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CN-121648249-B - Composite composition for regulating diabetes glycolipid metabolism and application thereof

CN121648249BCN 121648249 BCN121648249 BCN 121648249BCN-121648249-B

Abstract

The invention provides a composite composition for regulating diabetes glycolipid metabolism and application thereof, belonging to the technical field of medicines, foods or health care products. The composition is prepared from rhizoma polygonati enzymolysis extracts, chinese herbal compound extracts including astragalus membranaceus, ginseng, mulberry leaves, cinnamon, white kidney beans and balsam pears, probiotics including lactobacillus rhamnosus and bifidobacterium bifidum B11, hydrolyzed collagen peptide and tagatose, and is scientifically combined according to the principle of 'monarch, minister, assistant and guide' of traditional Chinese medicine. The composition can realize comprehensive regulation of multidimensional pathological characteristics such as diabetic glycolipid metabolic disorder, chronic inflammation, weight reduction and the like, plays a synergistic effect, has the effects of reducing blood sugar, regulating lipid, resisting inflammation and promoting weight recovery which are obviously superior to the superposition of the independent effects of the components, can obviously improve the levels of serum free fatty acid, fasting insulin and inflammatory factors, and provides a new scheme for developing safe and effective auxiliary treatment products for diabetes.

Inventors

  • Peng teng
  • PEI JUAN
  • Tao Sijin
  • Cui Shengxin
  • LONG FEI

Assignees

  • 成都中医药大学

Dates

Publication Date
20260505
Application Date
20260206

Claims (7)

  1. 1. The composite composition is characterized by being prepared from the following raw materials, by weight, 1-3 parts of a rhizoma polygonati enzymolysis extract, 1-3 parts of a traditional Chinese medicine compound extract, JYLR-005-3 parts of lactobacillus rhamnosus, 0.1-0.5 part of bifidobacterium bifidum B11.1-1 part of hydrolyzed collagen peptide and 1-3 parts of tagatose, wherein the traditional Chinese medicine compound extract is prepared by compounding (2-4) of white kidney beans, mulberry leaves, balsam pears, cinnamon, astragalus mongholicus and ginseng in a weight ratio of (0.5-2) of (weight ratio).
  2. 2. The composite composition of claim 1, which is characterized by being prepared from the following raw materials, by weight, 2 parts of rhizoma polygonati enzymolysis extract, 2 parts of traditional Chinese medicine compound extract, JYLR-005 parts of lactobacillus rhamnosus, 0.2 part of bifidobacterium bifidum B11, 0.5 part of hydrolyzed collagen peptide and 2 parts of tagatose, wherein the weight ratio of white kidney beans, mulberry leaves, balsam pears, cinnamon, astragalus mongholicus to ginseng in the traditional Chinese medicine compound extract is 3:1:1:1:1:1.
  3. 3. The composite composition according to claim 1, wherein the preparation of the rhizoma polygonati enzymatic hydrolysate comprises the steps of pretreating rhizoma polygonati medicinal materials, performing enzymolysis by adopting composite enzyme, and performing enzyme deactivation, filtration, concentration and drying on an enzymolysis solution, wherein the composite enzyme comprises cellulase and protease.
  4. 4. The composite composition according to claim 1, wherein the extraction method of the traditional Chinese medicine compound extract is water extraction and/or alcohol extraction, and the extract has a paste yield of 5-15 g medicinal materials/g extract.
  5. 5. The composite composition according to claim 1, wherein the viable count of lactobacillus rhamnosus JYLR-005 is greater than or equal to 100 hundred million CFU/g, the viable count of bifidobacterium bifidum B11 is greater than or equal to 1000 hundred million CFU/g, and the molecular weight of the hydrolyzed collagen peptide is 2000-3000Da.
  6. 6. Use of the composite composition according to any one of claims 1 to 5 for the preparation of a health food useful for maintaining blood glucose health levels.
  7. 7. Use of the composite composition according to any one of claims 1 to 5 for preparing a medicament for treating type II diabetes.

