CN-121868010-B - Self-powered electric stimulation bionic intervertebral disc

Abstract

The invention discloses a self-powered electric stimulation bionic intervertebral disc, which belongs to the technical field of implanted medical instruments, and comprises an upper endplate, an intervertebral disc core and a lower endplate, wherein the intervertebral disc core comprises an annular fiber, a nucleus pulposus and a collagen fiber transition area, the inner wall of the collagen fiber transition area is provided with honeycomb holes for generating electric energy through contact separation with the nucleus pulposus so as to promote bone tissue fusion, the phenomenon that the intervertebral disc is influenced by the multidirectional motion characteristics of a human body is generated according to a friction nano power generation mechanism, the nucleus pulposus in the intervertebral disc core is slightly contacted with the honeycomb holes in the inner wall of the collagen fiber transition area due to pressure, the contact separation between the inner wall of the collagen fiber transition area and the nucleus pulposus generates electric energy, the electric signal can activate bone cell activity, optimize osseointegration microenvironment, promote nutrient exchange and bone cell growth fusion, and remarkably reduce postoperative subsidence and loosening complications risks.

Inventors

• QIAN ZHIHUI
• YAN ZHENCHENG
• SUN YUSHAN
• YANG ZHUOLIN
• Qiao Chengxi
• Tang Mingwan
• ZHAO FEI
• REN LUQUAN

Assignees

• 吉林大学

Dates

Publication Date

20260508

Application Date

20260319

Claims (8)

1. 1. The utility model provides a self-powered electricity stimulated bionic intervertebral disc, includes last endplate (1), intervertebral disc core (2) and lower endplate (3), its characterized in that: the upper end plate (1) is provided with upper end plate fixing teeth (11); The intervertebral disc core (2) comprises an annulus fibrosus (21), a nucleus pulposus (22) and a collagen fiber transition zone (23), wherein the annulus fibrosus (21) is used as a peripheral structure of the intervertebral disc core (2) to form a closed inner cavity, the collagen fiber transition zone (23) is a ring-shaped structure which is used as a middle layer structure of the intervertebral disc core (2) and is embedded in the inner cavity of the annulus fibrosus (21), and the nucleus pulposus (22) is embedded in the ring-shaped interior of the collagen fiber transition zone (23) to simulate the elasticity of a natural nucleus pulposus; The fiber ring (21) consists of a collagen fiber matrix layer (211) and collagen fibers (212), wherein a plurality of fiber holes which are arranged in a staggered way are longitudinally and obliquely arranged on the collagen fiber matrix layer (211), the collagen fibers (212) are cylindrical, are obliquely arranged in the fiber holes of the collagen fiber matrix layer (211), and the oblique directions of the adjacent two rows of collagen fibers (212) are opposite; The inner wall of the collagen fiber transition zone (23) is provided with honeycomb holes for generating electric energy by contact separation with the nucleus pulposus (22) so as to promote bone tissue fusion; the collagen fiber matrix layer (211), the collagen fibers (212) and the collagen fiber transition zone (23) are printed in a 3D mode; The lower end plate (3) is provided with lower end plate fixing teeth (31); the cross sections of the upper end plate (1), the intervertebral disc core (2) and the lower end plate (3) are D-shaped.
2. 2. The self-powered electro-stimulated bionic intervertebral disc of claim 1, wherein the honeycomb holes formed in the inner wall of the collagen fiber transition region (23) are divided into three groups, the first group of holes (231) are formed in the front end of the D-shaped inner wall, the second group of holes (232) are formed in two sides of the D-shaped inner wall, the third group of holes (233) are formed in the rear end of the D-shaped inner wall, and the diameters of the first group of holes (231), the second group of holes (232) and the third group of holes (233) are sequentially decreased, and the depths of the holes are sequentially decreased.
3. 3. The self-powered electro-stimulated bionic intervertebral disc of claim 1, wherein the collagen fibers (212), the collagen fiber matrix layer (211) and the collagen fiber transition region (23) are printed according to the order of hardness from large to small, and mechanical support is provided for contact and separation of the inner wall of the collagen fiber transition region (23) and the nucleus pulposus (22).
4. 4. A self-powered electro-stimulated bionic disc according to claim 3, wherein the upper endplate (1) and the lower endplate (3) are made of electrically hard materials.
5. 5. The self-powered electro-stimulated bionic intervertebral disc of claim 4, wherein the upper endplate (1) and the lower endplate (3) are made of medical titanium alloy.
6. 6. The self-powered electro-stimulated bionic disc according to claim 2, wherein the first set of holes (231) has a side length of 1.2mm and a depth of 2.0mm, the second set of holes (232) has a side length of 1.0mm and a depth of 1.5mm, and the third set of holes (233) has a side length of 0.8mm and a depth of 1.0mm.
7. 7. The self-powered electro-stimulated bionic disc according to claim 1, wherein the collagen fiber matrix layer (211), the collagen fibers (212) and the collagen fiber transition region (23) are made of polymer materials.
8. 8. A self-powered electro-stimulated bionic disc according to claim 1, wherein the nucleus pulposus (22) is made of a conductive hydrogel material.

