an auxiliary diagnostic report according to the sample analysis image, the first abnormal feature information and/or the second abnormal feature information, the auxiliary diagnostic report comprising: auxiliary diagnostic category information; the target reference sample image is a reference image with similarity meeting preset conditions with the sample analysis image in a sample analysis image library, wherein the sample analysis image library comprises sample analysis images of historical diagnosis cases confirmed by microscopic examination; the auxiliary diagnostic report further comprises the sample analysis image carrying a positioning mark, wherein the positioning mark is used for showing the position of the first abnormal characteristic information in the sample analysis image; wherein the auxiliary diagnostic information providing means forms the positioning mark of the sample analysis image in any one of the following ways: performing gradient back propagation analysis based on the classification labels in the first abnormal feature information to obtain a thermodynamic diagram, identifying a highlight region in the thermodynamic diagram, constructing a minimum bounding rectangle based on the contour of the highlight region to form a positioning mark of the sample analysis image, or Identifying the sample analysis image by using a target detection neural network, outputting a corresponding classification label based on the identified abnormal features in the sample analysis image, and outputting a sample analysis image carrying a positioning mark, or Detecting whether abnormal features exist in the sample analysis image by adopting an image segmentation neural network to obtain a target detection result of a local image corresponding to the abnormal features, and determining the position of a positioning mark in the sample analysis image based on the target detection result of the local image, or And forming a positioning mark of the sample analysis image based on at least one mode of a target detection algorithm, a peak searching algorithm and a valley searching algorithm of the region of interest.
2. The auxiliary diagnostic information providing apparatus according to claim 1, wherein, When the category of the first abnormal characteristic information is a first type, the auxiliary diagnosis report comprises at least two target reference sample graphs with similarity meeting preset conditions, and the abnormality degree grades of the at least two target reference sample graphs are the same; and when the category of the first abnormal characteristic information is the second type, the auxiliary diagnosis comprises a target reference sample graph with highest similarity and at least one target state reference graph, and the target reference sample graph and the target state reference graph are different in abnormal degree level.
3. The auxiliary diagnostic information providing apparatus according to claim 1, wherein the auxiliary diagnostic report further comprises: A target state reference map which is matched with the sample analysis image and has different abnormality degree grades from the target reference sample map, wherein the abnormality degree grades comprise severity, moderate and mild; the abnormality degree level of the target reference sample map is one of a severity, a moderate, and a mildness, and the abnormality degree level of the target state reference map includes the other two of the severity, the moderate, and the mildness.
4. The auxiliary diagnostic information providing apparatus according to claim 1, wherein, The auxiliary diagnosis information providing device further comprises a reference image determining module, a target reference sample image determining module and a target reference sample image determining module, wherein the reference image determining module is used for determining a matched image set in a sample analysis image library according to the category of the first abnormal characteristic information, determining a target reference sample image with the similarity meeting a preset condition according to the similarity between the sample analysis image and a reference image in the matched image set, or determining a matched image set according to the category of the first abnormal characteristic information by carrying out primary searching according to the similarity in the sample analysis image library and carrying out secondary searching according to the similarity in the matched image set, and determining the target reference sample image with the similarity meeting the preset condition according to the secondary searching result.
5. The auxiliary diagnostic information providing apparatus according to claim 1, wherein the auxiliary diagnostic report further includes a target state reference map; The reference picture determining module is further used for determining the target state reference picture which is the same as the mode category and different from the target reference sample picture in the sample analysis image library according to the mode category to which the target reference sample picture belongs; At least one of the target reference sample diagram and the target state reference diagram carries a positioning mark, and the positioning mark carried by at least one of the target reference sample diagram and the target state reference diagram is used for highlighting the position of the diagnosis basis for obtaining the first abnormal characteristic information.
6. The auxiliary diagnostic information providing apparatus according to claim 1, wherein the auxiliary diagnostic report further comprises: the sample analysis image carrying a positioning mark, wherein the positioning mark is used for showing the position of the first abnormal characteristic information in the sample analysis image; The auxiliary diagnosis information providing device is also used for correspondingly adding positioning marks in the matched target reference sample graph according to the positions of the positioning marks in the sample analysis image.
7. An auxiliary diagnostic information providing apparatus, comprising: The acquisition module is used for acquiring a sample analysis image obtained by detecting and analyzing a biological sample of an object to be detected; The first abnormal recognition module is used for obtaining first abnormal characteristic information representing abnormal characteristics in the sample analysis image according to the sample analysis image; An output module for outputting an auxiliary diagnostic report according to the sample analysis image and the first abnormal characteristic information, wherein the auxiliary diagnostic report comprises: auxiliary diagnostic category information; the sample analysis image carrying a positioning mark, wherein the positioning mark is used for showing the position of the first abnormal characteristic information in the sample analysis image; The auxiliary diagnostic information providing apparatus forms the positioning mark of the sample analysis image in any one of the following ways: performing gradient back propagation analysis based on the classification labels in the first abnormal feature information to obtain a thermodynamic diagram, identifying a highlight region in the thermodynamic diagram, constructing a minimum bounding rectangle based on the contour of the highlight region to form a positioning mark of the sample analysis image, or Identifying the sample analysis image by using a target detection neural network, outputting a corresponding classification label based on the identified abnormal features in the sample analysis image, and outputting a sample analysis image carrying a positioning mark, or Detecting whether abnormal features exist in the sample analysis image by adopting an image segmentation neural network to obtain a target detection result of a local image corresponding to the abnormal features, and determining the position of a positioning mark in the sample analysis image based on the target detection result of the local image, or And forming a positioning mark of the sample analysis image based on at least one mode of a target detection algorithm, a peak searching algorithm and a valley searching algorithm of the region of interest.
