CN-121970847-A - Chinese herbal medicine feed additive for preventing and treating avian influenza and preparation method thereof

Abstract

The invention provides a Chinese herbal medicine feed additive for preventing and treating avian influenza and a preparation method thereof, belonging to the technical field of Chinese veterinary medicines. The Chinese herbal medicine feed additive for preventing and treating the avian influenza is prepared from the Chinese herbal medicines of cicada fungus, blackberry lily, arisaema cum bile, solidago, radix pseudostellariae, corious versicolor and liquorice as raw materials, is safe and nontoxic, can obviously inhibit proliferation of H9N2 subtype AIV in chick embryos under in vitro conditions, and has obvious antiviral effect. Meanwhile, the treatment effect on the avian influenza disease laying hen is remarkable, the death rate caused by the avian influenza is remarkably reduced, and the effective prevention of the avian influenza can be realized. The Chinese herbal medicine feed additive has great application potential in the aspect of treating and preventing the avian influenza.

Inventors

• YUAN KUICHAO
• WANG QINGFENG
• SUN HUAWEI
• HUANG FAMING
• SU WEI
• ZHANG WEIXI
• YAN WEI
• XIAO XUEGANG

Assignees

• 新蔡县动物疫病防疫检疫中心

Dates

Publication Date

20260505

Application Date

20260316

Claims (4)

1. 1. A Chinese herbal medicine feed additive for preventing and treating avian influenza is characterized by being prepared from the following raw materials, by weight, 20-40 parts of cordyceps cicadae, 20-40 parts of arisaema cum bile, 20-40 parts of solidago, 20-40 parts of blackberry lily, 20-40 parts of radix pseudostellariae, 20-40 parts of coriolus versicolor and 5-20 parts of liquorice.
2. 2. The Chinese herbal medicine feed additive for preventing and treating avian influenza according to claim 1, wherein the Chinese herbal medicine feed additive is prepared from the following raw materials, by weight, 30-40 parts of golden cicada fungus, 25-35 parts of arisaema cum bile, 25-35 parts of solidago, 30-40 parts of blackberry lily, 20-30 parts of radix pseudostellariae, 20-30 parts of coriolus versicolor and 10-20 parts of liquorice.
3. 3. The Chinese herbal medicine feed additive for preventing and treating avian influenza according to claim 1, wherein the Chinese herbal medicine feed additive is prepared from the following raw materials, by weight, 36 parts of cordyceps cicadae, 30 parts of arisaema cum bile, 28 parts of goldenrod, 32 parts of blackberry lily, 26 parts of radix pseudostellariae, 24 parts of corious versicolor and 14 parts of liquorice.
4. 4. The method for preparing the Chinese herbal medicine feed additive for preventing and treating avian influenza as claimed in claim 1, wherein the Chinese herbal medicine feed additive is prepared according to the following steps: (1) Weighing the raw materials of 20-40 parts of golden cicada, 20-40 parts of arisaema cum bile, 20-40 parts of solidago, 20-40 parts of blackberry lily, 20-40 parts of radix pseudostellariae, 20-40 parts of coriolus versicolor and 5-20 parts of liquorice, cleaning, drying, crushing and uniformly mixing to obtain the traditional Chinese medicine raw materials; (2) Adding 10-14 times of purified water into the traditional Chinese medicine raw materials, soaking for more than 30min, keeping a micro-boiling state for more than 2h after boiling with strong fire, filtering, separating a first decoction, adding 8-10 times of purified water into the dregs again, keeping the micro-boiling state for more than 1.5h after boiling with strong fire, filtering, separating a second decoction, adding 6-8 times of purified water into the dregs again, keeping the micro-boiling state for more than 1h after boiling with strong fire, filtering, separating a third decoction, combining the three decoctions, refrigerating and standing for 12h; (3) Filtering the decoction after standing, discarding the precipitate residue, and collecting clear filtrate for use; (4) Concentrating the clarified filtrate under reduced pressure at 60-70deg.C and-0.08 MPa to-0.1 MPa to obtain fluid extract with relative density of 1.15-1.25 at 60 deg.C; (5) Spray drying the fluid extract to obtain dry extract fine powder with water content below 5%; (6) Mixing anhydrous glucose and soluble starch according to a mass ratio of 2:1-1.5 as auxiliary materials, then mixing the dry extract fine powder and the auxiliary materials according to a mass ratio of 1:2-2.5, sieving with a 120-150 mesh sieve after uniform mixing, and obtaining the Chinese herbal medicine feed additive soluble powder.

