CN-121668569-B - Electrical impedance imaging-based electric field stimulation closed-loop control method and device

CN121668569BCN 121668569 BCN121668569 BCN 121668569BCN-121668569-B

Abstract

The invention discloses an electric field stimulation closed-loop control method and device based on electrical impedance imaging, wherein the method comprises the following steps: the method comprises the steps of obtaining measured voltage change information, coupling the measured voltage change information with a detection image and user breathing data to generate a digital twin model, obtaining sensitive fields corresponding to excitation measurement combinations according to the digital twin model and excitation constant current, performing differential imaging to obtain a reconstructed image, performing absolute conductivity assignment on the reconstructed image, performing convex optimization to obtain target optimization parameters, generating corresponding control instructions according to the target optimization parameters, and sending the control instructions to an electric stimulation unit. According to the electric field stimulation closed-loop control method based on the electrical impedance imaging, the digital twin model is constructed and the image processing is combined to optimize the initial control parameters, so that the accurate target optimization parameters are obtained, the application effect of electric field stimulation control is improved through closed-loop optimization, and the accuracy of electric field stimulation control is greatly improved.

Inventors

ZHANG MAOMAO
CHEN PENGFEI
WANG MINMIN
BAI LIBING

Assignees

电子科技大学(深圳)高等研究院

Dates

Publication Date: 20260512
Application Date: 20260212

Claims (8)

