CN-120324317-B - Eye repair anti-aging composition and preparation method thereof

CN120324317BCN 120324317 BCN120324317 BCN 120324317BCN-120324317-B

Abstract

The invention relates to an eye repair anti-aging composition and a preparation method thereof, belonging to the technical field of cosmetics. In particular to an eye repair and anti-aging composition containing a composite plant fermentation extract and a preparation method thereof. The synergistic effect of the specific plant fermentation extract and active ingredients such as nano-encapsulated retinol, acetyl hexapeptide-8 and the like can obviously improve the antioxidation, anti-wrinkle, moisturizing performance and light stability of the product, and is suitable for improving the aging problems such as loose skin around eyes, fine wrinkles, black eyes and the like.

Inventors

FANG BINGTING
XIE ZONGHUI
Fang Bingsheng
Fang Bingcheng

Assignees

广州芬臣生物科技有限公司

Dates

Publication Date: 20260508
Application Date: 20250522

Claims (4)

1. An eye repair and anti-aging composition is characterized by comprising the following components in parts by mass: 1-8 parts of composite plant fermentation extract; the composite plant fermentation extract is prepared by mixing green tea, coix seed and lucid ganoderma according to a mass ratio of 2:1:1, and extracting after co-fermenting lactobacillus suspension and saccharomycete suspension mixed according to a volume ratio of 1:1; the concentration of the lactobacillus suspension is 4 multiplied by 10 8 -6×10 8 CFU/mL, and the concentration of the saccharomycete suspension is 1 multiplied by 10 8 -3×10 8 CFU/mL; the co-fermentation condition is 30 ℃, and the pH= 5.5,7 days; the eye repair and anti-aging composition further comprises the following components in parts by mass: 0.1-2 parts of acetyl hexapeptide-8; 0.05-1 part of nano-wrapped retinol; 0.5-3 parts of sodium hyaluronate; 0.2-1.5 parts of ceramide NP; 0.5-2 parts of tocopheryl acetate; 1-5 parts of centella asiatica extract; 3-8 parts of glycerol; 2-6 parts of 1, 3-propanediol; the nano-encapsulated retinol is prepared by the following steps in parts by mass: w1, centrifuging the co-fermentation liquid 8000 rpm of green tea, semen Coicis and Ganoderma for 20 min, collecting supernatant, and filtering with 0.22 μm filter membrane to obtain pretreated fermentation liquid; W2, adding 4 times volume of absolute ethyl alcohol into the pretreated fermentation broth, standing at 4 ℃ for 12 hours, centrifuging at 10000 rpm for 15 minutes, collecting precipitate, redissolving the precipitate with ultrapure water, dialyzing for 48 hours with the molecular weight cutoff of 3.5 kDa, and freeze-drying to obtain compound plant fermentation polysaccharide; W3. dissolving 10 parts of composite plant fermentation polysaccharide in 90 parts of deionized water, and magnetically stirring at 600rpm and 50 ℃ until the composite plant fermentation polysaccharide is completely dissolved to obtain a composite plant fermentation polysaccharide solution; w4. dissolving 1 part of retinol in absolute ethanol to make the concentration of retinol be 5 mg/mL, then slowly dripping the retinol into the compound plant fermentation polysaccharide solution, homogenizing for 5 minutes at a high speed of 15000 and rpm; w5. parts of Tween 80 is added, and homogenized at 10000 rpm for 3 minutes to form colostrum; W6. mixing the colostrum with sodium tripolyphosphate solution with the mass volume concentration of 0.1% according to the volume ratio of 5:1, magnetically stirring for 30 minutes at 500 rpm and 25 ℃, centrifuging for 15 minutes by 12000 and rpm, washing, and dispersing in deionized water to obtain the nano-encapsulated retinol suspension.
2. The eye repair anti-aging composition of any one of claim 1, prepared by the steps of: X1. heating deionized water to 70-75deg.C, adding glycerol and 1, 3-propylene glycol, stirring and dissolving; X2. cooling to 40-45deg.C, sequentially adding sodium hyaluronate, ceramide NP, and tocopheryl acetate, homogenizing, and emulsifying for 10-15 min; x3. adding nano-encapsulated retinol, acetyl hexapeptide-8, herba Centellae extract and compound plant fermentation extract, homogenizing for 5 min; x4. adjusting pH to 5.5-6.0, and cooling to room temperature to obtain the composition for repairing and resisting aging of eye.
3. The composition of claim 2, wherein the homogenization speed of step X2 is 3000-5000 rpm.
4. The eye repair anti-aging composition according to claim 2, wherein the homogenization temperature of step X3 is 25-30 ℃.

