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CN-121130281-B - Wearable nail root nanocrystalline microneedle transdermal drug delivery device with vibration control

CN121130281BCN 121130281 BCN121130281 BCN 121130281BCN-121130281-B

Abstract

The invention relates to the technical field of medical instruments, in particular to a wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device, which comprises a shell, wherein two side ends of the shell are respectively provided with a group of positioning notches, each group of positioning notches is respectively provided with a number of threaded holes, four corners of the inner side of the shell are respectively provided with a group of supporting seats, the device also comprises a controller component, nanocrystalline microneedle components, a vibration component, a power component and a fixed ring component, the controller component is detachably arranged in the shell, the vibration component and the battery component are respectively arranged in the shell, the bottom end of the shell is detachably provided with a nanocrystalline microneedle component, two ends of the fixed ring component are detachably connected with one group of positioning notches, the nanocrystalline microneedle component is used for forming a microchannel between the epidermis of the root of a light nail and the edge of a deck, and the power component provides electric energy for the vibration component and the controller component, so that medicines can directly contact focuses.

Inventors

  • HE WENJING
  • YANG LIANJUAN

Assignees

  • 上海市皮肤病医院

Dates

Publication Date
20260508
Application Date
20251104

Claims (8)

  1. 1. The wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device comprises a shell (101), wherein a group of locating notches (102) are respectively arranged at two side ends of the shell (101), a first threaded hole (103) is respectively arranged at each group of locating notches (102), a group of supporting seats (104) are respectively arranged at four corners of the inner side of the shell (101), and the device is characterized by further comprising a controller component, nanocrystalline microneedle components, a vibration component, a power supply component and a fixed ring component, wherein the controller component is detachably arranged in the shell (101), the vibration component and a battery component are respectively arranged in the shell (101), the nanocrystalline microneedle components are detachably arranged at the bottom end of the shell (101), the two ends of the fixed ring component are respectively detachably connected with the group of locating notches (102), and the nanocrystalline microneedle components are used for lightly puncturing the skin of the nail root and the edge of a deck to form a micro-channel, and the power supply component provides electric energy for the vibration component and the controller component; The nanocrystalline microneedle assembly comprises a positioning frame (401), a positioning block (402), a second thread groove (403), a mounting seat (404), nanocrystalline microneedle bodies (405), third round holes (406), third bolts (407) and a fixing plate (408), two groups of positioning frames (401) are arranged at the bottom end of the shell (101), arc-shaped concave parts are arranged at the bottom end of the mounting seat (404), a plurality of groups of nanocrystalline microneedle bodies (405) are arranged in the arc-shaped concave parts, the plurality of groups of nanocrystalline microneedle bodies (405) are distributed in an array, arc-shaped concave surfaces are formed at the bottom ends of the plurality of groups of nanocrystalline microneedle bodies (405), two groups of positioning blocks (402) are arranged at the rear end of the mounting seat (404), the positioning blocks (402) are matched with the positioning frame (401), the fixing plate (408) is arranged at the front end of the mounting seat (404), the third round holes (406) are arranged on the fixing plate (408), the second thread groove (403) is arranged at the bottom end of the shell (101), and a group of third bolts (407) are arranged in the third round holes (406) in a penetrating mode; The vibration assembly comprises two groups of miniature direct current vibration motors (501), a fixing seat (502) and locking bolts (503), wherein the miniature direct current vibration motors (501) are arranged on the fixing seat (502), and the fixing seat (502) is fixedly arranged at the bottom end of the shell (101) through the locking bolts (503).
  2. 2. The wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device according to claim 1, wherein the controller assembly comprises a controller main body (201), a first thread groove (202), a first counter bore (203), a first bolt (204) and a touch display screen (205), the touch display screen (205) is arranged at the top end of the controller main body (201), the first thread groove (202) is arranged at the bottom end of the controller main body (201), the first counter bore (203) is arranged at the bottom end of the shell (101), and a group of first bolts (204) are arranged in the first counter bore (203) in a penetrating mode.
  3. 3. The wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device according to claim 1, wherein the fixing ring assembly comprises a fixing ring main body (301), a first round hole (302), a positioning plate (303), a second round hole (304) and a second bolt (305), the first round holes (302) are respectively arranged at two ends of the fixing ring main body (301), the number of the positioning plates (303) is two, a second round hole (304) is respectively arranged on each positioning plate (303), a second bolt (305) is respectively arranged on each circular hole (302), and the fixing ring main body (301) is made of elastic materials.
  4. 4. The wearable and vibration-controlled transdermal drug delivery device with a nail root nanocrystalline microneedle according to claim 1, wherein the power supply assembly comprises a clamping frame (601), a charging interface (602) and a battery body (603), the clamping frame (601) is arranged inside the shell (101), the battery body (603) is arranged inside the clamping frame (601), the charging interface (602) is arranged on the shell (101), a main board is arranged inside the shell (101), a power management circuit is integrated on the main board, the charging interface (602) is electrically connected with the power management circuit on the main board, the power management circuit is electrically connected with the battery body (603), and the charging interface (602) receives electric power and charges the battery body (603).
  5. 5. A wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device according to claim 3, characterized in that the retaining ring body (301) is made of medical silica gel.
  6. 6. The wearable and vibration-controlled percutaneous administration device for a nail root nanocrystalline microneedle, according to claim 1, wherein the length of the nanocrystalline microneedle body (405) is 0.3 mm-0.6 mm, and the nanocrystalline microneedle body (405) is made of medical stainless steel.
  7. 7. The wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device according to claim 2, further comprising a rubber sealing sleeve (206), wherein the rubber sealing sleeve (206) is sleeved outside the controller main body (201).
  8. 8. The wearable and shock-controlled nail root nanocrystalline microneedle transdermal drug delivery device according to claim 1, further comprising a concave groove (409), wherein the end of the fixing plate (408) away from the mounting base (404) is provided with the concave groove (409).

