CN-120919490-B - System and method for synchronously monitoring pH of gastroesophageal and laryngopharyngeal multichannel

CN120919490BCN 120919490 BCN120919490 BCN 120919490BCN-120919490-B

Abstract

The application provides a system and a method for synchronously monitoring the pH of multiple channels of gastroesophageal and laryngopharyngeal diseases. The system comprises a flexible catheter, a plurality of pH sensors, a signal collector and an analysis module, wherein the flexible catheter is used for being inserted into a monitoring position through a nasal cavity, the pH sensors are integrated on the flexible catheter and are respectively used for monitoring the pH values of the throat, the upper esophageal section and the lower esophageal section, the signal collector is connected with the proximal end of the flexible catheter and is used for synchronously collecting data of the pH sensors, and the analysis module is used for judging a reflux path and diagnosing according to the time sequence and the amplitude of the data change of the pH sensors. According to the application, the pH sensors are integrated on the single flexible catheter to monitor the pH of a plurality of parts simultaneously, and the pH data are synchronously acquired by the signal acquisition device, so that the synchronous monitoring of the gastroesophageal-laryngopharynx multi-channel pH is realized, the reflux path judgment and reflux diagnosis are carried out based on the synchronous monitoring data, and the accuracy of the reflux diagnosis is improved.

Inventors

YANG FAN
LIU XU
GENG ZHANXIAO
ZHAO HUITAO
LI ANG
AI SAN

Assignees

瑞思泰克(廊坊临空自贸区)智能科技有限公司

Dates

Publication Date: 20260508
Application Date: 20250826

Claims (7)

1. The system for synchronously monitoring the pH of the gastroesophageal and pharyngeal multichannel is characterized by comprising a flexible catheter, a plurality of pH sensors, a signal collector and an analysis module, wherein the flexible catheter is used for being inserted into a monitoring position through a nasal cavity, the pH sensors are integrated on the flexible catheter and are respectively used for monitoring the pH values of the pharyngeal throat and the esophageal position, the signal collector is connected with the proximal end of the flexible catheter and is used for synchronously collecting data of the pH sensors, and the analysis module is configured to: The method comprises the steps of carrying out denoising treatment on an original pH signal, marking an acid reflux suspected event based on the pH signal after denoising treatment, calculating the time difference of the acid reflux suspected event of an adjacent pH sensor, judging a reflux path according to the time difference and the occurrence sequence of the event, and screening data conforming to the reflux path for reflux diagnosis; The reflux path judging condition is that only the most remote pH sensor detects the suspected acid reflux event or The adjacent pH sensors monitor acid reflux suspected events, the acid reflux suspected events at the far end are before the acid reflux suspected events at the near end, and the conduction time difference does not exceed the preset conduction time; The proximal end is proximal to the outer body end and the distal end is distal to the outer body end.
2. The system of claim 1, wherein the plurality of pH sensors comprises a pharynx probe fixed to a middle portion of the flexible catheter body for monitoring pH of a throat portion, and a gastroesophageal probe fixed to an end portion of the flexible catheter body for monitoring pH of a target monitoring location in an esophagus.
3. The gastroesophageal and pharyngeal multichannel pH-synchronous monitoring system of claim 1, wherein the plurality of pH sensors includes a pharyngeal probe secured to a central portion of the flexible catheter body for monitoring a pH of a pharyngeal portion, a first gastroesophageal probe secured to an end of the flexible catheter body for monitoring a pH of a first target monitoring location within an esophagus, and a second gastroesophageal probe secured to a lower middle portion of the flexible catheter body for monitoring a pH of a second target monitoring location within the esophagus.
4. The gastroesophageal and pharyngeal multichannel pH-synchronized monitoring system of claim 1, wherein the acid regurgitation suspected events are marked by a pH below a threshold, or a pH continuously below a threshold for more than 5 seconds, or a pH rapidly decreasing within 2 seconds by an amount greater than 10% of the average of the previous 15 minutes.
5. The gastroesophageal and pharyngeal multichannel pH synchronous monitoring system of claim 1, wherein each of the plurality of pH sensors is a miniature pH electrode or a wireless pH capsule.
6. The gastroesophageal and pharyngeal multichannel pH synchronization monitoring system of claim 1, wherein the signal collector incorporates a real-time clock for generating a time stamp with a uniform time reference for the sampled data of all pH sensors.
7. The gastroesophageal and pharyngeal multichannel pH synchronization monitoring system of claim 1, wherein the flexible conduit has embedded therein signal transmission leads corresponding to each pH sensor, the signal transmission leads extending from each pH sensor to a proximal end of the flexible conduit and being connected to the signal collector by a single connection interface.

