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CN-119613839-B - Supermolecule antibacterial material constructed by oxazine functional groups, and preparation method and application thereof

CN119613839BCN 119613839 BCN119613839 BCN 119613839BCN-119613839-B

Abstract

The invention discloses a composition, a preparation method and application of a supermolecule antibacterial material constructed by oxazine functional groups, and belongs to the field of high polymer materials. The antibacterial material is composed of a supermolecular antibacterial agent, a high-molecular resin material, a compatilizer, an antioxidant and a lubricant, and is subjected to high-temperature mixing and molding to obtain antibacterial materials and products with various purposes.

Inventors

  • XIN ZHONG
  • HUANG SONGYANG

Assignees

  • 华东理工大学
  • 蚌埠爱默精细化学品有限公司

Dates

Publication Date
20260508
Application Date
20230912

Claims (4)

  1. 1. The supermolecular antibacterial material constructed by oxazine functional groups is characterized by comprising the following components in parts by weight and prepared by the following steps: Polyethylene resin 100 parts 0.5-10 Parts of supermolecule antibacterial agent 0.1-2 Parts of antioxidant 0.5-3 Parts of compatilizer 0.1-2 Parts of lubricant; Wherein: The antioxidant is a combination of hindered phenol antioxidant and phosphite antioxidant, the proportion of the hindered phenol antioxidant and the phosphite antioxidant is 1:1, The compatilizer is at least one of polypropylene grafted carboxylic acid, chlorinated polypropylene and polypropylene grafted maleic anhydride, The lubricant is at least one of N, N-ethylene bis-stearamide, liquid paraffin and hexapolyglycerol monostearate, The preparation raw materials of the supermolecular antibacterial agent comprise phenolic compounds, amine compounds and paraformaldehyde, wherein the molar ratio of the paraformaldehyde to the amine compounds is that the phenolic compounds=0.14:0.066:0.066, The phenolic compound is one or more selected from vanillin, vanillic acid, ethyl vanillin, vanillin and oleander, and the amine compound is one or more selected from octadecylamine, hexadecylamine, furfuryl amine and dodecyl primary amine; the supermolecule antibacterial material is prepared by the following steps: 1) Synthesis of supermolecular antibacterial agent built by oxazine functional group: uniformly mixing paraformaldehyde and amine compounds in a flask according to a proportion, adding 100 milliliters of solvent toluene/ethanol, heating in an oil bath kettle at 80-90 ℃ until solids are gradually dissolved, then adding phenol compounds, reacting reactants at 80-90 ℃ under stirring conditions for 12 h, cooling and crystallizing the solution after the reaction is finished for 12-h to obtain a large number of crystal products, washing the products with absolute ethanol for many times until an eluate is clear and transparent, grinding the eluate uniformly by a mortar, sieving by a 1000-mesh sieve, and drying in vacuum to obtain the supermolecular antibacterial agent; 2. ) Preparing a supermolecule antibacterial polymer material constructed by oxazine functional groups: Uniformly stirring the polyethylene resin, the supermolecular antibacterial agent, the antioxidant, the compatilizer and the lubricant according to a proportion, mixing the mixture at a high temperature in a double-screw extruder under the conditions of 160-200 rpm of a main screw, 18-22 rpm of a feeding screw, 170-210 ℃ of extrusion temperature and 13-16A of extruder current to obtain the supermolecular antibacterial polymer material constructed by oxazine functional groups, crushing and granulating, and performing injection molding to obtain various required products, wherein the injection molding pressure is 550 bar, the injection molding temperature is 180 ℃, the injection molding time is 30 s, the pressure maintaining pressure is 500 bar, the pressure maintaining temperature is 50 ℃ and the pressure maintaining time is 30 s.
  2. 2. The supermolecular antibacterial material according to claim 1, wherein the hindered phenol antioxidant is one or more of antioxidant 1010, antioxidant 1076, antioxidant GA-80 and antioxidant 702, and the phosphite antioxidant is one or more of antioxidant 168 and antioxidant P-EPQ.
  3. 3. The supermolecular antibacterial material as claimed in claim 1, wherein the supermolecular antibacterial material comprises the following components in parts by mass: Polyethylene resin 100 parts 2.5-7.5 Parts of supermolecule antibacterial agent 0.1-2 Parts of antioxidant 0.5-3 Parts of compatilizer 0.1-2 Parts of lubricant.
  4. 4. The use of the supramolecular antibacterial material constructed from oxazine functional groups according to claim 1, 2 or 3 for the preparation of medical materials for human implantation.

