CN-121678581-B - On-line anesthetic gas concentration detection system for accurate dosage regulation and control

CN121678581BCN 121678581 BCN121678581 BCN 121678581BCN-121678581-B

Abstract

The invention discloses an anesthetic gas concentration online detection system for accurate dosage regulation, which relates to the technical field of concentration measurement of anesthetic gas and can solve the technical problem of misalignment of measurement results in the anesthetic gas concentration online detection process, and comprises a data acquisition module, a data acquisition module and a control module, wherein the data acquisition module is used for acquiring infrared absorption spectrum data; the device comprises an infrared absorption spectrum data acquisition module, an interference identification module, a signal separation module, a concentration calculation module and a concentration calculation module, wherein the infrared absorption spectrum data acquisition module is used for acquiring infrared absorption spectrum data of target anesthetic gas, the interference identification module is used for determining the starting moment of alcohol disinfection according to the time sequence change of the infrared absorption spectrum data, the signal separation module is used for separating absorbance values of alcohol vapor under a plurality of preset wavelengths from the infrared absorption spectrum data and constructing an alcohol absorbance change model according to the absorbance values of the alcohol vapor under the plurality of preset wavelengths, the signal separation module is also used for determining the absorbance values of the target anesthetic gas under the plurality of preset wavelengths from the infrared absorption spectrum data, and the concentration calculation module is used for determining the concentration values of the target anesthetic gas according to the absorbance values of the target anesthetic gas under the plurality of preset wavelengths.

Inventors

Song Shuizhen
FU LI
Fan Huikun

Assignees

北京智想创源科技有限公司

Dates

Publication Date: 20260505
Application Date: 20260212

Claims (7)

1. The anesthetic gas concentration online detection system for accurate dosage regulation is characterized by comprising a data acquisition module, an interference identification module, a signal separation module and a concentration calculation module; The data acquisition module is used for acquiring infrared absorption spectrum data, wherein the infrared absorption spectrum data are used for representing absorbance values of an end-tidal gas sample of a patient under a plurality of preset wavelengths; The interference recognition module is used for determining the alcohol disinfection starting time according to the time sequence change of the infrared absorption spectrum data, wherein the alcohol disinfection starting time is used for representing the initial time point when alcohol steam starts to interfere with the detection of the concentration of anesthetic gas; The signal separation module is used for separating absorbance values of the alcohol vapor under the plurality of preset wavelengths from the infrared absorption spectrum data according to the starting time of alcohol disinfection, and constructing an alcohol absorbance change model according to the absorbance values of the alcohol vapor under the plurality of preset wavelengths; The signal separation module is further used for determining absorbance values of the target anesthetic gas under the preset wavelengths from the infrared absorption spectrum data according to the alcohol absorbance change model; the concentration calculation module is used for determining the concentration value of the target anesthetic gas according to the absorbance values of the target anesthetic gas at the plurality of preset wavelengths; The interference identification module specifically executes the following steps when determining the starting moment of alcohol disinfection according to the time sequence change of the infrared absorption spectrum data: The interference identification module is further used for calculating the change rate between the absorbance value at the current moment and the absorbance values at the first two moments according to each preset wavelength; The interference recognition module is further used for determining the current moment as the moment of starting the disinfection of the alcohol when the change rate exceeds a preset threshold value; the signal separation module specifically executes the following steps when constructing an alcohol absorbance change model according to absorbance values of the alcohol vapor at the plurality of preset wavelengths: The signal separation module is further used for determining a prediction error of a dual-phase attenuation model according to absorbance values of the alcohol vapor at the plurality of preset wavelengths, wherein the dual-phase attenuation model is used for describing attenuation characteristics of the change of the absorbance of the alcohol vapor along with time, and the prediction error is used for representing the difference degree between the predicted value and the actual absorbance value of the dual-phase attenuation model; The signal separation module is further used for determining the optimal parameters of the biphase attenuation model by minimizing the prediction error; the signal separation module is also used for predicting the absorbance value of the alcohol vapor at the subsequent moment by using the biphasic attenuation model determined by the optimal parameters.
2. The on-line detection system for concentration of anesthetic gas for accurate dosing control according to claim 1, wherein the signal separation module specifically performs the following steps when separating absorbance values of alcohol vapor at the plurality of preset wavelengths from the infrared absorption spectrum data according to the alcohol sterilization start time: The signal separation module is further used for selecting absorbance values of a plurality of historical moments before the alcohol disinfection starting moment according to each target moment after the alcohol disinfection starting moment, wherein the target moment is any moment after the alcohol disinfection starting moment, and the historical moments are a plurality of continuous moments before the alcohol disinfection starting moment; the signal separation module is further used for determining an initial absorbance value of the alcohol vapor at the target moment according to the difference between the absorbance value at the target moment and the absorbance values at the plurality of historical moments; The signal separation module is further used for carrying out weighted fusion on the initial absorbance values corresponding to the historical moments to obtain absorbance values of the alcohol vapor under the preset wavelengths.
3. The online detection system for concentration of anesthetic gases for precise dosage regulation of claim 2, wherein the signal separation module, when determining an initial absorbance value of alcohol vapor at the target time based on a difference between absorbance values at the target time and absorbance values at the plurality of historical times, specifically performs the following steps: The signal separation module is further configured to calculate, for each preset wavelength, the initial absorbance value according to a proportional relationship between the absorbance value at the target time and the absorbance value at the historical time at each target wavelength, where the target wavelength includes a preset wavelength and a wavelength on a left side and a right side of the preset wavelength.
4. The on-line detection system for concentration of anesthetic gas for accurate dosage regulation according to claim 1, wherein the signal separation module, when determining absorbance values of a target anesthetic gas at the plurality of preset wavelengths from the infrared absorption spectrum data according to the alcohol absorbance change model, specifically performs the following steps: the signal separation module is further used for removing absorbance values of the alcohol vapor under the preset wavelengths, which are predicted by the alcohol absorbance change model, from the infrared absorption spectrum data to obtain absorbance values of the target anesthetic gas under the preset wavelengths.
5. The on-line detection system for concentration of anesthetic gas for accurate dosage regulation according to claim 1, wherein the concentration calculation module, when determining the concentration value of the target anesthetic gas according to absorbance values of the target anesthetic gas at the plurality of preset wavelengths, specifically performs the following steps: The concentration calculation module is also used for establishing a multi-element equation set of absorbance values and concentration values when a plurality of anesthetic gases exist; The concentration calculation module is further used for solving the multi-element equation set by adopting a preset optimization algorithm to obtain the concentration value of each anesthetic gas.
6. The on-line detection system for concentration of anesthetic gas for accurate dosage regulation according to claim 1, wherein the data acquisition module is configured to perform the following steps when acquiring infrared absorption spectrum data: The data acquisition module is also used for acquiring an end-tidal gas sample of the patient; the data acquisition module is also used for carrying out water removal and filtration treatment on the end-tidal gas sample; The data acquisition module is further used for measuring absorbance values of the calling end gas sample under a plurality of preset wavelengths by utilizing an infrared spectrometer to generate infrared absorption spectrum data.
7. The on-line detection system for dose-accurate regulation of anesthetic gas concentration as recited in any one of claims 1-6, further comprising a control output module; the control output module is used for generating anesthetic infusion control instructions according to the target anesthetic gas concentration value determined by the concentration calculation module.

