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CN-121181866-B - Block copolymer for promoting collagen regeneration

CN121181866BCN 121181866 BCN121181866 BCN 121181866BCN-121181866-B

Abstract

The invention provides a segmented copolymer for promoting collagen regeneration, and relates to the technical field of polymers. The invention adopts the amphiphilic block copolymer with low molecular weight, the number average molecular weight of the amphiphilic block copolymer is not more than 5000g/mol, the hydrophobic chain segment can be biodegraded and induce collagen regeneration, and the amphiphilic block copolymer can be directly applied to the surface of skin in a stock solution form and can promote collagen regeneration after penetrating into the skin.

Inventors

  • LU SHAOPING
  • HU FANGFANG
  • Hong Enshu
  • LAN ZHIYUAN
  • LI YUN

Assignees

  • 厦门瑞聚医学科技有限公司

Dates

Publication Date
20260505
Application Date
20251124

Claims (8)

  1. 1. The use of a block copolymer for the preparation of a skin-applied care product, characterized in that the block copolymer has a structure represented by the following formulae (1), (2), (3) and/or (4), A-b-B(1); A-b-B-b-A(2); BA 3 (3); B-b-A-b-B(4); Wherein A is a hydrophobic chain segment, and B is a hydrophilic chain segment; The hydrophobic segment is biodegradable and induces collagen regeneration; The number average molecular weight of the block copolymer is 500-5000g/mol; The number average molecular weight of the hydrophilic segment is not more than 1000g/mol, and the hydrophilic segment is selected from polyethylene glycol segment, polyethylene glycol/polypropylene glycol copolymer segment, linear polyglycerol and/or glycerol polyethylene glycol segment; the hydrophobic chain segment is selected from one or two of a polylactic acid chain segment and a polycaprolactone chain segment; The number average molecular weight is tested by gel permeation chromatography; the block copolymer is applied directly to the surface of skin in the form of stock solution.
  2. 2. The use according to claim 1, wherein the number average molecular weight of the block copolymer is not more than 3000g/mol.
  3. 3. The use according to claim 1, wherein the number average molecular weight of the block copolymer is not more than 1500g/mol and the number average molecular weight of the hydrophilic segment is not more than 600g/mol.
  4. 4. The use according to claim 1, wherein the molecular weight distribution of the block copolymer is not more than 1.2.
  5. 5. The use according to claim 1, characterized in that the number average molecular weight of the hydrophobic segment does not exceed 2000g/mol.
  6. 6. The use according to claim 1, characterized in that the block copolymer consists of a high molecular weight copolymer and a low molecular weight copolymer; the number average molecular weight of the high molecular weight copolymer is 1500-5000g/mol; the low molecular weight copolymer has a number average molecular weight of 200-800g/mol.
  7. 7. The use according to claim 6, wherein the weight ratio of the high molecular weight copolymer to the low molecular weight copolymer is 1:0.1-5.
  8. 8. The method of using the block copolymer according to claim 6, wherein the block copolymer is applied to the skin surface after being prepared into a solution; the solution is an aqueous solution of the block copolymer.

Description

Block copolymer for promoting collagen regeneration Technical Field The invention belongs to the technical field of polymers, and relates to a block copolymer for promoting collagen regeneration. Background ‌ Collagen is a core component ‌ for maintaining skin elasticity and plumpness, and the collagen in a human body can be gradually reduced along with the aging or the influence of ultraviolet rays, bad living habits and other factors, so that the problems of skin looseness, fine lines and the like are caused. At present, the improvement of collagen loss is mainly achieved by two methods of exogenous supplement and endogenous stimulation. Biodegradable polymers (such as PLLA) are recognized by the human body after entering the dermis or subcutaneous tissue of the human body, and induce a slight inflammatory response, activate fibroblasts, and allow the fibroblasts to synthesize new collagen, so that the local skin becomes plump and compact gradually, which is an "endogenous stimulation" method, and can generally maintain an improvement effect for 1-2 years. The existing biodegradable polymers are generally prepared into microspheres and applied by an auxiliary mode of injection into skin and/or human body, and the method needs professional personnel to implement the method, has great inconvenience, has high implementation cost and has certain potential safety hazard. In addition, for biologically active substances that are applied directly to the skin surface and penetrate into the skin, it is generally believed that the molecular weight of such biologically active substances should not exceed 500g/mol, otherwise it would not penetrate into the skin surface, or it would require the synergistic effect of permeation enhancers, or it would require dispersion in water to form nano-sized particles, before penetration into the skin. Therefore, there is a need for improvement in the "endogenous stimulation" method for collagen regeneration, which can achieve the effect of directly applying bioactive substances to the skin surface in the form of a stock solution. Disclosure of Invention In order to solve the above problems, the present invention provides a block copolymer for promoting collagen regeneration. The technical scheme of the invention is as follows: A block copolymer for promoting collagen regeneration has a structure represented by the following formula (1), (2), (3) and/or (4), A-b-B(1); A-b-B-b-A(2); BA3(3); B-b-A-b-B(4); Wherein A is a hydrophobic chain segment, and B is a hydrophilic chain segment; The hydrophobic segment is biodegradable and induces collagen regeneration; the number average molecular weight of the block copolymer is not more than 5000g/mol; The number average molecular weight is tested by gel permeation chromatography; the block copolymer is applied directly to the surface of skin in the form of stock solution. Preferably, the number average molecular weight of the block copolymer is not more than 3000g/mol, and the number average molecular weight of the hydrophilic segment is not more than 1000g/mol. Preferably, the number average molecular weight of the block copolymer is not more than 1500g/mol and the number average molecular weight of the hydrophilic segment is not more than 600g/mol. Preferably, the hydrophilic segment is selected from polyethylene glycol segments, polyethylene glycol derivative segments, linear polyglycerol, poly (2-oxacyclic) and/or glycerol polyethylene glycol segments; The molecular weight distribution of the block copolymer is not more than 1.2. Preferably, the hydrophobic segment is selected from one or a combination of two or more of a polylactic acid segment, a polycaprolactone segment, a polyhydroxybutyrate segment, a polydioxanone segment, a poly (trimethylene carbonate) segment, and a polyhydroxyacetate segment. More preferably, the hydrophobic segment has a number average molecular weight of not more than 2000g/mol. Preferably, the surface applied to the skin is directly applied to the skin surface or covered on the skin surface in a transdermal manner. Preferably, the block copolymer consists of a high molecular weight copolymer and a low molecular weight copolymer; the number average molecular weight of the high molecular weight copolymer is 1500-5000g/mol; the low molecular weight copolymer has a number average molecular weight of 200-800g/mol. More preferably, the weight ratio of the high molecular weight copolymer to the low molecular weight copolymer is 1:0.1-5. More preferably, the block copolymer may be used by applying it to the skin surface after being formulated into a solution or dispersion. The beneficial effects of the invention are as follows: (1) The invention adopts an amphiphilic block copolymer with a certain molecular weight range (Mn is not more than 5000 g/mol), and can be directly coated on the skin in stock solution (100% of amphiphilic block copolymer content) so as to permeate into dermis or subcutaneous tissue. Compared