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CN-121668255-B - Traditional Chinese medicine composition for treating benign nodules and preparation method and application thereof

CN121668255BCN 121668255 BCN121668255 BCN 121668255BCN-121668255-B

Abstract

The invention provides a traditional Chinese medicine composition for treating benign nodules, and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials, by weight, 12-18 parts of bistort rhizome, 24-36 parts of hairyvein agrimony, 9.6-14.4 parts of Indian iphigenia bulb, 16-24 parts of weeping forsythiae capsule, 12-18 parts of platycodon root, 16-24 parts of thunberg fritillary bulb and 14.4-21.6 parts of calendula. The invention also provides a preparation method and application of the traditional Chinese medicine composition. The Chinese medicinal composition aims at the nuclear heart disease machine with the symptoms of sarcoidosis, qi stagnation and blood stasis, phlegm stagnation and heat transfer, has the effects of clearing heat, resolving masses, resolving phlegm, removing stasis, tonifying qi and strengthening body resistance, is used for treating benign nodules of lung, thyroid or mammary glands, achieves the effect of simultaneous treatment of different diseases, and has the advantages of definite curative effect, small side effect and relapse prevention.

Inventors

  • WANG QIANG
  • ZHU ZHIYOU
  • ZHAO LIANGBIN

Assignees

  • 成都拜特尔药业有限公司

Dates

Publication Date
20260508
Application Date
20260212

Claims (7)

  1. 1. A traditional Chinese medicine composition for treating benign nodules of qi stagnation and blood stasis is characterized by being prepared from the following raw materials in parts by weight: 12-18 parts of bistort rhizome, 24-36 parts of hairyvein agrimony, 9.6-14.4 parts of Indian iphigenia bulb, 16-24 parts of weeping forsythiae capsule, 12-18 parts of platycodon root, 16-24 parts of thunberg fritillary bulb and 14.4-21.6 parts of calendula; The nodule is a lung nodule, thyroid nodule or breast nodule.
  2. 2. The traditional Chinese medicine composition for treating benign nodules according to claim 1 is characterized by being prepared from the following raw materials in parts by weight: 15 parts of bistort rhizome, 30 parts of hairyvein agrimony, 12 parts of Indian iphigenia bulb, 20 parts of weeping forsythiae capsule, 15 parts of platycodon root, 20 parts of thunberg fritillary bulb and 18 parts of calendula.
  3. 3. The Chinese medicinal composition for treating benign nodules according to claim 1 or 2, wherein the Chinese medicinal composition is prepared from crude drug powder, water or organic solvent extract of the crude drug as an active ingredient, and pharmaceutically acceptable auxiliary materials or auxiliary components.
  4. 4. The Chinese medicinal composition for treating benign nodules of claim 3, wherein the preparation is in the form of a tablet, capsule, pill, granule, or oral liquid.
  5. 5. A method for preparing a Chinese medicinal composition for treating benign nodules according to any one of claims 1 to 4, which is characterized by comprising the following steps: a. Weighing the raw materials in weight ratio; b. pulverizing or extracting with water or organic solvent, adding pharmaceutically acceptable adjuvants or auxiliary components, and making into pharmaceutically common preparation.
  6. 6. The method for preparing a Chinese medicinal composition for treating benign nodules of claim 5, wherein the water extraction method in step b is as follows: Decocting with water twice for 60 min, decocting for 45 min, mixing decoctions, filtering, mixing filtrates, and concentrating to obtain extract with relative density of 1.07-1.11.
  7. 7. The use of the Chinese medicinal composition according to any one of claims 1 to 4 in the preparation of a medicament for treating benign nodules of qi stagnation and blood stasis, wherein the nodules are lung nodules, thyroid nodules or breast nodules.

