CN-121623118-B - Drug release capsule device based on external rotating magnetic field

CN121623118BCN 121623118 BCN121623118 BCN 121623118BCN-121623118-B

Abstract

The application relates to the field of medical equipment, and particularly discloses a drug release capsule device based on an external rotating magnetic field, which comprises a capsule shell, wherein liquid medicine is stored in the capsule shell, a drug release hole is formed in the side wall of the capsule shell, and a spiral strip is arranged on the outer side wall of the capsule shell; the capsule shell is internally and rotatably provided with a first magnet which is driven to rotate by an external rotating magnetic field, the first magnet is coaxially and fixedly connected with a cylindrical cam which is used for converting the rotating moment of the first magnet into axial thrust to push the medicine pushing rod, a spring which is used for applying elastic force opposite to the axial thrust direction to the medicine pushing rod is arranged in the capsule shell, and a second magnet which is used for keeping the capsule shell fixed under the action of the external static magnetic field is fixedly arranged in the capsule shell. The application adopts non-contact magnetic drive, and can realize fixed-point drug release and repeated quantitative drug release.

Inventors

LIU YIXUAN
FU CHENGJIN
YE BO

Assignees

湖北大学

Dates

Publication Date: 20260508
Application Date: 20260203

Claims (10)

1. The drug release capsule device based on the external rotating magnetic field is characterized by comprising: The capsule comprises a capsule shell, wherein liquid medicine is stored in the capsule shell, and a medicine release hole is formed in the side wall of the capsule shell; The walking structure is used for driving the capsule shell to walk along with the rotation of the capsule shell; the medicine pushing rod is arranged in the capsule shell in a sliding way along the axial direction of the capsule shell; the shielding piece is fixedly connected to the peripheral side of the medicine pushing rod, slides along the inner side wall of the capsule shell and is used for shielding or opening the medicine releasing hole; The first magnet is rotationally arranged in the capsule shell and driven by an external rotating magnetic field to rotate around the axis of the capsule shell; The torque conversion piece is coaxially and fixedly connected with the first magnet and is used for converting the rotation torque of the first magnet into axial thrust so as to drive the medicine pushing rod to axially translate along the medicine pushing rod; The elastic piece is used for applying elastic force to the medicine pushing rod, and the elastic force is opposite to the axial pushing force direction; The second magnet is fixedly arranged in the capsule shell, and the second magnet keeps the capsule shell fixed under the action of an external static magnetic field; The medicine releasing capsule device is provided with a walking mode and a medicine releasing mode, and the two modes are switched by adjusting the strength of an external rotating magnetic field, wherein in the walking mode, the strength of the external rotating magnetic field is not greater than a critical value, the rotating moment of a first magnet is insufficient to overcome the elasticity of an elastic piece, a medicine pushing rod is kept static, a shielding piece shields a medicine releasing hole, the first magnet and a capsule shell synchronously rotate around the axis of the first magnet and the capsule shell under the action of the external rotating magnetic field, so that the capsule shell walks, in the medicine releasing mode, the strength of the external rotating magnetic field is greater than the critical value, the rotating moment of the first magnet overcomes the elasticity of the elastic piece, the medicine pushing rod is driven to translate, and the shielding piece opens the medicine releasing hole.
2. The device for releasing medicine according to claim 1, wherein the walking structure comprises a spiral strip fixedly connected to the outer side wall of the capsule shell.
3. The drug delivery capsule device based on the external rotating magnetic field of claim 1, wherein the torque conversion part is a cylindrical cam, the cylindrical cam is provided with an inclined surface, one end of the drug pushing rod is eccentrically connected with an abutting joint, and the abutting joint abuts against the inclined surface.
4. The drug delivery capsule device based on the external rotating magnetic field of claim 3, wherein the surface of the abutting joint, which is in contact with the inclined surface, is a spherical surface.
5. The drug release capsule device based on the external rotating magnetic field of claim 1, wherein the elastic piece is a spring, and a sleeve for accommodating the spring is coaxially and fixedly connected in the capsule shell.
6. The device for releasing medicine according to claim 5, wherein a ball head is fixedly connected to one end of the medicine pushing rod, which is far away from the moment conversion piece, and the ball head is slidably arranged in the sleeve, and the ball head is abutted against one end of the spring.
7. The drug delivery capsule device based on the external rotating magnetic field of claim 1, wherein a guiding structure is arranged in the capsule shell and is used for guiding the sliding of the drug pushing rod along the axial direction of the capsule shell.
8. The drug delivery capsule device based on the external rotating magnetic field of claim 1, wherein a pushing plate is fixedly connected to the periphery of the drug pushing rod, and a gap is arranged between the pushing plate and the shielding piece.
9. The drug delivery capsule device based on the external rotating magnetic field of claim 1, wherein the first magnet and the second magnet are respectively positioned at two ends of the capsule shell, the magnetization direction of the first magnet is radial, and the magnetization direction of the second magnet is axial.
10. The device for releasing medicine according to any one of claims 1 to 9, wherein a plurality of medicine releasing holes are formed, the medicine releasing holes are spirally arranged on the capsule shell, and the shielding pieces are also formed and correspond to the medicine releasing holes one by one.

