Search

CN-119502501-B - High-barrier anti-leakage packaging bag for medical instrument storage and preparation method

CN119502501BCN 119502501 BCN119502501 BCN 119502501BCN-119502501-B

Abstract

The invention discloses a high-barrier anti-leakage packaging bag for medical instrument storage and a preparation method thereof, and belongs to the technical field of packaging bag preparation. The high-barrier anti-leakage packaging bag for medical instrument storage consists of an isolation layer, an adhesion layer and an inner wall layer, wherein the isolation layer, the adhesion layer and the inner wall layer are sequentially arranged from outside to inside, the isolation layer consists of composite polyester, the adhesion layer consists of ethylene acrylic resin, and the inner wall layer consists of polypropylene and an antibacterial agent. The packaging bag prepared by the method has excellent high-barrier permeation-preventing performance, and also has excellent flame-retardant and antibacterial properties.

Inventors

  • CHEN CHEN
  • Sun Muzi

Assignees

  • 江苏帕科医疗股份有限公司

Dates

Publication Date
20260508
Application Date
20241122

Claims (7)

  1. 1. The high-barrier anti-leakage packaging bag for storing medical equipment is characterized by comprising an isolation layer, an adhesion layer and an inner wall layer, wherein the isolation layer, the adhesion layer and the inner wall layer are sequentially arranged from outside to inside, the isolation layer is composed of composite polyester, the adhesion layer is composed of ethylene acrylic resin, and the inner wall layer is composed of polypropylene and an antibacterial agent; The preparation method of the composite polyester comprises the following steps: Q1, adding dimethyl methylphosphonate into a container, then adding monobutyl tin oxide, assembling a straight condensing tube, controlling the rotating speed and heating, then dripping 1, 5-pentanediol into the container, controlling the dripping speed, continuing to stir for reaction, and distilling under reduced pressure after the reaction is finished to obtain an intermediate product 1; q2, adding 5-amino-thiophene-2-methyl formate, 2, 5-thiophene dicarboxylic acid and an intermediate product 1 into a container provided with a nitrogen inlet, a mechanical stirring paddle and a hot water reflux spherical condenser pipe, adding titanium dioxide, heating for reaction, heating and reducing the pressure after the reaction is finished, and carrying out polycondensation reaction to obtain composite polyester after the reaction is finished; the preparation method of the antibacterial agent comprises the following steps: S1, adding formylhydrazine and acetonitrile into a container, uniformly stirring, adding triphenylphosphine, heating the container, dropwise adding carbon tetrachloride by using a constant-pressure dropping funnel under a constant-temperature environment, controlling the dropping time, continuing stirring for reaction after the dropping is finished, cooling, filtering, washing and drying to obtain a compound A; S2, adding sodium hydrosulfide into a container, then adding absolute ethyl alcohol, stirring at a low temperature, simultaneously slowly adding 4-chlorobenzamide by using a constant pressure dropping funnel, controlling the dropping time, continuing the reaction after the dropping is finished, acidifying, extracting, combining organic layers, drying and steaming in a rotary mode to obtain a compound B; And S3, adding phenylacetaldehyde and diethylamine into a container, then adding dichloromethane, stirring and dissolving, adding the compound A, dropwise adding a dichloromethane solution containing the compound B in a room temperature environment, reacting, steaming soon after the reaction is finished, and purifying to obtain the antibacterial agent.
  2. 2. The high barrier and leakage prevention packaging bag for medical equipment storage according to claim 1, wherein in the Q1, the molar ratio of methyl phosphonic acid dimethyl ester, monobutyl tin oxide and 1, 5-pentanediol is (1-1.5): 0.03-0.05): 2-2.8, the control rotation speed is 300-350rpm, the heating temperature is 170-180 ℃, the dripping speed is 2-3 drops/s, the stirring reaction time is 4-6h, and the reduced pressure distillation temperature is 140-145 ℃.
  3. 3. The high barrier and leakage prevention packaging bag for medical equipment storage according to claim 1, wherein in the Q2, the molar ratio of 5-amino-thiophene-2-carboxylic acid methyl ester, 2, 5-thiophene dicarboxylic acid, intermediate product 1 and titanium dioxide is (0.8-1.3): (0.9-1.3): (2-2.5): (0.03-0.045), the heating reaction temperature is 180-200 ℃, the reaction time is 4-5h, the heating temperature is 230-240 ℃, the pressure is reduced to below 100Pa, and the reaction time is 3-5h.
  4. 4. The high-barrier and anti-leakage packaging bag for medical equipment storage according to claim 1, wherein in the S1, the dosage ratio of formylhydrazine, acetonitrile, triphenylphosphine and carbon tetrachloride is (10-20) g (200-250) mL (62.3-100) g (40-80) mL, the heating temperature is 50-60 ℃, the dripping time is 1-2h, the stirring reaction temperature is 50-60 ℃ continuously, the time is 2-3h, the temperature is reduced to 30-35 ℃, and the washing is performed by using a mixed solution of petroleum ether and distilled water with the volume ratio of 20:1.
  5. 5. The high barrier and leakage prevention packaging bag for medical equipment storage according to claim 1, wherein in the S2, the low temperature environment is 10-12 ℃, the dripping time is 2-3h, the continuous reaction time is 1-2h, the acidification is carried out by 0.6mol/L hydrochloric acid, the extraction is carried out by diethyl ether, and the drying is carried out by anhydrous sodium sulfate.
  6. 6. The high-barrier and anti-leakage packaging bag for medical equipment storage according to claim 1, wherein in the S3, the molar ratio of phenylacetaldehyde to diethylamine to the compound A to the compound B is (1-2): 1.1-1.9): 1.1-1.8): 1-2.1, the stirring and dissolving time is 30-45min, the reaction time is 1-1.5h, and the eluent in the purification process is a mixed solution of petroleum ether and ethyl acetate in a volume ratio of 40:1.
  7. 7. A method for preparing a high barrier and leakage-proof packaging bag for medical equipment storage according to any one of claims 1 to 6, comprising the steps of: respectively adding the composite polyester and ethylene acrylic resin into a first screw extruder and a second screw extruder, extruding, and molding to obtain an insulating layer material and an adhesion layer material; Step two, after uniformly mixing polypropylene and an antibacterial agent, adding the mixture into a third screw extruder, extruding and molding to obtain an inner wall layer material; And thirdly, uniformly coating the adhesion layer material between the isolation layer material and the inner wall layer material in a hot pressing mode, bonding, cooling, shaping, cutting, making bags, and sterilizing to obtain the high-barrier anti-leakage packaging bag for storing the medical apparatus.

