CN-121641504-B - Oral cavity medicine accurate delivery and curative effect evaluation system based on micro-flow control

CN121641504BCN 121641504 BCN121641504 BCN 121641504BCN-121641504-B

Abstract

The invention relates to the technical field of microfluidic drug delivery, and discloses an oral drug accurate delivery and curative effect evaluation system based on microfluidics. The system comprises four modules, namely, signal acquisition and processing, instance identification and feature extraction, path generation and curative effect evaluation. The signal acquisition and processing module continuously acquires multidimensional signals delivered by oral medicaments through the microfluidic sensing array, and integrates the multidimensional signals into a unified data stream after real-time correction and structural normalization. The instance identification module identifies the delivery instance therefrom, extracts the temporal identification, the spatial location descriptor, and the medication class identifier. The route generation module is combined with the time mark division interval to aim the space information at the standard oral cavity model and generate a drug delivery route time sequence record. The curative effect evaluation module calculates the medicine distribution density of the target area according to the medicine classification aggregation example to generate a curative effect evaluation data set, so as to realize the accuracy of medicine delivery monitoring and curative effect evaluation.

Inventors

GAO JIANYONG
WANG MEITANG
TIAN GANG
ZHU QIANG
CHEN JING
XIAO YI
Gao Rongzhu
JIANG XIAOYU
CHEN TONG
REN HAOTIAN

Assignees

中国人民解放军海军军医大学

Dates

Publication Date: 20260512
Application Date: 20260203

Claims (7)

1. An oral drug delivery and efficacy assessment system based on microfluidics, the system comprising: the signal acquisition and processing module is used for continuously acquiring multidimensional signals in the oral cavity drug delivery process through the microfluidic sensing array, correcting the signals in real time and normalizing the structure, eliminating signal distortion and integrating unified data flow; An instance identification and feature extraction module for identifying drug delivery instances from a unified data stream, extracting instance temporal identifiers, spatial location descriptors, and drug class identifiers, comprising: scanning event characteristic modes in the unified data stream, detecting an instant point when drug delivery occurs, and recording a time mark; Retrieving position information from a data segment associated with the event feature pattern, and analyzing three-dimensional coordinates through a space decoding algorithm to generate a space position descriptor; the route generation module is used for dividing time intervals by using an instance time identification sequence, aligning the space position descriptor to a standard oral cavity model and generating a drug delivery route time sequence record; The curative effect evaluation module is used for aggregating delivery examples according to categories according to the time sequence record of the drug delivery path and the drug classification identifier, measuring and calculating the drug distribution density in the target oral cavity area, and generating a curative effect evaluation data set; the scanning of event feature patterns in a unified data stream, detecting the instant point of drug delivery, recording a time identifier, comprising: Identifying mutation points in the signals by adopting a pattern matching algorithm, verifying the consistency of the mutation points and drug delivery logic, marking time stamps, and further sequencing and de-duplicating the time stamps; The retrieving the position information from the data segment associated with the event feature pattern, resolving the three-dimensional coordinates by a spatial decoding algorithm, generating a spatial position descriptor, including: extracting an original reading of the position sensor, and converting the reading into a three-dimensional space point by applying a coordinate resolving algorithm; And carrying out cluster analysis on the three-dimensional space points, removing abnormal points, and generating a steady space position descriptor.
2. The microfluidic-based oral drug delivery and efficacy assessment system according to claim 1, wherein the continuous collection of multi-dimensional signals of the oral drug delivery process by the microfluidic sensor array, the real-time correction and structural normalization of the signals, the elimination of signal distortions, and the integration of unified data streams, comprises: The microfluidic sensing array generates a multi-source signal flow, the multi-source signal flow is converted into a digital format through signal conversion, and the signal level is adjusted by applying an amplitude normalization algorithm to make the signal dimension consistent; Carrying out structural integration on signal streams with consistent dimensions, identifying format differences of different signal sources, converting the format differences into a standard data template, removing noise components by adopting a filtering algorithm, and generating a purified signal set; and based on the time reference point, performing time synchronization processing on the purified signal set, compensating time delay, fusing multi-source data and outputting a unified data stream.
3. The microfluidic-based oral drug delivery and efficacy assessment system according to claim 2, wherein the application of the amplitude normalization algorithm to adjust the signal level to conform the signal dimension comprises: detecting peak values and valley values of the multi-source signal flow, calculating a dynamic range, and mapping signals to a common amplitude interval by using a scaling function to realize signal standardization; baseline correction is applied to the normalized signal, the dc offset is removed, and signal null alignment is ensured.
4. The microfluidic-based oral drug delivery and efficacy assessment system according to claim 3, wherein the structural integration of the dimension-consistent signal streams, the identification of format differences of different signal sources, the conversion to standard data templates, and the removal of noise components using a filtering algorithm, the generation of the purified signal set, comprises: analyzing the data head information of the signal flow with consistent dimension, extracting a format descriptor, matching field definition of a standard data template, and executing format conversion operation; a low-pass filter is applied to suppress high-frequency noise, an adaptive filter is used to eliminate environmental interference, and a clean signal set is output.
5. The microfluidic based oral drug delivery and efficacy assessment system according to claim 4, wherein the generating a drug delivery path timing record using an instance time stamp sequence to divide the time intervals and align the spatial location descriptor to a standard oral model comprises: dividing data according to long-time blocks according to the distribution of the instance time identifiers to form continuous time intervals; For each time interval, transforming the spatial position descriptor from a local coordinate system to a global coordinate system of a standard oral cavity model, and realizing point-to-point mapping by using a registration algorithm; The transformed position data is organized chronologically, and drug delivery attributes are attached to construct a drug delivery path timing record.
6. The microfluidic-based oral drug delivery and efficacy assessment system according to claim 5, wherein said transforming the spatial location descriptor from the local coordinate system to the global coordinate system of the standard oral model, using a registration algorithm, achieves a point-to-point mapping comprising: loading coordinate system definition of a standard oral cavity model, and calculating transformation parameters between a local coordinate system and a global coordinate system; and (3) re-projecting each spatial position descriptor to a global coordinate system by applying transformation parameters, verifying projection accuracy and adjusting errors.
7. The microfluidic-based oral drug delivery and efficacy assessment system according to claim 6, wherein the aggregating delivery instances by category based on the drug delivery path timing record and the drug class identifier, measuring and calculating the drug distribution density in the target oral area, generating the efficacy evaluation data set, comprises: grouping the drug delivery path timing records into a plurality of category subsets according to the drug class identifiers; For each subset of categories, counting the frequency of delivery and the amount of drug in the targeted oral area, calculating a density value in combination with the area of the area; The change in the density value over time is aggregated to generate a efficacy assessment dataset.