Description

Chinese herbal medicine feed additive for preventing and treating avian influenza and preparation method thereof Technical Field The invention relates to the technical field of traditional Chinese veterinary medicines, in particular to a Chinese herbal medicine feed additive for preventing and treating avian influenza and a preparation method thereof. Background Avian influenza virus (avian influenza virus, AIV) is a highly infectious pathogen that can cause severe respiratory disease in poultry and wild birds. In recent years, the large-scale spread of avian influenza virus in the global area has attracted a great deal of attention, and brings serious threat to the aspects of poultry farming industry, public health safety, ecological environment and the like. The vaccine immunization is the most main and effective prevention means at present, but the injection from the vaccine to the production of protective antibody needs a long time, so that the problems of window period of antibody production after immunization and the like exist, more importantly, because the antigen variability of the AIV is strong, even different strains in the same serotype have larger difference, the vaccine protection period is short, more and more vaccine use problems exist during the breeding period, so that the immunization pressure is continuously present, the effectiveness of the vaccine is obviously reduced, and the prevention and control effect of the AIV is often influenced. These deficiencies necessitate the study of anti-AIV drugs, which can act both prophylactically and therapeutically to minimize the threat of AIV. At present, although some western antiviral drugs are used for preventing and treating avian influenza, the curative effect is not ideal. Therefore, there is an urgent need to find drugs with safe and effective anti-avian influenza virus effects. The traditional Chinese medicine is a unique medicine system with long history and abundant resources, and has great research and application potential. In addition, the application of traditional Chinese medicine in preventing and treating infectious diseases has been thousands of years, and plays an important role in resisting the newly appeared viral diseases. Disclosure of Invention (One) solving the technical problems Aiming at the defects of the prior art, the invention provides a Chinese herbal medicine feed additive for preventing and treating avian influenza and a preparation method thereof. (II) technical scheme In order to achieve the above purpose, the invention is realized by the following technical scheme: The invention provides a Chinese herbal medicine feed additive for preventing and treating avian influenza, which is prepared from the following raw materials, by weight, 20-40 parts of golden cicada fungus, 20-40 parts of arisaema cum bile, 20-40 parts of goldenrod herb, 20-40 parts of blackberry lily, 20-40 parts of radix pseudostellariae, 20-40 parts of coriolus versicolor and 5-20 parts of liquorice. Further, the Chinese herbal medicine feed additive is prepared from the following raw materials, by weight, 30-40 parts of golden cicada fungus, 25-35 parts of arisaema cum bile, 25-35 parts of solidago, 30-40 parts of blackberry lily, 20-30 parts of radix pseudostellariae, 20-30 parts of corious versicolor and 10-20 parts of liquorice. Further, the Chinese herbal medicine feed additive is prepared from the following raw materials, by weight, 36 parts of golden cicada fungus, 30 parts of arisaema cum bile, 28 parts of solidago, 32 parts of blackberry lily, 26 parts of radix pseudostellariae, 24 parts of corious versicolor and 14 parts of liquorice. Secondly, the invention also provides a preparation method of the Chinese herbal medicine feed additive for preventing and treating the avian influenza, and the Chinese herbal medicine feed additive is prepared according to the following steps: (1) Weighing the raw materials of 20-40 parts of golden cicada, 20-40 parts of arisaema cum bile, 20-40 parts of solidago, 20-40 parts of blackberry lily, 20-40 parts of radix pseudostellariae, 20-40 parts of coriolus versicolor and 5-20 parts of liquorice, cleaning, drying, crushing and uniformly mixing to obtain the traditional Chinese medicine raw materials; (2) Adding 10-14 times of purified water into the traditional Chinese medicine raw materials, soaking for more than 30min, keeping a micro-boiling state for more than 2h after boiling with strong fire, filtering, separating a first decoction, adding 8-10 times of purified water into the dregs again, keeping the micro-boiling state for more than 1.5h after boiling with strong fire, filtering, separating a second decoction, adding 6-8 times of purified water into the dregs again, keeping the micro-boiling state for more than 1h after boiling with strong fire, filtering, separating a third decoction, combining the three decoctions, refrigerating and standing for 12h; (3) Filtering the decoction after standing, d