CN-121590966-B - Sterile conveying device for freeze-drying tray and tray feeding and discharging system

CN121590966BCN 121590966 BCN121590966 BCN 121590966BCN-121590966-B

Abstract

The invention discloses a freeze-drying tray sterile conveying device and a tray feeding and discharging system, which relate to the field of pharmacy, wherein the freeze-drying tray sterile conveying device comprises: a shell, wherein a closed accommodating space is formed in the shell; the freeze-drying device comprises a shell, a power supply component, a driving mechanism and a lifting mechanism, wherein the shell is internally provided with a freeze-drying tray, the power supply component is arranged in the shell to supply electric energy, the driving mechanism is arranged in the shell and is electrically connected with the power supply component to drive a conveying device to move along a preset path, and the lifting mechanism is arranged in the shell and is electrically connected with the power supply component, and an execution end of the lifting mechanism extends out of the shell to fork and place the freeze-drying tray. According to the invention, the fully-closed shell is arranged, and the drive mechanism and the lifting mechanism are combined to finish the fork taking and conveying of the freeze-drying tray, so that the sterile conveying of the freeze-drying tray is realized, the equipment structure is simplified, the cleaning maintenance difficulty and the operation energy consumption are reduced, and the sterility of the production of bulk drugs is ensured.

Inventors

ZHANG RANLONG
LI NING
ZHANG JIAN
ZOU HONGWU
LI QIXIONG
GUO CHENGHU
HOU GUOXU
ZHANG MING
DONG CHANGXIN
XUE LIANG

Assignees

山东新华医疗器械股份有限公司

Dates

Publication Date: 20260508
Application Date: 20260130

Claims (7)

1. A sterile delivery device for a lyophilization tray, comprising: The shell is internally provided with a closed accommodating space; The power supply assembly is arranged in the shell to supply electric energy; The driving mechanism is arranged in the shell and is electrically connected with the power supply assembly so as to drive the conveying device to move along a preset path; the lifting mechanism is arranged in the shell and is electrically connected with the power supply assembly, and the execution end of the lifting mechanism extends out of the shell to fork and place the freeze-drying disc; The driving mechanism comprises a first driving piece, a driving shaft, a shaft seal, a first driving piece, a second driving piece and a second driving piece, wherein the first driving piece is arranged in the shell and is electrically connected with the power supply assembly so as to convert electric energy of the power supply assembly into power; The lifting mechanism comprises a second driving piece, a freeze-drying tray fork, a transmission assembly, a lifting shaft seat, a lifting fork and a lifting vertical plate, wherein the second driving piece is arranged in the shell and is electrically connected with the power supply assembly to convert electric energy of the power supply assembly into power, the freeze-drying tray fork is used as an executing end of the lifting mechanism and is arranged on the outer side of the shell to fork and place a freeze-drying tray, the transmission assembly is connected with the second driving piece and the freeze-drying tray fork to transmit the power of the second driving piece to the freeze-drying tray fork and drive the freeze-drying tray fork to reciprocate along a preset stroke, the transmission assembly comprises an eccentric wheel, the lifting fork and the lifting vertical plate, the eccentric wheel is rotatably arranged in the shell and is fixedly connected with the output end of the second driving piece in a coaxial mode, the lifting fork is sleeved on the eccentric wheel and is matched with the eccentric wheel to convert rotary motion of the eccentric wheel into linear motion, the lifting vertical plate is connected with the connecting assembly, the connecting assembly comprises the lifting shaft seat, the lifting shaft seat is fixedly arranged on the lifting vertical plate, the lifting shaft seat is connected with the lifting shaft seat, the lifting plate is connected with the lifting shaft seat in a sliding mode, and is connected with the two ends of the lifting shaft seat in a sliding mode, and is connected with the sealing sleeve.
2. The sterile delivery device of a lyophilization tray according to claim 1, wherein the drive mechanism further comprises: the driving belt pulley is arranged on the outer side of the shell and coaxially sleeved on the driving shaft so as to synchronously rotate along with the driving shaft; the driven belt pulley is rotatably arranged on the outer side of the shell, and is arranged opposite to the driving belt pulley so as to form a transmission loop in cooperation with the driving belt pulley; And the synchronous belt is wound on the driving belt pulley and the driven belt pulley to transmit the power of the driving belt pulley to the driven belt pulley.
3. The sterile delivery device for a lyophilization tray according to claim 2, wherein the transmission assembly further comprises a transmission shaft rotatably disposed within the housing and fixedly coupled coaxially with the output end of the second drive member; The eccentric wheel is sleeved on the transmission shaft and is coaxially and fixedly connected with the transmission shaft.
4. A freeze-dried tray sterile conveying device according to claim 3, wherein the eccentric wheels and the lifting fork are all in a plurality, and the eccentric wheels and the lifting fork are arranged in a one-to-one correspondence.
5. The sterile delivery device for a freeze-dried tray according to claim 1, wherein a first sliding fitting is provided on an inner wall of the housing, a second sliding fitting is provided on the lifting riser, and the first sliding fitting is slidably fitted with the second sliding fitting, thereby achieving sliding connection of the lifting riser and the housing.
6. The sterile delivery device for a lyophilization tray according to claim 1, wherein the power supply assembly comprises: The battery is arranged in the shell to store electric energy and output the electric energy to the driving mechanism and the lifting mechanism; the power switch is arranged on the shell and is electrically connected with the battery to control the on-off of a circuit between the battery and the driving mechanism and between the battery and the lifting mechanism; The wireless charging receiver is arranged in the shell and is electrically connected with the battery so as to receive the electric energy of an external wireless charging transmitter and charge the battery; The wired charging port is arranged on the shell and is electrically connected with the battery so as to charge the battery through an external wired charger; And the charging sealing piece is arranged at the matching part of the wired charging port and the shell so as to seal a gap between the wired charging port and the shell.
7. An access disk system, comprising: the sterile delivery device for a freeze-dried tray according to any one of claims 1 to 6 to achieve sterile delivery and retrieval of the freeze-dried tray; the conveying track assembly is arranged on a preset path and matched with the driving mechanism so as to provide moving guide for the conveying device; The freeze-drying plate conveying mechanism is arranged at the starting end of the conveying track assembly, so that freeze-drying plates to be forked are conveyed to the conveying device.