Description

Wearable nail root nanocrystalline microneedle transdermal drug delivery device with vibration control Technical Field The invention relates to the technical field of medical appliances, in particular to a wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device. Background Onychomycosis (onychomycosis) is a clinically common dermatomycosis, and is caused by fungi invading the nail plate, the nail bed or the nail matrix, paronychia and other nail root diseases also face treatment dilemma for a long time. The current clinic mainly relies on oral antifungal medicines and external smearing medicines, and the two medicines have technical defects which are difficult to overcome: although the oral antifungal medicine has certain curative effect, the oral antifungal medicine needs to exert the effect through a whole body system, and is easy to cause liver function injury and medicine interaction after long-term use, has potential safety hazard for children, old people and patients with liver and kidney insufficiency, and has limited application range. The external application medicine has high safety, but is limited by physiological barriers of the nail, the medicine delivery efficiency is extremely low, firstly, the nail plate is composed of compact keratin, the nail root is provided with thick horny layer, the medicine (especially macromolecular medicine) is difficult to permeate into key focuses such as nail matrix, nail bed and the like, the treatment period is often more than several months to more than one year, the curative effect is limited, secondly, the medicine is retained on the surface or surrounding skin, the focus concentration is insufficient, the fungus resistance is easily caused, the local accumulation can cause stimulation, the medicine waste is caused by frequent replenishment, thirdly, the compliance of patients is reduced due to long treatment course and complicated medicine application, the high recurrence rate is caused due to irregular medicine application, the malignant circulation is formed, and fourthly, the focus is in a low medicine concentration environment for a long time, the fungus is easy to induce the drug resistance, and finally the treatment fails. In summary, the existing solutions have significant bottlenecks in drug delivery efficiency, therapeutic safety, and patient compliance, and there is a clinical need for a novel drug delivery device that breaks through the nail barrier and achieves accurate and efficient delivery of drugs. Disclosure of Invention In order to solve the technical problems, the invention provides the percutaneous drug delivery device of the nail root nanocrystalline microneedle with vibration control, which is capable of realizing rapid and efficient permeation of drugs at the nail root by virtue of an arc microneedle array and vibration assistance of an ergonomic design and has the functions of replacing a needle head and adjusting multiple vibration. The invention relates to a wearable and vibration-controlled nail root nanocrystalline microneedle transdermal drug delivery device, which comprises a shell, wherein two side ends of the shell are respectively provided with a group of positioning notches, each group of positioning notches is respectively provided with a screw hole, four corners of the inner side of the shell are respectively provided with a group of supporting seats, the wearable and vibration-controlled nail root nanocrystalline transdermal drug delivery device further comprises a controller assembly, a nanocrystalline microneedle assembly, a vibration assembly, a power assembly and a fixed ring assembly, the controller assembly is detachably arranged in the shell, the vibration assembly and a battery assembly are respectively arranged in the shell, the nanocrystalline microneedle assembly is detachably arranged at the bottom end of the shell, two ends of the fixed ring assembly are respectively detachably connected with a group of positioning notches, the nanocrystalline microneedle assembly is used for forming a microchannel between the epidermis of a light nail root and the edge of a deck, and the power assembly provides electric energy for the vibration assembly and the controller assembly. The controller component comprises a controller main body, a first thread groove and a touch display screen, wherein the touch display screen is arranged at the top end of the controller main body, the first thread groove is arranged at the bottom end of the controller main body, a first counter bore is formed in the bottom end of the shell, a group of first bolts are arranged in the first counter bore in a penetrating mode, when the controller main body is arranged in the inner side of the shell, the four groups of supporting seats are matched with each other to support and position the controller main body, the first thread groove coincides with the first counter bore, the first bolts penetrate t