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CN-120753730-B - Intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drug

CN120753730BCN 120753730 BCN120753730 BCN 120753730BCN-120753730-B

Abstract

The invention discloses an endothelial targeted controlled-release antithrombotic drug intelligent monitoring biodegradable heart plugging device, which relates to the field of medical instruments and comprises a plugging device main body and a sheath tube for regulating and controlling the plugging device main body, wherein the plugging device main body consists of a double-disc-shaped biological skeleton, a fixed deformation body and a biological flow blocking film, the double-disc-shaped biological skeleton consists of two attached discs which are mutually symmetrical to form a left heart disc surface and a right heart disc surface, the side surfaces of the attached discs are circumferentially provided with support outer discs, the surfaces of the support outer discs are provided with double-layer antithrombotic drug controlled-release layers, the two attached discs are tightly connected with the fixed deformation body, an ultrasonic blood flow sensor is arranged in the fixed deformation body, one side, which is positioned in the ultrasonic blood flow sensor, of the fixed deformation body is provided with an impedance sensor, and the biological flow blocking film is respectively arranged on the surfaces of the opposite sides of the two attached discs. The occluder is positioned in a patient for periodic degradation to reduce complications caused by foreign matter retention, and aims at the surface thrombosis of the occluder, and the systemic adverse reaction caused by long-term oral antithrombotic drug after the occlusion operation is reduced by locally releasing the medium-low dose antithrombotic drug. The risk of thrombus and the endothelialization progress of the occluder are dynamically monitored to assist in the repair and regeneration of heart tissue.

Inventors

  • Zou Huayiyang
  • SHI JING
  • LIU JING
  • ZHANG HAO
  • SUN WEI

Assignees

  • 江苏省人民医院（南京医科大学第一附属医院）

Dates

Publication Date
20260508
Application Date
20250819

Claims (6)

  1. 1. The intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drugs is characterized by comprising a plugging device main body and a sheath tube (1) for regulating and controlling the plugging device main body, wherein the plugging device main body is composed of a double-disc-shaped biological framework, a fixed deformation body (5) and a biological choked flow membrane (4), the double-disc-shaped biological framework is composed of two attaching discs (3) which are mutually symmetrical to form a left heart disc surface and a right heart disc surface, a support outer disc (11) is circumferentially arranged on the side surface of the attaching disc (3), and a double-layer anti-thrombus drug controlled-release layer (12) for rapidly releasing the thrombolytic drugs is arranged on the surface of the support outer disc (11); the two attaching discs (3) are tightly connected with a fixed deformation body (5), an ultrasonic blood flow sensor (9) for detecting local blood flow velocity is arranged in the fixed deformation body (5), an impedance sensor (10) for monitoring resistance change is arranged on one side of the ultrasonic blood flow sensor (9) in the fixed deformation body (5), the ultrasonic blood flow sensor (9) and the impedance sensor (10) are integrally integrated at the waist of the occluder and used for dynamically monitoring the thrombus risk signal-to-noise ratio, and the biological choked flow films (4) are respectively arranged on the surfaces of the opposite sides of the two attaching discs (3) so as to occlude and block blood flow instantly; The novel biological anti-blocking device is characterized in that a supporting steel cable (6) is arranged in the sheath tube (1), a compression flaring (8) is fixedly arranged at the top of the supporting steel cable (6), the tail end of the supporting steel cable (6) is inserted through the attaching disc (3) and the biological anti-blocking film (4) and provided with an extending support (2), and the extending support (2) is fixedly sleeved with the attaching disc (3) and the biological anti-blocking film (4); The fixed deformation body (5) comprises an extrusion deformation body (53) which is inserted and arranged on the top surface of the sheath tube (1), a supporting intermediate body (51) is fixedly arranged at the top of the extrusion deformation body (53), and a bending compression body (52) is fixedly arranged at one side, far away from the extrusion deformation body (53), of the supporting intermediate body (51); the tail end of the bent compression body (52) is provided with a reverse bending surface (54) which is bent inwards by taking the supporting steel cable (6) as a center, and a fixed clamping groove (55) is formed in the shrinkage tail end surface of the reverse bending surface (54); the top of the compression flaring (8) penetrates through the supporting steel cable (6) and is provided with a bracket recovery hole (14), and a plurality of pulling brackets (16) which are clamped with the bending compression body (52) are arranged in the bracket recovery hole (14).
  2. 2. The intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drug according to claim 1, wherein the tops of the pulling brackets (16) are respectively sleeved and abutted with the surface of the reverse bending surface (54) around the fixing clamping groove (55), and the bottoms of the pulling brackets (16) are respectively connected with an external recovery mechanism along the extension of the bracket recovery holes (14).
  3. 3. The intelligent endothelial targeted controlled-release antithrombotic drug monitoring biodegradable heart plugging device according to claim 1, wherein a telescopic bracket (17) is arranged in the middle of the pulling bracket (16), two sides of the tail end of the telescopic bracket (17) are positioned in a fixed clamping groove (55) and provided with a rotary clamp plate (18), and a limit lug (19) is fixedly arranged on the surface of the tail end of the telescopic bracket (17).
  4. 4. The intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drug according to claim 3, wherein the top surface of the sheath tube (1) is surrounded by a limit groove (15), and the limit groove (15) is in extrusion insertion connection with the bottom of the extrusion deformation body (53).
  5. 5. The intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drug according to claim 4, wherein the outer surface of the supporting steel cable (6) is provided with a furling sleeve (7) in a surrounding manner, and the inner surface of the furling sleeve (7) and the outer surface of the supporting steel cable (6) are provided with a pouring device for pouring bioprotein glue.
  6. 6. The intelligent endothelial targeted controlled-release antithrombotic drug monitoring biodegradable heart plugging device according to claim 5, wherein the inner parts of the attaching disc (3) and the biological choke film (4) are respectively provided with a deformation inner cavity (13) for reserving extrusion spaces for deformation of the attaching disc (3) and the biological choke film (4).

