CN-119817573-B - Phase-change eutectic carrier embedded with photo-thermal agent and preparation method and application thereof

Abstract

The invention relates to the technical field of pesticides, and discloses a phase-change eutectic carrier embedded with a photo-thermal agent, a preparation method and application thereof. The preparation has the advantages of simple preparation process, mild condition, no need of a large amount of auxiliary agents, quantitative preparation, capability of improving the dispersion and the utilization rate of the bactericide by eutectic melting, capability of improving the effectiveness of the bactericide, suitability for various application modes such as seed coating, soil treatment and the like, capability of exerting various synergistic functions such as temperature response release, prolonging the retention time of the medicine, enhancing the adhesiveness and the permeability on the surface of pathogenic bacteria and the like according to the use environment, environment-friendly and efficient bactericide preparation, and wide application prospect in green intelligent agriculture.

Inventors

• LI MENG
• JIA XIN
• PENG PENG
• HU JIE
• GUO YANG
• SU LIWEN
• SONG JIA
• ZHANG HAO

Assignees

• 石河子大学

Dates

Publication Date

20260505

Application Date

20250110

Claims (9)

1. 1. A phase-change eutectic carrier embedded with photo-thermal agent is characterized in that a material with photo-thermal property and the phase-change eutectic material are phase-change eutectic carriers embedded with photo-thermal agent, and pesticide bactericide is loaded; The material of the photo-thermal property is a photo-thermal agent, the photo-thermal agent is one of a carbon-based material, polydopamine and polydopamine-metal ion complex, the metal ion in the polydopamine-metal ion complex is one of Cu 2+ 、Ti 4+ 、Zn 2+ 、Mg 2+ 、Fe 3 + 、Fe 2+ 、Co 2+ 、Au 3+ 、Al 3+ and Ag + , and the mass fraction of the photo-thermal agent in the phase-change eutectic carrier is 1% -30%; the phase-change eutectic material comprises fatty acid, an organic solvent and water; the fatty acid is one of lauric acid, caprylic acid, capric acid, myristic acid, pelargonic acid, palmitic acid and stearic acid, and the mass fraction of the fatty acid in the phase-change eutectic carrier is 10% -60%; The organic solvent is a polar organic solvent which is mutually soluble with water, the mass fraction of the organic solvent in the phase-change eutectic carrier is 20% -40%, and the balance is water.
2. 2. The phase-change eutectic carrier embedded with a photothermal agent as set forth in claim 1, wherein the photothermal agent is in the form of one of a porous material, a microcapsule, a nanocrystal, a nanotube, a liposome, a nanoparticle and a nanobottle.
3. 3. The phase-change eutectic carrier with embedded photothermal agent of claim 1, wherein the organic solvent is one of ethanol, N-methylpyrrolidone, N-dimethylformamide, 2-pyrrolidone and dimethyl sulfoxide.
4. 4. A method for preparing the phase-change eutectic carrier of the embedded photo-thermal agent according to any one of claims 1-3, which is characterized by comprising the steps of mixing the photo-thermal agent with fatty acid, dispersing the mixture in an organic solvent, and forming a eutectic with water to obtain the phase-change eutectic carrier of the embedded photo-thermal agent.
5. 5. The method for preparing the phase-change eutectic carrier embedded with the photo-thermal agent, as claimed in claim 4, wherein the photo-thermal agent is a polydopamine-metal ion complex nanobottle, the polydopamine-metal ion complex nanobottle is prepared from dopamine and metal ions by a solution oxidation method to obtain a polydopamine-metal ion complex shell layer, and the nanobottle with an independent opening is prepared by a swelling-etching method.
6. 6. The method for preparing the phase-change eutectic carrier embedded with the photothermal agent according to claim 5, wherein the preparation of the polydopamine-metal ion complex nanobottle is as follows: 1) Preparing a polydopamine-metal ion complex shell layer by a solution oxidation method, adding dopamine hydrochloride and a metal ion compound into Tris buffer solution containing PS template pellets, stirring to form polydopamine-metal ion complex, and centrifugally collecting a lower-layer product; 2) Swelling, adding the obtained polydopamine-metal ion complex into PS mixed solution under the condition of oscillation at room temperature, and centrifugally collecting a lower-layer product; 3) Etching, namely adding the product collected in the step 2) into a PS template pellet good solvent under the condition of room temperature oscillation, and centrifugally collecting a lower product to obtain the polydopamine-metal ion complex nano bottle.
7. 7. The preparation method of the phase-change eutectic carrier embedded with the photothermal agent, which is characterized in that in the step 1), the mass ratio of dopamine hydrochloride to metal ion compound is 2-5:1, the content of PS template pellets is 0.125% w/v, the stirring rotation speed is 300-1200 rmp, and the stirring time is 8-24 h; The PS mixed solution in the step 2) comprises a good solvent and water, wherein the volume ratio of the good solvent to the water is 1:2-9, the good solvent is one of toluene, benzene, dimethylbenzene, dichloromethane, chloroform, carbon tetrachloride, tetrahydrofuran, acetone and ethyl acetate, and the shaking in the step 2) is intense shaking, and the rotating speed is 200-400 rm.
8. 8. The method for preparing the phase-change eutectic carrier embedded with the photothermal agent according to claim 6, wherein the good solvent in the step 3) is one of toluene, tetrahydrofuran and xylene, and the oscillation in the step 3) is intense, and the rotating speed is 200-400 rmp.
9. 9. Use of a phase-change eutectic carrier embedded with a photothermal agent as defined in any one of claims 1-3 as a carrier for a bactericide in crops.

