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CN-121970889-A - Edible fungus composition with intestinal flora regulating function and preparation method thereof

CN121970889ACN 121970889 ACN121970889 ACN 121970889ACN-121970889-A

Abstract

The invention is suitable for the technical field of health-care food, provides an edible fungus composition with intestinal flora regulating function and a preparation method thereof, the edible fungus composition comprises grifola frondosa polysaccharide, cordyceps militaris polysaccharide, ganoderma sinensis extract, hericium erinaceus polysaccharide, agaricus blazei polysaccharide, lentinan, pleurotus nebrodensis polysaccharide, white back fungus polysaccharide, agaricus bisporus polysaccharide and pachyman, and the proportion of the edible fungus composition is optimized based on 'monarch, minister, assistant and guide' theory. The preparation method comprises the steps of full-component stepped extraction of the ganoderma sinensis, functional guide grading extraction of other mushrooms and key gradient self-assembly process, wherein the method constructs composite particles with time sequence release characteristics through the gradient self-assembly process, realizes functional division of quick release of the upper digestive tract of an adjuvant and slow release of the intestinal tract of a monarch, achieves time sequence control of active ingredients, and has the effects of regulating immunity, improving intestinal flora and improving yang deficiency symptoms.

Inventors

  • LIU SHIZHU
  • WU XINCAN
  • Request for anonymity
  • FAN JIANDONG

Assignees

  • 浙江方格药业有限公司

Dates

Publication Date
20260505
Application Date
20260203

Claims (10)

  1. 1. The edible fungus composition with the intestinal flora regulating function is characterized by comprising the following active components in parts by weight: the principal medicine comprises 12-17 parts of grifola frondosa polysaccharide and 12-17 parts of cordyceps militaris polysaccharide; the ministerial components comprise 15-20 parts of ganoderma sinensis extract, 10-14 parts of hericium erinaceus polysaccharide and 8-12 parts of agaricus blazei polysaccharide; The adjuvant components comprise lentinan, pleurotus nebrodensis polysaccharide, white back fungus polysaccharide and agaricus bisporus polysaccharide, wherein each polysaccharide is 5-8 parts; The medicine composition includes pachyman 4-6 weight portions.
  2. 2. A method for preparing the edible fungus composition having an intestinal flora regulating function according to claim 1, comprising the steps of: s1, preparing a ganoderma sinensis extract; s2, preparing the fungus mushroom polysaccharide of monarch drug, adjuvant drug and messenger drug; S3, adopting a gradient self-assembly process, taking pachyman as a carrier matrix, firstly loading the lentinus edodes, the pleurotus nebrodensis, the white back fungus and the agaricus bisporus polysaccharide obtained in the step S2 on the outer layer of the carrier, then loading the ganoderma sinensis extract obtained in the step S1 and the grifola frondosa, the cordyceps militaris, the hericium erinaceus and the agaricus blazei polysaccharide obtained in the step S2 into the carrier, and drying to form composite particles.
  3. 3. The method for preparing an edible fungus composition with intestinal flora adjusting function according to claim 2, wherein in step S1, the method for preparing the ganoderma sinensis extract is as follows: Extracting Ganoderma raw material with supercritical CO 2 under 25-35MPa at 40-50deg.C to obtain liposoluble component; extracting the residue after extraction with hot water at 85-95deg.C for 2-3 hr, concentrating the extractive solution, and precipitating with ethanol to obtain water-soluble polysaccharide component; mixing the two components to obtain Ganoderma extract.
  4. 4. The method for preparing an edible fungus composition with intestinal flora adjusting function according to claim 2, wherein in step S2, the method for preparing the fungus polysaccharide of the monarch drug, the adjuvant drug and the messenger drug is as follows: extracting Maitake Mushroom and Cordyceps with 88-92 deg.C hot water; Extracting Lentinus Edodes, pleurotus nebrodensis, auricularia and Agaricus bisporus with 78-82 deg.C hot water; Extracting Poria with 68-72deg.C hot water; Concentrating the extractive solutions, concentrating with ultrafiltration membrane with molecular weight cut-off of 10-500 kDa, and drying to obtain refined polysaccharide of each mushroom.
  5. 5. The method for preparing an edible fungus composition having intestinal flora adjusting function according to claim 2, wherein the step S3 specifically comprises the steps of: S31, dissolving pachyman obtained in the step S2 and sodium alginate in water to form carrier liquid, and regulating the pH to 5.0-6.0; S32, adding the lentinus edodes, the pleurotus nebrodensis, the white back fungus and the agaricus bisporus polysaccharide obtained in the step S2 under stirring, adjusting the pH to 3.5-4.5, and adding a calcium ion source to form an adjuvant quick release layer; S33, adding the ganoderma sinensis extract obtained in the step S1 and the polysaccharide of grifola frondosa, cordyceps militaris, hericium erinaceus and agaricus blazei murill obtained in the step S2, adjusting the pH to 6.8-7.4, and adding sodium tripolyphosphate to form a monarch drug slow release core; And S34, finally, spray-drying the system to obtain the composite particles.
  6. 6. The method for preparing an edible fungus composition with intestinal flora adjusting function according to claim 5, wherein the weight ratio of pachyman to sodium alginate in step S31 is 3-8:1.
  7. 7. The method for preparing an edible fungus composition with intestinal flora adjusting function according to claim 5, wherein the calcium ion source in the step S32 is added in an amount of 5% -15% by weight of sodium alginate based on calcium ions.
  8. 8. The method for preparing an edible fungus composition with intestinal flora adjusting function according to claim 5, wherein the adding amount of sodium tripolyphosphate in the step S33 is 10% -20% of the weight of sodium alginate.
  9. 9. The method according to claim 5, wherein the solid content of the loading system is 15-20% before spray drying in step S34, the air inlet temperature of the spray drying is 150-170 ℃ and the air outlet temperature is 70-85 ℃.
  10. 10. Use of an edible fungus composition with intestinal flora regulating function according to claim 1 for the preparation of a product for regulating body immune function, improving intestinal flora structure, assisting in improving yang deficiency constitution or relieving physical fatigue.