Description

Drug release capsule device based on external rotating magnetic field Technical Field The application relates to the field of medical equipment, in particular to a drug release capsule device based on an external rotating magnetic field. Background Capsule medical devices are widely used in the field of digestive tract examination and targeted drug delivery, for example, by swallowing into the capsule endoscopic system of a body cavity, non-invasive diagnosis and treatment can be achieved. In the prior art, a capsule device is driven to move and release medicine in a multi-dependent internal battery or wireless energy supply mode, for example, a wireless energy supply-based external magnetic control medicine release capsule system is disclosed in a patent with publication number CN102090876A, medicine release is realized by combining an external magnetic field with wireless energy transmission, a leaf spring-driven magnetic control medicine application capsule robot is disclosed in a patent with publication number CN113576374B, medicine application is controlled by combining a leaf spring mechanism with an external magnetic field, and a magnetic control miniature soft medicine carrying capsule robot is disclosed in a patent with publication number CN115569298A, and medicine release is realized by utilizing a soft extrusion magnetic block. The magnetic control capsule system is driven by an external magnetic field, but the drug release control depends on auxiliary mechanisms such as wireless energy supply or plate springs, and the like, has a complex structure, is single in drug release mechanism, is often released once, is difficult to realize repeated circulation quantitative control, has low drug release precision, is difficult to realize fixed-point targeted drug delivery in complex body cavity environments, and influences the utilization rate and curative effect of drugs. Disclosure of Invention In order to realize non-contact magnetic driving and repeated quantitative drug release of the drug release capsule, the application provides a drug release capsule device based on an external rotating magnetic field. The application provides a drug release capsule device based on an external rotating magnetic field, which adopts the following technical scheme: A drug delivery capsule device based on an external rotating magnetic field, comprising: The capsule comprises a capsule shell, wherein liquid medicine is stored in the capsule shell, and a medicine release hole is formed in the side wall of the capsule shell; The walking structure is used for driving the capsule shell to walk along with the rotation of the capsule shell; the medicine pushing rod is arranged in the capsule shell in a sliding way along the axial direction of the capsule shell; the shielding piece is fixedly connected to the peripheral side of the medicine pushing rod, slides along the inner side wall of the capsule shell and is used for shielding or opening the medicine releasing hole; The first magnet is rotationally arranged in the capsule shell and driven by an external rotating magnetic field to rotate around the axis of the capsule shell; The torque conversion piece is coaxially and fixedly connected with the first magnet and is used for converting the rotation torque of the first magnet into axial thrust so as to drive the medicine pushing rod to axially translate along the medicine pushing rod; The elastic piece is used for applying elastic force to the medicine pushing rod, and the elastic force is opposite to the axial pushing force direction; the second magnet is fixedly arranged in the capsule shell, and the second magnet enables the capsule shell to be kept fixed under the action of an external static magnetic field. Further, the walking structure comprises a spiral strip fixedly connected to the outer side wall of the capsule shell. Further, the moment conversion piece is a cylindrical cam, the cylindrical cam is provided with an inclined plane, one end of the medicine pushing rod is eccentrically connected with a butt joint, and the butt joint is in butt joint with the inclined plane. Further, a surface of the abutting joint, which contacts the inclined surface, is a spherical surface. Further, the elastic piece is a spring, and a sleeve for accommodating the spring is coaxially and fixedly connected in the capsule shell. Further, a ball head is fixedly connected to one end of the medicine pushing rod, which is far away from the moment conversion piece, the ball head is arranged in the sleeve in a sliding manner, and the ball head is abutted to one end of the spring. Further, a guiding structure is arranged in the capsule shell and used for guiding the sliding of the medicine pushing rod along the axial direction of the capsule shell. Further, a pushing plate is fixedly connected to the peripheral side of the medicine pushing rod, and a gap is formed between the pushing plate and the shielding piece. Further, the first magnet