CN-121970918-A - Buccal tablet and preparation method thereof

CN121970918ACN 121970918 ACN121970918 ACN 121970918ACN-121970918-A

Abstract

The application belongs to the technical field of buccal tablets, and particularly relates to a buccal tablet and a preparation method thereof. The buccal tablet comprises a first supporting layer, an oil absorption layer and a second supporting layer which are sequentially laminated, wherein at least one of the first supporting layer and the second supporting layer is a water permeable layer, the oil absorption layer comprises an oil absorption matrix and oily liquid, and the oily liquid comprises oily base liquid and active substances and/or flavor substances dissolved in the oily base liquid. The oil absorption matrix can strongly absorb and lock the oily liquid by capillary action, thus preventing the oily liquid from leaking. The first support layer can also control the exudation rate of the active substance, and the synergistic effect of the first support layer and the second support layer ensures the stability of active substance release.

Inventors

HU ZHENG
ZHANG CHEN
Miao Xiushi
HE HAIBO
ZHANG BIN
YAN XINYANG
CHEN ZHICHAO

Assignees

爱奇迹创造有限公司

Dates

Publication Date: 20260505
Application Date: 20260202

Claims (10)

1. The buccal tablet is characterized by comprising a first supporting layer, an oil absorption layer and a second supporting layer which are sequentially laminated, wherein at least one of the first supporting layer and the second supporting layer is a water permeable layer, the oil absorption layer comprises an oil absorption matrix and oily liquid, and the oily liquid comprises oily base liquid and active substances and/or flavor substances dissolved in the oily base liquid; The oil absorption multiplying power of the oil absorption matrix is respectively larger than that of the first supporting layer and the second supporting layer.
2. The buccal tablet of claim 1 further comprising at least one water-absorbing layer disposed between the oil-absorbing layer and the water-permeable layer; The water absorption layer comprises a water absorption matrix, and the oil absorption multiplying power of the water absorption matrix is smaller than that of the oil absorption matrix.
3. A buccal tablet according to claim 2, wherein the water absorbing layer has a thickness of 0.1mm to 0.3mm, and/or, The water absorbing matrix is medical absorbent cotton.
4. A buccal tablet according to claim 1, wherein the active substance comprises at least one of nicotine and a nicotine derivative, and/or, The flavoring substance comprises at least one of essence, sweetener, cooling agent, salty agent and sour agent, and/or, The oily liquid may further comprise at least one of an antioxidant, a preservative, and/or, The oily base liquid comprises vegetable oil, the mass fraction of the vegetable oil in the oily liquid is not less than 20%, and/or, The oily liquid further comprises water, wherein the water content of the oily liquid is not less than 10%.
5. The buccal tablet according to any one of claims 1 to 4, wherein the first support layer and/or the second support layer is a nonwoven layer, and/or, The thickness of the first supporting layer and/or the second supporting layer is 0.14 mm-0.25 mm, and/or, The thickness of the oil absorption layer is 0.2 mm-0.4 mm, and/or, The oil absorption rate of the oil absorption matrix is 30 g/g-85 g/g, and/or, The oil retention rate of the oil absorption matrix is 95% -100%, and/or, The water content of the first support layer and the second support layer is not more than 3%, and/or, The material of the first supporting layer and/or the second supporting layer is viscose, and/or, The oil absorption matrix is made of modified polypropylene fiber non-woven fabrics.
6. The buccal tablet of claim 1 wherein the oil absorbing layer comprises at least two layers of the oil absorbing matrix.
7. The lozenge of claim 6, wherein an insulating layer is disposed between at least one pair of two of said oil absorbing substrates disposed adjacent thereto.
8. The buccal tablet of claim 1, further comprising a securing structure formed on a periphery of the buccal tablet.
9. A method for preparing buccal tablets according to any one of claims 1 to 8, comprising: Sequentially laminating the first supporting layer, the oil absorption layer and the second supporting layer, and pressing to obtain the buccal tablet; the oil absorption layer comprises an oil absorption matrix adsorbed with oily liquid, the oily liquid comprises oily base liquid and active substances and/or flavor substances dissolved in the oily base liquid, and the oil absorption multiplying power of the oil absorption matrix is respectively larger than that of the first supporting layer and the second supporting layer.
10. The method of claim 9, wherein the oil-absorbing layer comprises an oil-absorbing matrix having an oil-based liquid adsorbed thereon, and wherein injecting a fixed amount of the oil-based liquid into the oil-absorbing matrix to obtain the oil-absorbing layer.

