CN-121970903-A - Gamma-aminobutyric acid composition and preparation method and application thereof

Abstract

The invention provides a gamma-aminobutyric acid composition, a preparation method and application thereof, wherein the gamma-aminobutyric acid composition comprises, by mass, 5-10 parts of microcrystalline cellulose, 3-5 parts of gamma-aminobutyric acid, 1-2 parts of L-theanine, 0.05-0.1 part of vitamins, 2-5 parts of maltodextrin, 5-8 parts of modified binders and 0.1-5 parts of auxiliary agents, and the modified binders are products of the reaction of carboxymethyl cellulose and polyethylene glycol. The modified adhesive prepared by the green reaction is used as a component, so that the modified adhesive has good cohesiveness of carboxymethyl cellulose, excellent water solubility and stability of polyethylene glycol, good adhesion effect on a composition preparation and better affinity between components, thereby improving the stability of the composition, prolonging the shelf life of a product, facilitating the release and absorption of active ingredients, and ensuring the stable exertion of the tranquillizing and sleep-aiding effects.

Inventors

• CAO MENG
• GAO QIANG
• Tang Tongyi
• Xin Jiagang

Assignees

• 山东奥博生物科技有限公司

Dates

Publication Date

20260505

Application Date

20260210

Claims (9)

1. 1. The gamma-aminobutyric acid composition is characterized by comprising the following components in parts by weight: Microcrystalline cellulose 5-10 parts 3-5 Parts of gamma-aminobutyric acid L-theanine 1-2 parts 0.05-0.1 Part of vitamin Maltodextrin 2-5 parts 5-8 Parts of modified adhesive 0.1-5 Parts of auxiliary agent; the modified adhesive is a product of the reaction of carboxymethyl cellulose and polyethylene glycol.
2. 2. The gamma-aminobutyric acid composition of claim 1, wherein the vitamin comprises vitamin B6.
3. 3. The gamma-aminobutyric acid composition according to claim 1, wherein the auxiliary agent is one or more selected from the group consisting of flavors, colors, sweeteners, dispersants, lubricants, disintegrants.
4. 4. A process for producing a gamma-aminobutyric acid composition as claimed in any one of claims 1 to 3, characterized in that the process for producing a gamma-aminobutyric acid composition comprises the steps of: S1, mixing carboxymethyl cellulose, polyethylene glycol and a catalyst, heating and reacting to obtain a modified adhesive; S2, mixing the modified adhesive and other components, uniformly stirring, sieving and tabletting to obtain the gamma-aminobutyric acid composition.
5. 5. The method of preparing a gamma-aminobutyric acid composition according to claim 4, wherein the catalyst comprises phytic acid.
6. 6. The method for producing a gamma-aminobutyric acid composition according to claim 4, wherein the mass ratio of the carboxymethyl cellulose to the polyethylene glycol is 1 (0.5 to 3).
7. 7. The method for producing a gamma-aminobutyric acid composition according to claim 4, wherein the heating reaction is carried out at a temperature of 50 to 100 ℃ for a time of 4 to 8h.
8. 8. A gamma-aminobutyric acid composition according to any one of claims 1 to 3 for use in medicine.
9. 9. Use of the gamma-aminobutyric acid composition according to any one of claims 1 to 3 in health products.

Description

Gamma-aminobutyric acid composition and preparation method and application thereof Technical Field The invention relates to the technical field of health-care products, in particular to a gamma-aminobutyric acid composition and a preparation method and application thereof. Background Sleep disorders such as insomnia are increasingly common due to the acceleration of modern life rhythm, and a sleep-aiding formula taking gamma-aminobutyric acid (GABA) and vitamin B6 as cores is a mainstream research direction because of safety and independence. GABA can be used as central inhibitory neurotransmitter to calm and promote sleep, vitamin B6 can be used as synthetic coenzyme, and can participate in metabolism of human neurotransmitter, and the two can be compounded to realize synergistic sleep-promoting effect. In the preparation of the sleep-aiding formula, in addition to core efficacy components, the selection of auxiliary materials is important, for example, the adhesive has obvious influence on the molding effect, stability and solubility of the formula and the release efficiency of the active ingredients. At present, the conventional adhesives in the existing health care products and medical tablets mainly comprise carboxymethyl cellulose, starch, hydroxypropyl methyl cellulose and the like, however, the conventional adhesives have various defects such as slow dissolution speed of the carboxymethyl cellulose in water, easy formation of agglomerates, slow disintegration speed after formulation molding, difficult quick release of active ingredients and absorption by human bodies, influence on timely exertion of sleep-aiding efficacy, and the problems of high cost and unsatisfactory bonding effect of the hydroxypropyl methyl cellulose due to the fact that the starch has the problems of solubility, moisture absorption and insufficient bonding strength. Therefore, the conventional adhesive has the problems of insufficient stability and the like, is easily influenced by environmental factors such as temperature, humidity and the like in the storage process, causes the problems of cracking, deformation, deterioration and the like of the preparation, and reduces the storage stability of the product. Based on this, it is necessary to provide a new solution, so as to overcome the drawbacks existing in the prior art. Disclosure of Invention Based on the composition, the invention provides the gamma-aminobutyric acid composition, and the modified adhesive is prepared through green reaction to serve as a component, so that the modified adhesive has good cohesiveness of carboxymethyl cellulose, excellent water solubility and stability of polyethylene glycol, good adhesion effect on a composition preparation and better affinity between components, the stability of the composition is improved, the product is endowed with longer shelf life, the release and absorption of active ingredients are facilitated, and the stable exertion of the effects of tranquillization and sleep aiding is ensured. The invention aims at providing a gamma-aminobutyric acid composition, which comprises the following components in parts by weight: Microcrystalline cellulose 5-10 parts 3-5 Parts of gamma-aminobutyric acid L-theanine 1-2 parts 0.05-0.1 Part of vitamin Maltodextrin 2-5 parts 5-8 Parts of modified adhesive 0.1-5 Parts of auxiliary agent; the modified adhesive is a product of the reaction of carboxymethyl cellulose and polyethylene glycol. Further, the vitamins include vitamin B6. Further, the auxiliary agent is selected from one or more of essence, pigment, sweetener, dispersing agent, lubricant and disintegrating agent. Another object of the present invention is to provide a method for preparing the above-mentioned gamma-aminobutyric acid composition, comprising the steps of: S1, mixing carboxymethyl cellulose, polyethylene glycol and a catalyst, heating and reacting to obtain a modified adhesive; S2, mixing the modified adhesive and other components, uniformly stirring, sieving and tabletting to obtain the gamma-aminobutyric acid composition. Further, the catalyst comprises phytic acid. Further, the mass ratio of the carboxymethyl cellulose to the polyethylene glycol is 1 (0.5-3). Further, the temperature of the heating reaction is 50-100 ℃ and the time is 4-8 h. Another object of the present invention is to provide a pharmaceutical use of the above-mentioned gamma-aminobutyric acid composition. The invention also aims to provide an application of the gamma-aminobutyric acid composition in health care products. The invention has the following beneficial effects: The invention discloses a gamma-aminobutyric acid composition, which adopts gamma-aminobutyric acid, L-theanine, vitamin B6 and other substances as functional components, and plays roles of relieving anxiety, improving emotion, soothing nerves, tranquilizing and aiding sleep through the synergistic action of various active substances. Meanwhile, the modified adhesive is prepared