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CN-118948953-B - Pharmaceutical composition for burn and preparation method thereof

CN118948953BCN 118948953 BCN118948953 BCN 118948953BCN-118948953-B

Abstract

The invention provides a pharmaceutical composition for treating burns and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations, wherein the pharmaceutical composition comprises 6-9 parts of puffball powder, 6-9 parts of pollen typhae carbon powder, 1-2 parts of cortex moutan powder, 3-5 parts of peppermint powder and 3-5 parts of divaricate saposhnikovia root powder, the ointment comprises 6-12 parts of lithospermum, 5-9 parts of coptis chinensis, 5-9 parts of baical skullcap root, 5-9 parts of astragalus mongholicus, 5-9 parts of amur corktree bark, 5-9 parts of cape jasmine, 5-9 parts of kuh-seng, 5-9 parts of szechuan pepper, 5-9 parts of red sage root, 5-9 parts of Chinese angelica, 5-9 parts of ginseng, 5-9 parts of American ginseng, 5-9 parts of virgate wormwood herb, 5-9 parts of Chinese mugwort leaf, 5-9 parts of natural indigo, 2-5 parts of pearl powder, 2-5 parts of borneol, 5-9 parts of rosin, 150-200 parts of beeswax, 20-50 parts of white spirit with high degree and 900-1200 parts of vegetable oil. The invention has quick response and obvious curative effect on burn wound surfaces.

Inventors

  • ZHAO WANGUI

Assignees

  • 赵万贵

Dates

Publication Date
20260512
Application Date
20240808

Claims (8)

  1. 1. A pharmaceutical composition for treating burn is characterized by comprising medicinal powder and ointment; the medicinal powder is prepared from, by weight, 6-9 parts of puffball powder, 6-9 parts of pollen typhae carbon powder, 1-2 parts of cortex moutan powder, 3-5 parts of peppermint powder and 3-5 parts of divaricate saposhnikovia root powder; The ointment is prepared from, by weight, 6-12 parts of lithospermum, 5-9 parts of coptis chinensis, 5-9 parts of scutellaria baicalensis, 5-9 parts of astragalus membranaceus, 5-9 parts of phellodendron amurense, 5-9 parts of gardenia, 5-9 parts of radix sophorae flavescentis, 5-9 parts of ligusticum wallichii, 5-9 parts of pericarpium zanthoxyli, 5-9 parts of radix salviae miltiorrhizae, 5-9 parts of angelica sinensis, 5-9 parts of ginseng, 5-9 parts of American ginseng, 5-9 parts of herba artemisiae capillaries, 5-9 parts of artemisia argyi, 5-9 parts of indigo naturalis, 2-5 parts of pearl powder, 2-5 parts of borneol, 5-9 parts of rosin, 150-200 parts of beeswax, 20-50 parts of high-strength white spirit and 900-1200 parts of vegetable oil; The preparation method of the cortex moutan powder comprises the following steps: A1, weighing cortex moutan, cattail pollen carbon and radix sileris according to the mass ratio of (4-6) to (2-5), and mixing to obtain raw materials; a2, adding water with the mass 3-5 times of that of the raw materials obtained in the step A1, heating to 70-80 ℃, and preserving heat and soaking for 1-2 hours to obtain soaked materials; a3, adding water with the mass 5-7 times of that of the raw materials into the soaking material obtained in the step A2, and extracting for 7-9 hours by distillation and reflux to obtain a feed liquid; a4, concentrating the feed liquid obtained in the step A3 to 2-3 times of the mass of the raw materials, standing for 8-10h, precipitating, taking supernatant, concentrating under reduced pressure to a relative density of 1.16-1.18 at 60 ℃, spray drying, collecting powder, and crushing to obtain the cortex moutan powder; The medicinal powder and the ointment are matched for use, and when in use, the medicinal powder is sprayed on the burn wound surface, and then the ointment is smeared on the surface layer of the medicinal powder.
  2. 2. The pharmaceutical composition for burns according to claim 1, wherein the powder is prepared from 9 parts by weight of puffball powder, 9 parts by weight of pollen typhae carbon powder, 1.5 parts by weight of cortex moutan powder, 3 parts by weight of peppermint powder and 3 parts by weight of divaricate saposhnikovia root powder; The ointment is prepared from the following components, by weight, 12 parts of lithospermum, 8 parts of coptis chinensis, 8 parts of scutellaria baicalensis, 8 parts of astragalus membranaceus, 8 parts of phellodendron amurense, 9 parts of gardenia, 9 parts of radix sophorae flavescentis, 8 parts of ligusticum wallichii, 8 parts of pericarpium zanthoxyli, 6 parts of radix salviae miltiorrhizae, 8 parts of angelica sinensis, 6 parts of ginseng, 6 parts of American ginseng, 6 parts of herba artemisiae capillaries, 6 parts of folium artemisiae argyi, 8 parts of indigo naturalis, 3 parts of pearl powder, 3 parts of borneol, 6 parts of rosin, 160 parts of beeswax, 30 parts of white spirit with high alcohol degree and 1100 parts of vegetable oil.
  3. 3. The pharmaceutical composition for burns according to claim 1, wherein in A1, the mass ratio of moutan bark, cattail pollen carbon and ledebouriella root is 55:4:4.
  4. 4. A method of preparing a pharmaceutical composition for burns according to any one of claims 1 to 3, wherein a powder and an ointment are prepared separately, the powder being a powder and the ointment being a paste.
  5. 5. The method for preparing a pharmaceutical composition for burns according to claim 4, wherein the preparation method of the powder comprises mixing puffball powder, pollen typhae carbon powder, cortex moutan powder, peppermint powder and divaricate saposhnikovia root powder uniformly, and sieving with a 60-mesh sieve to obtain the powder.
  6. 6. The method for preparing a pharmaceutical composition for burns according to claim 4, wherein the ointment is prepared by the following steps: S1, mixing lithospermum, coptis chinensis, scutellaria baicalensis, astragalus membranaceus, phellodendron amurense, gardenia, radix sophorae flavescentis, ligusticum wallichii, pericarpium zanthoxyli, radix salviae miltiorrhizae, angelica sinensis, ginseng, american ginseng, herba artemisiae capillaries and folium artemisiae argyi, adding high-alcohol white spirit, and standing for 1h to obtain a soaking material; S2, adding the soaking material obtained in the step S1 into vegetable oil, heating, decocting until the vegetable oil is free from turbidity, and filtering to obtain filtrate; S3, adding natural indigo, pearl powder and borneol into the filtrate obtained in the S2, and uniformly mixing to obtain a primary material; And S4, after the rosin and the beeswax are melted, putting the melted rosin and the beeswax into the primary material obtained in the step S3, uniformly mixing, and cooling to obtain the ointment.
  7. 7. The method for preparing a pharmaceutical composition for burns according to claim 6, wherein in S1, the alcoholic strength of the high-strength white spirit is 55-65 degrees.
  8. 8. The method for preparing a pharmaceutical composition for burns according to claim 6, wherein the vegetable oil is selected from any one of sesame oil, olive oil and tea oil.