Description

Composite composition for regulating diabetes glycolipid metabolism and application thereof Technical Field The invention belongs to the technical field of medicines, foods or health care products, and particularly relates to a composite composition for regulating diabetes glycolipid metabolism and application thereof. Background Type II diabetes mellitus (Type 2 Diabetes Mellitus, T2 DM) is a global high-frequency chronic metabolic disease, and its core pathological features include insulin resistance, glycolipid metabolic disorders, and is often accompanied by chronic low-grade inflammation and oxidative stress. The long-term metabolism imbalance can cause a plurality of serious complications such as liver steatosis, cardiovascular diseases and the like, and seriously affects the life quality and prognosis of patients. According to the latest data of the international diabetes union (IDF), the number of global T2DM patients continues to rise, preventing and controlling severe conditions. At present, the blood glucose reducing drugs such as metformin, sodium-glucose cotransporter 2 (SGLT 2) inhibitors and the like are commonly used clinically, and have certain limitations in controlling blood glucose, such as side effects of easily causing gastrointestinal discomfort, renal function injury and the like after long-term use, and have limited improvement effects on metabolism related problems such as dyslipidemia, chronic inflammation and the like. Therefore, finding an auxiliary intervention strategy that can intervene in glycolipid metabolic disorders in multiple ways and multiple targets and has good safety is one of the important directions of current research. Disclosure of Invention Aiming at the technical problems of obvious side effect, insufficient improvement on blood lipid disorder and inflammatory state and limited regulation effect of single natural component of the existing hypoglycemic drug, the invention aims to provide a composite composition for regulating diabetes glycolipid metabolism and application thereof. The specific technical scheme of the invention is as follows: The invention provides a composite composition which is prepared from the following raw materials, by weight, 1-3 parts of a rhizoma polygonati enzymolysis extract, 1-3 parts of a traditional Chinese medicine compound extract, JYLR-005-3 parts of lactobacillus rhamnosus, 0.1-0.5 part of bifidobacterium bifidum B11.1-1 part of hydrolyzed collagen peptide and 1-3 parts of tagatose, wherein the traditional Chinese medicine compound extract is prepared by compounding (2-4) of white kidney beans, mulberry leaves, balsam pears, cinnamon, astragalus mongholicus and ginseng in a weight ratio of (0.5-2). The compound composition is prepared from the following raw materials, by weight, 2 parts of rhizoma polygonati enzymolysis extract, 2 parts of traditional Chinese medicine compound extract, JYLR-005 parts of lactobacillus rhamnosus, 0.2 part of bifidobacterium bifidum B, 0.5 part of hydrolyzed collagen peptide and 2 parts of tagatose, wherein the weight ratio of white kidney beans, mulberry leaves, balsam pears, cinnamon, astragalus mongholicus to ginseng in the traditional Chinese medicine compound extract is 3:1:1:1:1:1. The preparation method of the rhizoma polygonati enzymatic hydrolysis extract comprises the following steps of pretreating rhizoma polygonati medicinal materials, carrying out enzymolysis by adopting compound enzyme, and inactivating enzyme, filtering, concentrating and drying enzymatic hydrolysate to obtain the rhizoma polygonati enzymatic hydrolysis extract, wherein the compound enzyme comprises cellulase and protease. Further, the preparation of the rhizoma polygonati enzymolysis extract comprises the following steps: (1) Removing impurities and fibrous roots from fresh rhizoma Polygonati, cleaning, air drying for 12-36h, placing in a 30-50deg.C oven, drying for 12-36h to make its water content reach 25-40%, taking out cut thick slices 5-10mm, drying for 12-36h in a 40 deg.C oven to make its water content reach 15-24%, slicing the dried rhizoma Polygonati, placing in a steaming container, steaming for 4-8h, taking out, drying for 10-20h with 55-80 deg.C hot air to make its water content reach 12-15%, obtaining one-steaming rhizoma Polygonati, repeating above operation four times to obtain five-steaming five-sun rhizoma Polygonati, placing five-steaming five-sun rhizoma Polygonati in the steaming container, steaming for 4-8h, taking out, and drying with 70-80 deg.C hot air to make its water content reach 7%, so as to obtain six-steaming six-sun rhizoma Polygonati. Adding 10 times volume (v/w) of water, adjusting pH to 5 at 50deg.C, adding 4% (w/w) of enzyme (cellulase: pectase=1:1) for preparing rhizoma Polygonati, and reacting for 3 hr; (2) Under the condition of 45 ℃, the constant pH value is 8.5, and 4% (w/w) alkaline protease of the prepared rhizoma polygonati is added for reaction for 3 hours; (3) Adding 4