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CN-119736484-B - Recovery and purification method of nickel target in Cu-64 preparation process

CN119736484BCN 119736484 BCN119736484 BCN 119736484BCN-119736484-B

Abstract

The invention belongs to the technical field of medical isotope production, relates to a target recovery and purification method, and in particular relates to a recovery and purification method for a nickel target in the process of preparing Cu-64. Adding acid into the recovered nickel solution in the Cu-64 preparation process to adjust the concentration of hydrogen ions to 6-8 mol/L to obtain an acidic nickel solution, performing primary column separation on the acidic nickel solution by adopting TK201 resin to obtain an effluent, and performing secondary column separation on the effluent by adopting AGMP-1 resin to obtain the recovered and purified nickel solution. The recovery and purification method provided by the invention can obviously reduce impurity elements such as Cu, co and the like, greatly improve the purity of nickel in the recovered nickel target material, and has higher recovery rate of nickel.

Inventors

  • LI MINGMING
  • ZHANG ZHIPENG
  • LEI YUTING
  • WU LINGQIAN
  • Pan Dashu
  • LI TENGJIAO
  • HOU HAO
  • FU JING
  • XIA HAIHONG

Assignees

  • 国电投核素同创(重庆)科技有限公司

Dates

Publication Date
20260508
Application Date
20241121

Claims (12)

  1. 1. The recovery and purification method of the nickel target material in the process of preparing Cu-64 is characterized by comprising the following steps: Adding an acid solution into a recovered nickel solution in the Cu-64 preparation process to adjust the concentration of hydrogen ions to 6-8 mol/L, so as to obtain an acidic nickel solution; performing primary column separation on the acidic nickel solution by adopting TK201 resin to obtain effluent; and carrying out secondary column separation on the effluent liquid by adopting AGMP-1 resin to obtain a recovered and purified nickel solution.
  2. 2. The method for recovering and purifying a nickel target in a Cu-64 production process according to claim 1, wherein the acid solution is hydrochloric acid; or the volume ratio of the acidic nickel solution to the TK201 resin is 5:1-5.
  3. 3. The method for recycling and purifying a nickel target in the process of preparing Cu-64 according to claim 1, wherein the volume ratio of the acidic nickel solution to the TK201 resin is 5:1-1.2.
  4. 4. The method for recovering and purifying a nickel target in a Cu-64 preparation process according to claim 1, wherein an acid solution with a hydrogen ion concentration of 6-8 mol/L is adopted to wash a separation column after primary column separation, and washing liquid and effluent liquid are mixed and then secondary column separation is carried out.
  5. 5. The method for recovering and purifying a nickel target in a Cu-64 preparation process according to claim 4, wherein the ratio of the volume of the acid solution used for washing to the volume of the TK201 resin column is 1:1-5.
  6. 6. The method for recovering and purifying a nickel target in a Cu-64 preparation process according to claim 1, wherein the column loading speed of the acidic nickel solution is 0.1-2 mL/min during one column separation.
  7. 7. The method for recovering and purifying a nickel target in a Cu-64 preparation process according to claim 1, wherein the column loading speed of the acidic nickel solution is 0.5-1.0 mL/min during one column separation.
  8. 8. The method for recovering and purifying a nickel target in a Cu-64 preparing process according to claim 1, wherein the particle size of the TK201 resin is 100-150 μm.
  9. 9. The method for recovering and purifying a nickel target in a Cu-64 manufacturing process according to claim 1, wherein AGMP-1 resin has a mesh number of 100-200 mesh.
  10. 10. The method for recovering and purifying a nickel target in the process of preparing Cu-64 according to claim 1, wherein after primary column separation, an acid solution with a pH of 2-3 is used for eluting TK201 resin after primary column separation or after washing with 6-8 mol/L of acid solution.
  11. 11. A recovery and purification system for a nickel target in a Cu-64 production process, wherein the recovery and purification method of claim 1 is implemented, comprising: The acidity regulator of the recovered nickel solution is used for regulating the concentration of hydrogen ions in the recovered nickel solution in the Cu-64 preparation process; a first separation column filled with TK201 resin for performing a primary column separation of the acidic nickel solution from the recovered nickel solution acidity adjustment device; And a second separation column filled with AGMP-1 resin for performing a secondary column separation on the effluent from the first separation column.
  12. 12. The system for recovering and purifying a nickel target in a Cu-64 production process according to claim 11, comprising an acid liquid storage device and a mixing device, wherein the acid liquid storage device supplies an acid solution to the first separation column after primary column separation, the TK201 resin in the first separation column is washed, washing liquid after washing enters the mixing device, effluent liquid after primary column separation enters the mixing device, and the washing liquid and the effluent liquid enter the second separation column for secondary column separation after mixing in the mixing device.