Description

Phase-change eutectic carrier embedded with photo-thermal agent and preparation method and application thereof Technical Field The invention relates to the technical field of pesticides, in particular to a phase-change eutectic carrier embedded with a photo-thermal agent, and a preparation method and application thereof. Background Soil-borne diseases refer to diseases caused by the invasion of pathogens such as fungi, bacteria, nematodes and viruses from the roots or stems of crops when the conditions are appropriate, by living in the soil with the disease residues. Among them, fungi such as Pythum spp causing seedling rot and damping-off of crops, rhizoctonia cerealis Rhizoctonia solani Kuhn causing seedling damping-off, fusarium oxysporum Fusariumoxysporum causing plant wilting, dying, verticillium chrysosporium Verticilliumalboatum, and the like are dominant. Soil-borne diseases are rapid in onset and few in control means, so that huge economic losses are caused for agricultural production. At present, chemical bactericides are still the main control strategy for soil-borne diseases, and the main bactericides comprise copper bactericides, organic sulfur bactericides, triazole bactericides, methoxy acrylic acid ester bactericides, benzimidazole bactericides and the like. However, the original bactericide is difficult to dissolve in water, various auxiliary agents and organic solvents are needed to be added, and the bactericide is prepared into dosage forms such as Wettable Powder (WP), suspending agent (SC), emulsifiable Concentrate (EC) and the like through special processes. Environmental pollution and ecological toxicity caused by chemical synthesis aids (such as surfactants, thickeners and the like) and solvents (such as toluene, xylene and the like) are not ignored. Therefore, the development of a green and efficient Pesticide Delivery System (PDS) is a research hotspot in the field of pesticide formulations. The phase change material is a material which undergoes solid-liquid and liquid-solid phase change under an external temperature stimulus. Because of its temperature sensitivity, it has been widely studied in drug delivery. Eutectic is a phenomenon common in solid-state mass systems, which refers to a mixture of different substances (usually two or more components) in a certain proportion, melting at a certain temperature with the lowest melting point, and at this temperature all the components start to melt at the same time. The phase-change eutectic material is used as a pesticide carrier, so that the functions of pesticide stabilization increase, temperature response release, sustained and controlled release and the like can be realized. Therefore, the phase-change eutectic carrier has great application prospect in the aspect of 'decrement efficiency improvement' of pesticides. Disclosure of Invention The invention aims to provide a phase-change eutectic carrier embedded with a photo-thermal agent, and a preparation method and application thereof. The preparation method is simple and mild, 100% of active drugs remain in the carrier during the preparation process, and the active drugs can be uniformly dispersed in the carrier, so that the active drugs are convenient to store and transport. The preparation has simple formulation, green and safe, has temperature response and sustained and controlled release performance, and can cooperate with bactericide raw medicine and carrier for antibiosis. Is especially suitable for seed coating, soil treatment and other modes to achieve the effect of reducing and enhancing the bactericide. The scheme of the invention is as follows: The invention provides a phase-change eutectic carrier embedded with a photo-thermal agent, which comprises the photo-thermal agent, a phase-change eutectic material, a pesticide bactericide, an organic solvent and water; The photo-thermal agent is one of black phosphorus, a difunctional phase change material, a metal nano material, a metal oxide, a Transition Metal Disulfide (TMDs), MXenes (two-dimensional transition metal carbide or nitride), a carbon-based material, polydopamine and polydopamine-metal ion complex, and the metal ion is one of Cu2+、Ti4+、Zn2+、Mg2+、Fe3+/Fe2+、Co2+、Au3+、Al3+ and Ag +. As a preferable technical scheme, the photothermal agent is polydopamine-metal ion complex (Cu-PDA). As a preferable technical scheme, the metal ion is Cu 2+. The shape of the photo-thermal agent is one of porous materials, microcapsules, nanocrystals, nanotubes, liposomes, nanoparticles and nanobottles, and the mass fraction of the photo-thermal agent in the phase-change eutectic carrier embedded with the photo-thermal agent is 1% -30%. As a preferred technical scheme, the nano-bottle. According to an embodiment of the invention, the nanobottle has a morphology as shown in fig. 2. As the preferable technical scheme, the diameter and the bottle opening size of the nano bottle are in nano level, the diameter of the nano bottle is 600-