1. The electric field stimulation closed-loop control method based on electrical impedance imaging is characterized in that the method is applied to a control terminal, the control terminal is in communication connection with an excitation acquisition unit and an electric stimulation unit to realize data information transmission, the excitation acquisition unit and the electric stimulation unit are respectively and electrically connected with an electrode array, and the electrode array is worn on a stimulation part, and the method comprises the following steps: Acquiring voltage change information obtained by measurement of the excitation acquisition unit according to the input initial control parameters; Coupling the voltage change information and the user breathing data according to the input detection image to obtain a corresponding digital twin model; obtaining sensitive fields corresponding to each excitation measurement combination according to the digital twin model and the excitation constant current in the initial control parameters; differential imaging is carried out on the sensitive field according to the user breathing data and the digital twin model so as to obtain a corresponding reconstructed image; Performing absolute conductivity assignment on the reconstructed image according to the digital twin model to obtain a corresponding absolute conductivity assignment result; Performing convex optimization on the initial control parameters according to a preset convex optimization rule and the absolute conductivity assignment result to obtain corresponding target optimization parameters; Generating a corresponding control instruction according to the target optimization parameters and sending the control instruction to the electric stimulation unit so as to control the electrode array through the electric stimulation unit; The differential imaging of the sensitive field according to the user breathing data and the digital twin model to obtain a corresponding reconstructed image comprises: Dividing the complete respiratory phase according to the respiratory data of the user to obtain a plurality of corresponding respiratory phases; Coupling the respiratory phases according to the digital twin model to generate conductivity images corresponding to the respiratory phases; performing image reconstruction on the conductivity image according to the sensitive field and the objective function to obtain an image corresponding to the minimum function value of the objective function as a reconstructed image; the image reconstruction is performed on the conductivity image according to the sensitive field and the objective function, so as to obtain an image corresponding to the minimum function value of the objective function as a reconstructed image, and the method comprises the following steps: Acquiring a measured phase position corresponding to a voltage measurement mean value in the voltage change information according to the digital twin model; Acquiring a conductivity tag of a phase adjacent to the measured phase position in the conductivity image according to the respiratory phase; Respectively carrying out cross gradient operation on the conductivity labels of adjacent phases according to a cross gradient coupling algorithm and the conductivity distribution corresponding to the conductivity image to obtain gradient values corresponding to the conductivity labels; Inputting the conductivity distribution corresponding to the conductivity image, the voltage measured value in the voltage change information and the gradient value into the objective function to calculate a corresponding function value; and carrying out image reconstruction on the conductivity image according to the function value change of the objective function so as to obtain an image with the minimum function value of the objective function as a reconstructed image.
2. The electrical impedance imaging-based electric field stimulation closed-loop control method according to claim 1, wherein the obtaining the sensitive field corresponding to each excitation measurement combination according to the digital twin model and the excitation constant current in the initial control parameter comprises: Performing grid division on the digital twin model and constructing a corresponding rigidity matrix based on grid units obtained by division; calculating to obtain corresponding potential distribution according to the excitation constant current and the rigidity matrix; A sensitive field is acquired for each excitation measurement combination corresponding to the potential profile.
3. The electrical impedance imaging-based electric field stimulation closed-loop control method according to claim 1 or 2, wherein the performing absolute conductivity assignment on the reconstructed image according to the digital twin model to obtain a corresponding absolute conductivity assignment result comprises: Carrying out normalization processing on the reconstructed image to obtain a corresponding normalized image; And carrying out absolute conductivity assignment on the normalized image according to the digital twin model to obtain a corresponding absolute conductivity assignment result.
4. The electrical impedance imaging-based electric field stimulation closed-loop control method according to claim 3, wherein the performing convex optimization on the initial control parameter according to a preset convex optimization rule and the absolute conductivity assignment result to obtain a corresponding target optimization parameter comprises: calculating to obtain a corresponding lead field matrix according to the electric field distribution of each given current vector in the absolute conductivity assignment result; And performing convex optimization on the initial control parameters according to the optimization function in the convex optimization rule and the lead field matrix to obtain corresponding target optimization parameters.
5. The electrical impedance imaging-based electric field stimulation closed-loop control method according to claim 3, wherein the step of obtaining voltage variation information measured by the excitation acquisition unit according to the input initial control parameter comprises the steps of: generating an initial control instruction according to the initial control parameter, sending the initial control instruction to the excitation acquisition unit, acquiring initial state voltage measurement acquired by the excitation acquisition unit, and calibrating a measurement signal to obtain calibration measurement information; Generating a sequential excitation instruction of adjacent electrodes according to the initial control parameters and sending the sequential excitation instruction to the excitation acquisition unit so as to acquire voltage change measurement information obtained in the whole respiratory process by measurement of the excitation acquisition unit; And combining the calibration measurement information with the voltage change measurement information to obtain corresponding voltage change information.
6. An electric field stimulation closed-loop control device based on electrical impedance imaging, wherein the device is configured in a control terminal, the control terminal is in communication connection with an excitation acquisition unit and an electrical stimulation unit to realize data information transmission, the excitation acquisition unit and the electrical stimulation unit are respectively and electrically connected with an electrode array, the electrode array is worn at a stimulation site, and the device is used for executing the electric field stimulation closed-loop control method based on electrical impedance imaging as claimed in any one of claims 1 to 5, and the device comprises: the voltage change information acquisition unit is used for acquiring voltage change information obtained by measurement of the excitation acquisition unit according to the input initial control parameters; The coupling unit is used for coupling the voltage change information and the user breathing data according to the input detection image to obtain a corresponding digital twin model; the sensitive field acquisition unit is used for acquiring sensitive fields corresponding to each excitation measurement combination according to the digital twin model and the excitation constant current in the initial control parameters; the reconstructed image acquisition unit is used for carrying out differential imaging on the sensitive field according to the user breathing data and the digital twin model so as to obtain a corresponding reconstructed image; the assignment unit is used for carrying out absolute conductivity assignment on the reconstructed image according to the digital twin model to obtain a corresponding absolute conductivity assignment result; The optimization unit is used for performing convex optimization on the initial control parameters according to a preset convex optimization rule and the absolute conductivity assignment result so as to obtain corresponding target optimization parameters; and the control instruction sending unit is used for generating a corresponding control instruction according to the target optimization parameter and sending the control instruction to the electric stimulation unit so as to control the electrode array through the electric stimulation unit.
7. A computer device, comprising a processor, a communication interface, a memory and a communication bus, wherein the processor, the communication interface and the memory communicate with each other through the communication bus; a memory for storing a computer program; A processor for implementing the steps of the electrical impedance imaging-based electric field stimulation closed-loop control method according to any one of claims 1 to 5 when executing a program stored on a memory.
8. A computer readable storage medium, on which a computer program is stored, characterized in that the computer program, when being executed by a processor, implements the steps of the electrical impedance imaging based electric field stimulation closed loop control method as claimed in any of claims 1-5.

