CN-121754720-B - Self-drying gel and preparation method and application thereof

Abstract

The invention relates to self-drying gel, which is prepared from cationic imidazolium salt, dopamine hydrochloride, ammonium carboxylate zwitterionic monomer and carboxyl chitosan. The self-drying gel provided by the invention has the advantages of coating and forming, in-situ self-drying, adhesion resistance, good biocompatibility and high immune compatibility, so that the self-drying gel is not easy to cause secondary injury during clinical replacement, and can promote wound repair by regulating immune reaction.

Inventors

• SHEN JIAN
• Xia ao
• MA JIANHUA

Assignees

• 南京师范大学

Dates

Publication Date

20260512

Application Date

20260302

Claims (20)

1. 1. The self-drying gel is characterized in that the self-drying gel is prepared from cationic imidazolium salt, dopamine hydrochloride, ammonium carboxylate zwitterionic monomer and carboxyl chitosan; the cationic imidazole salt is selected from one or more of 1-butyl-2, 3-dimethyl imidazole chloride, 1-ethyl-3-methyl imidazole bromide and 1-butyl-3-methyl imidazole chloride; the carboxyammonium zwitterionic monomer is selected from the group consisting of carboxybetaines; the carboxylic acid betaine is selected from one or more of methacrylic acid carboxyl betaine and acryloylethyl carboxyl betaine; the carboxyl chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan and N, O-carboxymethyl chitosan; The molar ratio of the cationic imidazole salt to the dopamine hydrochloride to the carboxyl-ammonium type zwitterionic monomer to the carboxyl chitosan is (1-2)/(5-15)/(1-10).
2. 2. A self-drying gel according to claim 1, wherein the starting material further comprises an initiator.
3. 3. Self-drying gel according to claim 2, characterized in that the initiator is selected from aromatic ketones.
4. 4. A self-drying gel according to claim 3, wherein the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-propanone, 2-hydroxy-4- (2-hydroxyethoxy) -2-methylpropionne.
5. 5. A self-drying gel according to claim 1, wherein the raw materials further comprise a crosslinking agent.
6. 6. The self-drying gel according to claim 5, wherein the crosslinking agent is selected from one or more of polyethylene glycol diacrylate, N' -methylenebisacrylamide.
7. 7. Self-drying gel according to claim 1, characterized in that the cationic imidazolium salt is added in the form of an aqueous solution thereof, the concentration of the cationic imidazolium salt in the aqueous solution being 0.01mol/L to 0.05mol/L.
8. 8. The self-drying gel according to claim 2, wherein the initiator is used in an amount of 0.1% -0.5% of the molar amount of the ammonium carboxylate zwitterionic monomer and the cationic imidazolium salt.
9. 9. The self-drying gel according to claim 5, wherein the amount of the crosslinking agent is 0.1% -0.5% of the molar amount of the carboxyammonium zwitterionic monomer and the carboxyl chitosan.
10. 10. The method for preparing the self-drying gel according to any one of claims 1 to 9, comprising the following steps: S1, crosslinking a cationic imidazole salt, dopamine hydrochloride, a carboxyammonium zwitterionic monomer, carboxyl chitosan, an initiator and a crosslinking agent to obtain self-drying gel.
11. 11. The method according to claim 10, wherein the step S1 further comprises the steps of: S1a, crosslinking a cationic imidazole salt, dopamine hydrochloride, a carboxyammonium zwitterionic monomer, carboxyl chitosan, an initiator and a crosslinking agent to obtain a self-drying gel water solution, and adding a dried product of the self-drying gel water solution into water for mixing, wherein the volume ratio of the dried product to the water is 1 (0.5-2), so as to obtain the self-drying gel.
12. 12. The method according to claim 10, wherein the crosslinking is carried out at a reaction temperature of 40 ℃ to 60 ℃ for 1 to 5 hours.
13. 13. The method according to claim 10, wherein the crosslinking is performed under irradiation of ultraviolet light at a wavelength of 260nm to 390 nm.
14. 14. The method according to claim 11, wherein in step S1a, the drying is performed by drying the self-drying aqueous gel solution to a water content of 3% or less.
15. 15. The preparation method of the self-drying gel flexible film is characterized by comprising the following steps of: S2, coating and drying the self-drying gel according to any one of claims 1-9 or the self-drying gel prepared by the preparation method of the self-drying gel according to any one of claims 10-14 to obtain the self-drying gel flexible film.
16. 16. The self-drying gel flexible film according to claim 15, wherein in step S2, the drying condition is a temperature of 30 ℃ to 40 ℃ and a relative humidity of 60% to 80%.
17. 17. The self-drying gel flexible film according to claim 15, wherein in step S2, the drying is drying the self-drying gel to a water content of 10% or less.
18. 18. The self-drying gel flexible film according to claim 15, wherein the self-drying gel flexible film has a maximum strain of 621% -852%.
19. 19. The self-drying gel flexible film according to claim 15, wherein the self-drying gel flexible film has a maximum stress of 3252kpa to 269kpa.
20. 20. The self-drying gel flexible film according to claim 15, wherein the step S2 further comprises the steps of: The self-drying gel according to any one of claims 1 to 9 or the self-drying gel prepared by the method for preparing the self-drying gel according to any one of claims 10 to 14, wherein the self-drying gel is dried to a flexible film with a water content of less than 5% under the conditions of a temperature of 37 ℃ and a relative humidity of 70%.