Description

Traditional Chinese medicine composition for treating benign nodules and preparation method and application thereof Technical Field The invention relates to a traditional Chinese medicine composition for treating benign nodules, and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. Background Modern medicine refers to nodules (e.g., lung nodules, thyroid nodules, breast nodules, etc.) that are clinically common diseases, often associated with inflammation, hyperplasia, or preneoplastic lesions. In the theory of traditional Chinese medicine, the nodules belong to the categories of goiter, nodules of breast and pulmonary arthralgia, the symptoms of qi stagnation and blood stasis are common and key symptoms of benign nodules of lung, thyroid, mammary gland and the like, the core pathogenesis is that qi is first deficiency caused by various reasons such as improper diet, overstrain, liver failure and diarrhea, and the like, so that qi movement is blocked, further body fluid is coagulated into phlegm, blood is stopped into stasis, and the four are mutually cemented, so that the shaped nodule is finally formed. The pathogenesis evolution and circulation of qi stagnation, phlegm coagulation/blood stasis, phlegm stasis accumulation, heat transformation due to depression and impairment of the healthy energy are not controlled, so that the heat toxin is exuberant and malignant tumor is easy to form. Thyroid nodules are a clinically common endocrine disorder that produces one or more clusters due to abnormal proliferation of thyroid cells, and are seen in all ages. Epidemiological investigation shows that female thyroid nodules have a higher prevalence than male thyroid nodules and have an increasing prevalence with age. And thyroid nodule is more likely to appear in people with high working pressure, long-term mental stress state, insomnia and anxiety. Most benign thyroid nodule patients have no obvious clinical symptoms, but certain patients, especially single-shot nodule patients, can have symptoms such as hoarseness, dysphagia, unsmooth breathing and the like when the nodule presses surrounding tissues, and can also induce other complications such as cardiovascular diseases, diabetes and the like, and even canceration. At present, the most widely applied and most dependent examination item for clinically diagnosing thyroid nodule is ultrasonic examination. The Western medicine treatment method of thyroid nodule mainly comprises thyroid hormone inhibitor treatment, radioiodination treatment, radio frequency ablation therapy, percutaneous absolute ethyl alcohol injection therapy, operation therapy and the like, and has the defects of great adverse reaction, easy permanent hypothyroidism, increased risk of body injury and postoperative complications and the like although the Western medicine treatment method has certain effects. The traditional Chinese medicine considers that thyroid nodule is a pathological product of qi stagnation, blood stasis, turbid phlegm and the like formed in front of the neck due to internal injury of organism emotion, liver qi stagnation, easy accumulation of body fluid into phlegm or improper diet, improper water and soil, spleen failing to transport and transform water dampness, unsmooth qi and blood circulation. Qi is yang, blood is yin, yin and yang are mutually root, and qi and blood are mutually bred and interdependence. The thyroid nodule with qi stagnation and blood stasis is a pathological state of blood stasis caused by qi stagnation and unsmooth operation, and is easy to form lumps and nodules due to blood stasis accumulation without dispersion. The method for treating benign thyroid nodule mainly comprises the steps of Chinese medicine oral administration, plaster external application, acupuncture treatment and the like, and although the methods are different, the treatment takes the principles of soothing liver and regulating qi, resolving phlegm and resolving masses, clearing heat and detoxicating, activating blood and promoting diuresis and warming yang and tonifying qi (Sun Qianqian, and the like), and the effect of combining the safflower Xiaoyao tablet with the left thyroxine sodium tablet for treating benign thyroid nodule qi stagnation and blood stasis syndrome and the influence on thyroid function is adopted, and the clinical misdiagnosis is misdiagnosed in 2022, 9 months, 35 th and 9 th). Benign nodules of the breast are common breast diseases in women and comprise a wide range of pathological diagnostic categories such as fibroadenomas, cysts, fibrocystic changes, papillomas, ductal epithelial hyperplasia with or without dysplasia, and the like. The main clinical manifestations of benign nodules in the breast are breast pain, nodular states or masses. Currently, western medicine mostly adopts psychological dispersion and lifestyle guidance for benign nodules of breast, and adopts estrogen receptor modulators or su