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CN-121970829-A - Pet food compositions

CN121970829ACN 121970829 ACN121970829 ACN 121970829ACN-121970829-A

Abstract

Described herein are controlled release pet food compositions comprising a matrix comprising a fiber component comprising a high-solubility fiber source and a low-solubility fiber source, and a polyphenol source, wherein the matrix is adapted to deliver the polyphenol source to the lower Gastrointestinal (GI) tract of a mammal after ingestion by the mammal. Methods of making and using these compositions are also described.

Inventors

  • MATTHEW JACKSON
  • DENNIS EDWARD JEWELL

Assignees

  • 希尔氏宠物营养品公司

Dates

Publication Date
20260505
Application Date
20151230

Claims (10)

  1. 1. A controlled release pet food composition comprising: A substrate, the substrate comprising: A fibrous component comprising a high-solubility fibrous source and a low-solubility fibrous source, and A polyphenol source; wherein the matrix is adapted to deliver the polyphenol source to the lower Gastrointestinal (GI) tract of a mammal after ingestion by the mammal.
  2. 2. The pet food composition of claim 1, wherein the weight ratio of the high-solubility fiber source to the low-solubility fiber source is: (i) About 1:20 to about 1:1; (ii) About 1:15 to about 1:2; (iii) About 1:10 to about 1:3, or (Iv) About 1:5 to about 1:3.
  3. 3. The pet food composition of claim 1, wherein the weight ratio of the high-solubility fiber source to the low-solubility fiber source is about 1:4.
  4. 4. The pet food composition of any preceding claim, wherein: (i) The high-solubility fiber source comprises oat bran, buckwheat kernel, pea bran, barley, tomato pomace, citrus pulp, beet pulp, and combinations of two or more thereof, and/or (Ii) The low-solubility fiber source comprises cellulosic material, hickory fiber, or a combination thereof.
  5. 5. The pet food composition of any preceding claim, wherein: (i) The polyphenol source is of food or plant origin, optionally including polyphenols of fruit or vegetable origin; (ii) The polyphenol source comprises flavonoids or phenolic acids, and/or (Iii) The polyphenol source provides a polyphenol selected from the group consisting of dehydroxylated rosmarinic acid, coumaroyl pseudoschizonepeta glycoside, eupatorium lutein, carnosol, scutellarin, kaempferol, rosmarinic acid, thistle flavin, luteolin, 6-methoxy-luteolin, 7-epi-rosmarinic acid, quercetin, catechin, hesperidin, cyanidin, and combinations of two or more thereof.
  6. 6. The pet food composition of any preceding claim, further comprising a hydrolyzed animal or plant protein source comprising an amino acid profile, optionally wherein the hydrolyzed animal or plant protein source comprises chicken liver, optionally wherein the hydrolyzed animal or plant protein source is present at about 25% to about 45% by weight active content.
  7. 7. The pet food composition of any preceding claim, wherein the active content of the high docosahexaenoic acid fish oil is from about 0.5 to about 2.5% by weight.
  8. 8. Use of an effective amount of the composition of any one of claims 1 to 7 for the manufacture of a medicament for treating, preventing or ameliorating a symptom of an inflammatory disease, disorder or condition in a mammal, wherein the medicament is formulated for administration to a mammal in need thereof, wherein the mammal is a canine or a feline.
  9. 9. Use of an effective amount of the composition according to any one of claims 1 to 7 for the manufacture of a medicament for beneficially manipulating the intestinal microbiota of a mammal, wherein the medicament is formulated for administration to a mammal in need thereof, wherein the mammal is a canine or a feline.
  10. 10. A method of forming a pet food composition comprising the steps of: extruding a matrix, the matrix comprising: A fibrous component comprising a high-solubility fibrous source and a low-solubility fibrous source, and A polyphenol source; Applying a surface coating to the coarse abrasive particles; wherein the matrix is adapted to deliver the polyphenol source to the lower Gastrointestinal (GI) tract of a mammal after ingestion by the mammal.

