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CN-121970760-A - Fluoconazole and thixotrope mixed composition and application thereof in treatment of sigatoka

CN121970760ACN 121970760 ACN121970760 ACN 121970760ACN-121970760-A

Abstract

The invention relates to the technical field of banana leaf spot disease control, and discloses a epoxiconazole and thixotrope mixed composition and application thereof to treatment of banana leaf spot disease, wherein the composition comprises the following components in percentage by mass: 26% -34% of active composition, 1% -3% of wetting agent, 3% -7% of dispersing composition, 0.1% -0.5% of thickener, 0.3% -0.8% of magnesium aluminum silicate and the balance of deionized water, wherein the active composition consists of epoxiconazole and thixotrope. The triazole action mechanism of the epoxiconazole is used for inhibiting the synthesis of fungus ergosterol, simultaneously copper ions released by the thixotrope are combined to destroy the cell membrane protein structure of bacteria, double killing of cercospora banana and pathogenic bacteria is realized, and the synergistic compounding of the epoxiconazole and the thixotrope realizes the broad-spectrum prevention and control of fungi and bacteria, so that the limitation of a single medicament is broken through, the efficient broad-spectrum prevention and control of a mixed pathogenic system is realized, and the development of drug resistance is obviously delayed.

Inventors

  • ZHANG HONG

Assignees

  • 浙江东风化工有限公司

Dates

Publication Date
20260505
Application Date
20260331

Claims (10)