Description

Sterile conveying device for freeze-drying tray and tray feeding and discharging system Technical Field The invention relates to the field of pharmacy, in particular to a freeze-drying tray sterile conveying device and a tray inlet and outlet system. Background In the pharmaceutical industry, the long-term preservation of the bulk drug is of great importance, and the freeze-drying technology is widely applied to the field of bulk drug processing because the original activity of the drug can be maintained and the breeding of microorganisms is avoided. In the vacuum freeze-drying production flow of the bulk drug, the prepared bulk drug liquid is required to be filled into a freeze-drying disc, then the freeze-drying disc is conveyed to a plate layer in the box body of the freeze-drying machine for freeze-drying treatment, and the freeze-drying disc is required to be taken out from the box body of the freeze-drying machine after freeze-drying is finished so as to finish material receiving operation, so that a disc inlet and outlet link of the freeze-drying disc is a key step in the freeze-drying production process of the bulk drug, and the quality and the production efficiency of the drug are directly influenced by the operation standardization. Along with the continuous improvement of the requirements for aseptic production in the pharmaceutical industry, the aseptic control of the freeze-drying tray inlet and outlet links becomes the focus of industry attention, and the optimization and upgrading of related equipment have important significance for guaranteeing the sterility of drug production, reducing the production cost and improving the production convenience, and the demands for the freeze-drying tray inlet and outlet equipment with reasonable structure, reliable aseptic performance and convenient operation and maintenance in the industry are increasingly urgent. In current drug substance freeze-drying production practices, there are a variety of lyophilization tray access methods. One is a manual operation mode, an operator uses hooks to manually push freeze-drying trays to a plate layer in a freeze dryer one by one through gloves, after freeze-drying of materials is completed, the freeze-drying trays are pulled out through the hooks, the other is an automatic tray pushing mechanism mode, a tray pushing mechanism with freely telescopic push rods is respectively arranged in front of and behind a freeze-drying box, when the tray is fed, the freeze-drying trays are pushed to a box plate layer through push rods in the front of the program-controlled freeze-drying box, and when the tray is discharged, the freeze-drying trays are pushed out of the box body from the plate layer through push rods in the rear of the program-controlled freeze-drying box. The existing freeze-drying plate feeding and discharging mode has the problem of influencing the aseptic production of medicines, metal particles can be generated by direct friction between the bottom of the freeze-drying plate and the plate layer during manual operation, the metal particles possibly enter the medicines to influence the aseptic property of the medicines, and the automatic plate pushing mechanism is provided with more sealing structures and transmission mechanisms, so that the cleaning difficulty is high, the aseptic production risk is increased, the overall cost of the system is high, and the operation and maintenance difficulty is high. Disclosure of Invention In order to solve the problems that sterility of the existing freeze-drying tray feeding and discharging mode is difficult to guarantee, the structure is complex, cleaning and maintenance are inconvenient, the operation cost is high and the like, the full-closed shell is arranged, and the drive mechanism and the lifting mechanism are combined to finish freeze-drying tray forking and conveying, so that sterile conveying of freeze-drying trays is realized, the equipment structure is simplified, the cleaning and maintenance difficulty and the operation energy consumption are reduced, and the sterility of bulk drug production is guaranteed. Based on this, in a first aspect of the present invention, a freeze-dried disc sterile delivery device is presented, comprising: A shell, wherein a closed accommodating space is formed in the shell; the power supply assembly is arranged in the shell to supply electric energy; the driving mechanism is arranged in the shell and is electrically connected with the power supply assembly so as to drive the conveying device to move along a preset path; the lifting mechanism is arranged in the shell and is electrically connected with the power supply assembly, and the execution end of the lifting mechanism extends out of the shell so as to fork and place the freeze-drying disc. Optionally, the shell comprises a frame, an upper panel and a lower bottom plate, the frame is formed into an annular structure with openings at the upper side and the lower side, the upper