Description

Intelligent monitoring biodegradable heart plugging device for endothelial targeted controlled-release antithrombotic drug Technical Field The invention relates to medical equipment, in particular to an implantable intravascular filter, and specifically relates to an endothelial targeted controlled-release antithrombotic drug intelligent monitoring biodegradable heart plugging device. Background The heart occluder is a medical device for treating heart structural abnormalities (especially congenital heart diseases), the development process and the technical background of the heart occluder represent continuous progress of medicine and material science, the traditional heart occluder is mostly made of nickel-titanium alloy materials, has super elasticity and durability, can adapt to heart dynamic environment, but can be permanently remained in the body after implantation, can cause long-term complications such as metal allergy and vascular wall abrasion, can even influence heart structures or functions, can easily cause thrombosis on the metal surface, increases the risks of thromboembolism and the like, and can induce systemic bleeding risks in the process of taking an antiplatelet or anticoagulant drug with a larger dose until endothelialization of the occluder is completed (half a year to 1 year) in order to inhibit thrombosis. Although degradable occluders have been developed and marketed gradually over the last 2 years, the existing degradable occluders on the market have higher anti-platelet strength after surgery for longer anti-platelet time (greater than 1 year), resulting in a significant increase in bleeding risk. And the existing degradable occluder is difficult to recover after release, the endothelialization process is difficult to monitor, and the repair and regeneration support of heart tissues is limited. Disclosure of Invention In order to improve the bleeding risk caused by long-term oral antithrombotic drug after plugging operation, the specific process monitoring problem of the thrombosis on the surface of the plugging device and the endothelialization of the plugging device, the risk caused by the conventional plugging device remained in a patient, the difficulty in recovering the plugging device and the problem that the heart tissue repair and regeneration cannot be assisted, the invention provides the intelligent monitoring biodegradable heart plugging device for the endothelialization targeted controlled-release antithrombotic drug. The invention provides an endothelial targeted controlled-release antithrombotic drug intelligent monitoring biodegradable heart plugging device, which adopts the following technical scheme: The intelligent endothelial targeted controlled-release antithrombotic drug monitoring biodegradable heart occluder comprises an occluder main body and a sheath tube for regulating and controlling the occluder main body, wherein the occluder main body consists of a double-disc-shaped biological framework, a fixed deformation body and a biological choked flow membrane, the double-disc-shaped biological framework consists of two attached discs which are mutually symmetrical to form a left heart disc face and a right heart disc face, the side surface of the attached disc is provided with a support outer disc in a surrounding manner, and the surface of the support outer disc is provided with a double-layer antithrombotic drug controlled-release layer for rapidly releasing the thrombolytic drug; The device comprises a fixed deformation body, an ultrasonic blood flow sensor, an impedance sensor and biological choked films, wherein the fixed deformation body is connected between two attached plates in a clinging manner, the ultrasonic blood flow sensor is arranged in the fixed deformation body and used for detecting local blood flow velocity, the impedance sensor used for monitoring resistance change is arranged on one side of the ultrasonic blood flow sensor in the fixed deformation body, the ultrasonic blood flow sensor and the impedance sensor are integrally integrated at the waist of the plugging device and used for dynamically monitoring thrombus risk signal-to-noise ratio, and the biological choked films are respectively arranged on the surfaces of the opposite sides of the two attached plates to block blood flow instantly. The inside ultrasonic blood flow sensor that is used for detecting local blood flow velocity that is provided with of fixed deformation body, be provided with the impedance sensor that is used for monitoring resistance variation in the inside one side that is located ultrasonic blood flow sensor of fixed deformation body, ultrasonic blood flow sensor and impedance sensor are whole to be integrated in the stopper waist and are used for carrying out dynamic monitoring to thrombus risk signal to noise ratio. By adopting the technical scheme, the double-layer controlled release medicine of the attaching disc is released slowly and released quickly, so t