  1. 1. The epoxiconazole and thixotrope mixed composition is characterized by comprising the following components in percentage by mass: 26-34% of active composition, 1-3% of wetting agent, 3-7% of dispersing composition, 0.1-0.5% of thickener, 0.3-0.8% of magnesium aluminum silicate and the balance of deionized water; Wherein the active composition consists of epoxiconazole and thixotrope, 8-12% of epoxiconazole and 18-22% of thixotrope; The dispersion composition consists of methylene bisacrylamide and cellulose sodium sulfate, 2-4% of methylene bisacrylamide and 1-3% of cellulose sodium sulfate; The wetting agent is sodium dodecyl benzene sulfonate, and the thickening agent is xanthan gum; the thixotropic index of the composition is 1.8-2.2, the suspension rate is more than or equal to 96%, and the atomization particle diameter CV value is less than or equal to 12%; The epoxiconazole is a nano-scale crystal particle, the particle diameter D 90 is less than or equal to 1 mu m, the purity is more than or equal to 98%, the thixotrope is a surface modified copper complex, the specific surface area is more than or equal to 8m 2 /g, and the copper ion release rate is stabilized at 0.15-0.20 mg/(cm 2 . D).
  2. 2. The epoxiconazole and thixotrope mixed composition of claim 1, wherein the sulfonation degree of cellulose sodium sulfate is 1.2-1.8 mmol/g, the substitution degree is more than or equal to 0.85, the mass ratio of the cellulose sodium sulfate to methylene bisacrylamide is 1:1.5-2.5, a three-dimensional crosslinked network is formed, and the Zeta potential of an active ingredient is stabilized at-40 mV to-45 mV.
  3. 3. The epoxiconazole and thixotrope mixed composition of claim 1, wherein the magnesium aluminum silicate is a layered silicate modified material, the interlayer spacing is 1.2-1.8 nm, and the adsorption capacity is more than or equal to 200mg/g after surface hydroxylation treatment, so as to inhibit the crystal form transformation of the epoxiconazole.
  4. 4. A method for preparing a epoxiconazole and thixotrope compound composition, which is characterized by being used for the epoxiconazole and thixotrope compound composition as claimed in any one of claims 1 to 3, and comprising the following steps: Step one, placing a epoxiconazole raw material in a liquid nitrogen environment for superfine grinding for 20-30 minutes to obtain nanoscale crystal particles with the particle diameter D 90 less than or equal to 1 mu m, wherein the purity is more than or equal to 98%, and simultaneously, mixing the thixotrope and polyethylene glycol-6000 according to the mass ratio of 1:0.05; Secondly, adding the epoxiconazole, the thixotrope and 30% of total water into a high-speed shearing emulsifying machine, shearing and dispersing for 25 minutes at a rotating speed of 3000-4000 rpm under the protection of nitrogen, and strictly controlling the temperature at 28-32 ℃ so as to prevent degradation of active ingredients; Sequentially adding sodium dodecyl benzene sulfonate, methylene bisacrylamide and cellulose sodium sulfate after pre-dispersion is completed, starting a two-stage grinding process, then heating to 60-65 ℃, switching to nano silicon carbide beads, and continuously grinding until the particle size D 90 is less than or equal to 5 mu m, wherein the specific surface area of the particles reaches 5.0-5.8 m 2 /g, and obviously improving the penetrability of the liquid medicine on a leaf surface waxy layer; step four, after finishing grinding, adding the layered magnesium aluminum silicate and the xanthan gum which are subjected to hydroxylation treatment into a system, adopting a stepped thickening process, and then carrying out homogenizing circulation for 4 times under high pressure of 35MPa to ensure that the surface roughness of particles is less than or equal to 0.08 mu m, and ensuring that the preparation is stored for a long time without sedimentation; And fifthly, supplementing the rest deionized water, filtering to remove impurities through a 0.2 mu m microfiltration membrane, filling into a light-resistant container, filling nitrogen and sealing to prepare the stable suspending agent with the thixotropic index of 1.8-2.2 and the suspension rate of more than or equal to 96%.
  5. 5. The method for preparing a epoxiconazole and thixotrope mixed composition according to claim 4, wherein in the fourth step, the viscosity is detected by standing for 10 minutes after 0.05% of xanthan gum is added until the viscosity of the system is stabilized at 800-1500 mPa.s (25 ℃).
  6. 6. The method for preparing a epoxiconazole and thixotrope compounded composition according to claim 4, wherein in the third step, the two-stage grinding comprises: The first stage is to grind the mixture at the temperature of 40-50 ℃ until the grain diameter D 90 is less than or equal to 10 mu m; the second stage is to grind the mixture at 55-65 ℃ until the grain diameter D 90 is less than or equal to 5 mu m; wherein the specific surface area of the particles after two-stage grinding is 4.5-5.8 m < 2 >/g, and the surface roughness is less than or equal to 0.1 mu m.
  7. 7. The method for preparing a epoxiconazole and thixotrope mixed composition according to claim 4, wherein in the first step, after the thixotrope is mixed with polyethylene glycol-6000, the mixture is stirred for 2 hours at 50-60 ℃ to form a surface modified copper complex, the copper ion slow-release rate is ensured to be stabilized at 0.15-0.20 mg/(cm 2 -d), and the copper ion slow-release rate deviation of the modified thixotrope is less than or equal to 5%.
  8. 8. The method for preparing a epoxiconazole and thixotrope mixed composition according to claim 4, wherein in the fourth step, layered magnesium aluminum silicate has an interlayer spacing of 1.2-1.8 nm and an adsorption capacity of not less than 200mg/g.
  9. 9. Use of a epoxiconazole and thixotrope compounded composition according to any one of claims 1 to 3, characterized in that it is used in a epoxiconazole and thixotrope compounded composition: the epoxiconazole and thixotrope mixed composition is used for treating the sigatoka and comprises the following steps of: Cleaning the surfaces of banana leaves with 0.1% citric acid solution to remove waxy layer impurities; Diluting the composition according to a ratio of 1:500-1:800, adding 0.1% of organic silicon auxiliary agent, and adjusting the pH to 6.0-6.5; Controlling the particle size of the fog drops to be 50-100 mu m by adopting ultra-low-volume spraying equipment, spraying at the pressure of 0.3-0.5 MPa, and controlling the application amount to be 250-350L/ha; The first application is carried out at the initial disease stage, the second application is carried out at intervals of 10 days, the continuous application is carried out for 3 times, the liquid medicine penetration depth is more than or equal to 80 mu m, and the lasting period is more than or equal to 15 days.
  10. 10. The preparation method of the epoxiconazole and thixotrope mixed composition according to claim 9, wherein the organosilicon auxiliary agent enables the contact angle of the liquid medicine on the surface of the blade to be less than or equal to 20 degrees, and the control efficiency is more than or equal to 95 percent.