Description

Recovery and purification method of nickel target in Cu-64 preparation process Technical Field The invention belongs to the technical field of medical isotope production, relates to a target recovery and purification method, and in particular relates to a recovery and purification method for a nickel target in the process of preparing Cu-64. Background The disclosure of this background section is only intended to increase the understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art already known to those of ordinary skill in the art. Cu-64 is an important medical radioisotope, can emit beta - (0.653 MeV, 17.4%) and beta + (0.579 MeV, 3.9%), has a half-life of 12.7h, can perform PET (positron emission tomography) diagnosis and treatment simultaneously, and is expected to be used for diagnosis and treatment integrated research based on radionuclides. Because of the convenience of production and the limitation of half-life, cu-64 is usually produced by irradiating Ni-64 through an accelerator, and then separating by AG1-X8 to obtain Cu-64 meeting the standard product. As a raw material for producing Cu-64, ni-64 has higher market price, is an important proportion of Cu-64 production cost, and generally needs to be recycled in the Cu-64 production process. While the purity of the recovered Ni-64 directly affects the purity of the Cu-64 product. If the impurity content of other radionuclides such as Fe, cu, zn, co, au in Ni-64 can be reduced, the amount of impurities generated during irradiation can be reduced, thereby improving the yield and nuclear purity of Cu-64. The existing separation method for preparing positron nuclide Cu-64 by irradiating nickel with an accelerator comprises anion column separation, cu resin separation and the like. The anion column separation is to form complex with different degrees with chloride ions by Cu, co and Ni under the condition of hydrochloric acidAnd separating, wherein Cu and Co can form complex anions in a hydrochloric acid medium and are adsorbed on the anion resin, the complexing capacity of Cu is stronger than that of Co, and the adsorption capacity of the anion resin on Cu and Co is greatly different under the conditions of 4mol/L and 5mol/L hydrochloric acid. And nickel has little complexing ability on chloride ions and is not adsorbed by resin, thereby completing the separation of Cu, co and Ni. The ion exchange resin for separating Cu has the advantages that the available Ni raw material target material is purified and recovered to a certain extent, but the purity is not high. The Cu resin is used as the extraction resin, has specific adsorption capacity to copper under the condition of pH=2 to 5, almost has no adsorption to Co and Ni, and can better separate Cu from other elements. After the target product Cu is obtained, the massive element Ni remained in the solution can be reused as the raw material for the next targeting production due to high price, but impurities with different contents exist in the Ni due to different purification methods and efficiency of the Cu, and the impurities can influence the purity of the recovered Ni, so that the generated impurities are excessive during the next targeting, and the separation and purification of copper are puzzled. Disclosure of Invention In order to solve the problem that a large amount of impurities (Fe, cu, zn, co, au and the like) exist in a nickel target material recovered in the process of preparing Cu-64 so as to improve the yield and the nuclear purity of the preparation of Cu-64 by adopting the recovered nickel target material, the invention aims to provide a recovery and purification method of the nickel target material in the process of preparing Cu-64. In order to achieve the above purpose, the technical scheme of the invention is as follows: In a first aspect, a method for recovering and purifying a nickel target in a Cu-64 preparation process includes the steps of: Adding an acid solution into a recovered nickel solution in the Cu-64 preparation process to adjust the concentration of hydrogen ions to be 6-8 mol/L, so as to obtain an acidic nickel solution; performing primary column separation on the acidic nickel solution by adopting TK201 resin to obtain effluent; and carrying out secondary column separation on the effluent liquid by adopting AGMP-1 resin to obtain a recovered and purified nickel solution. The extraction agent loaded by the TK201 resin is tertiary amine, the tertiary amine can be combined with hydrogen ions, and the degree of the tertiary amine combined with the hydrogen ions is different under the condition of different hydrogen ion concentrations (namely acidity), the acidity of the recovered nickel solution is firstly adjusted, and researches show that when the acidity is 6-8 mol/L, the distribution coefficient of the TK201 resin to elements such as Cu, zn a