CN-119157936-B - Compound dripping pill of Chinese medicinal extract, and its preparation method and application

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine extract compound dripping pill, a preparation method and application thereof. The compound dripping pill of the traditional Chinese medicine extract comprises, by weight, 6-15 parts of total saponins of panax notoginseng, 2-6 parts of breviscapine and 4-8 parts of extract of hawthorn leaves. The invention solves the problems of long acting time and large dosage of the medicine for treating the hyperlipidemia, and the traditional Chinese medicine extract compound dripping pill provided by the invention has obvious curative effects on both a mixed hyperlipidemia model and an acute hyperlipidemia model, and has the advantages of short acting time, low dosage, no toxicity and convenience in administration, storage and carrying.

Inventors

• ZHANG YUNSHENG

Assignees

• 云南金七制药有限公司

Dates

Publication Date

20260512

Application Date

20240924

Claims (4)

1. 1. A Chinese medicinal extract compound dripping pill for treating hyperlipidemia is characterized by comprising, by weight, 6-15 parts of pseudo-ginseng total saponins, 2-6 parts of breviscapine, 4-8 parts of hawthorn leaf extracts and 4000 30 parts of polyethylene glycol.
2. 2. The compound dripping pill of the traditional Chinese medicine extract for treating hyperlipidemia according to claim 1, wherein the compound dripping pill of the traditional Chinese medicine extract comprises, by weight, 10 parts of total saponins of panax notoginseng, 4 parts of breviscapine, 6 parts of extract of hawthorn leaves and 4000 30 parts of polyethylene glycol.
3. 3. A method for preparing a compound dripping pill of a Chinese medicinal extract for treating hyperlipidemia according to claim 1 or 2, which is characterized by comprising the steps of uniformly mixing according to a formula, heating and melting, and dripping into cooled liquid paraffin to obtain the compound dripping pill of the Chinese medicinal extract.
4. 4. The use of the compound dripping pill of Chinese medicinal extract for treating hyperlipidemia according to claim 1 or 2 in preparing medicines for treating hyperlipidemia.

Description

Compound dripping pill of Chinese medicinal extract, and its preparation method and application Technical Field The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine extract compound dripping pill, a preparation method and application thereof. Background Hyperlipidemia, also known as hyperlipidemia, refers to elevated Triglycerides (TG) and/or Total Cholesterol (TC) in plasma, and also includes elevated low density lipoprotein cholesterol (LDL-C) and lowered high density lipoprotein cholesterol (HDL-C). The excessive blood lipid level can cause coronary atherosclerosis heart disease, hypertension and other diseases. The existing hypolipidemic drugs mainly comprise statins (atorvastatin, lovastatin and simvastatin), fibrates and nicotinic acids, wherein the statins are selected, have strong hypolipidemic effect and definite action mechanism, but can generate reactions such as liver injury, muscle lesions, skin allergy, digestive system diseases, urinary system diseases and the like. In recent years, research on traditional Chinese medicines for treating hyperlipidemia is increasing. Notoginseng radix is a plant of Panax of Araliaceae, has sweet, slightly bitter and warm nature, has pharmacological effects of detumescence, relieving pain, removing blood stasis, stopping bleeding, lowering blood sugar, reducing blood lipid, and resisting tumor, and has been used for treating coronary heart disease, angina pectoris, diabetes and thrombosis, and also for treating hyperlipidemia. The Chinese patent publication No. CN106983786B discloses a Chinese medicinal composition for preventing and/or treating hyperlipemia and its preparation method, which comprises ginseng 3-12 g, baikal skullcap root 15-60 g, white atractylodes rhizome 5-20 g, wild jujube seed 15-60 g, root of red rooted saliva 15-60 g, ligusticum wallichii 6-24 g, kudzuvine root 15-60 g, haw 15-60 g, licorice root 6-24 g, notoginseng 5-20 g, leech 2-10 g and rhubarb horsetails 1-6 g. The medicine provided by the technical scheme can obviously reduce the blood lipid level in the DM hyperlipidemic mouse, reduce the FBG content of the model mouse and improve the liver function of the DM hyperlipidemic mouse. However, the technical proposal has high cost because the preparation contains more medicinal materials and is easy to produce a large burden on the liver after long-term administration, so the irradiation treatment is needed. The Chinese patent publication No. CN102727680B discloses a traditional Chinese medicine for reducing blood fat and a preparation method thereof, wherein the traditional Chinese medicine comprises dried extract of water decoction or ethanol reflux extraction of the mixture of rhizoma alismatis, hawthorn, gynostemma pentaphylla, radix puerariae and medlar and pseudo-ginseng powder. The technical proposal screens the formula based on the principle of removing dampness and turbidity, dispersing blood stasis and dredging collaterals, can nourish yin blood of liver and kidney, can prevent the defect of excessive consumption of hawthorn and gynostemma pentaphylla, and provides a new traditional Chinese medicine variety with remarkable curative effect for treating hyperlipidemia. However, the technical proposal has obvious blood fat reducing effect only when the dosage is 0.64g/kg after the continuous administration for 10 weeks, and has long acting time and large dosage. In addition, since the hyperlipidemia patients need to take medicine for a long period of time, it is necessary to consider whether the dosage form thereof is convenient for taking, storing and carrying when developing new traditional Chinese medicine. Disclosure of Invention The invention provides a compound dripping pill of Chinese medicinal extract, a preparation method and application thereof, aiming at the problems of long acting time and large dosage of the existing medicament for treating hyperlipoidemia, the compound dripping pill of the traditional Chinese medicine extract provided by the invention has obvious curative effects on both mixed hyperlipidemia models and acute hyperlipidemia models, and has the advantages of short onset time, low dosage, no toxicity and convenience in administration, storage and carrying. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: The invention provides a compound dripping pill of a traditional Chinese medicine extract, which comprises the following components, by weight, 6-15 parts of total saponins of panax notoginseng, 2-6 parts of breviscapine and 4-8 parts of extract of hawthorn leaves. Preferably, the compound dripping pill of the traditional Chinese medicine extract comprises, by weight, 8-12 parts of total saponins of panax notoginseng, 3-5 parts of breviscapine and 5-7 parts of extract of hawthorn leaves. Preferably, the weight ratio of the total saponins of panax notoginseng to the br