Description

Eye repair anti-aging composition and preparation method thereof Technical Field The invention belongs to the technical field of cosmetics, and relates to an eye repair anti-aging composition and a preparation method thereof. Background The periocular skin is susceptible to oxidative stress, photoaging and collagen loss due to its weak barrier structure and frequent muscle activity. The prior art has the following limitations that 1, an antioxidant system is single, components such as vitamin C, coenzyme Q10 and the like are relied on, the components are easy to inactivate and cannot form a multi-dimensional defense network, 2, the transdermal absorption efficiency is low, the active components are difficult to penetrate through a stratum corneum to influence the deep restoration effect, 3, the stability of the photosensitive components is poor, the molecular structure of the common retinol contains more unsaturated bonds, the unsaturated bonds are easy to undergo oxidation reaction under illumination, so that the retinol is decomposed, the activity of the retinol is reduced, the efficacy is reduced, harmful substances are possibly generated, and the skin is adversely affected. The invention innovatively introduces the composite plant fermentation extract prepared by co-fermenting green tea, coix seed and lucid ganoderma, is rich in micromolecular polyphenol, polysaccharide and polypeptide, can enhance the antioxidation capability, promote the permeation of active ingredients, and stabilizes photosensitive ingredients by a natural polysaccharide encapsulation technology, thereby realizing lasting repair. Disclosure of Invention The invention aims to provide an eye repair and anti-aging composition and a preparation method thereof, and the composition has the characteristics of good anti-wrinkle, moisturizing and repairing effects and good illumination stability. The aim of the invention can be achieved by the following technical scheme: an eye repair and anti-aging composition comprises the following components in parts by mass: 1-8 parts of composite plant fermentation extract. 0.1-2 Parts of acetyl hexapeptide-8; 0.05-1 part of nano-wrapped retinol; 0.5-3 parts of sodium hyaluronate; 0.2-1.5 parts of ceramide NP; 0.5-2 parts of tocopheryl acetate; 1-5 parts of centella asiatica extract; 3-8 parts of glycerol; 2-6 parts of 1, 3-propanediol. As a preferable technical scheme of the invention, the composite plant fermentation extract is prepared by mixing green tea, coix seed and lucid ganoderma according to a mass ratio of 2:1:1, and extracting after co-fermenting lactobacillus suspension and saccharomycete suspension mixed according to a volume ratio of 1:1. As a preferable embodiment of the invention, the concentration of the lactobacillus suspension is 4×10 8-6×108 CFU/mL, and the concentration of the yeast suspension is 1×10 8-3×108 CFU/mL. As a preferred embodiment of the present invention, the co-fermentation conditions are 30 ℃, ph= 5.5,7 days. As a preferable technical scheme of the invention, the nano-encapsulated retinol is prepared by the following steps in parts by mass: w1, centrifuging the co-fermentation liquid 8000 rpm of green tea, semen Coicis and Ganoderma for 20 min, collecting supernatant, and filtering with 0.22 μm filter membrane to obtain pretreated fermentation liquid; W2, adding 4 times volume of absolute ethyl alcohol into the pretreated fermentation broth, standing at 4 ℃ for 12 hours, centrifuging at 10000 rpm for 15 minutes, collecting precipitate, redissolving the precipitate with ultrapure water, dialyzing for 48 hours with the molecular weight cutoff of 3.5 kDa, and freeze-drying to obtain compound plant fermentation polysaccharide; W3. dissolving 10 parts of composite plant fermentation polysaccharide in 90 parts of deionized water, and magnetically stirring at 600rpm and 50 ℃ until the composite plant fermentation polysaccharide is completely dissolved to obtain a composite plant fermentation polysaccharide solution; w4. dissolving 1 part of retinol in absolute ethanol to make the concentration of retinol be 5 mg/mL, then slowly dripping the retinol into the compound plant fermentation polysaccharide solution, homogenizing for 5 minutes at a high speed of 15000 and rpm; w5. parts of Tween 80 is added, and homogenized at 10000 rpm for 3 minutes to form colostrum; W6. mixing the colostrum with sodium tripolyphosphate solution with the mass volume concentration of 0.1% according to the volume ratio of 5:1, magnetically stirring for 30 minutes at 500 rpm and 25 ℃, centrifuging for 15 minutes by 12000 and rpm, washing, and dispersing in deionized water to obtain the nano-encapsulated retinol suspension. An eye repair anti-aging composition as described above prepared by the steps of: X1. heating deionized water to 70-75deg.C, adding glycerol and 1, 3-propylene glycol, stirring and dissolving; X2. cooling to 40-45deg.C, sequentially adding sodium hyaluronate, ceramide NP, and toc