Description

Self-powered electric stimulation bionic intervertebral disc Technical Field The invention relates to the technical field of implanted medical instruments, in particular to a self-powered electro-stimulated bionic intervertebral disc. Background Lower back pain caused by disc degeneration has become a global public health problem. Artificial disc replacement is one of the clinically effective treatment regimens because of its advantage of preserving motion of the lumbar spine segment. Literature studies show that the traditional artificial intervertebral disc prosthesis has an essential difference from a natural intervertebral disc in terms of structure-material-function, for example, the traditional artificial intervertebral disc prosthesis mostly adopts a limiting structure, mainly adopts a combination of non-bionic materials and single materials, has homogeneous rigidity, and has limitations on biomechanical suitability and long-term stability. In recent years, the bionic intervertebral disc based on natural intervertebral disc heuristic is rapidly developed and becomes an important direction for developing intervertebral disc prostheses, the bionic intervertebral disc simulates and reproduces the structure and mechanical properties of the natural intervertebral disc to a certain extent, and the matching property between the bionic intervertebral disc and the three-dimensional physiological motion of the spinal column segment after implantation is greatly improved. However, in the case of lumbar disc replacement, the existing bionic disc is mainly connected and fixed to the vertebrae of a person through the tooth-shaped protrusions provided on the upper and lower endplates. Although the surface of the protrusion of the end plate is often coated with a coating (such as a hydroxyapatite coating) to promote the osseointegration between the bionic intervertebral disc and the vertebrae, the problems of low speed, unsatisfactory effect and the like of bone tissue growth on the interface of the bionic intervertebral disc and the vertebrae generally exist, so that the bionic intervertebral disc is difficult to firmly anchor on the vertebrae, and complications such as postoperative sinking and loosening are finally caused. The electric stimulation technology has great potential in the medical field as an important biophysical regulating factor and a non-drug intervention means in clinical environment. The technology has remarkable capabilities of influencing cell activity and promoting tissue repair, and has important help for promoting bone cell fusion after bionic intervertebral disc implantation, thereby improving intervertebral disc stability. Traditional electrical stimulation therapies rely on cumbersome equipment and specific instrumentation, reducing patient comfort and limiting personalized therapy, impeding their further clinical use. In recent years, the advent of self-powered technologies, based on friction nano-generation technology, opens up new possibilities for implantable applications of electro-stimulated medical devices. The technology can directly convert mechanical energy into electric energy, and realize self supply and utilization of energy. The patent of the invention, which is entitled "in-vivo service movement and stress state personalized self-monitoring intelligent bionic intervertebral disc" with bulletin number CN118902703B, discloses an intelligent bionic intervertebral disc which can have a real-time continuous monitoring function (including direction, angle and external load change). Under the enlightenment of the technical proposal of the invention, on the basis of developing a novel artificial intervertebral disc which is close to the characteristics of a natural intervertebral disc, an endogenous electric field is endowed, namely, a self-powered electric stimulation bionic intervertebral disc is developed, and the artificial intervertebral disc has important scientific significance and clinical value for the short-term rehabilitation process and the long-term movement stability of patients after intervertebral disc operation, and can further promote the integration of bone tissues between the bionic intervertebral disc and a human body interface. Disclosure of Invention The invention aims to solve the problems that the existing bionic intervertebral disc still has complications such as sinking, loosening and the like after an intervertebral disc replacement operation, and provides a self-powered electric stimulation bionic intervertebral disc. A self-powered electro-stimulated bionic intervertebral disc comprises an upper endplate, an intervertebral disc core and a lower endplate. The upper end plate is provided with upper end plate fixing teeth. The intervertebral disc core comprises an annulus fibrosus, a nucleus pulposus and a collagen fiber transition zone, wherein the annulus fibrosus is used as a peripheral structure of the intervertebral disc core to form a closed inner