Description

System and method for synchronously monitoring pH of gastroesophageal and laryngopharyngeal multichannel Technical Field The application relates to the technical field of medical detection equipment, in particular to a system and a method for synchronously monitoring the pH of multiple channels of gastroesophageal and laryngopharynx. Background Gastroesophageal airway reflux disease (gastroesophageal airway reflux disease, GARD) is a disease caused by irritation of digestive tract reflux and injury to the esophagus and airway, with gastroesophageal reflux disease (gastroesophageal reflux disease, GERD) and laryngopharyngeal reflux (laryngopharyngeal reflux, LPR) being two common types of GARD. Gastroesophageal reflux disease is a series of clinical syndromes caused by reflux of gastroduodenal contents into the esophagus and outside the esophagus. Laryngopharyngeal reflux is considered an extra-esophageal variant of GERD. Dynamic pH monitoring is a key means to assess gastric acid reflux into the esophagus and throat. At present, for the clinical scene of simultaneously monitoring the pH value in the throat and the esophagus, a separated independent measurement mode is mainly adopted, wherein a sensor is arranged in the esophagus for the first time of monitoring, and the sensor is arranged near the throat for the second time of monitoring. The monitoring data come from different time periods, the influence of external interference (such as drinking water, swallowing and coughing) on the two measurements cannot be identified, the data accuracy is low, the pH states of the same time point or the same reflux event in the throat and esophagus cannot be synchronously associated, and the path of the reflux event and the influence of the reflux event on the throat are difficult to accurately analyze. Disclosure of Invention In order to solve the defects in the prior art, the application aims to provide a system and a method for synchronously monitoring the pH of multiple channels of the gastroesophageal and the laryngopharynx, which can simplify the operation and improve the reflux analysis precision while synchronously monitoring the pH of the multiple channels of the gastroesophageal and the laryngopharynx. To achieve the above object, the present application provides a gastroesophageal and pharyngeal multichannel pH synchronization monitoring system, comprising: the plurality of pH sensors includes: the pharyngeal probe is fixed in the middle of the flexible catheter main body and is used for monitoring the pH value of the pharyngeal portion; and the gastroesophageal probe is fixed at the tail end of the flexible catheter body and is used for monitoring the pH value of a target monitoring position in the esophagus. Further, the plurality of pH sensors includes: the pharyngeal probe is fixed in the middle of the flexible catheter main body and is used for monitoring the pH value of the pharyngeal portion; A first gastroesophageal probe fixed at the end of the flexible catheter body for monitoring the pH of a first target monitoring location within the esophagus; and the second gastroesophageal probe is fixed at the middle lower part of the flexible catheter main body and is used for monitoring the pH value of a second target monitoring position in the esophagus. Further, the analysis module is configured to: Denoising the original pH signal; Marking an acid reflux suspected event based on the denoised pH signal; calculating the time difference of the acid reflux suspected events of the adjacent pH sensors; Judging a reverse flow path according to the time difference and the event occurrence sequence; data conforming to the regurgitation path is screened for regurgitation diagnosis. Further, the labeling conditions of the acid reflux suspected event are: pH value below threshold value, or The pH value being continuously lower than the threshold value for more than 5 seconds, or The pH rapidly decreased within 2 seconds by more than 10% of the average value of the previous 15 minutes. Further, the reverse flow path determination condition is: 1) Only the most distal pH sensor detects an acid reflux suspected event, or 2) The adjacent pH sensors detect the suspected acid reflux event and The remote acid reflux suspected event occurs before the near-end acid reflux suspected event, and The conduction time difference does not exceed a preset conduction time; The proximal end is proximal to the outer body end and the distal end is distal to the outer body end. Further, each of the plurality of pH sensors is a miniature pH electrode or a wireless pH capsule. Further, the signal collector is internally provided with a real-time clock and is used for generating time stamps with uniform time references for sampling data of all pH sensors. Further, the flexible catheter is embedded with signal transmission wires corresponding to the pH sensors, and the signal transmission wires extend from the pH sensors to the proximal end