CN-121970748-A - Application of nitrostyrene compound in prevention and/or control of pathogenic microorganisms and medicine

Abstract

The invention discloses application of nitrostyrenes compounds in preventing and/or controlling pathogenic microorganisms, a medicament, a pharmaceutical preparation containing the nitrostyrenes compounds, and relates to the technical field of pharmaceutical chemistry, the nitrostyrene compound discovered by the invention is easy to synthesize, has broad spectrum of pathogenic microorganisms, has better application prospect in the aspect of preventing and controlling agricultural pathogenic fungi, agricultural pathogenic bacteria and agricultural pathogenic nematodes, and is hopeful to be developed into a novel antibacterial or nematicidal active ingredient.

Inventors

• LIU YINGQIAN
• SUN YUCHEN
• ZHANG YUE
• ZHANG BAOQI
• MOU GUOLIANG
• ZHANG ZHIJUN
• ZHANG LIJING
• YANG LIU

Assignees

• 广西田园生化股份有限公司

Dates

Publication Date

20260505

Application Date

20260122

Claims (10)

1. 1. Use of nitrostyrenes for the prevention and/or control of pathogenic microorganisms, characterized in that the nitrostyrenes have a structure selected from the group consisting of: 。
2. 2. the use according to claim 1, wherein the nitrostyrene structure is selected from the group consisting of: 。
3. 3. The use according to claim 1, wherein the pathogenic microorganisms comprise agricultural pathogenic fungi, agricultural pathogenic bacteria, agricultural pathogenic nematodes.
4. 4. Use according to claim 3, wherein the agropathogenic fungi comprise rhizoctonia solani Rhizoctonia solani, sclerotinia sclerotiorum Sclerotinia sclerotiorum, botrytis cinerea, fusarium graminearum Fusarium graminearum, fusarium graminearum Magnaporthe oryzae and fusarium graminearum Fusarium pseudograminearum.
5. 5. The use according to claim 3, wherein said agricultural pathogenic bacteria include rice bacterial blight Xanthomonas oryzae PXO a, citrus canker Xanthomonas axonopodis jx-6 and pseudomonas solanacearum Pseudomonas solanacearum.
6. 6. The use according to claim 3, wherein the agropathogenic nematodes are at least one of meloidogyne incognita Meloidogyne incongnita, pine wood nematodes Busaphelenchus xylophilus.
7. 7. A pharmaceutical preparation for preventing and/or controlling pathogenic microorganisms, which is characterized by comprising the nitrostyrenes compound according to claim 1-6.
8. 8. The pharmaceutical preparation according to claim 7, wherein the nitrostyrene compound is used as the only active ingredient and the weight percentage of the nitrostyrene compound is 1-99%.
9. 9. The pharmaceutical formulation of claim 7, further comprising a pharmaceutically acceptable adjuvant selected from one or more of a dispersant, a wetting agent, a filler, an emulsifier, a thickener, a dispersion medium, a disintegrant, a solvent, a preservative, an antifreeze, a specific gravity regulator, an antifoaming agent, an oil phase wall, an aqueous phase wall, and water.
10. 10. The pharmaceutical formulation of claim 7, wherein the formulation of the pharmaceutical formulation is one of a granule, a dry suspension, an aqueous suspension, a dispersible oil suspension, a microcapsule suspension, a wettable powder, an emulsifiable concentrate, an aqueous emulsion, a water dispersible granule, a seed treatment.

Description

Application of nitrostyrene compound in prevention and/or control of pathogenic microorganisms and medicine Technical Field The invention relates to the technical field of pharmaceutical chemistry, relates to application of nitrostyrenes compounds in preventing and/or controlling pathogenic microorganisms, and in particular relates to application of nitrostyrenes compounds in preventing and/or controlling pathogenic microorganisms and a medicament. Background Pathogenic microorganisms are widely used as micro-organism groups in nature, cover various types of fungi, bacteria, nematodes, viruses and the like, attack on the core field of human society is never stopped, and sustainable and cross-field serious threats are formed for key industries such as agricultural production, medical treatment and health and the like. In the agricultural field, diseases caused by various pathogenic microorganisms have become one of the core bottlenecks restricting global grain safety and agricultural product quality improvement. The seedling blight caused by fungi can infect various crops such as wheat, cotton, vegetables and the like, so that seedlings die, the field emergence rate is greatly reduced, the sclerotium disease of rape is taken as a typical fungal disease, and can spread in the flowering and pod forming period of rape, the stalk and the pod are destroyed, the yield of the rape can be reduced by more than 30% when serious, the quality of the rape is also influenced, the bacterial leaf blight of rice is caused by xanthomonas, the bacterial leaf spot of the rice appears after the infection is spread through wind, rain and agriculture operation, photosynthesis is hindered, and the empty shell rate of the rice is directly increased. In addition, nematode diseases are not ignored, groups such as root knot nematodes can be parasitic on crop roots to form root knots and destroy nutrient absorption channels, so that crop growth vigor is weakened, stress resistance is reduced, crop yield reduction risks are further aggravated, and outbreaks of the diseases not only affect farmer income, but also form challenges for the stability of a global grain supply chain. Therefore, scientific, effective and accurate prevention and control of various pathogenic microorganisms are provided, and the method is a basis for guaranteeing high-quality and safe supply of agricultural products and stabilizing agricultural production order. Currently, chemical bactericides, nematicides and various antibacterial drugs have the advantages of direct effect and quick response by virtue of the effect, are still the main stream means for preventing and controlling pathogenic microorganisms in the global scope, and play an irreplaceable role in agricultural pest control and clinical infection treatment. However, for a long time, whether the dosage is increased blindly for pursuing high yield in agricultural production, the administration period is prolonged, or the phenomenon that antibacterial drugs are unreasonably used in medical clinic, a common problem, namely the continuous enhancement of drug resistance of pathogenic microorganisms, is caused. From the mechanism, the selective pressure of single medicine can promote the survival and mass propagation of drug-resistant mutant strains in pathogenic microorganism groups, and meanwhile, the drug-resistant group can be further expanded through the transmission of drug-resistant genes among different strains, so that the prevention and treatment effect of the medicine is finally reduced year by year, the dosage of the medicine is forced to be increased continuously, and the vicious circle of 'medicine-drug resistance-dosing-more serious medicine resistance' is formed. The cycle not only continuously increases the infection rate and the disease severity of pathogenic microorganisms in agricultural production, but also increases the production cost and the environmental pressure, and further causes the treatment of infectious diseases to be in dilemma in the medical field, thereby further aggravating public health risks. Therefore, in order to break through the limitation of the traditional medicines, the research and development of novel, efficient, safe and low-drug-resistance sterilization/nematicide and antibacterial medicines have become the core direction and urgent need of scientific research work in the fields of agricultural plant protection, medicine research and development and the like. Disclosure of Invention Aiming at the defects, the invention provides application and a medicament of nitrostyrene compounds in preventing and/or controlling agricultural pathogenic fungi, agricultural pathogenic bacteria and agricultural pathogenic nematodes, solves the problems of large dosage, poor control effect and easy drug resistance of the existing microbial antibacterial agent, can be used for controlling various diseases caused by pathogenic microorganisms, and has the following specific technical