Description

Fluoconazole and thixotrope mixed composition and application thereof in treatment of sigatoka Technical Field The invention relates to the technical field of banana leaf spot disease control, in particular to a epoxiconazole and thixotrope mixed composition and application thereof to treatment of banana leaf spot disease. Background Bananas are one of the world's important fruit crops, widely cultivated in tropical and subtropical regions of the world. However, sigatoka is one of the most serious diseases in banana production, severely affecting banana yield and quality. Sigatoka is a complex disease caused by mixed infestations of a variety of fungi and bacteria. Common pathogenic bacteria include fungi such as cercospora banana, and some pathogenic varieties of bacteria. At the initial stage of disease, water stain-like small points appear on banana leaves, then the banana leaves gradually expand into oval or irregular disease spots, and when serious, the disease spots are connected, so that the leaves are withered and yellow and are presenility, the photosynthesis of banana plants is affected, the fruits are maldeveloped, and the yield is greatly reduced. At present, the prevention and treatment of the sigatoka mainly depend on chemical agents, however, epoxiconazole is used alone for a long time, pathogenic bacteria are easy to induce to generate drug resistance, the prevention and treatment effect is reduced, and meanwhile, the epoxiconazole has little prevention and treatment effect on bacterial pathogenic bacteria in the sigatoka. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a epoxiconazole and thixotrope mixed composition and application thereof to treatment of sigatoka, and solves the problems that the epoxiconazole is singly used for a long time, pathogenic bacteria are easy to induce to generate drug resistance and the control effect is reduced. The invention aims at realizing the purposes by adopting the following technical scheme that the epoxiconazole and thixotrope mixed composition comprises the following components in percentage by mass: 26-34% of active composition, 1-3% of wetting agent, 3-7% of dispersing composition, 0.1-0.5% of thickener, 0.3-0.8% of magnesium aluminum silicate and the balance of deionized water; Wherein the active composition consists of epoxiconazole and thixotrope, 8-12% of epoxiconazole and 18-22% of thixotrope; The dispersion composition consists of methylene bisacrylamide and cellulose sodium sulfate, 2-4% of methylene bisacrylamide and 1-3% of cellulose sodium sulfate; The wetting agent is sodium dodecyl benzene sulfonate, and the thickening agent is xanthan gum; the thixotropic index of the composition is 1.8-2.2, the suspension rate is more than or equal to 96%, and the atomization particle diameter CV value is less than or equal to 12%; The epoxiconazole is a nano-scale crystal particle, the particle diameter D90 is less than or equal to 1 mu m, the purity is more than or equal to 98%, the thixotrope is a surface modified copper complex, the specific surface area is more than or equal to 8m <2 >/g, and the copper ion release rate is stabilized at 0.15-0.20 mg/(cm 2. D). According to the technical scheme, the proportion of the active composition ensures that the synergistic toxicity index is more than or equal to 120, epoxiconazole EC 50 is reduced to 0.85 mug/mL (single dose of 1.52 mug/mL), the slow-release rate of the copper ion of the thixotrope is stabilized at 0.18 mg/(cm < 2 >. D), and the single dose prevention and control limitation is broken through; dispersing the composition, inhibiting aggregation of active ingredients by a three-dimensional crosslinked network, stabilizing Zeta potential at-40 mV to-45 mV, and controlling the suspension rate to be more than or equal to 96 percent (the conventional preparation is less than or equal to 90 percent); the surface tension of the wetting agent and the thickening agent is reduced to 28mN/m, the CV value of the atomized particle diameter is less than or equal to 12 percent (the industry standard is less than or equal to 20 percent), and the uniformity of the leaf surface coverage is improved. Preferably, the sulfonation degree of the cellulose sodium sulfate salt is 1.2-1.8 mmol/g, the substitution degree is more than or equal to 0.85, the mass ratio of the cellulose sodium sulfate salt to the methylenebisacrylamide is 1:1.5-2.5, a three-dimensional cross-linked network is formed, and the Zeta potential of the active ingredient is stabilized at-40 mV to-45 mV. According to the technical scheme, the cellulose sodium sulfate has the advantages that the anion adsorption capacity is enhanced due to high sulfonation degree, the crosslinking density is optimized according to the mass ratio of 1:1.5-2.5, and the grinding energy consumption is reduced by 30%. Preferably, the magnesium aluminum silicate is a layered silicate modified material, the interlayer spacing is 1.