Description

On-line anesthetic gas concentration detection system for accurate dosage regulation and control Technical Field The invention relates to the technical field of concentration measurement of anesthetic gas, in particular to an online anesthetic gas concentration detection system for accurate dosage regulation. Background The on-line detection of the concentration of the anesthetic gas is a key link for realizing accurate drug administration in modern general anesthesia, and a doctor can accurately control the anesthesia depth by monitoring the concentration of the end-expiratory gas of a patient in real time so as to avoid risks of knowing or over-deep anesthesia in the operation. At present, a gas concentration detection technology based on infrared spectrometry is commonly adopted in an operating room, and the technology inverts the concentration of anesthetic gas molecules by measuring the characteristic absorption of the anesthetic gas molecules under specific wavelengths according to the lambert-beer law. However, in an actual clinical environment, the steam volatilized by alcohol widely used in surgical disinfection can interfere with the detection process, and the existing detection system is difficult to effectively distinguish signal sources due to the overlapping absorption spectrum of alcohol and narcotic molecules in the infrared band, so that the accuracy and reliability of concentration detection results are obviously reduced, and the accurate regulation and control of narcotic administration are directly affected. Disclosure of Invention In order to solve the technical problem that the measurement result is misaligned in the online detection process of the concentration of the anesthetic gas due to the mutual interference of the infrared absorption spectrums of the alcohol vapor and the anesthetic gas in the present stage, the invention aims to provide an online detection system for the concentration of the anesthetic gas for accurate dosage regulation, and the adopted technical scheme is as follows: The invention provides an on-line anesthetic gas concentration detection system for accurate regulation and control of dosage, which comprises a data acquisition module, an interference identification module, a signal separation module and a concentration calculation module, wherein the data acquisition module is used for acquiring infrared absorption spectrum data, the infrared absorption spectrum data are used for representing absorbance values of a patient's last gas sample at a plurality of preset wavelengths, the interference identification module is used for determining an alcohol disinfection starting moment according to time sequence changes of the infrared absorption spectrum data, the alcohol disinfection starting moment is used for representing an initial time point when alcohol vapor starts to interfere with anesthetic gas concentration detection, the signal separation module is used for separating absorbance values of the alcohol vapor at the plurality of preset wavelengths from the infrared absorption spectrum data according to the alcohol disinfection starting moment and constructing an alcohol absorbance change model according to the absorbance values of the alcohol vapor at the plurality of preset wavelengths, and the concentration calculation module is used for determining the concentration value of a target anesthetic gas according to the absorbance values of the target anesthetic gas at the plurality of preset wavelengths from the infrared absorption spectrum data. In one possible implementation, the interference recognition module is specifically configured to, when determining the alcohol disinfection starting time according to the time sequence change of the infrared absorption spectrum data, calculate, for each preset wavelength, a change rate between the absorbance value at the current time and the absorbance values at the first two times, and determine, when the change rate exceeds a preset threshold, the current time as the alcohol disinfection starting time. In a possible implementation manner, when the signal separation module separates absorbance values of alcohol vapor at a plurality of preset wavelengths from infrared absorption spectrum data according to alcohol disinfection starting time, the signal separation module is specifically used for selecting absorbance values of a plurality of historical times before the alcohol disinfection starting time for each target time after the alcohol disinfection starting time, wherein the target time is any time after the alcohol disinfection starting time, the historical times are a plurality of continuous times before the alcohol disinfection starting time, the signal separation module is also used for determining initial absorbance values of the alcohol vapor at the target time according to differences between the absorbance values of the target time and the absorbance values of the plurality of historical times, and the si