Description

Edible fungus composition with intestinal flora regulating function and preparation method thereof Technical Field The invention belongs to the technical field of health-care foods, and particularly relates to an edible fungus composition based on the theoretical compatibility of monarch, minister, assistant and guide in traditional Chinese medicine and a systematic collaborative preparation method thereof. Background The edible fungi are rich in bioactive substances such as polysaccharide, polypeptide, triterpene, etc., and have various physiological functions such as immunoregulation, anti-tumor, antioxidation, etc. There are many health products on the market which mainly contain single or multiple edible fungus extracts, however, most of these products have the following disadvantages: (1) The formula design is based on simple superposition or experience combination of components, and lacks systematic theoretical guidance, so that the synergistic effect among the components is undefined, and the efficacy is single or limited; (2) The final product is mostly a physical mixture of extracts, and the release, absorption and action time sequence of each component in the body are difficult to control, which can influence the overall bioavailability and expected synergy logic. The application of the traditional Chinese medicine compound theory to edible fungi compatibility is a promising direction, but the key point is how to convert the theory into a product with a specific structure and function by a modern preparation technology, and the conventional extraction, mixing and granulating processes can not realize the ordered distribution of active ingredients in space and the controllable release in time sequence, so that the edible fungi compound preparation which can embody the essence of the traditional Chinese medicine compatibility and has innovative structure and release characteristics and the preparation method thereof are developed, and have important value. Disclosure of Invention The invention provides an edible fungus composition with an intestinal flora regulating function and a preparation method thereof, and aims to solve the problems. The invention is realized in such a way that the edible fungus composition with the intestinal flora regulating function comprises the following active components in parts by weight: the principal medicine comprises 12-17 parts of grifola frondosa polysaccharide and 12-17 parts of cordyceps militaris polysaccharide; the ministerial components comprise 15-20 parts of ganoderma sinensis extract, 10-14 parts of hericium erinaceus polysaccharide and 8-12 parts of agaricus blazei polysaccharide; The adjuvant components comprise lentinan, pleurotus nebrodensis polysaccharide, white back fungus polysaccharide and agaricus bisporus polysaccharide, wherein each polysaccharide is 5-8 parts; The medicine composition includes pachyman 4-6 weight portions. Preferably, the preparation method of the ganoderma sinensis extract comprises the following steps: Extracting Ganoderma sinensis raw material with supercritical CO 2 under 25-35 MPa at 40-50deg.C to obtain liposoluble component; Pulverizing (or rehydrating) the residue, adding purified water and complex enzyme for enzymolysis, extracting with hot water at 85-95deg.C (feed liquid ratio of 1:10-20 (w/v)) for 2-3 hr, concentrating the extractive solution, and precipitating with ethanol to obtain water-soluble polysaccharide component; Mixing the two parts to obtain a ganoderma extract, extracting fat-soluble essence by supercritical CO 2, extracting the residues by enzyme assisted hot water to obtain water-soluble polysaccharide, and combining to obtain the ganoderma extract with complete efficacy, wherein the weight ratio of the fat-soluble component to the water-soluble polysaccharide component in the ganoderma extract is preferably 1:3-1:5. Preferably, the preparation method of the fungus mushroom polysaccharide of the monarch drug, the adjuvant drug and the messenger drug comprises the following steps: extracting Maitake Mushroom and Cordyceps with 88-92 deg.C hot water; Extracting Lentinus Edodes, pleurotus nebrodensis, auricularia and Agaricus bisporus with 78-82 deg.C hot water; Extracting Poria with 68-72deg.C hot water; Concentrating the extractive solutions respectively, concentrating with ultrafiltration membrane with molecular weight cut-off of 10-500 kDa, ultrafiltering at transmembrane pressure of 0.1-0.3MPa, concentrating multiple of 1/8 of original volume, and drying to obtain refined polysaccharide of each mushroom. Aiming at the functional roles of different mushrooms in the compound, the differential optimal temperature (88-92 ℃ for monarch drugs, 78-82 ℃ for adjuvant drugs and 68-72 ℃ for guiding drugs) is adopted for extraction, and active polysaccharide fragments with target molecular weight (10-500 kDa) are enriched through membrane separation, so that the function-oriented enrichment is realized. The in