Description

Pharmaceutical composition for burn and preparation method thereof Technical Field The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a pharmaceutical composition for burns and a preparation method thereof. Background Burn and scald belongs to common accidental injury in life, and is often caused by complex skin diseases caused by the actions of boiled water, boiling oil, fire, acid and alkali and the like on human skin. The skin is damaged by the degree I burn or scald, the skin layer is red and swollen, but no bubble phenomenon exists, the skin is partially red and swollen, heated and painful due to the degree II burn or scald, obvious blisters exist, and the degree III burn or scald is severe burn or scald, can damage muscle tissues, bones and nerve cells, causes the skin to be burnt and necrotic, and causes severe pain. Burns and scalds can cause infection and scars if not treated in time, and the functions of limbs are affected. At present, the pain relieving medicine for treating the burn and wound mostly contains poisonous hemp and corrosive component medicines, the ointment matrix mostly contains chemical matrix and preservative, the effect taking speed is slow, and the final treatment effect is still to be further improved. Disclosure of Invention In order to solve the problems in the background technology, the invention provides a pharmaceutical composition for burn and a preparation method thereof, and herbal plant components have no toxic or side effect, and have quick response and obvious curative effect on burn wounds. In order to achieve the above object, in a first aspect, the present invention provides a pharmaceutical composition for burn, comprising a powder and an ointment; The medicinal powder comprises, by weight, 6-9 parts of puffball powder, 6-9 parts of pollen typhae carbon powder, 1-2 parts of cortex moutan powder, 3-5 parts of peppermint powder and 3-5 parts of divaricate saposhnikovia root powder; The ointment comprises, by weight, 6-12 parts of lithospermum, 5-9 parts of coptis chinensis, 5-9 parts of scutellaria baicalensis, 5-9 parts of astragalus membranaceus, 5-9 parts of phellodendron amurense, 5-9 parts of gardenia, 5-9 parts of radix sophorae flavescentis, 5-9 parts of ligusticum chuanxiong, 5-9 parts of pericarpium zanthoxyli, 5-9 parts of radix salviae miltiorrhizae, 5-9 parts of angelica sinensis, 5-9 parts of ginseng, 5-9 parts of American ginseng, 5-9 parts of herba artemisiae capillaries, 5-9 parts of artemisia argyi, 5-9 parts of indigo naturalis, 2-5 parts of pearl powder, 2-5 parts of borneol, 5-9 parts of rosin, 150-200 parts of beeswax, 20-50 parts of high-strength white spirit and 900-1200 parts of vegetable oil. The related medicinal effects of the above medicinal components are as follows: The puffball powder is mainly used for clearing lung-heat, relieving sore throat, detoxifying and stopping bleeding, is suitable for treating symptoms such as cough due to lung heat, sore throat, bleeding and the like, and is beneficial for reducing inflammation and promoting wound healing. The pollen Typhae carbon powder has effects of astringing to stop bleeding, promoting blood circulation to relieve pain, promoting urination and relieving swelling, and can be used for treating various bleeding symptoms including traumatic hemorrhage. The cortex moutan powder has effects of clearing heat, cooling blood, promoting blood circulation, and removing blood stasis, and is suitable for treating symptoms such as warm disease, heat entering blood system, macula, and epistaxis. The mint powder has the effects of dispelling wind-heat, clearing head and eyes, soothing liver and relieving depression, is suitable for treating symptoms such as wind-heat type common cold, fever, headache and conjunctival congestion, sore throat and the like, and is helpful for reducing inflammation and promoting wound healing under the condition of burn. The radix Saposhnikoviae powder has effects of dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness and relieving pain. Radix Arnebiae has effects of cooling blood, promoting blood circulation, removing toxic substances, promoting eruption, promoting wound healing, resisting bacteria, and relieving inflammation. Rhizoma Coptidis has effects of clearing heat, eliminating dampness, purging pathogenic fire, and removing toxic substances. The radix Scutellariae has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage. Astragalus mongholicus has the effects of tonifying qi, consolidating superficial resistance, promoting urination, expelling toxin, expelling pus and promoting granulation. Cortex Phellodendri has effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, and removing bone steaming. Fructus Gardeniae has effects of purg