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CN-121970848-A - Composite functional feed additive for pelteobagrus fulvidraco as well as preparation method and application thereof

CN121970848ACN 121970848 ACN121970848 ACN 121970848ACN-121970848-A

Abstract

The invention belongs to the technical field of feed additives, and discloses a pelteobagrus fulvidraco compound functional feed additive, a preparation method and application thereof. The invention creatively provides the multi-target and synergistic pelteobagrus fulvidraco compound functional feed additive by scientifically compounding the antibacterial peptide, the eucommia ulmoides extract, the eucalyptus essential oil and the sodium butyrate and assisting the carrier. The composite functional feed additive is not a simple superposition of functions of all components, but can systematically improve the health level and disease resistance of pelteobagrus fulvidraco through synergism from multiple layers such as pathogen inhibition, immunoregulation, antioxidation stress, intestinal barrier repair and the like, and can replace or reduce the use of antibiotics.

Inventors

  • SHI PENG
  • WANG LEI
  • YUAN BIAO

Assignees

  • 广东海锐生物技术有限公司

Dates

Publication Date
20260505
Application Date
20260120

Claims (10)

  1. 1. A feed additive comprises antibacterial peptide, eucommiae cortex extract, oleum Eucalypti, sodium butyrate and carrier.
  2. 2. The feed additive according to claim 1, wherein the antibacterial peptide comprises cecropin antibacterial peptide, and/or the carrier comprises at least one of rice hull powder, bran, peanut hull powder, corncob powder, zeolite powder, and diatomaceous earth.
  3. 3. The feed additive according to claim 2, wherein the amino acid sequence of the antibacterial peptide is shown in SEQ ID NO. 1.
  4. 4. A feed additive according to any one of claims 1-3, wherein the eucommia ulmoides extract is an aqueous extract of eucommia ulmoides leaves; preferably, the eucommia ulmoides extract is prepared by mixing eucommia ulmoides leaves with water and decocting to obtain the eucommia ulmoides extract.
  5. 5. A feed additive according to any one of claims 1 to 3, wherein the feed additive comprises 5 to 40 parts by mass of the antibacterial peptide, and/or The feed additive comprises 5-40 parts of eucommia ulmoides extract and/or The feed additive comprises 5-25 parts by mass of eucalyptus essential oil and/or The feed additive comprises 5-25 parts by mass of sodium butyrate and/or The feed additive comprises 5-80 parts of carrier by mass.
  6. 6. A method for preparing a feed additive according to any one of claims 1 to 5, comprising the step of mixing the antibacterial peptide, eucommia ulmoides extract, eucalyptus essential oil, sodium butyrate and a carrier to obtain the feed additive.
  7. 7. Use of a feed additive according to any one of claims 1-5 for the preparation of a feed.
  8. 8. A feed comprising the feed additive of any one of claims 1-5 and a basal feed; Preferably, the content of the feed additive in the feed is 0.5wt% to 1.5wt%; Preferably, the basic feed comprises fish meal, corn gluten meal, chicken meal, soybean meal, wheat starch, soybean oil, fish oil, monocalcium phosphate, vitamin premix and mineral premix.
  9. 9. Use of the feed additive of any one of claims 1-5 or the feed of claim 8 in aquaculture of aquatic animals.
  10. 10. Use of a feed additive according to any one of claims 1 to 5 or a feed according to claim 8 for the preparation of a product for improving the antibacterial ability and liver and intestine protecting function of an aquatic animal.

Description

Composite functional feed additive for pelteobagrus fulvidraco as well as preparation method and application thereof Technical Field The invention belongs to the technical field of feed additives, and particularly relates to a pelteobagrus fulvidraco compound functional feed additive, a preparation method and application thereof. Background Yellow catfish (Pelteobagrus fulvidraco), commonly called yellow bone fish and yellow spicy blocks, is a small-sized freshwater economic fish belonging to the genus yellow catfish of the family Cryptophannaceae, and is widely distributed in main water systems of Yangtze river, yellow river, zhujiang river and the like in China. The aquaculture feed is tender in meat quality, delicious in taste, free of intramuscular thorns, rich in amino acids and unsaturated fatty acids, high in nutritive value and important in special aquaculture varieties. Along with the expansion of market demands, the pelteobagrus fulvidraco breeding industry rapidly develops, the total national yield in 2020 reaches 56.54 ten thousand tons, and intensive and high-density breeding becomes a mainstream mode. Under the high-density cultivation condition, the primary problem faced by pelteobagrus fulvidraco is disease frequently. Because the body surface is free of scales, the skin barrier function is relatively weak, bacterial diseases such as septicemia, enteritis and the like caused by streptococcus, edwardsiella and the like are easily infected in a high-density stress environment, and the large-scale death is often caused, so that serious economic loss is caused. In addition, the general nonspecific health problems of 'body of flowers', 'rotten body', 'body abnormal body color', 'liver lesions' (such as yellow liver and green liver), dyspepsia and the like in the cultivation process also seriously affect the selling phase, quality and cultivation survival rate of commercial fishes. These problems are not only related to direct infection of pathogenic bacteria, but also are due to oxidative stress, immune function decline and liver and intestine function injury caused by high-density culture environment, and the three are related to each other to form vicious circle. Traditionally, farmers often rely on the addition of antibiotics to feed to prevent and treat bacterial diseases. However, the long-term and abusive use of antibiotics has resulted in enhanced drug resistance of pathogenic bacteria and reduced control effect, and simultaneously causes drug residues, threatens the safety of aquatic products and the health of consumers, and metabolic products of the antibiotics also pollute the water environment and destroy ecological balance. Therefore, the search for safe and efficient antibiotic alternatives has become an important direction in the development of aquatic feeds. At present, research on feed additives for healthy culture of pelteobagrus fulvidraco has been explored to some extent. Mainly comprises microecological preparation, antibacterial peptide, chinese herbal medicine and extracts thereof, plant essential oil, functional oligosaccharides and the like. However, the prior art scheme still has the following defects that 1) the function is single, the comprehensive challenges are difficult to cope with, most additives are focused on antibacterial, antioxidant or growth promotion, and the comprehensive health problems of pelteobagrus fulvidraco under high-density cultivation are difficult to solve through multi-target and multi-channel synergy such as antibacterial, antioxidant, liver protection, intestine strengthening, immunoregulation and the like. The diseases and health problems of pelteobagrus fulvidraco are often the result of multi-factor interweaving, and the effect of the additive with single function is limited. 2) The synergistic effect is unknown, the scientific compatibility is lacking, the prior art is mostly simple stacking of different functional substances, and the scientific compatibility and the synergistic mechanism between different components (such as antibacterial peptide, plant essential oil, plant extract and intestinal regulator) cannot be deeply explored. Simple physical mixing may not exert the effect of "1+1>2", and may even reduce efficacy due to antagonism. 3) The comprehensive protection of the liver and intestinal axis is insufficient, namely, the liver and the intestinal tract are core organs of fish body nutrition metabolism, immune defense, detoxification and toxin expelling, and are closely related and mutually influenced through the liver and intestinal axis. The existing scheme only pays attention to one aspect (such as protecting liver or strengthening intestine) and fails to form a systematic protection scheme for liver and intestine health, which is the core for solving the key problems of yellow catfish such as 'body of flowers', liver diseases, digestive disorder and the like. 4) The systemic regulation of antioxidant stress is deficient, whic