Description

Self-drying gel and preparation method and application thereof Technical Field The invention belongs to the technical field of medical gel dressing, and relates to self-drying gel and a preparation method and application thereof. Background Traditional wound dressing (such as gauze, cotton pad, oil gauze, etc.) are mostly inert dressing, and mainly play a role in covering and protecting wounds. However, its ability to absorb exudates is limited and the dressing is prone to sticking to the wound. When replaced, the adhered dressing is prone to causing mechanical damage again to the new tissue, causing pain, bleeding, and delayed wound healing. Compared with the limitation of the traditional solid dressing (such as gauze, sheet hydrocolloid and the like) in the aspects of fitting a special wound surface, managing seepage and avoiding replacement damage, the self-drying flexible dressing (usually in the form of hydrogel) can be coated, and has obvious advantages. The wound dressing can be formed in situ, perfectly fits the shape of a complex wound, the provided airtight and moist environment is favorable for cell migration, healing can be accelerated, pain can be relieved, and meanwhile, the wound dressing has good air permeability and transparency and is convenient to observe. For severe wounds such as burns, frequent mechanical debridement and replacement of solid dressings are extremely prone to secondary damage, and the coatable dressing is expected to reduce such damage. Therefore, developing a novel gel dressing with the characteristics of coating forming, in-situ self-drying, anti-adhesion, good biocompatibility and the like to realize perfect fitting and protection of wound surfaces and furthest avoid secondary damage during replacement has become an important research direction in the current wound care field. Disclosure of Invention The self-drying gel has the advantages of adhesion resistance and high immune compatibility, so that the self-drying gel is not easy to cause secondary injury during clinical replacement, and the self-drying gel flexible film prepared from the self-drying gel has the advantages of strong plasticity, good laminating property and effective wound closing. In order to solve the technical problems, the invention adopts the following technical scheme: the invention provides self-drying gel, which is prepared from cationic imidazolium salt, dopamine hydrochloride, ammonium carboxylate zwitterionic monomer and carboxyl chitosan. Preferably, the cationic imidazole salt is selected from one or more of 1-butyl-2, 3-dimethylimidazole chloride, 1-ethyl-3-methylimidazole bromide and 1-butyl-3-methylimidazole chloride; and/or, the carboxyammonium zwitterionic monomer is selected from the group consisting of carboxybetaines; and/or the carboxylic acid betaine is selected from one or more of methacrylic acid carboxyl betaine and acryloylethyl carboxyl betaine; and/or the carboxyl chitosan is selected from O-carboxymethyl chitosan, N-carboxymethyl chitosan and N, O-carboxymethyl chitosan. Preferably, the raw materials further comprise an initiator; and/or the initiator is selected from aromatic ketones; And/or the aromatic ketone compound is selected from one or more of 2-hydroxy-2-methyl-1-phenyl-1-acetone and 2-hydroxy-4- (2-hydroxyethoxy) -2-methyl propiophenone; and/or the raw materials further comprise a cross-linking agent; And/or the cross-linking agent is selected from one or more of polyethylene glycol diacrylate and N, N' -methylene bisacrylamide. Preferably, the molar ratio of the cationic imidazole salt to the dopamine hydrochloride to the carboxyl chitosan is (1-2): 5-15): 1-10; And/or the cationic imidazole salt is added in the form of an aqueous solution, and the concentration of the cationic imidazole salt in the aqueous solution is 0.01 mol/L-0.05 mol/L; and/or the dosage of the initiator is 0.1% -0.5% of the molar quantity of the ammonium carboxylate zwitterionic monomer and the cationic imidazole salt; And/or the dosage of the cross-linking agent is 0.1% -0.5% of the molar quantity of the ammonium carboxylate zwitterionic monomer and the carboxyl chitosan. The invention also provides a preparation method of the self-drying gel, which comprises the following steps: S1, crosslinking a cationic imidazole salt, dopamine hydrochloride, a carboxyammonium zwitterionic monomer, carboxyl chitosan, an initiator and a crosslinking agent to obtain self-drying gel. Preferably, the step S1 further includes the steps of: s1a, crosslinking a cationic imidazole salt, dopamine hydrochloride, a carboxyammonium zwitterionic monomer, carboxyl chitosan, an initiator and a crosslinking agent to obtain an self-drying gel water solution, adding a dried product of the self-drying gel water solution into water, and mixing, wherein the volume ratio of the dried product to the water is 1 (0.5-2), so as to obtain self-drying gel; And/or the reaction temperature of the crosslinking is 40-60 ℃ and the