8. The auxiliary diagnostic information providing apparatus as claimed in claim 7, wherein said first abnormality identifying module includes: The abnormal feature classification module is used for determining classification labels of abnormal features in the sample analysis image through an image classification neural network model to obtain first abnormal feature information; The auxiliary diagnostic information providing apparatus further includes: The activation graph forming module is used for carrying out gradient back propagation analysis based on the classification labels in the first abnormal characteristic information to obtain a thermodynamic diagram, and the thermodynamic diagram is overlapped with the sample analysis image after being amplified to obtain the activation graph; and the positioning mark module is used for forming a positioning mark on the sample analysis image based on the highlight area of the activation graph.
9. A blood analysis system, comprising: The sampling assembly is used for collecting and distributing a biological sample of an object to be detected, wherein the biological sample is a blood sample; the reaction component is used for processing the biological sample to form a liquid to be tested; The driving assembly is used for driving a liquid path between the sampling assembly and the reaction assembly; the detection component is used for classifying and counting blood cells contained in the liquid to be detected to obtain sample detection data containing sample detection parameters and/or sample analysis images; The auxiliary diagnostic information providing apparatus according to any one of claims 1 to 8, configured to output an auxiliary diagnostic report based on the sample detection data.

Description

Auxiliary diagnostic information providing device and blood analysis system The application is a divisional application, the application number of the original application is 202310323347.9, the application date is 2023, 3 and 30 days, and the application is named as an auxiliary diagnosis information providing device and a blood analysis system. Technical Field The present application relates to the technical field of medical assistance, and in particular, to an auxiliary diagnostic information providing apparatus and a blood analysis system. Background In the field of medical diagnosis, it is very common practice to collect biological samples such as blood, urine, saliva, etc. of a patient and perform detection analysis to obtain sample detection data, which can provide a doctor with a judgment that the patient may have a certain disease. At present, sample detection data obtained by detecting and analyzing biological samples is mainly completed by doctors according to experience and learning. On one hand, the utilization of sample detection data is very limited by personal experience and learning of doctors, important information is easy to appear and cannot be effectively identified and utilized, and on the other hand, the identification of a large amount of sample detection data can occupy time and energy of doctors greatly, so that diagnosis efficiency is seriously affected. With the improvement of the technological and informationized degree of the medical industry, in recent years, an auxiliary diagnosis application system based on computer intelligent assistance starts to develop gradually, and analysis and identification are performed on sample detection data through the auxiliary diagnosis application system so as to identify abnormal information in the sample detection data and provide the abnormal information for doctors, so that the doctors are assisted in making diagnosis decisions. However, in the scheme of the auxiliary diagnostic application system which is currently known to be adopted, a doctor often cannot know how to determine whether the auxiliary diagnostic application system obtains abnormal information, so that the doctor has great trouble on whether to adopt the identification information provided by the auxiliary diagnostic application system, and practical application and development of the auxiliary diagnostic technology are greatly limited. Disclosure of Invention In order to solve the technical problems, the application provides an auxiliary diagnosis information providing device and a blood analysis system which are accurate, efficient and capable of effectively verifying auxiliary diagnosis results. In a first aspect of an embodiment of the present application, there is provided an auxiliary diagnostic information providing apparatus including: The system comprises an acquisition module, a detection module and a detection module, wherein the acquisition module is used for acquiring sample detection data obtained by detecting and analyzing a biological sample of an object to be detected, and the sample detection data comprises a sample analysis image and sample detection parameters; The first abnormal recognition module is used for obtaining first abnormal characteristic information representing abnormal characteristics in the sample analysis image according to the sample analysis image; A second abnormality identification module for obtaining second abnormality characteristic information characterizing abnormality of a parameter value in the biological sample, which is determined based on the sample detection parameter; the output module is used for outputting an auxiliary diagnosis report according to the sample analysis image, the first abnormal characteristic information and the second abnormal characteristic information, and the auxiliary diagnosis report comprises: auxiliary diagnostic category information; An activation map for highlighting the diagnostic basis of the first abnormal feature information, the activation map being superimposed by a thermodynamic diagram obtained based on a feature map of the sample analysis image and the biological sample analysis image, wherein the thermodynamic diagram characterizes the degree of decision impact of each unit region of the sample analysis image on determining the first abnormal feature information; The sample analysis image carries a positioning mark, wherein the positioning mark is used for showing the position of the first abnormal characteristic information in the sample analysis image. In a second aspect of the embodiment of the present application, there is provided an auxiliary diagnostic information providing apparatus including: The system comprises an acquisition module, a detection module and a detection module, wherein the acquisition module is used for acquiring sample detection data obtained by detecting and analyzing a biological sample of an object to be detected, and the sample detection data comprises a