Description

Electrical impedance imaging-based electric field stimulation closed-loop control method and device Technical Field The invention relates to the technical field of intelligent control of electric field stimulation, in particular to an electric field stimulation closed-loop control method and device based on electrical impedance imaging. Background In the prior art, a low-intensity alternating electric field with specific frequency can be adopted to interfere with tumor cell division so as to inhibit tumor growth, and the principle is that the electric field is used for destroying tubulin assembly and chromosome separation in tumor cells in the division stage, so that the mitosis of the tumor cells is inhibited so as to inhibit the growth of the tumor cells, and normal cells are less affected because of slower division. In the practical application process, the electric field distribution generated in the body is a key factor affecting the inhibition effect. However, the control method for generating the electric field stimulation in the related art method has a problem of insufficient accuracy. Disclosure of Invention The embodiment of the invention provides an electric field stimulation closed-loop control method and device based on electrical impedance imaging, and aims to solve the problem of insufficient accuracy of a control method for generating electric field stimulation in the prior art. In a first aspect, an embodiment of the present invention provides a closed-loop control method for electric field stimulation based on electrical impedance imaging, where the method is applied to a control terminal, the control terminal is in communication connection with an excitation acquisition unit and an electrical stimulation unit to implement transmission of data information, the excitation acquisition unit and the electrical stimulation unit are respectively electrically connected with an electrode array, and the electrode array is worn on a stimulation site, and the method includes: Acquiring voltage change information obtained by measurement of the excitation acquisition unit according to the input initial control parameters; Coupling the voltage change information and the user breathing data according to the input detection image to obtain a corresponding digital twin model; obtaining sensitive fields corresponding to each excitation measurement combination according to the digital twin model and the excitation constant current in the initial control parameters; differential imaging is carried out on the sensitive field according to the user breathing data and the digital twin model so as to obtain a corresponding reconstructed image; Performing absolute conductivity assignment on the reconstructed image according to the digital twin model to obtain a corresponding absolute conductivity assignment result; Performing convex optimization on the initial control parameters according to a preset convex optimization rule and the absolute conductivity assignment result to obtain corresponding target optimization parameters; and generating a corresponding control instruction according to the target optimization parameter, and sending the control instruction to the electric stimulation unit so as to control the electrode array through the electric stimulation unit. In a second aspect, an embodiment of the present invention further provides an electric field stimulation closed-loop control device based on electrical impedance imaging, where the device is configured in a control terminal, the control terminal is in communication connection with an excitation acquisition unit and an electrical stimulation unit to implement transmission of data information, the excitation acquisition unit and the electrical stimulation unit are respectively electrically connected with an electrode array, the electrode array is worn on a stimulation site, and the device is configured to perform the electric field stimulation closed-loop control method based on electrical impedance imaging according to the first aspect, where the device includes: the voltage change information acquisition unit is used for acquiring voltage change information obtained by measurement of the excitation acquisition unit according to the input initial control parameters; The coupling unit is used for coupling the voltage change information and the user breathing data according to the input detection image to obtain a corresponding digital twin model; the sensitive field acquisition unit is used for acquiring sensitive fields corresponding to each excitation measurement combination according to the digital twin model and the excitation constant current in the initial control parameters; the reconstructed image acquisition unit is used for carrying out differential imaging on the sensitive field according to the user breathing data and the digital twin model so as to obtain a corresponding reconstructed image; the assignment unit is used for carrying out abso