Description

Pet food compositions The application is a divisional application of Chinese patent application with the application date of 2015, 12 months and 30 days, the application number of 201580085631.0 and the name of 'pet food composition'. Technical Field The present invention relates to a pet food composition. Background The pet needs a healthy diet and proper digestion to maintain growth and normal health. However, gastrointestinal discomfort often prevents normal digestion of ordinary pet food compositions. Some of these problems, such as Inflammatory Bowel Disease (IBD) and other chronic digestive disorders, can be very severe. IBD is often accompanied by diarrhea, which can be very unpleasant for the pet carrying the disorder or for the pet owner who must follow the pet for cleaning, especially in the case of chronic diseases. One mechanism for treating IBD and improving the inflammatory state of pets is by the administration of beneficial agents such as drugs, prebiotics, probiotics, and the like, via conventional pet food compositions. However, ensuring delivery of beneficial agents to a target site has been challenging. Thus, there is a need for pet food compositions that are capable of controlling the release of beneficial agents and ensuring delivery of the beneficial agents to a target site. Embodiments of the present invention are designed to meet these needs. Disclosure of Invention In some embodiments, the present invention provides a controlled release pet food composition comprising a matrix comprising a fibrous component comprising a high solubility fiber source and a low solubility fiber source, and a polyphenol source, wherein the matrix is adapted to deliver the polyphenol source to the lower Gastrointestinal (GI) tract of a mammal after ingestion by the mammal. Other embodiments provide a method of forming a pet food composition comprising the steps of extruding a matrix composition to form controlled release kibbles, the matrix composition comprising a fibrous component comprising a high-solubility fiber source and a low-solubility fiber source, and a polyphenol source, wherein the matrix is adapted to ensure that the polyphenol source is not easily digested or absorbed in the upper Gastrointestinal (GI) tract of a mammal when ingested by the mammal, and applying a surface coating to the kibbles. Further embodiments provide a method for treating, preventing or ameliorating a symptom of an inflammatory disease, disorder or condition, such as inflammatory bowel disease, in a mammal, comprising administering any of the compositions described herein to a mammal, such as a companion animal, in need thereof. Some embodiments provide a method of beneficially manipulating the intestinal microbiota of a mammal comprising administering any of the compositions described herein to a mammal, such as a companion animal, in need thereof. Drawings Figures 1A, 1B and 1C depict data showing that exemplary compositions of the present invention successfully provide polyphenols to the colon, which are metabolized by the intestinal microbiota in which they reside. Figures 2A, 2B and 2C depict data showing that exemplary compositions of the present invention provide elevated serum levels of microbial probiotics (post-biotics). Detailed Description In some embodiments, the pet food compositions described herein provide multifactorial therapies based on nutritional dietary factors that (1) reduce allergenicity due to the use of hydrolyzed proteins, (2) provide readily digestible macronutrients, (3) provide glutaminyl amino acids that provide metabolic intermediates to intestinal epithelial cells, (4) provide immunomodulators that reduce inflammatory responses, and (5) provide microbial cell wall fractions that promote tolerance or hindgut commensal populations. In other embodiments, the pet food composition increases intestinal microbial production of metabolic end products of dietary polyphenols and/or enhances absorption of these dietary polyphenols into the systemic circulation. In some embodiments, the pet food compositions of the present invention comprise a matrix comprising a dietary component capable of providing the desired immune optimizing effect. In particular, the composition may comprise a matrix comprising an inert non-fermentable fiber source having polyphenols chemically or physically bonded thereto so as not to be readily digested or absorbed in the upper Gastrointestinal (GI) tract. In some embodiments, these fiber-bound polyphenols bypass the upper gastrointestinal tract and reach the colon of the animal intact. It is believed that the intestinal microorganisms metabolize the dietary fibers and in the process release polyphenols that bind the fibers. These newly released polyphenols are also subject to microbial metabolism, producing small biomolecules called "probiotics". The probiotics are absorbed and distributed throughout the colon, with pleiotropic effects therein, including immunomodulati