Search

CN-121971019-A - Capsule probe for noninvasively measuring duodenal calcium absorption rate and application thereof

CN121971019ACN 121971019 ACN121971019 ACN 121971019ACN-121971019-A

Abstract

The invention discloses a capsule probe for noninvasively measuring the duodenal calcium absorption rate and application thereof, wherein the head part of a capsule body is provided with a detection module, the middle part of the capsule body is provided with a fixing module, the tail part of the capsule body is provided with a medicine storage cavity, and the inside of the capsule body is provided with a control module; the device comprises a detection module, a fixing module, a control module and a flow control unit, wherein a sustained release opening is formed in the top of the detection module, the fixing module comprises a balloon and an inflation assembly, a position sensing assembly is arranged on the outer surface of the balloon, and the control module comprises a power supply module, a data processing module and a flow control unit. The invention adopts the cooperation of the pH and the pressure sensor as the position sensing component to identify the duodenum, and combines the saccule driven by the micro air pump to carry out physical fixation, thereby ensuring that the detection occurs at an accurate anatomical position, ensuring that the probe position is stable during the whole detection period, and avoiding the measurement error caused by the displacement of the probe or the too fast passage due to the intestinal peristalsis.

Inventors

  • YU YIKANG
  • LV GUIYUAN
  • GAO SHIYU
  • CHEN SUHONG
  • SU JIE
  • Zhou Hengpu

Assignees

  • 浙江中医药大学

Dates

Publication Date
20260505
Application Date
20260313

Claims (9)

  1. 1. A capsule probe for noninvasively measuring the duodenal calcium absorption rate comprises a capsule body and is characterized in that a detection module is arranged at the head part of the capsule body, a fixing module is arranged at the middle part of the capsule body, a medicine storage cavity (7) is arranged at the tail part of the capsule body, and a control module is arranged in the capsule body; The detection module comprises a photosensitive sensor (2) and a resistance sensor (3), and a slow release opening (8) is arranged at the top of the resistance sensor (3); The fixing module comprises a balloon (4) and an inflation assembly (5), wherein the outer surface of the balloon (4) is provided with a position sensing assembly (6), the inflation assembly (5) comprises a miniature air pump (12), an air port of the miniature air pump (12) is connected with the balloon (4), and a one-way valve (13) is arranged at the air port of the miniature air pump (12); The control module comprises a power supply module (11), a data processing module (10) and a flow control unit (9), wherein the data processing module (10) is electrically connected with the detection module, the position sensing assembly (6), the inflation assembly (5) and the flow control unit (9), and the power supply module (11) supplies power for the data processing module (10), the detection module, the position sensing assembly (6), the inflation assembly (5) and the flow control unit (9).
  2. 2. The capsule probe according to claim 1, wherein the position sensing assembly (6) comprises a pH sensor (15) and a pressure sensor (16), and the capsule probe is cooperatively judged whether the capsule probe reaches the duodenum by detecting the pH value and peristaltic pressure in the intestinal tract.
  3. 3. The capsule probe according to claim 1, wherein the photosensitive sensor (2) is a high-sensitivity silicon-based photodiode with a detection wavelength range of 510-520nm, and the resistance sensor (3) is a platinum electrode.
  4. 4. The capsule probe according to claim 1, wherein the inflation pressure of the micro air pump (12) is 0.02-0.05MPa.
  5. 5. The capsule probe according to claim 1, wherein the drug storage cavity (7) is loaded with a fluorescent calcium-containing agent.
  6. 6. The capsule probe according to claim 5, wherein the flow control unit (9) controls the release rate of the fluorescent calcium-containing agent to be 0.1-0.5 mL/h.
  7. 7. The capsule probe according to claim 1, wherein the capsule body is externally provided with a capsule housing (1).
  8. 8. A method for determining the rate of duodenal calcium absorption using the capsule probe of any one of claims 1-7, comprising the steps of: S1, injecting a fluorescent calcium-containing agent into a medicine storage cavity (7) of the capsule probe, and then delivering the capsule probe into the alimentary canal of an object to be detected; S2, judging whether the capsule probe reaches the duodenal area through the position sensing assembly (6), and expanding the balloon (4) through the inflation assembly (5) when the capsule probe reaches the duodenal area, so as to fix the probe on the duodenal wall; s3, starting the flow control unit (9) to release the fluorescent calcium-containing agent into the duodenum at a constant rate; s4, detecting the decay rate of the fluorescence intensity in the capsule through the photosensitive sensor (2) and detecting the change of the resistance value of the solution in the duodenum through the resistance sensor (3) simultaneously or after releasing the fluorescence-containing calcium agent; And S5, calculating and obtaining the duodenal calcium absorption rate based on the fluorescence intensity attenuation rate and the resistance value change.
  9. 9. Use of a capsule probe according to any one of claims 1-7 for the manufacture of a medical device for diagnosing or assessing diseases related to calcium malabsorption.

