CN-121015458-B - Composite root canal filling agent of premixed calcium silicate-niobium compound, preparation method and application

Abstract

The invention relates to the technical field of medical materials, in particular to a composite root canal filling agent of a premixed calcium silicate-niobium compound, a preparation method and application thereof. The composite root canal filling agent comprises (a) a calcium silicate compound, (b) a phosphate compound, (c) a calcium compound, (d) a niobium compound, (e) a radiation blocking material, (f) a water-miscible non-aqueous phase solvent and (g) an organic substance, wherein the components (a, b, c, d, e) and g account for 60% -95% of the total mass of the filling agent, and the component (f) accounts for 5% -40% of the total mass of the filling agent. The filling agent of the invention has the advantages of quick solidification, good biological activity, excellent antibacterial performance and convenient popularization and application.

Inventors

• GUO RUI
• LI SHAOJUN

Assignees

• 暨南大学

Dates

Publication Date

20260508

Application Date

20250724

Claims (4)

1. 1. A composite root canal filling agent of a premixed calcium silicate-niobium compound is characterized by comprising: (a) a calcium silicate compound, (b) a phosphate compound, (c) a calcium compound, (d) a niobium compound, (e) a radiation blocking material, (f) a non-aqueous phase solvent miscible with water, and (g) an organic substance, wherein the components (a), (b), (c), (d), (e) and (g) account for 60% -95% of the total mass of the filler, and the component (f) accounts for 5% -40% of the total mass of the filler; The component (a) is selected from tricalcium silicate powder and dicalcium silicate powder, and the particle size is 100 mu m; The component (b) is selected from calcium phosphate powder, and the particle size is 100 mu m; the component (c) is selected from calcium hydroxide powder, and the particle size is 100 mu m; the component (d) is selected from niobium pentoxide powder, and the particle size is 200nm; the component (e) is selected from zirconia powder, and the particle size is 200nm; Said component (f) is selected from polyethylene glycol-400; The component (g) is selected from hydroxypropyl methyl cellulose, is crystalline powder, and has a particle size of 200nm.
2. 2. The composite root canal filler of claim 1, wherein the mass ratio of tricalcium silicate powder to dicalcium silicate powder is 2:1.
3. 3. The method for preparing the composite root canal filling agent according to claim 1 or 2, which is characterized by comprising the steps of uniformly mixing the component (a), the component (b), the component (c), the component (d), the component (e), the component (f) and the component (g) by ball milling, transferring the mixed paste into a medical injector, packaging and sterilizing to obtain the composite root canal filling agent.
4. 4. Use of a composite root canal filling agent according to claim 1 or 2 for the preparation of a root canal filling material for the treatment of dental pulp diseases.

Description

Composite root canal filling agent of premixed calcium silicate-niobium compound, preparation method and application Technical Field The invention relates to the technical field of medical materials, in particular to a composite root canal filling agent of a premixed calcium silicate-niobium compound, a preparation method and application thereof. Background Root canal disease mainly covers two common conditions, pulpitis and periapical inflammation. Pulpitis often occurs as a result of dental pulp tissue suffering from bacterial infection or irritation, typical symptoms of which include localized pain of the teeth, a sensitive response to hot and cold irritation, and the like. Periapical inflammation causes infection to spread to periapical tissue due to untimely or incompletely cured pulpitis, thereby causing local inflammatory reaction and bone damage. While current endodontic treatments have some effectiveness, many challenges remain, such as the complex structure of the root canal system and multiple difficulties in the treatment process. Necrotic pulp is a breeding ground for microorganisms that multiply in the form of planktonic cells, aggregates, or biofilms. Enterococcus faecalis is the most common isolated bacterium in root canals of patients with persistent root tip periodontitis. Enterococcus faecalis can penetrate into dentinal tubules with depth of 159-1790 mu m and can survive root canal treatment, and the capability of the enterococcus faecalis to adapt to changing environments and form a single biological film is helpful for the enterococcus faecalis to endure severe microenvironment encountered in teeth after root canal treatment, so that the prevalence of secondary root canal infection is 24% -77%. Studies have shown that these diseases, if not treated effectively, may result in loss of teeth or serious oral infections. Root canal therapy includes physiotherapy, chemotherapy, and biological therapy. The pain point at the physical level during the overall treatment is that the mechanical device cannot completely eradicate the intraductal infection, which can result in the device treatment not taking into account 2.66-79.0% of the surface of the tube. Second, the complex microstructure inside the root canal includes a small channel system, side branch channels and nonlinear contours, which not only increase the technical difficulty of root canal treatment, but also affect the success rate and prognosis of treatment. The complex internal structure of the root canal provides an ideal living environment for oral pathogens such as enterococcus faecalis, which can form biofilms in pulp chambers and side branch passages. The presence of biofilm not only enhances the drug resistance and viability of the flora, but also makes effective irrigation during root canal treatment more difficult and complicated, and irrigation-based disinfection plays an indispensable role in the purification of microorganisms and their by-products. Among the various irrigants, sodium hypochlorite remains the preferred irrigant due to its antibacterial and pulp tissue dissolving activity. However, it has a high risk of tissue damage, is prone to dentin decalcification, and is cytotoxic, whereas at low concentrations, the rinsing effect is poor. Root canal treatment is a very challenging technical task in modern dentistry, mainly due to the complex structure of the root canal system and the multiple difficulties involved in the treatment process. Micro-channels, side branch channels and non-linear contours within the root canal system constitute the primary challenge in therapy. Secondly, the treatment process involves not only simple removal of the root tip tissue or tip, but more importantly ensures complete closure of the root canal system, preventing reinfection. Under the condition, if the root canal filling material has effective antibacterial performance, the continuous antibacterial effect can be still exerted after the root canal is filled, and the infection of microorganisms in the root canal and biomembrane outside the root tip hole can be effectively controlled, the success rate of root canal treatment can be increased, and the incidence rate of refractory periapical periodontitis can be reduced. The bioceramic root canal filling paste contains components such as calcium phosphate, calcium silicate, zirconium oxide, calcium hydroxide, etc., and has a composition similar to white MTA. These materials are approved for their good sealing, stability and bacteriostasis. Is insoluble in tissue fluid, can maintain long-term stability, and releases hydroxide ions during coagulation and a period of time thereafter to maintain a high pH, thereby inhibiting bacterial growth. In addition, the bioceramic root canal filling paste has good biocompatibility and no toxic or side effect, and can be used for root tip induction and root canal internal repair. However, such biologic-filled pastes have certain limitations in promotin