CN-121129685-B - Composition containing blue copper peptide for repairing photo-thermal injury and application thereof

Abstract

The invention relates to the field of cosmetics, in particular to a composition containing blue copper peptide for repairing photo-thermal injury and application thereof. The composition comprises compound polypeptide, galactose yeast fermentation product filtrate and blue algae extract, wherein the compound polypeptide comprises blue copper peptide, saccharomycete polypeptide and hexapeptide-11, and the expression level of heat shock protein is improved by compounding the specific compound polypeptide with the galactose fermentation product filtrate and the blue algae extract, so that the composition has excellent effect of repairing the photo-thermal injury, is mild and does not stimulate, and can be widely applied to cosmetics.

Inventors

• CHEN ZHICHAO
• XU LI
• Yan Canliang

Assignees

• 广东柏文生物科技股份有限公司

Dates

Publication Date

20260505

Application Date

20251117

Claims (6)

1. 1. The composition containing the blue-copper peptide for repairing the photo-thermal injury is characterized by comprising a composite polypeptide, galactose yeast fermentation product filtrate and blue-green algae extract, wherein the composite polypeptide comprises the blue-copper peptide, saccharomycete polypeptide and hexapeptide-11, the composite polypeptide comprises the blue-copper peptide, saccharomycete polypeptide and hexapeptide-11 in a mass ratio of 1:0.3-0.5:0.5-0.7, the composite polypeptide, galactose yeast fermentation product filtrate and blue-green algae extract in a mass ratio of 1:6-8:4-6, and blue-green algae raw materials in the blue-green algae extract comprise water front temple blue-green algae powder, spirulina platensis powder and hair weeds powder in a mass ratio of 1:0.5-1.5:3-5.
2. 2. The composition of claim 1, wherein the method of preparing the cyanobacteria extract comprises the steps of: a1, uniformly mixing the blue algae powder, the spirulina platensis powder and the hair weeds powder according to the formula amount to obtain blue algae raw material powder; a2, uniformly mixing blue algae raw material powder with deionized water according to a ratio of 1:20g/mL, adding 0.5-1wt% of mixed enzyme, carrying out enzymolysis for 1-2h under the condition that the temperature is 40+/-2℃, pH is 4.0+/-0.5, after the enzymolysis is finished, heating to deactivate enzyme, homogenizing for 2-3 times under high pressure to obtain blue algae slurry, filtering insoluble substances, and freeze-drying to obtain blue algae extract.
3. 3. The composition of claim 2, wherein the mixed enzyme comprises cellulase, pectase, acid protease in a mass ratio of 1:1-3:0.5-1.5.
4. 4. The composition of claim 2, wherein the high pressure homogenization is carried out at a pressure of 60-80MPa and a temperature of 30-40 ℃ for a single homogenization time of 10-20min.
5. 5. Use of a composition according to any one of claims 1 to 4 for the preparation of a skin care product.
6. 6. The use according to claim 5, wherein the skin care product is a leave-on skin care product.

Description

Composition containing blue copper peptide for repairing photo-thermal injury and application thereof Technical Field The invention relates to the technical field of cosmetics, in particular to a composition containing blue copper peptide for repairing photo-thermal injury and application thereof. Background In the cosmetic field, skin photothermal injury (such as ultraviolet radiation, high temperature environment or medical and aesthetic photoelectric treatment) can cause skin cell protein denaturation, cell membrane structure destruction and inflammatory factor release, thereby causing the problems of impaired skin barrier function, aggravated water loss, sensitive weakness and the like. When photothermal damage occurs, skin cells initiate stress expression mechanisms of Heat Shock Proteins (HSPs) to repair damaged proteins, maintaining cellular homeostasis. However, excessive or sustained photo-thermal damage may exceed the regulatory capacity of the cells' own HSPs, leading to insufficient repair efficiency, even causing chronic inflammation or accelerating skin aging. Currently, repair products on the market focus on relief or moisturization in a single dimension, lacking a systematic solution for modulating HSPs expression levels to achieve the efficacy of photothermal damage repair. For example, some products rely on single peptide components to promote cell regeneration, or passive protection from photo-thermal damage by mineral sunscreens, but are not effective in activating endogenous protective mechanisms of the skin. Therefore, there is a need to develop a composition that can actively elevate HSPs expression levels to achieve repair of photo-thermal injury. Disclosure of Invention In order to solve the technical problems, the invention aims to provide a composition containing blue copper peptide for repairing photo-thermal damage and application thereof, so as to overcome the defects of the prior art. In order to achieve the technical effects, the invention adopts the following technical scheme: In a first aspect, the invention provides a composition for repairing photo-thermal injury, comprising a composite polypeptide, galactose yeast fermentation product filtrate, and blue algae extract. Preferably, the compound polypeptide comprises blue copper peptide, saccharomycete polypeptide and hexapeptide-11 in a mass ratio of 1:0.3-0.5:0.5-0.7. Preferably, the mass ratio of the compound polypeptide to the galactose yeast fermentation product filtrate to the blue algae extract is 1:6-8:4-6. Preferably, the blue algae raw material in the blue algae extract comprises at least one of blue algae of the mosque, spirulina platensis, nostoc flagelliforme, oscillatoria, and blue-green algae. Preferably, the blue algae raw materials in the blue algae extract comprise the water front temple blue algae powder, the spirulina platensis powder and the hair weeds powder with the mass ratio of 1:0.5-1.5:3-5. Preferably, the preparation method of the blue algae extract comprises the following steps: A1, uniformly mixing the water temple blue algae powder, the spirulina platensis powder and the hair weeds powder according to the mass ratio of 1:0.5-1.5:3-5 to obtain blue algae raw material powder; a2, uniformly mixing blue algae raw material powder with deionized water according to a ratio of 1:20g/mL, adding 0.5-1wt% of mixed enzyme, carrying out enzymolysis for 1-2h under the condition that the temperature is 40+/-2℃, pH is 4.0+/-0.5, after the enzymolysis is finished, heating to deactivate enzyme, homogenizing for 2-3 times under high pressure to obtain blue algae slurry, filtering insoluble substances, and freeze-drying to obtain blue algae extract. Preferably, the mixed enzyme comprises cellulase, pectase and acid protease with the mass ratio of 1:1-3:0.5-1.5. Preferably, the pressure of the high-pressure homogenization is 60-80MPa, the temperature is 30-40 ℃, and the single homogenization time is 10-20min. In a second aspect, the invention also provides an application of the composition containing blue copper peptide for repairing photo-thermal injury in preparing skin care products. Preferably, the skin care product is a resident skin care product. Compared with the prior art, the invention has the beneficial effects that: The invention constructs a repair system for multidimensional regulation and control of expression of Heat Shock Proteins (HSPs) by synergistic compatibility of composite polypeptide, galactose yeast fermentation product filtrate and blue algae extract, wherein blue copper peptide in the composite polypeptide is used as a signal molecule to target and combine with heat shock factor (HSF-1) to start gene transcription, the stability of the HSF-1 is enhanced by the yeast polypeptide through phosphorylating MAPK/ERK channel key protein, the ubiquitin-proteasome system is inhibited by hexapeptide-11 to prolong the half life of the HSPs, the three form a cascade effect of activating, strengthenin