CN-121797360-B - Photocatalysis nano composite material and preparation method and application thereof

Abstract

The invention relates to the technical field of nanocomposite materials, in particular to a photocatalysis nanocomposite material, a preparation method and application thereof. The preparation method comprises three steps of molybdenum disulfide nanoparticle preparation, precursor dispersion and in-situ compounding, and has the advantages of simple working procedure, low energy consumption and high production efficiency, and can realize high-efficiency and low-cost large-scale preparation of the photocatalysis nanocomposite. The photocatalysis nano composite material is composed of two semiconductor photocatalysis materials with staggered energy bands, not only can adjust the light absorption range, but also can realize the effective separation of the photon-generated electron-hole pairs by transferring the photon-generated electron and hole to different semiconductor photocatalysis materials. The photo-generated electrons and holes generated by light excitation can enable the composite material to obtain stronger oxidation-reduction capability, and can be used for preparing products for regulating mitochondrial functions so as to accurately interfere mitochondrial electron transfer chains and realize oxidation of NADH and reduction of cytochrome C.

Inventors

• LI SHULAN
• HOU HUAYING
• LI ZHUOYUAN
• CHENG GUODONG
• LIU YI

Assignees

• 天津工业大学

Dates

Publication Date

20260512

Application Date

20260312

Claims (8)

1. 1. The application of the photocatalysis nano composite material is characterized in that the photocatalysis nano composite material is used for preparing a product for regulating mitochondrial function, and the photocatalysis nano composite material can oxidize NADH into NAD + and reduce cytochrome C (Fe 3+ ) into cytochrome C (Fe 2+ ); The photocatalytic nanocomposite comprises molybdenum disulfide nanoparticles and cuprous oxide, wherein the cuprous oxide is loaded on the surface layer of the molybdenum disulfide nanoparticles; The preparation method of the photocatalysis nano composite material comprises the following steps: S100, preparing molybdenum disulfide nano particles by taking sodium molybdate and glutathione as raw materials and utilizing a hydrothermal reaction; s200, uniformly dispersing a molybdenum disulfide nanoparticle precursor in a solvent to obtain a precursor solution; s300, adding soluble copper salt, complexing agent and dispersing agent into the precursor solution, uniformly mixing, adding reducing agent at 40-60 ℃, and stirring and reacting for 1.5-2.5 h to obtain the photocatalysis nanocomposite.
2. 2. The application of the photocatalytic nanocomposite according to claim 1, wherein in the step S100, the reaction temperature of the hydrothermal reaction is 190 ℃ to 210 ℃ and the reaction time is 12h to 36h.
3. 3. The application of the photocatalytic nanocomposite according to claim 1, characterized in that in step S100, the particle size of the molybdenum disulfide nanoparticle is 10nm to 20nm.
4. 4. The use of the photocatalytic nanocomposite according to claim 1, wherein in step S200, the concentration of the precursor solution is 0.5mg/mL to 1.5mg/mL.
5. 5. The use of the photocatalytic nanocomposite as set forth in claim 1, wherein in step S300, the complexing agent is selected from sodium citrate.
6. 6. The use of the photocatalytic nanocomposite as set forth in claim 1, wherein in step S300, the dispersant is selected from polyvinylpyrrolidone.
7. 7. The use of the photocatalytic nanocomposite according to claim 1, characterized in that in step S300, the reducing agent is selected from ascorbic acid.
8. 8. The use of the photocatalytic nanocomposite as set forth in claim 1, wherein the photocatalytic nanocomposite has a 0.27nm and 0.25nm lattice structure; And in the X-ray diffraction pattern of the photocatalysis nano composite material, characteristic diffraction peaks are arranged at 32.8 degrees and 36.5 degrees.