Description

Buccal tablet and preparation method thereof Technical Field The application belongs to the technical field of buccal products, and particularly relates to a buccal tablet and a preparation method thereof. Background In the related art, the buccal tablet takes a coated composite film or a powder tablet as a main formulation, and the core is to release functional substances with activity or flavor through oral mucosa. The existing buccal tablet has the following defects that the coating composite film relies on the matrix to dissolve or swell to release active substances, so that the initial active substances are released quickly, the later active substances are released slowly, the concentration fluctuation is large, withdrawal symptoms cannot be continuously relieved, the matrix coating property is poor, the disintegration phenomenon is easy to occur during use, and the release stability of the active substances is further influenced. Therefore, developing a buccal tablet with a novel structure is a technical problem to be solved currently. Disclosure of Invention The application aims to provide a buccal tablet and a preparation method thereof, which are used for solving the problems of poor active substance release stability, poor onset speed and poor buccal tablet shape stability of the existing buccal tablet. In order to solve the technical problems, the application provides a buccal tablet, which comprises a first supporting layer, an oil absorption layer and a second supporting layer which are sequentially stacked, wherein at least one of the first supporting layer and the second supporting layer is a water permeable layer, the oil absorption layer comprises an oil absorption matrix and oily liquid, the oily liquid comprises an oily base liquid and active substances and/or flavor substances dissolved in the oily base liquid, and the oil absorption multiplying power of the oil absorption matrix is respectively larger than that of the first supporting layer and the second supporting layer. In one embodiment, the buccal tablet further comprises at least one water absorption layer, wherein the water absorption layer is arranged between the oil absorption layer and the water permeable layer, the water absorption layer comprises a water absorption matrix, and the oil absorption multiplying power of the water absorption matrix is smaller than that of the oil absorption matrix. In one embodiment, the thickness of the water absorbing layer is 0.1 mm-0.3 mm, and/or the water absorbing matrix is medical absorbent cotton. In one embodiment, the active substance comprises at least one of nicotine and nicotine derivatives, and/or the flavoring substance comprises at least one of essence, sweetener, cooling agent, salty agent, and sour agent, and/or the oily liquid further comprises at least one of antioxidant and antiseptic, and/or the oily base liquid comprises vegetable oil with mass fraction of not less than 20% in the oily liquid, and/or the oily liquid further comprises water, wherein the water content of the oily liquid is not less than 10%. In one embodiment, the first support layer and/or the second support layer are/is a non-woven fabric layer, and/or the thickness of the first support layer and/or the second support layer is 0.14 mm-0.25 mm, and/or the thickness of the oil absorption layer is 0.2 mm-0.4 mm, and/or the oil absorption multiplying power of the oil absorption matrix is 30 g/g-85 g/g, and/or the oil retention rate of the oil absorption matrix is 95% -100%, and/or the water content of the first support layer and/or the second support layer is not more than 3%, and/or the material of the first support layer and/or the second support layer is viscose fiber, and/or the material of the oil absorption matrix is modified polypropylene fiber non-woven fabric. In one embodiment, the oil absorbing layer comprises at least two layers of the oil absorbing matrix. In one embodiment, an isolation layer is disposed between at least one pair of two adjacent oil absorbing substrates. In one embodiment, the buccal tablet further comprises a fixing structure formed on the periphery of the buccal tablet. The application also provides a preparation method of the buccal tablet, which comprises the steps of sequentially laminating a first supporting layer, an oil absorption layer and a second supporting layer, and obtaining the buccal tablet after pressing, wherein the oil absorption layer comprises an oil absorption matrix adsorbed with oily liquid, the oily liquid comprises oily base liquid and active substances and/or flavor substances dissolved in the oily base liquid, and the oil absorption multiplying power of the oil absorption matrix is respectively larger than that of the first supporting layer and that of the second supporting layer. In one embodiment, the oil absorption layer comprises an oil absorption matrix with an oil liquid adsorbed thereon, and the method comprises injecting a quantitative amount of