Description

Supermolecule antibacterial material constructed by oxazine functional groups, and preparation method and application thereof Technical Field The invention relates to a supermolecular antibacterial material, in particular to a supermolecular antibacterial material constructed by oxazine functional groups, and a preparation method and application thereof. Belonging to the field of high polymer materials. Background Polyethylene resins are among the most widely used polymeric resin materials, and include Low Density Polyethylene (LDPE), linear Low Density Polyethylene (LLDPE), high Density Polyethylene (HDPE), and the like. LDPE is odorless, odorless and nontoxic, has good extensibility, softness, transparency, easy processing, electrical insulation and air permeability, and has stable physical and chemical properties, alkali resistance and partial organic solvents. The product is widely used as medical materials such as various supports and films, food packages of tea leaves and the like, medicine packages of powder, tablets and the like, fiber product packages of knitted cotton products, chemical fiber products and the like, daily chemical product packages of detergents, cosmetics and the like, agricultural films and the like. LLDPE has excellent environmental stress cracking resistance and electrical insulation property, higher heat resistance, impact resistance, puncture resistance and the like, and is applied to the production of films, daily necessities, pipes, wires and cables and the like. The HDPE can resist most of acid and alkali corrosion, has small water absorption, can keep softness at low temperature, has high electrical insulation, and is suitable for being used as medical materials such as artificial joints, artificial bones, artificial throats, orthopedic repair materials and the like. However, polyethylene resin itself has no antibacterial effect, and is liable to cause bacterial proliferation when used as food, medicine and daily chemical packaging, and problems such as bacterial adhesion proliferation, biofilm accumulation, and reduced service life occur when used as medical materials. Patent CN108892851A discloses a polyethylene antibacterial plastic and a preparation method thereof, polyethylene, acetone, isothiazolinone, an antioxidant, a compatilizer, a plasticizer, a dispersing agent, benzalkonium chloride, glass fiber, chitosan, phosphorus oxide, nano titanium dioxide and the like are mixed in proportion, extruded, granulated, dried and then injection molded. The patent CN114262506A discloses an antibacterial degradable food packaging material and a preparation method thereof, polyethylene, polyvinyl alcohol, polybutylene succinate, nanocellulose and filler are mixed in a high-speed mixer for 3-8min, then a bio-based antibacterial agent, a flame retardant and a lubricant are added for continuous mixing for 8-20min to obtain a mixed material, and the mixed material is added into a double-screw extruder for extrusion granulation. The antibacterial degradable food packaging material has good antibacterial property and degradation performance, is safe and nontoxic, but has complex and time-consuming preparation process and limited application range of the synergistic effect of various plastics. Therefore, new, environment-friendly, efficient, long-lasting and simple-process antibacterial polymer materials should be further researched and developed. Disclosure of Invention Aiming at the defects of the prior art, the invention discloses a novel antibacterial polymer material with simple process and a preparation method thereof, and the invention is realized by the following technical scheme: The supermolecular antibacterial material constructed by oxazine functional groups is characterized by comprising the following components in parts by weight: Polyethylene resin 100 parts 0.5-10 Parts of supermolecule antibacterial agent 0.1-2 Parts of antioxidant 0.5-3 Parts of compatilizer 0.1-2 Parts of lubricant; Wherein: the antioxidant is a combination of hindered phenol antioxidant and phosphite antioxidant, the ratio of the hindered phenol antioxidant to the phosphite antioxidant is 1:1, The compatilizer is at least one of polypropylene grafted carboxylic acid, chlorinated polypropylene and polypropylene grafted maleic anhydride, The lubricant is at least one of N, N-ethylene bis-stearamide, liquid paraffin and hexapolyglycerol monostearate, The supermolecule antibacterial agent comprises the following components in parts by mass: Phenolic compound 1 part Amine compound 1 part Paraformaldehyde 2 parts The phenolic compound is one or more selected from vanillin, vanillic acid, ethyl vanillin, vanillin and oleander, and the amine compound is one or more selected from octadecylamine, hexadecylamine, furfuryl amine and dodecyl primary amine. The hindered phenol antioxidant is one or more of antioxidant 1010, antioxidant 1076, antioxidant GA-80 and antioxidant 702, and the phosphite vinegar antioxi