Description

Photocatalysis nano composite material and preparation method and application thereof Technical Field The invention relates to the technical field of nanocomposite materials, in particular to a photocatalysis nanocomposite material, a preparation method and application thereof. Background Mitochondria serve as energy metabolism centers of cells, not only energy factories of cells, but also play an important role in the regulation of various cell functions, including the generation of reactive oxygen species (Reactive oxygen species, ROS), the regulation of cell death pathways, and the like. Compared with normal cells, mitochondria of cancer cells can adaptively adjust metabolic phenotype of the cancer cells to meet higher energy requirements of the cancer cells and provide support for macromolecular synthesis, so that an active but relatively fragile mitochondrial electron transport chain (Mitochondrial Electron Transport Chain, mito-ETC) is formed. Studies have shown that interfering with Mito-ETC can induce mitochondrial damage and promote cell death. However, existing interfering means for Mito-ETC face a number of challenges, including cancer-related resistance, cellular detoxification mechanisms, and severe toxicity to normal tissues. The photocatalysis system is introduced into mitochondria of cancer cells, and can promote the oxidation reaction of reduced adenine dinucleotide (NADH) in the mitochondria to generate oxidized nicotinamide adenine dinucleotide (NAD +) in a light control mode, and simultaneously reduce cytochrome C (Fe 3+) into cytochrome C (Fe 2+), so that Mito-ETC of the cancer cells is damaged, and finally the mitochondria is damaged and apoptosis is initiated. However, conventional semiconductor catalysts generally have limitations such as high activation energy and rapid electron-hole recombination. Therefore, developing a high-efficiency photocatalytic nanocomposite is a technical problem to be solved currently. Disclosure of Invention The present invention is directed to solving at least one of the technical problems existing in the related art. To this end, a first object of the present invention is to provide a method for preparing a photocatalytic nanocomposite, a second object of the present invention is to provide a photocatalytic nanocomposite, and a third object of the present invention is to provide an application of the photocatalytic nanocomposite. In order to achieve the first object, the invention adopts the following technical scheme: a method for preparing a photocatalysis nano composite material, comprising the following steps: S100, preparing molybdenum disulfide nano particles by taking sodium molybdate and glutathione as raw materials and utilizing a hydrothermal reaction; s200, uniformly dispersing a molybdenum disulfide nanoparticle precursor in a solvent to obtain a precursor solution; s300, adding soluble copper salt, complexing agent and dispersing agent into the precursor solution, uniformly mixing, adding reducing agent at 40-60 ℃, and stirring and reacting for 1.5-2.5 h to obtain the photocatalysis nanocomposite. The preparation method provided by the invention comprises three steps of molybdenum disulfide nanoparticle preparation, precursor dispersion and in-situ compounding, and has the advantages of simple working procedure, low energy consumption and high production efficiency, and can realize high-efficiency and low-cost large-scale preparation of the photocatalysis nanocomposite. The preparation method comprises the steps of preparing raw materials such as sodium molybdate, glutathione and soluble copper salt, wherein the raw materials are wide in source and low in cost, the glutathione has the functions of a sulfur source and a mild reducing agent, a reaction system is nontoxic and harmless, hydrothermal reaction conditions are mild, high-temperature calcination or complex equipment is not needed, molybdenum disulfide nano particles with good dispersibility and uniform size can be directly obtained, copper-based components are deposited on the surfaces of MoS 2 nano particles in situ, two-phase interfaces are in close contact, separation and migration of photo-generated carriers can be effectively promoted, electron-hole recombination is inhibited, photocatalytic activity is remarkably improved, the reduction compounding stage only needs 40-60 ℃ and 1.5-2.5 h of reaction, conditions are mild, energy consumption is low, equipment requirements are low, the preparation method is suitable for industrial amplification, and the complexing agent and the dispersing agent are added into the system, so that particle aggregation can be effectively prevented, the finally obtained composite material is uniform in particle size and good in dispersibility, and the number of effective active sites in the photocatalytic reaction is facilitated to be improved. Preferably, in step S100, the reaction temperature of the hydrothermal reaction is 190 ℃ to 210 ℃ and the re