Description

Capsule probe for noninvasively measuring duodenal calcium absorption rate and application thereof Technical Field The invention relates to the technical field of biomedical detection, in particular to a capsule probe for noninvasively measuring the duodenal calcium absorption rate and application thereof. Background The accurate measurement of the duodenal calcium absorption rate has important clinical significance for diagnosing and evaluating the treatment effect of calcium metabolism related diseases (such as osteoporosis, parathyroid dysfunction and the like). At present, the existing duodenal calcium absorption rate measuring method has the defects that the fluorescent attenuation rate measuring method under the anatomical direct vision is gold standard, but belongs to invasive detection, an experimental animal or a patient needs to be subjected to invasive or endoscopic operation, the wound is large, the repeatability is poor, dynamic real-time monitoring cannot be realized, the conventional blood biochemical index detecting method can only indirectly reflect the whole condition of calcium absorption, the accurate positioning to the duodenal part cannot be realized, the time resolution and the spatial resolution are low, part of non-invasive detecting devices lack of effective intestinal fixing mechanisms and are easily taken away by intestinal peristalsis, the detecting part deviates from a target area, the accuracy of a detecting result is difficult to ensure, and meanwhile, most detecting devices only adopt a single detecting mode, and the problems of large detecting error, weak anti-interference capability and the like exist. Therefore, developing a device that can realize noninvasive, accurate, real-time positioning to the duodenum and cooperatively detect the calcium absorption rate through multiple parameters becomes a technical problem to be solved in the art. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a capsule probe for noninvasively measuring the duodenal calcium absorption rate and application thereof, which realize accurate fixation of the duodenal part and multi-parameter cooperative detection and improve the accuracy and noninvasive property of calcium absorption rate measurement. In order to achieve the above purpose, the invention adopts the following technical scheme: The invention provides a capsule probe for noninvasively measuring duodenal calcium absorption rate, which comprises a capsule body, wherein the head part of the capsule body is provided with a detection module, the middle part of the capsule body is provided with a fixing module, the tail part of the capsule body is provided with a medicine storage cavity, and the inside of the capsule body is provided with a control module; The detection module comprises a photosensitive sensor and a resistance sensor, and a slow release opening is arranged at the top of the resistance sensor; the fixing module comprises a balloon and an inflation assembly, wherein the outer surface of the balloon is provided with a position sensing assembly, the inflation assembly comprises a micro air pump, an air port of the micro air pump is connected with the balloon, and a one-way valve is arranged at the air port of the micro air pump; the control module comprises a power supply module, a data processing module and a flow control unit, wherein the data processing module is electrically connected with the detection module, the position sensing assembly, the inflation assembly and the flow control unit, and the power supply module supplies power for the data processing module, the detection module, the position sensing assembly, the inflation assembly and the flow control unit. Further, the position sensing assembly comprises a pH sensor and a pressure sensor, and whether the capsule probe reaches the duodenum is judged through detecting the pH value and peristaltic pressure in the intestinal tract in a cooperative mode. Further, the photosensitive sensor is a high-sensitivity silicon-based photodiode, the detection wavelength range of the photosensitive sensor is 510-520nm, and the resistance sensor is a platinum electrode. Further, the inflation pressure of the miniature air pump is 0.02-0.05MPa. Further, the medicine storage cavity is loaded with a fluorescent calcium-containing agent. Further, the flow control unit controls the release rate of the fluorescent calcium-containing agent to be 0.1-0.5 mL/h. Further, a capsule housing is provided outside the capsule body. In a second aspect, the present invention provides a method for determining the duodenal calcium absorption rate using the capsule probe described above, comprising the steps of: s1, injecting a fluorescent calcium-containing agent into a medicine storage cavity of the capsule probe, and then delivering the capsule probe into a digestive tract of an object to be detected; S2, judging whether the capsule probe reaches the duodenal area