CN-121422179-B - Traditional Chinese medicine compound for treating non-lactation mastitis and application thereof

Abstract

The invention provides a traditional Chinese medicine compound for non-lactation mastitis and application thereof, relating to the technical field of traditional Chinese medicine pharmacy, the Chinese herbal compound is composed of cornu Cervi Degelatinatum, bulbus Iphigeniae Indicae, rhizoma Zingiberis Preparata, semen Sinapis Albae, herba Speranskiae Tuberculatae, radix Adenophorae, herba Taraxaci, radix Ampelopsis, pericarpium Citri Tangerinae, halloysitum rubrum, and fructus Lipuidambaris. Animal experiments show that the traditional Chinese medicine compound can effectively reduce the mammary gland induration volume of a non-lactating rat, reduce the mammary gland inflammation index of a model rat, effectively inhibit the over-expression of key pro-inflammatory factors TNF-alpha and IL-6 in pathological tissues, and clinical researches show that the traditional Chinese medicine compound can effectively relieve the core clinical symptoms of breast tumor, pain, red swelling and the like of a non-lactating mastitis patient, obviously improve the life quality of the patient, and simultaneously can lower the serum SP and PRL levels. In conclusion, the traditional Chinese medicine compound disclosed by the invention has definite curative effect and definite mechanism for treating non-lactation mastitis, provides a safe and effective traditional Chinese medicine scheme for treating non-lactation mastitis, and has a good application prospect.

Inventors

• Lei Huiqing

Assignees

• 郑州大学第一附属医院

Dates

Publication Date

20260508

Application Date

20251219

Claims (2)

1. 1. A traditional Chinese medicine compound for non-lactation mastitis is characterized by being prepared from the following raw materials, by weight, 15 parts of cornu Cervi Degelatinatum, 9 parts of Indian iphigenia bulb, 8 parts of baked ginger, 10 parts of white mustard seed, 8 parts of garden balsam stem, 12 parts of radix adenophorae, 15 parts of dandelion, 12 parts of Japanese ampelopsis root, 8 parts of tangerine pith, 12 parts of red halloysite and 12 parts of fructus liquidambaris.
2. 2. The use of a herbal compound as claimed in claim 1 for the manufacture of a medicament for the treatment of non-lactating mastitis.

Description

Traditional Chinese medicine compound for treating non-lactation mastitis and application thereof Technical Field The invention relates to the technical field of traditional Chinese medicine pharmacy, in particular to a traditional Chinese medicine compound for treating non-lactation mastitis and application thereof. Background Non-lactation mastitis (non-puerperal mastitis, NPM) is a group of non-specific inflammatory diseases of unknown etiology that occur in women during non-lactation, including ductal hyperplasia of mammary glands (duct ectasia of the breast, MDE) and granulomatous lobular mastitis (granulomatous lobular mastitis, GLM). NPM is mainly clinically manifested by breast lumps, nipple invaginations, nipple discharge and breast pain, wherein the breast lumps can be secondarily infected with acute infection to form abscesses on the basis of chronic diseases, and the terminal-stage abscesses can form breast fistulae, sinus passages or ulcers, and the breast lumps are not healed for a long time, so that the life quality of patients is seriously affected. At present, the etiology and pathogenesis of non-lactation mastitis are not completely defined, and the existing research considers that the pathogenesis of the non-lactation mastitis is related to various factors such as autoimmune dysfunction (such as abnormal rise of prolactin), breast duct obstruction, infection, genetics, environment and the like. The current treatment scheme commonly used in clinic mainly comprises western medicine treatment and traditional Chinese medicine treatment, but has obvious limitations, and is difficult to meet the clinical diagnosis and treatment requirements. In Western medicine treatment, antibiotic, hormone, operation and other modes are mainly adopted. The antibiotic treatment only has a certain effect on the cases of combined definite bacterial infection, but most of non-lactation mastitis is aseptic inflammation or related to autoimmunity, so that the overall effective rate of the antibiotic treatment is low, adverse reactions such as drug resistance and intestinal flora imbalance are easy to cause after long-term use, the hormone treatment can relieve inflammation symptoms in a short period, but serious side effects such as osteoporosis, blood sugar rise and immunosuppression can be caused after long-term use, the recurrence rate after drug withdrawal is extremely high, although the lesion can be directly excised through operation treatment (such as lumpectomy and mastectomy), the wound is large, the mammary tissue and nipple areola complex are easily damaged, the breast appearance is influenced, and the risk of recurrence after operation is high for patients with wide lesion range or hidden lesions, and psychological burden brought by operation is also not ignored. The traditional Chinese medicine belongs to the categories of 'acnes acute mastitis', 'acute mastitis', and the like, considers that the core pathogenesis of the mastitis is related to phlegm stasis coagulation, cold coagulation, qi stagnation, liver depression, qi stagnation, deficiency of vital energy, residual toxin, residual and the like, and treats the mastitis by taking the core principles of warming and expelling cold, resolving phlegm and resolving masses, soothing liver and regulating qi, tonifying qi and nourishing yin, clearing heat and detoxicating, and the like. However, the traditional Chinese medicine treatment scheme disclosed in the prior art still has the defects that firstly, the formula is not accurate enough, partial formulas have the problems of excessive dryness and easy yin injury, excessive coldness and easy yang injury, adverse reactions such as gastrointestinal discomfort and the like are easy to cause after long-term use, secondly, the traditional Chinese medicine scheme has limited curative effect, and the traditional Chinese medicine scheme can only relieve partial symptoms, has unsatisfactory effects on mass dissipation, inflammation control and relapse rate reduction, and has low overall clinical effective rate. Based on the defects of the prior art, a traditional Chinese medicine compound with scientific and reasonable formula, relatively clear action mechanism, definite and stable curative effect and capability of effectively controlling symptoms is urgently needed in the field. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a traditional Chinese medicine compound for treating non-lactation mastitis and application thereof. (II) technical scheme In order to achieve the above purpose, the invention is realized by the following technical scheme: the invention provides a traditional Chinese medicine compound for non-lactation mastitis, which is prepared from the following raw materials, by weight, 5-25 parts of cornu Cervi Degelatinatum, 3-20 parts of edible tulip, 3-18 parts of baked ginger, 3-20 parts of semen brassicae, 3-18 parts of g