Description

Oral cavity medicine accurate delivery and curative effect evaluation system based on micro-flow control Technical Field The invention relates to the technical field of microfluidic drug delivery, in particular to an oral drug accurate delivery and curative effect evaluation system based on microfluidic. Background In the treatment of oral diseases, the accuracy of drug delivery and objectivity of efficacy assessment are always core challenges in clinical practice. The oral cavity is used as a complex physiological environment, and multiple dynamic interference factors such as saliva flow, mucous membrane tissue heterogeneity, chewing movement and the like exist, and the factors directly lead to the difficulty in realizing accurate enrichment of the medicine in a target focus area in the traditional oral medicine delivery mode. The existing oral pharmaceutical dosage forms such as gargle, patch, gel and the like commonly used in clinic have the problems of uncontrollable drug release and dispersed action range, and part of drugs quickly run off under the flushing of saliva, so that the utilization rate of the drugs is reduced, and adverse reactions such as local stimulation and the like can be possibly caused by the residues of the drugs in non-target areas. There are also significant limitations to the prior art in terms of monitoring and efficacy assessment of drug delivery processes. The traditional method relies on visual observation of doctors, subjective feeling feedback of patients or indirect modes such as in-vitro sample detection to obtain curative effect information, dynamic changes in the drug delivery process are difficult to capture in the modes, evaluation results are easily influenced by subjective factors, and quantitative data support is lacked. Even if a sensing technology is introduced in part of researches for collecting oral cavity signals, most of the researches are single-dimension sensing, and key information such as time, space, medicine characteristics and the like of medicine delivery cannot be comprehensively reflected. Meanwhile, the acquired signals are often distorted due to factors such as electromagnetic interference and temperature fluctuation in the oral environment, and an effective correction and normalization means are lacked in the signal processing process, so that signals from different sources are difficult to integrate to form a unified data stream, and further the system analysis of the drug delivery process is restricted. The microfluidic technology has wide application prospect in the biomedical detection field by virtue of the advantages of miniaturization, integration and low consumption, and partial research attempts are made to construct a drug delivery system, but the conventional microfluidic related technology still has a plurality of defects in oral drug application. Most microfluidic systems only focus on the realization of drug delivery functions, and delivery process monitoring and efficacy evaluation are not designed integrally, so that a direct correspondence relationship between drug delivery effect and efficacy cannot be established. In addition, the suitability design of the special oral environment is missing, so that the stability of the microfluidic sensing unit in the oral cavity is poor, and the sustainability and reliability of signal acquisition are difficult to guarantee. On the data processing level, the lack of a special instance identification and feature extraction algorithm for oral drug delivery scenes cannot accurately extract key parameters of drug delivery from complex signals, and thus cannot provide effective data input for efficacy evaluation. These problems together lead to the mutual disjoint of drug delivery and efficacy assessment in oral drug therapy, which makes it difficult to meet the clinical demands for accurate therapy, and an integrated system capable of achieving accurate drug delivery monitoring and objective efficacy assessment is needed. Disclosure of Invention The invention aims to provide an oral cavity drug accurate delivery and curative effect assessment system based on micro-flow control so as to solve the problems in the background technology. To achieve the above object, the present invention provides a microfluidic-based oral drug accurate delivery and efficacy assessment system, the system comprising: the signal acquisition and processing module is used for continuously acquiring multidimensional signals in the oral cavity drug delivery process through the microfluidic sensing array, correcting the signals in real time and normalizing the structure, eliminating signal distortion and integrating unified data flow; An instance identification and feature extraction module for identifying drug delivery instances from the unified data stream, extracting instance temporal identifiers, spatial location descriptors, and drug class identifiers; The route generation module is used for dividing time intervals by