CN-121970776-A - Calcium hypochlorite sustained release tablet and preparation method thereof

CN121970776ACN 121970776 ACN121970776 ACN 121970776ACN-121970776-A

Abstract

The invention discloses a calcium hypochlorite sustained release tablet and a preparation method thereof, which relate to the field of calcium hypochlorite sustained release medicaments and aim at solving the problem of short limited chlorine release period in the prior art. The calcium hypochlorite is compounded into the slow release system, so that the release of the available chlorine is more uniform, the release period of the available chlorine is prolonged, the release period of the available chlorine can be further prolonged by the high-content calcium hypochlorite, and the pH of the system can be more uniform by drying, sieving and adjusting the mixing sequence of raw materials.

Inventors

LIU GUANRUI
WANG GONGKE
CHENG KANG
LIU HAIWU
HAO TONGHUI
YAN FUQUAN

Assignees

河南智水同创科技有限公司

Dates

Publication Date: 20260505
Application Date: 20260212

Claims (9)

1. The calcium hypochlorite sustained release tablet is characterized by comprising the following components: calcium hypochlorite, calcium hydroxide, copper sulfate, bentonite, carboxymethyl cellulose, an adhesive and a water-retaining agent; wherein the mass ratio of bentonite to carboxymethyl cellulose is 4:1, and the pH value of the calcium hypochlorite sustained release tablet is controlled to be 8-9 by the calcium hydroxide; The calcium hypochlorite sustained release tablet has the advantages that the loss rate of the available chlorine after mixing the components is not more than 2.5%, the release uniformity of the available chlorine is not more than 5%, the tablet hardness is 30-40 HR, the system precipitation generation rate is not more than 1.5%, and the available chlorine sustained release period is not shorter than 30 hours.
2. The calcium hypochlorite sustained-release tablet according to claim 1, wherein the binder is starch slurry, the mass fraction of the binder is not more than 3%, and the water-retaining agent is a microparticle aerogel water-retaining agent, and is prepared by compounding nano silicon dioxide and sodium polyacrylate.
3. The calcium hypochlorite sustained-release tablet according to claim 1 or 2, wherein the following components are mixed according to parts by weight: 55 parts of calcium hypochlorite, 20 parts of calcium hydroxide, 3 parts of copper sulfate, 12 parts of bentonite, 3 parts of carboxymethyl cellulose, 2 parts of adhesive and 5 parts of water-retaining agent.
4. A method for preparing the calcium hypochlorite sustained release tablet according to claim 1, comprising the steps of: step 1, the raw materials are pretreated, Respectively drying and sieving calcium hypochlorite powder, calcium hydroxide and copper sulfate, wherein the water content of the calcium hypochlorite is controlled to be not higher than 2%, grinding bentonite and sieving the bentonite, drying the bentonite, grinding carboxymethyl cellulose and sieving the carboxymethyl cellulose; Step 2, mixing ingredients, The calcium hypochlorite, the calcium hydroxide, the copper sulfate, the bentonite, the carboxymethyl cellulose and the water-retaining agent are weighed according to the weight parts and are uniformly mixed to obtain mixed powder; step 3, granulating, Adding an adhesive into the mixed powder obtained in the step 2, stirring to form a wet soft material, and extruding and granulating to obtain wet particles with uniform particle size; Step 4, drying the mixture, And (3) drying the wet granules obtained in the step (3) to obtain dry granules with the water content of 3-4%.
5. The method according to claim 4, wherein in step 1, a starch slurry having a mass concentration of 10% is also prepared.
6. The method of claim 4, wherein in the step 1, the calcium hypochlorite powder is sieved by a 200-mesh sieve, large-particle impurities and caking are removed, and the calcium hypochlorite powder is dried in a drying oven at 50-55 ℃ for 3 hours, and the water content is controlled to be less than or equal to 2 percent for later use; sieving calcium hydroxide and copper sulfate with 180 mesh sieve, and drying; grinding bentonite, sieving with 180 mesh sieve, and drying at 60deg.C for 2 hr; and grinding carboxymethyl cellulose, and sieving with 180 mesh sieve for use.
7. The method of claim 4, wherein in step 2, dry-mixing is performed in a high-speed mixer, the high-speed mixer rotates at a speed of 300rpm, calcium hypochlorite, bentonite and carboxymethyl cellulose are dry-mixed for 10min, then calcium hydroxide, copper sulfate and water-retaining agent are added, and the total dry-mixing time is prolonged to 15-20min.
8. The method according to claim 4, wherein in the step 3, the wet soft material is extruded through a 16-mesh sieve for granulation.
9. The method of claim 4, wherein the dried granules obtained in step 4 are fed into a tablet press after being removed of fine powder and agglomeration, and the tabletting pressure is adjusted to 7-9MPa, and the granules are pressed into tablets.

