CN-119746005-B - Traditional Chinese medicine composition for treating insomnia and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating insomnia, and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises, by mass, 12-17 parts of selfheal, 7-11 parts of grassleaf sweelflag rhizome, 4-8 parts of common cephalanoplos herb, 7-13 parts of platycladi seed and 4-8 parts of bamboo shavings. The traditional Chinese medicine composition is prepared from five specific traditional Chinese medicines, namely selfheal serving as a monarch, grassleaved sweetflag rhizome and common cephalanoplos herb serving as ministerial drugs, platycladi seed and bamboo shavings serving as adjuvant drugs, the selfheal with the efficacy of clearing liver fire, the grassleaved sweetflag rhizome with the efficacy of inducing resuscitation and eliminating phlegm, refreshing mind and improving intelligence, and other common cephalanoplos herb and platycladi seed for strengthening the efficacy of clearing liver fire and nourishing heart and tranquillizing, and the bamboo shavings with sweet and cold are added to prepare the traditional Chinese medicine preparation for treating insomnia. The traditional Chinese medicine composition has the effects of soothing liver, relieving heat, relieving restlessness and soothing nerves, has obvious curative effects on sleep dysfunction caused by excessive liver fire and phlegm-heat yin deficiency, and can help patients to relieve insomnia symptoms and improve sleep quality through endogenous treatment.

Inventors

• CHENG FAFENG
• WANG XUEQIAN
• WANG QINGGUO

Assignees

• 北京中医药大学

Dates

Publication Date

20260512

Application Date

20241213

Claims (8)

1. 1. The application of the traditional Chinese medicine composition in preparing the medicine for treating insomnia is characterized in that the traditional Chinese medicine composition is prepared from 12-17 parts by mass of selfheal, 7-11 parts by mass of grassleaf sweelflag rhizome, 4-8 parts by mass of common cephalanoplos herb, 7-13 parts by mass of platycladi seed and 4-8 parts by mass of bamboo shavings.
2. 2. The use according to claim 1, further comprising pharmaceutically acceptable excipients.
3. 3. The use according to claim 1, wherein the dosage form of the Chinese medicinal composition is an oral preparation, wherein the oral preparation is selected from the group consisting of granules, powders, tablets, pills, oral liquids and capsules.
4. 4. The use according to claim 1, wherein the method of preparing the Chinese medicinal composition comprises the steps of: S1, extracting volatile oil of grassleaf sweelflag rhizome and platycladi seed by adopting steam distillation to obtain volatile oil, medicinal residues and medicinal liquid; S2, mixing the residues, carrying out water extraction and/or alcohol extraction on the mixture of the residues, the selfheal, the herba cepbalanoplosis segeti and the caulis bambusae in taeniam, mixing the liquid medicine and the extracting solution, and concentrating to obtain an extract; and S3, mixing the volatile oil with the extract to prepare the traditional Chinese medicine composition.
5. 5. The use according to claim 4, wherein the mass ratio of the water distilled by water to the sum of grassleaf sweelflag rhizome and platycladi seed is 15-20:1; and/or the time of the steam distillation is 5-7h.
6. 6. The use according to claim 4, wherein the mass ratio of water usage of the water extract to the sum of the residues and other raw materials is 15-25:1; and/or the water extraction time is 1-2 h; and/or the temperature of the water extraction is 90-100 ℃.
7. 7. The method of claim 4, further comprising the step of forming the volatile oil into an inclusion compound and combining the inclusion compound with the extract.
8. 8. The use according to claim 1, wherein insomnia is an insomnia disorder which is characterized by liver depression transforming into fire and/or phlegm fire disturbing the heart in the Chinese medicine.

Description

Traditional Chinese medicine composition for treating insomnia and preparation method and application thereof Technical Field The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating insomnia as well as a preparation method and application thereof. Background Insomnia is very common in clinic, and has the basic guarantee of normal operation of various necessary physiological functions such as human body immunity maintenance, brain protection, organism restoration, physical strength supplement, fatigue relief and the like, and insomnia can lead to cognitive hypofunction, depression, obesity, reproductive hypofunction and a series of cardiovascular and cerebrovascular diseases and the like. Western medicines for treating insomnia at present have certain sedative-hypnotic effects, but often show more side effects after being taken, and are easy to cause addiction and tolerance. The traditional Chinese medicine has long history in the aspect of treating insomnia, and has reliable clinical curative effect and good safety. Along with the increase of the demand for treating insomnia, the Chinese patent medicine with more definite clinical effect and more definite action mechanism is developed, and has important clinical value and market demand. The theory of traditional Chinese medicine holds that sleeping is a process of changing from yang to yin, from dynamic to static and from opening to closing, so that convergence and silence are required. From the perspective of traditional Chinese medicine, insomnia may be caused by stagnation of liver-qi, phlegm-fire disturbing heart, yin deficiency and fire excess, deficiency of both heart and spleen, incoordination between heart and kidney, etc. Modern life has the problems of high working pressure and lack of food and drink, and the like, and the modern life has the problems of easy generation of fire heat, easy dissipation and agitation due to yang evil, so that fire in the body is most easy to consume heart spirit to cause insomnia, thereby causing excessive pattern insomnia. The traditional Chinese medicine insomnia preparation produced by the traditional pharmaceutical factory is mainly used for treating insomnia deficiency syndrome patients (such as semen Ziziphi Spinosae paste, wuling Capsule, baile sleep capsule, six-ingredient nerve-soothing capsule and the like). According to clinical experience taught by the state doctor Wang Qingguo, the insomnia patients with the two excess symptoms of liver depression transforming into fire and phlegm heat are more than 1/3 of the insomnia patients, but the traditional Chinese medicine preparation for treating the excess symptoms of insomnia still lacks in the market at present and has quick effect. Disclosure of Invention In order to overcome the problems of the prior art, one of the purposes of the present invention is to provide a traditional Chinese medicine composition. The second purpose of the present invention is to provide a method for preparing the above-mentioned Chinese medicinal composition. The invention also aims at providing the application of the traditional Chinese medicine composition. In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: The first aspect of the invention provides a traditional Chinese medicine composition, which is prepared from the following raw materials, by mass, 12-17 parts of selfheal, 7-11 parts of grassleaf sweelflag rhizome, 4-8 parts of common cephalanoplos herb, 7-13 parts of platycladi seed and 4-8 parts of bamboo shavings. According to the theory of dialectical treatment such as 'tonifying deficiency' and 'treating the disease is necessary in the present' of traditional Chinese medicine, the invention skillfully aims at the cause of the disease according to the complementarity of different medicines from multiple aspects, adopts the 'pungent, sweet and cold' legislation, prepares the traditional Chinese medicine preparation for treating insomnia by using the common selfheal fruit-spike with the efficacy of clearing liver fire, the grassleaf sweetflag rhizome with the efficacy of inducing resuscitation, eliminating phlegm, refreshing mind and promoting intelligence, other traditional Chinese medicines for strengthening the efficacy of clearing liver fire and nourishing heart and tranquillizing, and the bamboo shavings with sweet and cold. In the traditional Chinese medicine formula, selfheal is monarch, grassleaved sweetflag rhizome and common cephalanoplos herb are ministerial drugs, platycladi seed and bamboo shavings are adjuvant drugs. Spica Prunellae is used as principal drug, and has effects of clearing liver fire, nourishing liver blood, rhizoma Acori Graminei is used as ministerial drug, tranquilizing mind and improving intelligence, herba Cephalanoploris is used as ministerial drug, cooling blood and removing blood sta