Description

High-barrier anti-leakage packaging bag for medical instrument storage and preparation method Technical Field The invention belongs to the technical field of packaging bag preparation, and particularly relates to a high-barrier anti-leakage packaging bag for medical instrument storage and a preparation method thereof. Background The choice of packaging material is critical in the storage and transportation of medical devices. This is not only relevant to the safety and effectiveness of the medical device, but also directly affects the overall quality of the medical service and the health and safety of the patient. With the continuous advancement of medical technology and the increasing medical demands, higher demands are being placed on the packaging of medical devices, in particular with regard to barrier properties, leakage resistance and environmental protection. Medical devices are of various kinds, including surgical devices, diagnostic devices, implantable devices, etc., and these devices are of different materials and have different packaging requirements. For example, some delicate electronic medical instruments need to be moisture-proof and dust-proof to avoid degradation or damage of performance due to environmental humidity and dust, while some instruments in contact with human tissues or body fluids need to have excellent barrier properties for packaging materials to prevent invasion of external microorganisms, moisture, oxygen, etc., thereby ensuring sterility of the instruments and effectiveness for long-term storage. Traditional packaging materials such as polyolefin, PVC, etc., while meeting the packaging requirements of medical devices to some extent, have significant drawbacks in terms of barrier properties, environmental protection and safety. The polyolefin packaging material has unsatisfactory barrier properties, is difficult to effectively block permeation of moisture and oxygen, and affects the shelf life and performance stability of medical devices. PVC materials are gradually eliminated by the market due to the insufficient environmental protection performance and safety performance. Therefore, the development of a novel high-barrier anti-leakage packaging bag becomes a problem to be solved in the field of medical instrument packaging. Patent CN111483202a discloses a high-barrier impermeable heavy packaging film and a preparation method thereof, the high-barrier impermeable heavy packaging film comprises an outer layer, a middle layer and an inner layer which are sequentially attached and co-extruded, the outer layer comprises low-density polyethylene, linear low-density polyethylene, medium-density polyethylene, high-density polyethylene and ethylene-vinyl acetate copolymer, the middle layer comprises adhesive resin, the inner layer comprises polyamide resin, and the obtained high-barrier impermeable heavy packaging film has mechanical properties and excellent barrier properties, but the barrier properties, the anti-leakage properties and the antibacterial properties of the packaging bag prepared by the method still have room for improvement. Disclosure of Invention The invention aims to provide a high-barrier anti-leakage packaging bag for medical instrument storage and a preparation method thereof, which are used for solving the technical problems of poor barrier property, anti-leakage property and antibacterial property of the packaging bag in the prior art. In order to achieve the above purpose, the present invention adopts the following technical scheme: the invention provides a high-barrier anti-leakage packaging bag for medical instrument storage, which consists of an isolation layer, an adhesion layer and an inner wall layer, wherein the isolation layer, the adhesion layer and the inner wall layer are sequentially arranged from outside to inside, the isolation layer consists of composite polyester, the adhesion layer consists of ethylene acrylic resin, and the inner wall layer consists of polypropylene and an antibacterial agent. Preferably, the preparation method of the composite polyester comprises the following steps: Q1, adding dimethyl methylphosphonate into a container, then adding monobutyl tin oxide, assembling a straight condensing tube, controlling the rotating speed and heating, then dripping 1, 5-pentanediol into the container, controlling the dripping speed, continuing to stir for reaction, and distilling under reduced pressure after the reaction is finished to obtain an intermediate product 1; q2, adding 5-amino-thiophene-2-methyl formate, 2, 5-thiophene dicarboxylic acid and an intermediate product 1 into a container provided with a nitrogen inlet, a mechanical stirring paddle and a hot water reflux spherical condenser, adding titanium dioxide, heating for reaction, heating and reducing pressure after the reaction is finished, performing polycondensation reaction, and obtaining the composite polyester after the reaction is finished. In the above process, the