Description

Calcium hypochlorite sustained release tablet and preparation method thereof Technical Field The invention relates to the technical field of calcium hypochlorite sustained release medicament, in particular to a calcium hypochlorite sustained release tablet and a preparation method thereof. Background The traditional calcium hypochlorite products are mostly in powder form, and have obvious defects of short disinfection duration time caused by too high release rate of available chlorine, frequent supplement, easy secondary pollution caused by too high local concentration, corrosiveness to metal, easy decomposition due to temperature and humidity in the storage process, quick loss of active ingredients, manual proportioning during use, complex operation and difficult accurate control of dosage. In order to solve the above problems, in the prior art (for example, chinese patent CN 107047614B), there is a solution for preparing slow release disinfectant from calcium hypochlorite, hydroxide, bentonite, carboxymethyl cellulose, etc., which can effectively solve the above problems, but if the content of calcium hypochlorite is low, the effective chlorine release duration is short, if the content of calcium hypochlorite is increased (for example, to more than 50%), after mixing with alkaline auxiliary material (hydroxide), the effective chlorine is easily decomposed in advance due to exceeding of local humidity, and the soft material is easily agglomerated in the granulating process, and has poor fluidity. Disclosure of Invention The invention aims to overcome the existing defects, and provides a calcium hypochlorite sustained-release tablet and a preparation method thereof, which can effectively solve the problems in the background art. In order to achieve the aim, the invention firstly discloses a calcium hypochlorite sustained release tablet, which adopts the technical scheme that the tablet comprises the following components: calcium hypochlorite, calcium hydroxide, copper sulfate, bentonite, carboxymethyl cellulose, an adhesive and a water-retaining agent; wherein the mass ratio of bentonite to carboxymethyl cellulose is 4:1, and the pH value of the calcium hypochlorite sustained release tablet is controlled to be 8-9 by the calcium hydroxide; The calcium hypochlorite sustained release tablet has the advantages that the loss rate of the available chlorine after mixing the components is not more than 2.5%, the release uniformity of the available chlorine is not more than 5%, the tablet hardness is 30-40 HR, the system precipitation generation rate is not more than 1.5%, and the available chlorine sustained release period is not shorter than 30 hours. The release rate of available chlorine can be influenced by the proportion of bentonite to carboxymethyl cellulose, if the bentonite is too much, the problem of excessive slow release can occur, so that the release of available chlorine is insufficient, and if the bentonite is too little or the pretreatment degree of the bentonite and the carboxymethyl cellulose is smaller, the slow release failure can be caused, so that the release of available chlorine is too fast, and the tablet hardness is lower. By controlling the mass ratio of bentonite to carboxymethyl cellulose, a proper slow-release effect can be obtained. As a preferable technical scheme of the invention, the adhesive is starch slurry, the mass fraction of the adhesive is not more than 3%, and the water-retaining agent is a microparticle aerogel water-retaining agent and is prepared by compounding nano silicon dioxide and sodium polyacrylate. As a preferable technical scheme of the invention, the components are as follows in parts by weight: 55 parts of calcium hypochlorite, 20 parts of calcium hydroxide, 3 parts of copper sulfate, 12 parts of bentonite, 3 parts of carboxymethyl cellulose, 2 parts of adhesive and 5 parts of water-retaining agent. The invention also discloses a preparation method of the calcium hypochlorite sustained-release tablet, which adopts the technical scheme that the preparation method comprises the following steps: step 1, the raw materials are pretreated, Respectively drying and sieving calcium hypochlorite powder, calcium hydroxide and copper sulfate, wherein the water content of the calcium hypochlorite is controlled to be not higher than 2%, grinding bentonite and sieving the bentonite, drying the bentonite, grinding carboxymethyl cellulose and sieving the carboxymethyl cellulose; Step 2, mixing ingredients, The calcium hypochlorite, the calcium hydroxide, the copper sulfate, the bentonite, the carboxymethyl cellulose and the water-retaining agent are weighed according to the weight parts and are uniformly mixed to obtain mixed powder; step 3, granulating, Adding an adhesive into the mixed powder obtained in the step 2, stirring to form a wet soft material, and extruding and granulating to obtain wet particles with uniform particle size; Step 4, drying the mixture, And (3) dryi